메뉴 건너뛰기




Volumn 54, Issue , 2014, Pages 90-93

Naive T cells: The crux of cellular immune aging?

Author keywords

Aging; Function; Homeostasis; Na ve T cells; Priming; TCR repertoire; Thymus

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84898826928     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.01.003     Document Type: Review
Times cited : (87)

References (48)
  • 2
    • 60549106099 scopus 로고    scopus 로고
    • Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice
    • Ahmed M., Lanzer K.G., Yager E.J., Adams P.S., Johnson L.L., Blackman M.A. Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J. Immunol. 2009, 182:784-792.
    • (2009) J. Immunol. , vol.182 , pp. 784-792
    • Ahmed, M.1    Lanzer, K.G.2    Yager, E.J.3    Adams, P.S.4    Johnson, L.L.5    Blackman, M.A.6
  • 6
    • 84856844011 scopus 로고    scopus 로고
    • Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
    • Decman V., Laidlaw B.J., Doering T.A., Leng J., Ertl H.C., Goldstein D.R., Wherry E.J. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J. Immunol. 2012, 188:1933-1941.
    • (2012) J. Immunol. , vol.188 , pp. 1933-1941
    • Decman, V.1    Laidlaw, B.J.2    Doering, T.A.3    Leng, J.4    Ertl, H.C.5    Goldstein, D.R.6    Wherry, E.J.7
  • 14
    • 0037083612 scopus 로고    scopus 로고
    • Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
    • Foulds K.E., Zenewicz L.A., Shedlock D.J., Jiang J., Troy A.E., Shen H. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J. Immunol. 2002, 168:1528-1532.
    • (2002) J. Immunol. , vol.168 , pp. 1528-1532
    • Foulds, K.E.1    Zenewicz, L.A.2    Shedlock, D.J.3    Jiang, J.4    Troy, A.E.5    Shen, H.6
  • 15
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14:428-436.
    • (2013) Nat. Immunol. , vol.14 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2
  • 18
    • 84877016468 scopus 로고    scopus 로고
    • Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses
    • Jiang J., Fisher E.M., Murasko D.M. Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses. Exp. Gerontol. 2013, 48:579-586.
    • (2013) Exp. Gerontol. , vol.48 , pp. 579-586
    • Jiang, J.1    Fisher, E.M.2    Murasko, D.M.3
  • 19
    • 84871835297 scopus 로고    scopus 로고
    • Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age
    • Johnson P.L., Yates A.J., Goronzy J.J., Antia R. Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:21432-21437.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 21432-21437
    • Johnson, P.L.1    Yates, A.J.2    Goronzy, J.J.3    Antia, R.4
  • 20
    • 10344257508 scopus 로고    scopus 로고
    • Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
    • Khan N., Hislop A., Gudgeon N., Cobbold M., Khanna R., Nayak L., Rickinson A.B., Moss P.A. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 2004, 173:7481-7489.
    • (2004) J. Immunol. , vol.173 , pp. 7481-7489
    • Khan, N.1    Hislop, A.2    Gudgeon, N.3    Cobbold, M.4    Khanna, R.5    Nayak, L.6    Rickinson, A.B.7    Moss, P.A.8
  • 22
    • 33646161724 scopus 로고    scopus 로고
    • Human cytomegalovirus infection and T cell immunosenescence: a mini review
    • Koch S., Solana R., Dela Rosa O., Pawelec G. Human cytomegalovirus infection and T cell immunosenescence: a mini review. Mech. Ageing Dev. 2006, 127:538-543.
    • (2006) Mech. Ageing Dev. , vol.127 , pp. 538-543
    • Koch, S.1    Solana, R.2    Dela Rosa, O.3    Pawelec, G.4
  • 23
    • 59649094871 scopus 로고    scopus 로고
    • + T-cell subsets
    • + T-cell subsets. Blood 2009, 113:769-774.
    • (2009) Blood , vol.113 , pp. 769-774
    • Kohler, S.1    Thiel, A.2
  • 24
    • 84856822945 scopus 로고    scopus 로고
    • Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses
    • Lachmann R., Bajwa M., Vita S., Smith H., Cheek E., Akbar A., Kern F. Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses. J. Virol. 2012, 86:1001-1009.
    • (2012) J. Virol. , vol.86 , pp. 1001-1009
    • Lachmann, R.1    Bajwa, M.2    Vita, S.3    Smith, H.4    Cheek, E.5    Akbar, A.6    Kern, F.7
  • 25
    • 79955955068 scopus 로고    scopus 로고
    • Impact of age on T cell signaling: a general defect or specific alterations?
    • Larbi A., Pawelec G., Wong S.C., Goldeck D., Tai J.J., Fulop T. Impact of age on T cell signaling: a general defect or specific alterations?. Ageing Res. Rev. 2011, 10:370-378.
    • (2011) Ageing Res. Rev. , vol.10 , pp. 370-378
    • Larbi, A.1    Pawelec, G.2    Wong, S.C.3    Goldeck, D.4    Tai, J.J.5    Fulop, T.6
  • 27
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li G., Yu M., Lee W.W., Tsang M., Krishnan E., Weyand C.M., Goronzy J.J. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 2012, 18:1518-1524.
    • (2012) Nat. Med. , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 28
    • 84868210702 scopus 로고    scopus 로고
    • Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    • Li G., Smithey M.J., Rudd B.D., Nikolich-Zugich J. Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 2012, 11:968-977.
    • (2012) Aging Cell , vol.11 , pp. 968-977
    • Li, G.1    Smithey, M.J.2    Rudd, B.D.3    Nikolich-Zugich, J.4
  • 29
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 2004, 5:133-139.
    • (2004) Nat. Immunol. , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 31
    • 22544459957 scopus 로고    scopus 로고
    • The unmet need in the elderly: designing new influenza vaccines for older adults
    • McElhaney J.E. The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine 2005, 23(Suppl. 1):S10-S25.
    • (2005) Vaccine , vol.23 , Issue.SUPPL. 1
    • McElhaney, J.E.1
  • 33
    • 71849099712 scopus 로고    scopus 로고
    • Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen
    • Moretto M.M., Lawlor E.M., Khan I.A. Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen. J. Immunol. 2008, 181:7977-7984.
    • (2008) J. Immunol. , vol.181 , pp. 7977-7984
    • Moretto, M.M.1    Lawlor, E.M.2    Khan, I.A.3
  • 35
    • 46249132015 scopus 로고    scopus 로고
    • Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    • Nikolich-Zugich J. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat. Rev. Immunol. 2008, 8:512-522.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 512-522
    • Nikolich-Zugich, J.1
  • 36
    • 44649127931 scopus 로고    scopus 로고
    • + T cell precursor frequency regulates primary and memory responses to infection
    • + T cell precursor frequency regulates primary and memory responses to infection. Immunity 2008, 28:859-869.
    • (2008) Immunity , vol.28 , pp. 859-869
    • Obar, J.J.1    Khanna, K.M.2    Lefrancois, L.3
  • 41
    • 23944501611 scopus 로고    scopus 로고
    • Signal transduction in the aging immune system
    • Sadighi Akha A.A., Miller R.A. Signal transduction in the aging immune system. Curr. Opin. Immunol. 2005, 17:486-491.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 486-491
    • Sadighi Akha, A.A.1    Miller, R.A.2
  • 44
    • 0036198778 scopus 로고    scopus 로고
    • T cell receptor excision circle assessment of thymopoiesis in aging mice
    • Sempowski G.D., Gooding M.E., Liao H.X., Le P.T., Haynes B.F. T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol. Immunol. 2002, 38:841-848.
    • (2002) Mol. Immunol. , vol.38 , pp. 841-848
    • Sempowski, G.D.1    Gooding, M.E.2    Liao, H.X.3    Le, P.T.4    Haynes, B.F.5
  • 47
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
    • Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F.G. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 1998, 102:187-198.
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 187-198
    • Wikby, A.1    Maxson, P.2    Olsson, J.3    Johansson, B.4    Ferguson, F.G.5
  • 48
    • 41149170727 scopus 로고    scopus 로고
    • Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    • Yager E.J., Ahmed M., Lanzer K., Randall T.D., Woodland D.L., Blackman M.A. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 2008, 205:711-723.
    • (2008) J. Exp. Med. , vol.205 , pp. 711-723
    • Yager, E.J.1    Ahmed, M.2    Lanzer, K.3    Randall, T.D.4    Woodland, D.L.5    Blackman, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.