메뉴 건너뛰기




Volumn 37, Issue 4, 2015, Pages 914-923

The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis

Author keywords

atherosclerosis; epigenetic modifications; inflammation; monocytes

Indexed keywords

CYTOKINE;

EID: 84939938448     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2015.01.008     Document Type: Review
Times cited : (57)

References (70)
  • 2
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 3
    • 84904730036 scopus 로고    scopus 로고
    • PET imaging of inflammation in atherosclerosis
    • J.M. Tarkin, F.R. Joshi, and J.H. Rudd PET imaging of inflammation in atherosclerosis Nat Rev Cardiol 11 2014 443 457
    • (2014) Nat Rev Cardiol , vol.11 , pp. 443-457
    • Tarkin, J.M.1    Joshi, F.R.2    Rudd, J.H.3
  • 4
    • 34250671221 scopus 로고    scopus 로고
    • Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease
    • V.A. Triant, H. Lee, C. Hadigan, and S.K. Grinspoon Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease J Clin Endocrinol Metab 92 2007 2506 2512
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2506-2512
    • Triant, V.A.1    Lee, H.2    Hadigan, C.3    Grinspoon, S.K.4
  • 5
    • 84987896973 scopus 로고    scopus 로고
    • Cardiovascular risk in rheumatoid arthritis: Recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment
    • E. Choy, K. Ganeshalingam, and A.G. Semb Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment Rheumatology (Oxford) 53 2014 2143 2154
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 2143-2154
    • Choy, E.1    Ganeshalingam, K.2    Semb, A.G.3
  • 6
    • 84904543855 scopus 로고    scopus 로고
    • Anti-inflammatory therapies for cardiovascular disease
    • P.M. Ridker, and T.F. Luscher Anti-inflammatory therapies for cardiovascular disease Eur Heart J 35 2014 1782 1791
    • (2014) Eur Heart J , vol.35 , pp. 1782-1791
    • Ridker, P.M.1    Luscher, T.F.2
  • 7
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • I. Tabas, K.J. Williams, and J. Boren Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications Circulation 116 2007 1832 1844
    • (2007) Circulation , vol.116 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Boren, J.3
  • 8
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis. the road ahead
    • C.K. Glass, and J.L. Witztum Atherosclerosis. the road ahead Cell 104 2001 503 516
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 9
    • 0032572719 scopus 로고    scopus 로고
    • Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    • L. Boring, J. Gosling, M. Cleary, and I.F. Charo Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis Nature 394 1998 894 897
    • (1998) Nature , vol.394 , pp. 894-897
    • Boring, L.1    Gosling, J.2    Cleary, M.3    Charo, I.F.4
  • 10
    • 84855928422 scopus 로고    scopus 로고
    • The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    • J.M. van Gils, M.C. Derby, and L.R. Fernandes The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques Nat Immunol 13 2012 136 143
    • (2012) Nat Immunol , vol.13 , pp. 136-143
    • Van Gils, J.M.1    Derby, M.C.2    Fernandes, L.R.3
  • 11
    • 72949116358 scopus 로고    scopus 로고
    • Macrophage death and defective inflammation resolution in atherosclerosis
    • I. Tabas Macrophage death and defective inflammation resolution in atherosclerosis Nat Rev Immunol 10 2010 36 46
    • (2010) Nat Rev Immunol , vol.10 , pp. 36-46
    • Tabas, I.1
  • 12
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • K.J. Moore, and I. Tabas Macrophages in the pathogenesis of atherosclerosis Cell 145 2011 341 355
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 13
    • 77957796096 scopus 로고    scopus 로고
    • The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1beta, IL-6, and IL-10 secretion in human monocytes and macrophages
    • L. Chavez-Sanchez, K. Chavez-Rueda, and M.V. Legorreta-Haquet The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1beta, IL-6, and IL-10 secretion in human monocytes and macrophages Lipids Health Dis 9 2010 117
    • (2010) Lipids Health Dis , vol.9 , pp. 117
    • Chavez-Sanchez, L.1    Chavez-Rueda, K.2    Legorreta-Haquet, M.V.3
  • 14
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • C.R. Stewart, L.M. Stuart, and K. Wilkinson CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer Nat Immunol 11 2010 155 161
    • (2010) Nat Immunol , vol.11 , pp. 155-161
    • Stewart, C.R.1    Stuart, L.M.2    Wilkinson, K.3
  • 15
    • 77954760594 scopus 로고    scopus 로고
    • Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response
    • L. Chavez-Sanchez, A. Madrid-Miller, and K. Chavez-Rueda Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response Hum Immunol 71 2010 737 744
    • (2010) Hum Immunol , vol.71 , pp. 737-744
    • Chavez-Sanchez, L.1    Madrid-Miller, A.2    Chavez-Rueda, K.3
  • 16
    • 57549112353 scopus 로고    scopus 로고
    • Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    • A.C. Newby Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability Arterioscler Thromb Vasc Biol 28 2008 2108 2114
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2108-2114
    • Newby, A.C.1
  • 17
    • 84867404418 scopus 로고    scopus 로고
    • CD14++CD16+ monocytes independently predict cardiovascular events: A cohort study of 951 patients referred for elective coronary angiography
    • K.S. Rogacev, B. Cremers, and A.M. Zawada CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography J Am Coll Cardiol 60 2012 1512 1520
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1512-1520
    • Rogacev, K.S.1    Cremers, B.2    Zawada, A.M.3
  • 18
    • 84863903383 scopus 로고    scopus 로고
    • Myocardial infarction accelerates atherosclerosis
    • P. Dutta, G. Courties, and Y. Wei Myocardial infarction accelerates atherosclerosis Nature 487 2012 325 329
    • (2012) Nature , vol.487 , pp. 325-329
    • Dutta, P.1    Courties, G.2    Wei, Y.3
  • 19
    • 84908101608 scopus 로고    scopus 로고
    • Effects of intra-abdominal sepsis on atherosclerosis in mice
    • A.M. Kaynar, S. Yende, and L. Zhu Effects of intra-abdominal sepsis on atherosclerosis in mice Crit Care 18 2014 469
    • (2014) Crit Care , vol.18 , pp. 469
    • Kaynar, A.M.1    Yende, S.2    Zhu, L.3
  • 20
    • 33845970192 scopus 로고    scopus 로고
    • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    • F.K. Swirski, P. Libby, and E. Aikawa Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata J Clin Invest 117 2007 195 205
    • (2007) J Clin Invest , vol.117 , pp. 195-205
    • Swirski, F.K.1    Libby, P.2    Aikawa, E.3
  • 21
    • 33845989083 scopus 로고    scopus 로고
    • Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    • F. Tacke, D. Alvarez, and T.J. Kaplan Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques J Clin Invest 117 2007 185 194
    • (2007) J Clin Invest , vol.117 , pp. 185-194
    • Tacke, F.1    Alvarez, D.2    Kaplan, T.J.3
  • 22
    • 84901017361 scopus 로고    scopus 로고
    • Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis
    • T. Seijkens, M.A. Hoeksema, and L. Beckers Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis FASEB J 28 2014 2202 2213
    • (2014) FASEB J , vol.28 , pp. 2202-2213
    • Seijkens, T.1    Hoeksema, M.A.2    Beckers, L.3
  • 23
    • 84908305639 scopus 로고    scopus 로고
    • Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis
    • E. van Kampen, A. Jaminon, T.J. van Berkel, and M. Van Eck Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis J Leukoc Biol 96 2014 833 841
    • (2014) J Leukoc Biol , vol.96 , pp. 833-841
    • Van Kampen, E.1    Jaminon, A.2    Van Berkel, T.J.3    Van Eck, M.4
  • 25
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • T. Kouzarides Chromatin modifications and their function Cell 128 2007 693 705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 26
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • A.J. Bannister, and T. Kouzarides Regulation of chromatin by histone modifications Cell Res 21 2011 381 395
    • (2011) Cell Res , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 27
    • 84859893371 scopus 로고    scopus 로고
    • Histone methylation: A dynamic mark in health, disease and inheritance
    • E.L. Greer, and Y. Shi Histone methylation: a dynamic mark in health, disease and inheritance Nat Rev Genet 13 2012 343 357
    • (2012) Nat Rev Genet , vol.13 , pp. 343-357
    • Greer, E.L.1    Shi, Y.2
  • 30
    • 84900389583 scopus 로고    scopus 로고
    • Innate immune memory: Implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
    • O. Levy, and M.G. Netea Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines Pediatr Res 75 2014 184 188
    • (2014) Pediatr Res , vol.75 , pp. 184-188
    • Levy, O.1    Netea, M.G.2
  • 31
    • 84880711233 scopus 로고    scopus 로고
    • Training innate immunity: The changing concept of immunological memory in innate host defence
    • M.G. Netea Training innate immunity: the changing concept of immunological memory in innate host defence Eur J Clin Invest 43 2013 881 884
    • (2013) Eur J Clin Invest , vol.43 , pp. 881-884
    • Netea, M.G.1
  • 32
    • 84907483941 scopus 로고    scopus 로고
    • Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
    • S. Saeed, J. Quintin, and H.H. Kerstens Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Science 345 2014 1251086
    • (2014) Science , vol.345 , pp. 1251086
    • Saeed, S.1    Quintin, J.2    Kerstens, H.H.3
  • 33
    • 84909578049 scopus 로고    scopus 로고
    • MTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity
    • S.C. Cheng, J. Quintin, and R.A. Cramer mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity Science 345 2014 1250684
    • (2014) Science , vol.345 , pp. 1250684
    • Cheng, S.C.1    Quintin, J.2    Cramer, R.A.3
  • 34
    • 84867909516 scopus 로고    scopus 로고
    • Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
    • J. Kleinnijenhuis, J. Quintin, and F. Preijers Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes Proc Natl Acad Sci U S A 109 2012 17537 17542
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17537-17542
    • Kleinnijenhuis, J.1    Quintin, J.2    Preijers, F.3
  • 35
    • 84896361510 scopus 로고    scopus 로고
    • Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity
    • J. Kleinnijenhuis, J. Quintin, and F. Preijers Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity J Innate Immun 6 2014 152 158
    • (2014) J Innate Immun , vol.6 , pp. 152-158
    • Kleinnijenhuis, J.1    Quintin, J.2    Preijers, F.3
  • 36
    • 84865119423 scopus 로고    scopus 로고
    • Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes
    • J. Quintin, S. Saeed, and J.H. Martens Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes Cell Host Microbe 12 2012 223 232
    • (2012) Cell Host Microbe , vol.12 , pp. 223-232
    • Quintin, J.1    Saeed, S.2    Martens, J.H.3
  • 37
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • R. Ostuni, V. Piccolo, and I. Barozzi Latent enhancers activated by stimulation in differentiated cells Cell 152 2013 157 171
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1    Piccolo, V.2    Barozzi, I.3
  • 38
    • 84862060628 scopus 로고    scopus 로고
    • Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression
    • D.R. Donohoe, and S.J. Bultman Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression J Cell Physiol 227 2012 3169 3177
    • (2012) J Cell Physiol , vol.227 , pp. 3169-3177
    • Donohoe, D.R.1    Bultman, S.J.2
  • 40
    • 0033033391 scopus 로고    scopus 로고
    • Immunization with bacillus Calmette-Guerin vaccine increases aortic atherosclerosis in the cholesterol-fed rabbit
    • D.J. Lamb, L.J. Eales, and G.A. Ferns Immunization with bacillus Calmette-Guerin vaccine increases aortic atherosclerosis in the cholesterol-fed rabbit Atherosclerosis 143 1999 105 113
    • (1999) Atherosclerosis , vol.143 , pp. 105-113
    • Lamb, D.J.1    Eales, L.J.2    Ferns, G.A.3
  • 41
    • 84904605889 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes
    • S. Bekkering, J. Quintin, and L.A. Joosten Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes Arterioscler Thromb Vasc Biol 34 2014 1731 1738
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1731-1738
    • Bekkering, S.1    Quintin, J.2    Joosten, L.A.3
  • 42
    • 79958135357 scopus 로고    scopus 로고
    • MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr(-/-)Apob(100/100) mouse
    • D. Wagsater, C. Zhu, and J. Bjorkegren MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr(-/-)Apob(100/100) mouse Int J Mol Med 28 2011 247 253
    • (2011) Int J Mol Med , vol.28 , pp. 247-253
    • Wagsater, D.1    Zhu, C.2    Bjorkegren, J.3
  • 43
    • 59749094084 scopus 로고    scopus 로고
    • Epigenetic histone acetylation modifiers in vascular remodelling: New targets for therapy in cardiovascular disease
    • D. Pons, F.R. de Vries, and P.J. van den Elsen Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease Eur Heart J 30 2009 266 277
    • (2009) Eur Heart J , vol.30 , pp. 266-277
    • Pons, D.1    De Vries, F.R.2    Van Den Elsen, P.J.3
  • 44
    • 77955162230 scopus 로고    scopus 로고
    • Epigenetics in atherosclerosis and inflammation
    • R.J. Wierda, S.B. Geutskens, and J.W. Jukema Epigenetics in atherosclerosis and inflammation J Cell Mol Med 14 2010 1225 1240
    • (2010) J Cell Mol Med , vol.14 , pp. 1225-1240
    • Wierda, R.J.1    Geutskens, S.B.2    Jukema, J.W.3
  • 46
    • 85026338471 scopus 로고    scopus 로고
    • Epigenetic modifications: Basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)
    • J. Loscalzo, and D.E. Handy Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series) Pulm Circ 4 2014 169 174
    • (2014) Pulm Circ , vol.4 , pp. 169-174
    • Loscalzo, J.1    Handy, D.E.2
  • 47
    • 79955928265 scopus 로고    scopus 로고
    • Atherosclerosis: An epigenetic balancing act that goes wrong
    • G. Lund, and S. Zaina Atherosclerosis: an epigenetic balancing act that goes wrong Curr Atheroscler Rep 13 2011 208 214
    • (2011) Curr Atheroscler Rep , vol.13 , pp. 208-214
    • Lund, G.1    Zaina, S.2
  • 48
    • 84864007379 scopus 로고    scopus 로고
    • Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction
    • Y.R. Kim, C.S. Kim, and A. Naqvi Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction Am J Physiol Heart Circ Physiol 303 2012 H189 H196
    • (2012) Am J Physiol Heart Circ Physiol , vol.303 , pp. H189-H196
    • Kim, Y.R.1    Kim, C.S.2    Naqvi, A.3
  • 49
    • 79961041729 scopus 로고    scopus 로고
    • Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation
    • S. Mitra, M. Khaidakov, and J. Lu Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation Am J Physiol Heart Circ Physiol 301 2011 H506 H513
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. H506-H513
    • Mitra, S.1    Khaidakov, M.2    Lu, J.3
  • 50
    • 84902549379 scopus 로고    scopus 로고
    • Posttranslational modifications of histone deacetylases: Implications for cardiovascular diseases
    • G.H. Eom, and H. Kook Posttranslational modifications of histone deacetylases: implications for cardiovascular diseases Pharmacol Ther 143 2014 168 180
    • (2014) Pharmacol Ther , vol.143 , pp. 168-180
    • Eom, G.H.1    Kook, H.2
  • 51
    • 84897402053 scopus 로고    scopus 로고
    • Epigenetics in vascular disease - Therapeutic potential of new agents
    • S.S. Xu, S. Alam, and A. Margariti Epigenetics in vascular disease - therapeutic potential of new agents Curr Vasc Pharmacol 12 2014 77 86
    • (2014) Curr Vasc Pharmacol , vol.12 , pp. 77-86
    • Xu, S.S.1    Alam, S.2    Margariti, A.3
  • 52
    • 84882380404 scopus 로고    scopus 로고
    • Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells
    • Y. Wang, T. Chen, and H. Yan Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells J Cell Biochem 114 2013 2231 2239
    • (2013) J Cell Biochem , vol.114 , pp. 2231-2239
    • Wang, Y.1    Chen, T.2    Yan, H.3
  • 53
    • 61549114350 scopus 로고    scopus 로고
    • Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells
    • P. Dje N'Guessan, F. Riediger, and K. Vardarova Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells Arterioscler Thromb Vasc Biol 29 2009 380 386
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 380-386
    • Dje N'Guessan, P.1    Riediger, F.2    Vardarova, K.3
  • 54
    • 42549129871 scopus 로고    scopus 로고
    • Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells
    • B. Schmeck, W. Beermann, and P.D. N'Guessan Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells Circ Res 102 2008 888 895
    • (2008) Circ Res , vol.102 , pp. 888-895
    • Schmeck, B.1    Beermann, W.2    N'Guessan, P.D.3
  • 55
    • 74549187447 scopus 로고    scopus 로고
    • Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow
    • A. Zampetaki, L. Zeng, and A. Margariti Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow Circulation 121 2010 132 142
    • (2010) Circulation , vol.121 , pp. 132-142
    • Zampetaki, A.1    Zeng, L.2    Margariti, A.3
  • 56
    • 76149146414 scopus 로고    scopus 로고
    • Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature
    • F.E. Alkemade, P. van Vliet, and P. Henneman Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature Am J Pathol 176 2010 542 548
    • (2010) Am J Pathol , vol.176 , pp. 542-548
    • Alkemade, F.E.1    Van Vliet, P.2    Henneman, P.3
  • 57
    • 84872130535 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in chronic disease: Challenges and opportunities
    • I. Tabas, and C.K. Glass Anti-inflammatory therapy in chronic disease: challenges and opportunities Science 339 2013 166 172
    • (2013) Science , vol.339 , pp. 166-172
    • Tabas, I.1    Glass, C.K.2
  • 58
    • 84916940981 scopus 로고    scopus 로고
    • Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions
    • M.A. Hoeksema, M.J. Gijbels, and J. Van den Bossche Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions EMBO Mol Med 6 2014 1124 1132
    • (2014) EMBO Mol Med , vol.6 , pp. 1124-1132
    • Hoeksema, M.A.1    Gijbels, M.J.2    Van Den Bossche, J.3
  • 59
    • 84863393715 scopus 로고    scopus 로고
    • Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
    • C. Bellenguez, S. Bevan, and A. Gschwendtner Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke Nat Genet 44 2012 328 333
    • (2012) Nat Genet , vol.44 , pp. 328-333
    • Bellenguez, C.1    Bevan, S.2    Gschwendtner, A.3
  • 60
    • 84906938566 scopus 로고    scopus 로고
    • Histone deacetylase 9 represses cholesterol efflux and generation of alternatively activated macrophages in atherosclerosis development
    • Q. Cao, S. Rong, and J.J. Repa Histone deacetylase 9 represses cholesterol efflux and generation of alternatively activated macrophages in atherosclerosis development Arterioscler Thromb Vasc Biol 34 2014 1871 1879
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1871-1879
    • Cao, Q.1    Rong, S.2    Repa, J.J.3
  • 61
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • D.B. Seligson, S. Horvath, and T. Shi Global histone modification patterns predict risk of prostate cancer recurrence Nature 435 2005 1262 1266
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3
  • 62
    • 84891486208 scopus 로고    scopus 로고
    • Design of small molecule epigenetic modulators
    • B. Pachaiyappan, and P.M. Woster Design of small molecule epigenetic modulators Bioorg Med Chem Lett 24 2014 21 32
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 21-32
    • Pachaiyappan, B.1    Woster, P.M.2
  • 64
    • 79959804516 scopus 로고    scopus 로고
    • Histone deacetylases as regulators of inflammation and immunity
    • M.R. Shakespear, M.A. Halili, and K.M. Irvine Histone deacetylases as regulators of inflammation and immunity Trends Immunol 32 2011 335 343
    • (2011) Trends Immunol , vol.32 , pp. 335-343
    • Shakespear, M.R.1    Halili, M.A.2    Irvine, K.M.3
  • 65
    • 27644550272 scopus 로고    scopus 로고
    • Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice
    • J.H. Choi, K.H. Nam, and J. Kim Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice Arterioscler Thromb Vasc Biol 25 2005 2404 2409
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2404-2409
    • Choi, J.H.1    Nam, K.H.2    Kim, J.3
  • 66
    • 85027911527 scopus 로고    scopus 로고
    • Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis
    • [E-pub ahead of print]
    • X.Q. Zhang, O. Even-Or, and X. Xu Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis Adv Healthc Mater 2014 Aug 22 [E-pub ahead of print]
    • (2014) Adv Healthc Mater
    • Zhang, X.Q.1    Even-Or, O.2    Xu, X.3
  • 67
    • 84912571814 scopus 로고    scopus 로고
    • Platelet-like nanoparticles: Mimicking shape, flexibility, and surface biology of platelets to target vascular injuries
    • A.C. Anselmo, C.L. Modery-Pawlowski, and S. Menegatti Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries ACS Nano 8 2014 11243 11253
    • (2014) ACS Nano , vol.8 , pp. 11243-11253
    • Anselmo, A.C.1    Modery-Pawlowski, C.L.2    Menegatti, S.3
  • 68
    • 84901649581 scopus 로고    scopus 로고
    • Vascular targeting of nanocarriers: Perplexing aspects of the seemingly straightforward paradigm
    • M. Howard, B.J. Zern, and A.C. Anselmo Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm ACS Nano 8 2014 4100 4132
    • (2014) ACS Nano , vol.8 , pp. 4100-4132
    • Howard, M.1    Zern, B.J.2    Anselmo, A.C.3
  • 69
    • 84892865604 scopus 로고    scopus 로고
    • A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation
    • R. Duivenvoorden, J. Tang, and D.P. Cormode A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation Nat Commun 5 2014 3065
    • (2014) Nat Commun , vol.5 , pp. 3065
    • Duivenvoorden, R.1    Tang, J.2    Cormode, D.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.