Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

Biochemical Journal

Volumn 465, Issue , 2015, Pages 227-238

  Knight, John R P ^a   Bastide, Amandine ^a   Roobol, Anne ^b   Roobol, Jo ^b   Jackson, Thomas J ^a   Utami, Wahyu ^a   Barrett, David A ^c   Smales, C Mark ^b   Willis, Anne E ^a  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Calcium; Cold shock; Eukaryotic elongation factor 2 (eEF2); Eukaryotic elongation factor 2 kinase (eEF2K); Hypothermia; Protein synthesis

Indexed keywords

ADENOSINE PHOSPHATE; CALCIUM ION; CALMODULIN; ELONGATION FACTOR 2; ELONGATION FACTOR 2 KINASE; INITIATION FACTOR 2; ADENOSINE TRIPHOSPHATE; CALCIUM; EEF2K PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ARTICLE; CALCIUM TRANSPORT; COLD STRESS; CONTROLLED STUDY; COOLING; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAMMAL CELL; METABOLIC RATE; POLYSOME; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RIBOSOME; COLD SHOCK RESPONSE; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RNA TRANSLATION;

EUKARYOTA;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; CALCIUM; COLD-SHOCK RESPONSE; ELONGATION FACTOR 2 KINASE; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PHOSPHORYLATION;

EID: 84920558510     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141014     Document Type: Article

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