A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses

Autophagy

Volumn 5, Issue 3, 2009, Pages 393-396

  Benedicte F ^a   Boyce, Michael ^a,b   Yuan, Junying ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autophagy; eEF 2; eEF 2K; eIF2 ; ER stress; Starvation

Indexed keywords

ELONGATION FACTOR 2 KINASE; INITIATION FACTOR 2ALPHA;

ARTICLE; AUTOPHAGY; CALCIUM TRANSPORT; CELL STRESS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STARVATION;

EUKARYOTA;

EID: 65249084046     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.3.7762     Document Type: Article

References (26)

1. Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 2006; 34:7-11.
2. Hinnebusch A. Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. In: Sonenberg N, Hershey JWB, Mathews MB, (ed). Translational control of gene expression. Cold Spring Harbor Laboratory Press: Cold Spring Harbor 2000; 185-244.
3. Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, et al. Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2α phosphorylation and translation of a small upstream open reading frame. J Biol Chem 2002; 277:2050-8.
4. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000; 6:1099-108.
5. Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 2000; 154:787-801.
6. Williams BR. PKR; a sentinel kinase for cellular stress. Oncogene 1999; 18:6112-20.
7. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5:897-904.
8. Chen JJ. Heme-regulated eIF2α kinase. In: Sonenberg N, Hershey JWB, Mathews M.B. (ed). Translational Control of Gene Expression. Cold Spring Harbor Laboratory Press: Cold Spring Harbor 2000; 529-46.
9. Tallóczy Z, Jiang W, Virgin HW IV, Leib DA, Scheuner D, Kaufman RJ, et al. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc Natl Acad Sci USA 2002; 99:190-5.
10. Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, et al. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 2007; 14:230-9.
11. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, et al. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 2005; 307:935-9.
12. Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, Ma D, et al. A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Cell Death Differ 2008; 15:589-99.
13. Merrick WC and Nyborg J. The Protein Biosynthesis Elongation Cycle. In: Sonenberg N, Hershey JWB, Mathews MB, (ed). Translational Control of Gene Expression. Cold Spring Harbor Laboratory Press: Cold Spring Harbor 2000; 89-126.
14. Nairn AC, Palfrey HC. Identification of the major Mr 100,000 substrate for calmodulin- dependent protein kinase III in mammalian cells as elongation factor-2. J Biol Chem 1987; 262:17299-303.
15. Ryazanov AG, Davydova EK. Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation. FEBS Lett 1989;251:187-90.
16. Ryazanov AG, Shestakova EA, Natapov PG. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature 1988; 334:170-3.
17. Ryazanov AG. Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett 2002; 514:26-9.
18. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001;7:1165-76.
19. Wu H, Yang JM, Jin S, Zhang H, Hait WN. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 2006; 66:3015-23.
20. Hait WN, Wu H, Jin S, Yang JM. Elongation factor-2 kinase: its role in protein synthesis and autophagy. Autophagy 2006; 2:294-6.
21. 2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells. Biochem Biophys Res Commun 1991; 180:1372-6.
22. Parmer TG, Ward MD, Yurkow EJ, Vyas VH, Kearney TJ, Hait WN. Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer. Br J Cancer 1999; 79:59-64.
23. Arora S, Yang JM, Kinzy TG, Utsumi R, Okamoto T, Kitayama T, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res 2003; 63:6894-9.
24. Parmer TG, Ward MD, Hait WN. Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability and cell cycle distribution in malignant glioma cells. Cell Growth Differ 1997; 8:327-34.
25. Yorimitsu T, Nair U, Yang Z, Klionsky DJ. Endoplasmic reticulum stress triggers autophagy. J Biol Chem 2006; 281:30299-304.
26. Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26:9220-31.