Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress

Science Signaling

Volumn 5, Issue 227, 2012, Pages

  Kruiswijk, Flore ^a   Yuniati, Laurensia ^a   Magliozzi, Roberto ^a   Low, Teck Yew ^b,c   Lim, Ratna ^a   Bolder, Renske ^a   Mohammed, Shabaz ^b,c   Proud, Christopher G ^d   Heck, Albert J R ^b,c   Pagano, Michele ^e,f   Guardavaccaro, Daniele ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; DNA; ELONGATION FACTOR 2; ELONGATION FACTOR 2 KINASE; EUKARYOTIC ELONGATION FACTOR 2 KINASE; PROTEASOME; SERINE; SKP1 CUL1 F BOX PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; MUTAGENIC AGENT;

ARTICLE; AUTOPHOSPHORYLATION; CELL CYCLE CHECKPOINT; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; ENZYME ACTIVATION; GENE SILENCING; GENOTOXIC STRESS; HUMAN; HUMAN CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RIBOSOME; STRESS; TRANSLATION REGULATION; UBIQUITINATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS;

ADENYLATE KINASE; DNA DAMAGE; ELONGATION FACTOR 2 KINASE; ENZYME ACTIVATION; MUTAGENS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; STRESS, PHYSIOLOGICAL;

EID: 84862116855     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002718     Document Type: Article

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