Ribosomal stress activates eEF2K-eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

Nucleic Acids Research

Volumn 42, Issue 10, 2014, Pages 12668-12680

  Gismondi, Angelo ^a   Caldarola, Sara ^a   Lisi, Gaia ^a   Juli, Giada ^a   Chellini, Lidia ^a   Iadevaia, Valentina ^b   Proud, Christopher G ^b   Loreni, Fabrizio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR 2; ELONGATION FACTOR 2 KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PYRIMIDINE; TERMINAL OLIGOPYRIMIDINE; UNCLASSIFIED DRUG; EEF2K PROTEIN, HUMAN; EUKARYOTIC PEPTIDE INITIATION FACTOR-1A; INITIATION FACTOR 1; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; RIBOSOME PROTEIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL STRESS; CONTROLLED STUDY; HUMAN; HUMAN CELL; POLYSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RIBOSOMAL STRESS; RIBOSOME; TRANSLATION ELONGATION; TRANSLATION REGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; RNA TRANSLATION; TERMINAL OLIGOPYRIMIDINE TRACT; TUMOR CELL LINE;

EUKARYOTA;

CELL LINE, TUMOR; ELONGATION FACTOR 2 KINASE; EUKARYOTIC INITIATION FACTOR-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MULTIPROTEIN COMPLEXES; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDE ELONGATION FACTOR 2; POLYRIBOSOMES; RIBOSOMAL PROTEINS; RIBOSOMES; RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES;

EID: 84923882251     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku996     Document Type: Article

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