-
1
-
-
0035449393
-
Gross CE Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
-
Bezard E, Dovero S, Prunier C, et al. Gross CE Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J Neurosci 2011;21:6853-6861.
-
(2011)
J Neurosci
, vol.21
, pp. 6853-6861
-
-
Bezard, E.1
Dovero, S.2
Prunier, C.3
-
2
-
-
0141741347
-
Parkinson's disease: mechanisms and models
-
Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003;39:889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
3
-
-
14844300111
-
Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
-
Hilker R, Schweitzer K, Coburger S, et al. Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Arch Neurol 2005;62:378-382.
-
(2005)
Arch Neurol
, vol.62
, pp. 378-382
-
-
Hilker, R.1
Schweitzer, K.2
Coburger, S.3
-
4
-
-
0030463280
-
Regional changes in [18F]dopametabolism in the striatum in Parkinson's disease
-
Morrish PK, Sawle GV, Brooks DJ. Regional changes in [18F]dopametabolism in the striatum in Parkinson's disease. Brain 1996;119:2097-2103
-
(1996)
Brain
, vol.119
, pp. 2097-2103
-
-
Morrish, P.K.1
Sawle, G.V.2
Brooks, D.J.3
-
5
-
-
77953666105
-
Genetic animal models of Parkinson's disease
-
Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron 2010;66:646-661.
-
(2010)
Neuron
, vol.66
, pp. 646-661
-
-
Dawson, T.M.1
Ko, H.S.2
Dawson, V.L.3
-
7
-
-
84929513259
-
Neuronal hyperactivity--A key defect in Alzheimer's disease?
-
Busche MA, Konnerth A. Neuronal hyperactivity--A key defect in Alzheimer's disease? Bioessays 2015;37:624-632.
-
(2015)
Bioessays
, vol.37
, pp. 624-632
-
-
Busche, M.A.1
Konnerth, A.2
-
8
-
-
84916884392
-
Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia
-
Crabtree GW, Gogos JA. Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. Front Synaptic Neurosci 2014;6:28.
-
(2014)
Front Synaptic Neurosci
, vol.6
, pp. 28
-
-
Crabtree, G.W.1
Gogos, J.A.2
-
9
-
-
77953275175
-
Synaptopathy: dysfunction of synaptic function?
-
Brose N, O'Connor V, Skehel P. Synaptopathy: dysfunction of synaptic function? Biochem Soc Trans 2010;38:443-444.
-
(2010)
Biochem Soc Trans
, vol.38
, pp. 443-444
-
-
Brose, N.1
O'Connor, V.2
Skehel, P.3
-
10
-
-
84924625546
-
Impaired intracellular trafficking defines early Parkinson's disease
-
Hunn BH, Cragg SJ, Bolam JP, et al. Impaired intracellular trafficking defines early Parkinson's disease. Trends Neurosci 2015;38:178-188.
-
(2015)
Trends Neurosci
, vol.38
, pp. 178-188
-
-
Hunn, B.H.1
Cragg, S.J.2
Bolam, J.P.3
-
12
-
-
0027195844
-
Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats
-
Jiang H, Jackson-Lewis V, Muthane U, et al. Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats. Brain Res 1993;613:347-351.
-
(1993)
Brain Res
, vol.613
, pp. 347-351
-
-
Jiang, H.1
Jackson-Lewis, V.2
Muthane, U.3
-
13
-
-
77955961925
-
Neuroprotection and functional recovery associated with decreased microglial activation following selective activation of mGluR2/3 receptors in a rodent model of Parkinson's disease
-
Chan H, Paur H, Vernon AC, et al. Neuroprotection and functional recovery associated with decreased microglial activation following selective activation of mGluR2/3 receptors in a rodent model of Parkinson's disease. Parkinsons Dis 2010; pii: 190450.
-
(2010)
Parkinsons Dis
, pp. 190450
-
-
Chan, H.1
Paur, H.2
Vernon, A.C.3
-
14
-
-
79958204001
-
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease
-
Ilijic E, Guzman JN, Surmeier DJ. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis 2011;43:364-371.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 364-371
-
-
Ilijic, E.1
Guzman, J.N.2
Surmeier, D.J.3
-
15
-
-
0037133163
-
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
-
Bjorklund LM, Sanchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 2002;99:2344-2349.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 2344-2349
-
-
Bjorklund, L.M.1
Sanchez-Pernaute, R.2
Chung, S.3
-
16
-
-
0037007106
-
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
-
Kirik D, Georgievska B, Burger C, et al. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proc Natl Acad Sci U S A 2002;99:4708-4713.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 4708-4713
-
-
Kirik, D.1
Georgievska, B.2
Burger, C.3
-
17
-
-
33750706917
-
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
-
Roy NS, Cleren C, Singh SK, et al. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 2006;12:1259-1268.
-
(2006)
Nat Med
, vol.12
, pp. 1259-1268
-
-
Roy, N.S.1
Cleren, C.2
Singh, S.K.3
-
18
-
-
34247469023
-
Dopamine-mediated regulation of corticostriatal synaptic plasticity
-
Calabresi P, Picconi B, Tozzi A, et al. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends Neurosci 2007;30:211-219.
-
(2007)
Trends Neurosci
, vol.30
, pp. 211-219
-
-
Calabresi, P.1
Picconi, B.2
Tozzi, A.3
-
19
-
-
0037407907
-
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
-
Picconi B, Centonze D, Hakansson K, et al. Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nat Neurosci 2003;6:501-506.
-
(2003)
Nat Neurosci
, vol.6
, pp. 501-506
-
-
Picconi, B.1
Centonze, D.2
Hakansson, K.3
-
20
-
-
77958523402
-
Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition
-
Paillé V, Picconi B, Bagetta V, et al. Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition. J Neurosci 2010;30:14182-14193.
-
(2010)
J Neurosci
, vol.30
, pp. 14182-14193
-
-
Paillé, V.1
Picconi, B.2
Bagetta, V.3
-
21
-
-
0024326094
-
Spine density on neostriatal neurons changes with 6-hydroxydopamine lesions and with age
-
Ingham CA, Hood SH, Arbuthnott GW. Spine density on neostriatal neurons changes with 6-hydroxydopamine lesions and with age. Brain Res 1989;503:334-338.
-
(1989)
Brain Res
, vol.503
, pp. 334-338
-
-
Ingham, C.A.1
Hood, S.H.2
Arbuthnott, G.W.3
-
22
-
-
20144389550
-
Evidence of a breakdown of corticostriatal connections in Parkinson's disease
-
Stephens B, Mueller AJ, Shering AF, et al. Evidence of a breakdown of corticostriatal connections in Parkinson's disease. Neuroscience 2005;132:741-754.
-
(2005)
Neuroscience
, vol.132
, pp. 741-754
-
-
Stephens, B.1
Mueller, A.J.2
Shering, A.F.3
-
23
-
-
13244287684
-
Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
-
Zaja-Milatovic S, Milatovic D, Schantz AM, et al. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Neurology 2005;64:545-547.
-
(2005)
Neurology
, vol.64
, pp. 545-547
-
-
Zaja-Milatovic, S.1
Milatovic, D.2
Schantz, A.M.3
-
24
-
-
53149107120
-
Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains
-
Smith Y, Villalba R. Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains. Mov Disord 2008;23(Suppl 3):S534-S547.
-
(2008)
Mov Disord
, vol.23
, pp. S534-S547
-
-
Smith, Y.1
Villalba, R.2
-
25
-
-
71849087825
-
Striatal spine plasticity in Parkinson's disease: pathological or not?
-
Smith Y, Villalba RM, Raju DV. Striatal spine plasticity in Parkinson's disease: pathological or not? Parkinsonism Relat Disord 2009;15(Suppl 3):S156-S161.
-
(2009)
Parkinsonism Relat Disord
, vol.15
, pp. S156-S161
-
-
Smith, Y.1
Villalba, R.M.2
Raju, D.V.3
-
26
-
-
84891672613
-
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
-
Toy WA, Petzinger GM, Leyshon BJ, et al. Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiol Dis 2014;63:201-209.
-
(2014)
Neurobiol Dis
, vol.63
, pp. 201-209
-
-
Toy, W.A.1
Petzinger, G.M.2
Leyshon, B.J.3
-
27
-
-
58149488975
-
Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys
-
Villalba R. M., Lee H., Smith Y. Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys. Exp Neurol 2009;215:220-227.
-
(2009)
Exp Neurol
, vol.215
, pp. 220-227
-
-
Villalba, R.M.1
Lee, H.2
Smith, Y.3
-
28
-
-
38949177433
-
Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
-
Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat Disord 2007;13(Suppl 3):S251-S258.
-
(2007)
Parkinsonism Relat Disord
, vol.13
, pp. S251-S258
-
-
Deutch, A.Y.1
Colbran, R.J.2
Winder, D.J.3
-
29
-
-
4544273531
-
Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP
-
Betarbet R, Greenamyre JT. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Exp Neurol 2004;189:393-403.
-
(2004)
Exp Neurol
, vol.189
, pp. 393-403
-
-
Betarbet, R.1
Greenamyre, J.T.2
-
30
-
-
33751305122
-
Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats
-
Ba M, Kong M, Yang H, et al. Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats. Neurochem Res 2006;31:1337-1347.
-
(2006)
Neurochem Res
, vol.31
, pp. 1337-1347
-
-
Ba, M.1
Kong, M.2
Yang, H.3
-
32
-
-
79957608284
-
A tale on animal models of Parkinson's disease
-
Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Mov Disord 2011;26:993-1002.
-
(2011)
Mov Disord
, vol.26
, pp. 993-1002
-
-
Bezard, E.1
Przedborski, S.2
-
33
-
-
0842305633
-
Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant
-
Wersinger C, Vernier P, Sidhu A. Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry 2004;43:1242-1253.
-
(2004)
Biochemistry
, vol.43
, pp. 1242-1253
-
-
Wersinger, C.1
Vernier, P.2
Sidhu, A.3
-
34
-
-
0034708767
-
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations
-
McLean PJ, Kawamata H, Ribich S, et al. Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. J Biol Chem 2000;275:8812-8816.
-
(2000)
J Biol Chem
, vol.275
, pp. 8812-8816
-
-
McLean, P.J.1
Kawamata, H.2
Ribich, S.3
-
36
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease Neurobiol Aging 2003;24:197-211.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rüb, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
37
-
-
33846997878
-
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
-
Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007;27:1405-1410.
-
(2007)
J Neurosci
, vol.27
, pp. 1405-1410
-
-
Kramer, M.L.1
Schulz-Schaeffer, W.J.2
-
38
-
-
0030744876
-
Mutation in the alpha synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
-
39
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Krüger R, Kuhn W, Müller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998;18:106-108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
-
40
-
-
0242300619
-
Alpha-synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J, et al. Alpha-synuclein locus triplication causes Parkinson's disease. Science 2003;302:841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
-
41
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gómez-Esteban JC, et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 2004;55:164-173.
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gómez-Esteban, J.C.3
-
42
-
-
46749144187
-
Genomic investigation of alpha-synuclein multiplication and Parkinsonism
-
Ross OA, Braithwaite AT, Skipper LM, et al. Genomic investigation of alpha-synuclein multiplication and Parkinsonism. Ann Neurol 2008;63:743-750.
-
(2008)
Ann Neurol
, vol.63
, pp. 743-750
-
-
Ross, O.A.1
Braithwaite, A.T.2
Skipper, L.M.3
-
43
-
-
0141499226
-
The role of alpha-synuclein in Parkinson's disease: insights from animal models
-
Maries E, Dass B, Collier TJ, et al. The role of alpha-synuclein in Parkinson's disease: insights from animal models. Nat Rev Neurosci 2003;4:727-738.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 727-738
-
-
Maries, E.1
Dass, B.2
Collier, T.J.3
-
44
-
-
84861898518
-
Mechanisms underlying altered striatal synaptic plasticity in old A53T-alpha synuclein overexpressing mice
-
Tozzi A, Costa C, Siliquini S, et al. Mechanisms underlying altered striatal synaptic plasticity in old A53T-alpha synuclein overexpressing mice. Neurobiol Aging 2012;33:1792-1799.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 1792-1799
-
-
Tozzi, A.1
Costa, C.2
Siliquini, S.3
-
45
-
-
84947307318
-
Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses
-
Rafalovich IV, Melendez AE, Plotkin JL, Tanimura A, Zhai S, Surmeier DJ. Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Cell Rep 2015;13:1336-1342.
-
(2015)
Cell Rep
, vol.13
, pp. 1336-1342
-
-
Rafalovich, I.V.1
Melendez, A.E.2
Plotkin, J.L.3
Tanimura, A.4
Zhai, S.5
Surmeier, D.J.6
-
46
-
-
0033119685
-
A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression
-
Calabresi P, Gubellini P, Centonze D, et al. A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression. J Neurosci 1999;19:2489-499.
-
(1999)
J Neurosci
, vol.19
, pp. 2489-2499
-
-
Calabresi, P.1
Gubellini, P.2
Centonze, D.3
-
47
-
-
84977625900
-
Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit
-
Tozzi A, de Iure A, Bagetta V, et al. Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit. Biol Psychiatry 2015. pii: S0006-3223(15)00678-2.
-
(2015)
Biol Psychiatry
-
-
Tozzi, A.1
de Iure, A.2
Bagetta, V.3
-
48
-
-
10944243102
-
Role of alpha-synuclein in presynaptic dopamine recruitment
-
Yavich L, Tanila H, Vepsäläinen S, et al. Role of alpha-synuclein in presynaptic dopamine recruitment. J Neurosci 2004;24:11165-11170.
-
(2004)
J Neurosci
, vol.24
, pp. 11165-11170
-
-
Yavich, L.1
Tanila, H.2
Vepsäläinen, S.3
-
49
-
-
84904006504
-
Synucleins regulate the kinetics of synaptic vesicle endocytosis
-
Vargas KJ, Makani S, Davis T, et al. Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci 2014;34:9364-9376.
-
(2014)
J Neurosci
, vol.34
, pp. 9364-9376
-
-
Vargas, K.J.1
Makani, S.2
Davis, T.3
-
50
-
-
73549085595
-
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani VM, Lu W, Berge V, et al. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 2010;65:66-79.
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
-
51
-
-
84885743813
-
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
-
Janezic S, Threlfell S, Dodson PD, et al. Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A 2013;110:E4016-F4025.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E4016-F4025
-
-
Janezic, S.1
Threlfell, S.2
Dodson, P.D.3
-
52
-
-
84867787595
-
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
-
Burré J, Sharma M, Südhof TC. Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. J Neurosci 2012;32:15227-15242.
-
(2012)
J Neurosci
, vol.32
, pp. 15227-15242
-
-
Burré, J.1
Sharma, M.2
Südhof, T.C.3
-
53
-
-
84886427013
-
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
-
Taylor TN, Potgieter D, Anwar S, et al. Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse. Neurobiol Dis 2014;62:193-207.
-
(2014)
Neurobiol Dis
, vol.62
, pp. 193-207
-
-
Taylor, T.N.1
Potgieter, D.2
Anwar, S.3
-
54
-
-
79955629341
-
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
-
Lam HA, Wu N, Cely I, et al. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein. J Neurosci Res 2011;89:1091-1102.
-
(2011)
J Neurosci Res
, vol.89
, pp. 1091-1102
-
-
Lam, H.A.1
Wu, N.2
Cely, I.3
-
55
-
-
84857716290
-
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
-
Lundblad M, Decressac M, Mattsson B, Björklund A. Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons. Proc Natl Acad Sci U S A 2012;109:3213-3219.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 3213-3219
-
-
Lundblad, M.1
Decressac, M.2
Mattsson, B.3
Björklund, A.4
-
56
-
-
84866436990
-
An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
-
Pacheco C, Aguayo LG, Opazo C. An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain. Front Physiol 2012;3:297.
-
(2012)
Front Physiol
, vol.3
, pp. 297
-
-
Pacheco, C.1
Aguayo, L.G.2
Opazo, C.3
-
57
-
-
84893858665
-
Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases
-
Lee HJ, Bae EJ, Lee SJ. Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases. Nat Rev Neurol 2014;10:92-98.
-
(2014)
Nat Rev Neurol
, vol.10
, pp. 92-98
-
-
Lee, H.J.1
Bae, E.J.2
Lee, S.J.3
-
58
-
-
77951885732
-
Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions
-
Jang A, Lee HJ, Suk JE, Jung JW, Kim KP, Lee SJ. Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem 2010;113:1263-1274.
-
(2010)
J Neurochem
, vol.113
, pp. 1263-1274
-
-
Jang, A.1
Lee, H.J.2
Suk, J.E.3
Jung, J.W.4
Kim, K.P.5
Lee, S.J.6
-
59
-
-
79955660630
-
Dopamine promotes formation and secretion of non-fibrillar α-synuclein oligomers
-
Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ. Dopamine promotes formation and secretion of non-fibrillar α-synuclein oligomers. Exp Mol Med 2011;43:216-222.
-
(2011)
Exp Mol Med
, vol.43
, pp. 216-222
-
-
Lee, H.J.1
Baek, S.M.2
Ho, D.H.3
Suk, J.E.4
Cho, E.D.5
Lee, S.J.6
-
60
-
-
77952648551
-
Cell-produced alpha-synuclein is secreted in a calcium- dependent manner by exosomes and impacts neuronal survival
-
Emmanouilidou E, Melachroinou K, Roumeliotis T, et al. Cell-produced alpha-synuclein is secreted in a calcium- dependent manner by exosomes and impacts neuronal survival. J Neurosci 2010; 30:6838-6851.
-
(2010)
J Neurosci
, vol.30
, pp. 6838-6851
-
-
Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
-
61
-
-
84865202477
-
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation
-
Diógenes MJ, Dias RB, Rombo DM, et al. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J Neurosci 2012;32:11750-11762.
-
(2012)
J Neurosci
, vol.32
, pp. 11750-11762
-
-
Diógenes, M.J.1
Dias, R.B.2
Rombo, D.M.3
-
62
-
-
70350447105
-
LRRK2 in Parkinson's disease: genetic and clinical studies from patients
-
Kumari U, Tan EK. LRRK2 in Parkinson's disease: genetic and clinical studies from patients. FEBS J 2009;276:6455-6463.
-
(2009)
FEBS J
, vol.276
, pp. 6455-6463
-
-
Kumari, U.1
Tan, E.K.2
-
63
-
-
84925884090
-
The role of the LRRK2 gene in Parkinsonism
-
Li JQ, Tan L, Yu JT. The role of the LRRK2 gene in Parkinsonism. Mol Neurodegener 2014;9:47.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 47
-
-
Li, J.Q.1
Tan, L.2
Yu, J.T.3
-
64
-
-
35948952469
-
The roles of kinases in familial Parkinson's disease
-
Cookson MR, Dauer W, Dawson T, et al. The roles of kinases in familial Parkinson's disease. J Neurosci 2007;27:11865-11868.
-
(2007)
J Neurosci
, vol.27
, pp. 11865-11868
-
-
Cookson, M.R.1
Dauer, W.2
Dawson, T.3
-
65
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West AB, Moore DJ, Biskup S, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 2005;102:16842-16847.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
-
66
-
-
33846562487
-
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
West AB, Moore DJ, Choi C, et al. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum Mol Genet 2007;16:223-232.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
-
67
-
-
78650389179
-
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
-
Lee S, Liu HP, Lin WY, et al. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci 2010;30:16959-16969.
-
(2010)
J Neurosci
, vol.30
, pp. 16959-16969
-
-
Lee, S.1
Liu, H.P.2
Lin, W.Y.3
-
68
-
-
84866510734
-
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
-
Matta S, Van Kolen K, da Cunha R, et al. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron 2012;75:1008-1021.
-
(2012)
Neuron
, vol.75
, pp. 1008-1021
-
-
Matta, S.1
Van Kolen, K.2
da Cunha, R.3
-
69
-
-
67649813448
-
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
Li Y, Liu W, Oo TF, et al. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci 2009;12:826-828.
-
(2009)
Nat Neurosci
, vol.12
, pp. 826-828
-
-
Li, Y.1
Liu, W.2
Oo, T.F.3
-
70
-
-
70349103837
-
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
-
Ng CH, Mok SZ, Koh C, et al. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J Neurosci 2009;29:11257-11262.
-
(2009)
J Neurosci
, vol.29
, pp. 11257-11262
-
-
Ng, C.H.1
Mok, S.Z.2
Koh, C.3
-
71
-
-
70350683754
-
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease
-
Venderova K, Kabbach G, Abdel-Messih E, et al. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet 2009;18:4390-4404.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4390-4404
-
-
Venderova, K.1
Kabbach, G.2
Abdel-Messih, E.3
-
72
-
-
74949089639
-
Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease
-
Lin TK, Liou CW, Chen SD, et al. Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease. Chang Gung Med J 2009;32:589-599.
-
(2009)
Chang Gung Med J
, vol.32
, pp. 589-599
-
-
Lin, T.K.1
Liou, C.W.2
Chen, S.D.3
-
73
-
-
72149109520
-
Alpha-synuclein and LRRK2: partners in crime
-
Tong Y, Shen J. Alpha-synuclein and LRRK2: partners in crime. Neuron 2009;64:771-773.
-
(2009)
Neuron
, vol.64
, pp. 771-773
-
-
Tong, Y.1
Shen, J.2
-
74
-
-
84939145610
-
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
-
Daher JP, Abdelmotilib HA, Hu X, et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J Biol Chem 2015;290:19433-19444.
-
(2015)
J Biol Chem
, vol.290
, pp. 19433-19444
-
-
Daher, J.P.1
Abdelmotilib, H.A.2
Hu, X.3
-
75
-
-
84920809166
-
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor
-
Henderson JL, Kormos BL, Hayward MM, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2, 3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem 2015;58:419-432.
-
(2015)
J Med Chem
, vol.58
, pp. 419-432
-
-
Henderson, J.L.1
Kormos, B.L.2
Hayward, M.M.3
-
76
-
-
79951534656
-
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
-
Piccoli G, Condliffe SB, Bauer M, et al. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci 2011;31:2225-2237.
-
(2011)
J Neurosci
, vol.31
, pp. 2225-2237
-
-
Piccoli, G.1
Condliffe, S.B.2
Bauer, M.3
-
77
-
-
84901320074
-
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain
-
Piccoli G, Onofri F, Cirnaru MD, et al. Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain. Mol Cell Biol 2014;34:2147-2161.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 2147-2161
-
-
Piccoli, G.1
Onofri, F.2
Cirnaru, M.D.3
-
78
-
-
84896736721
-
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
-
Parisiadou L, Yu J, Sgobio C, et al. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci 2014;17:367-376.
-
(2014)
Nat Neurosci
, vol.17
, pp. 367-376
-
-
Parisiadou, L.1
Yu, J.2
Sgobio, C.3
-
79
-
-
84924455094
-
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory
-
Beccano-Kelly DA, Volta M, Munsie LN, et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Hum Mol Genet 2015 1;24:1336-1349.
-
(2015)
Hum Mol Genet
, vol.1
, Issue.24
, pp. 1336-1349
-
-
Beccano-Kelly, D.A.1
Volta, M.2
Munsie, L.N.3
-
80
-
-
84907573660
-
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
-
Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, et al. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Front Cell Neurosci 2014;8:301.
-
(2014)
Front Cell Neurosci
, vol.8
, pp. 301
-
-
Beccano-Kelly, D.A.1
Kuhlmann, N.2
Tatarnikov, I.3
-
81
-
-
70149124508
-
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
-
Tong Y, Pisani A, Martella G, et al. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A 2009;106:14622-14627.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14622-14627
-
-
Tong, Y.1
Pisani, A.2
Martella, G.3
-
82
-
-
77957794336
-
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
-
Melrose HL, Dächsel JC, Behrouz B, et al. Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 2010;40:503-517.
-
(2010)
Neurobiol Dis
, vol.40
, pp. 503-517
-
-
Melrose, H.L.1
Dächsel, J.C.2
Behrouz, B.3
-
83
-
-
84928594767
-
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
-
Yue M, Hinkle KM, Davies P, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis 2015;78:172-195.
-
(2015)
Neurobiol Dis
, vol.78
, pp. 172-195
-
-
Yue, M.1
Hinkle, K.M.2
Davies, P.3
-
84
-
-
76149134717
-
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
-
Li X, Patel JC, Wang J, et al. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci 2010;30:1788-797.
-
(2010)
J Neurosci
, vol.30
, pp. 1788-1797
-
-
Li, X.1
Patel, J.C.2
Wang, J.3
-
85
-
-
84928611110
-
Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging
-
Walker MD, Volta M, Cataldi S, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. J Parkinsons Dis 2014;4:483-498.
-
(2014)
J Parkinsons Dis
, vol.4
, pp. 483-498
-
-
Walker, M.D.1
Volta, M.2
Cataldi, S.3
-
86
-
-
84881376726
-
Advances in the genetics of Parkinson disease
-
Trinh J, Farrer M. Advances in the genetics of Parkinson disease. Nat Rev Neurol 2013;9:445-454.
-
(2013)
Nat Rev Neurol
, vol.9
, pp. 445-454
-
-
Trinh, J.1
Farrer, M.2
-
87
-
-
84860617691
-
Aberrant striatal synaptic plasticity in monogenic parkinsonisms
-
Madeo G, Martella G, Schirinzi T, et al. Aberrant striatal synaptic plasticity in monogenic parkinsonisms. Neuroscience 2012;211:126-35.
-
(2012)
Neuroscience
, vol.211
, pp. 126-135
-
-
Madeo, G.1
Martella, G.2
Schirinzi, T.3
-
88
-
-
84904747061
-
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease
-
Dave KD, De Silva S, Sheth NP, et al. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiol Dis 2014;70:190-203.
-
(2014)
Neurobiol Dis
, vol.70
, pp. 190-203
-
-
Dave, K.D.1
De Silva, S.2
Sheth, N.P.3
-
89
-
-
34250372427
-
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
-
Klein C, Lohmann-Hedrich K, Rogaeva E, et al. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662.
-
(2007)
Lancet Neurol
, vol.6
, pp. 652-662
-
-
Klein, C.1
Lohmann-Hedrich, K.2
Rogaeva, E.3
-
90
-
-
77953186796
-
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
-
Eggers C, Schmidt A, Hagenah J, et al. Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit. Neurology 2010;74:1798-1805.
-
(2010)
Neurology
, vol.74
, pp. 1798-1805
-
-
Eggers, C.1
Schmidt, A.2
Hagenah, J.3
-
91
-
-
72849153163
-
Mapping preclinical compensation in Parkinson's disease: an imaging genomics approach
-
van Nuenen BF, van Eimeren T, van der Vegt JP, et al. Mapping preclinical compensation in Parkinson's disease: an imaging genomics approach. Mov Disord 2009;24:S703-S710.
-
(2009)
Mov Disord
, vol.24
, pp. S703-S710
-
-
van Nuenen, B.F.1
van Eimeren, T.2
van der Vegt, J.P.3
-
92
-
-
84865687744
-
Considerations regarding the etiology and future treatment of autosomal recessive versus idiopathic Parkinson disease
-
Kitada T, Tomlinson JJ, Ao HS, et al. Considerations regarding the etiology and future treatment of autosomal recessive versus idiopathic Parkinson disease. Curr Treat Options Neurol 2012;14:230-240.
-
(2012)
Curr Treat Options Neurol
, vol.14
, pp. 230-240
-
-
Kitada, T.1
Tomlinson, J.J.2
Ao, H.S.3
-
93
-
-
84892946302
-
PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity
-
Madeo G, Schirinzi T, Martella G, et al. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Mov Disord 2014;29:41-53.
-
(2014)
Mov Disord
, vol.29
, pp. 41-53
-
-
Madeo, G.1
Schirinzi, T.2
Martella, G.3
-
94
-
-
84920184454
-
An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions
-
Johnson ME, Bobrovskaya L. An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions. Neurotoxicology 2015;46:101-116.
-
(2015)
Neurotoxicology
, vol.46
, pp. 101-116
-
-
Johnson, M.E.1
Bobrovskaya, L.2
-
95
-
-
84960848269
-
Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice
-
Martella G, Madeo G, Maltese M, et al. Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice. Neurobiol Dis 2016;91:21-36.
-
(2016)
Neurobiol Dis
, vol.91
, pp. 21-36
-
-
Martella, G.1
Madeo, G.2
Maltese, M.3
-
96
-
-
84892926880
-
Lazy" nigrostriatal synapses in the heterozygous PINK1 mouse model of familial Parkinson's disease
-
Calabresi P, Ghiglieri V. "Lazy" nigrostriatal synapses in the heterozygous PINK1 mouse model of familial Parkinson's disease. Mov Disord 2014;29:11-14.
-
(2014)
Mov Disord
, vol.29
, pp. 11-14
-
-
Calabresi, P.1
Ghiglieri, V.2
-
97
-
-
34547489872
-
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
-
Kitada T, Pisani A, Porter DR, et al. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 2007;104:11441-1446.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11441-11446
-
-
Kitada, T.1
Pisani, A.2
Porter, D.R.3
-
98
-
-
44549088952
-
Parkinson's disease and pesticides: a toxicological perspective
-
Hatcher JM, Pennell KD, Miller GW. Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol Sci 2008;29:322-329.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 322-329
-
-
Hatcher, J.M.1
Pennell, K.D.2
Miller, G.W.3
-
99
-
-
33845645902
-
Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation
-
Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW. Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci 2007;95:163-171.
-
(2007)
Toxicol Sci
, vol.95
, pp. 163-171
-
-
Ramachandiran, S.1
Hansen, J.M.2
Jones, D.P.3
Richardson, J.R.4
Miller, G.W.5
-
101
-
-
77956975355
-
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment
-
George S, Mok SS, Nurjono M, et al. α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment. J Mol Neurosci 2010;42:243-254.
-
(2010)
J Mol Neurosci
, vol.42
, pp. 243-254
-
-
George, S.1
Mok, S.S.2
Nurjono, M.3
-
102
-
-
84872532026
-
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats
-
Mulcahy P, O'Doherty A, Paucard A, O'Brien T, Kirik D, Dowd E. The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats. Behav Brain Res 2013;243:6-15.
-
(2013)
Behav Brain Res
, vol.243
, pp. 6-15
-
-
Mulcahy, P.1
O'Doherty, A.2
Paucard, A.3
O'Brien, T.4
Kirik, D.5
Dowd, E.6
-
103
-
-
84936818605
-
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model
-
Zharikov AD, Cannon JR, Tapias V, et al. shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. J Clin Invest 2015;125:2721-2735.
-
(2015)
J Clin Invest
, vol.125
, pp. 2721-2735
-
-
Zharikov, A.D.1
Cannon, J.R.2
Tapias, V.3
-
105
-
-
84885347308
-
The enemy within: propagation of aberrant corticostriatal learning to cortical function in Parkinson's disease
-
Beeler JA, Petzinger G, Jakowec MW. The enemy within: propagation of aberrant corticostriatal learning to cortical function in Parkinson's disease. Front Neurol 2013;4:134.
-
(2013)
Front Neurol
, vol.4
, pp. 134
-
-
Beeler, J.A.1
Petzinger, G.2
Jakowec, M.W.3
-
106
-
-
84931957048
-
Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease
-
Cazorla M, Kang UJ, Kellendonk C. Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease. Mov Disord 2015;30:895-903.
-
(2015)
Mov Disord
, vol.30
, pp. 895-903
-
-
Cazorla, M.1
Kang, U.J.2
Kellendonk, C.3
-
107
-
-
84904961722
-
Direct and indirect pathways of basal ganglia: a critical reappraisal
-
Calabresi P, Picconi B, Tozzi A, Ghiglieri V, Di Filippo M. Direct and indirect pathways of basal ganglia: a critical reappraisal. Nat Neurosci 2014:17:1022-1030.
-
(2014)
Nat Neurosci
, vol.17
, pp. 1022-1030
-
-
Calabresi, P.1
Picconi, B.2
Tozzi, A.3
Ghiglieri, V.4
Di Filippo, M.5
-
108
-
-
84891772350
-
Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry
-
Cazorla M, de Carvalho FD, Chohan MO, et al. Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry. Neuron 2014;81:153-164.
-
(2014)
Neuron
, vol.81
, pp. 153-164
-
-
Cazorla, M.1
de Carvalho, F.D.2
Chohan, M.O.3
-
109
-
-
84873733797
-
Concurrent activation of striatal direct and indirect pathways during action initiation
-
Cui G, Jun SB, Jin X, et al. Concurrent activation of striatal direct and indirect pathways during action initiation. Nature 2013;494:238-242.
-
(2013)
Nature
, vol.494
, pp. 238-242
-
-
Cui, G.1
Jun, S.B.2
Jin, X.3
-
110
-
-
84896722491
-
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences
-
Jin X, Tecuapetla F, Costa RM. Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nat Neurosci 2014;17:423-430.
-
(2014)
Nat Neurosci
, vol.17
, pp. 423-430
-
-
Jin, X.1
Tecuapetla, F.2
Costa, R.M.3
-
111
-
-
20344383535
-
Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
-
Pisani A, Centonze D, Bernardi G, Calabresi P. Striatal synaptic plasticity: implications for motor learning and Parkinson's disease. Mov Disord 2005;20:395-402.
-
(2005)
Mov Disord
, vol.20
, pp. 395-402
-
-
Pisani, A.1
Centonze, D.2
Bernardi, G.3
Calabresi, P.4
-
112
-
-
33644824423
-
Timing of treatment initiation in Parkinson's disease: a need for reappraisal?
-
Schapira AH, Obeso J. Timing of treatment initiation in Parkinson's disease: a need for reappraisal? Ann. Neurol 2006:59:559-562.
-
(2006)
Ann. Neurol
, vol.59
, pp. 559-562
-
-
Schapira, A.H.1
Obeso, J.2
-
113
-
-
0025169590
-
Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
-
Bergman H, Wichmann T, DeLong M.R. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990;249:1436-1438.
-
(1990)
Science
, vol.249
, pp. 1436-1438
-
-
Bergman, H.1
Wichmann, T.2
DeLong, M.R.3
-
114
-
-
0037384803
-
Presymptomatic compensation in Parkinson's disease is not dopamine-mediated
-
Bezard E, Gross CE, Brotchie JM. Presymptomatic compensation in Parkinson's disease is not dopamine-mediated. Trends Neurosci 2003;26:215-221.
-
(2003)
Trends Neurosci
, vol.26
, pp. 215-221
-
-
Bezard, E.1
Gross, C.E.2
Brotchie, J.M.3
-
115
-
-
0036589838
-
Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: implications for the pathophysiology of cortical function
-
Gilio F, Currà A, Inghilleri M, Lorenzano C, Manfredi M, Berardelli A. Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: implications for the pathophysiology of cortical function. Mov Disord 2002;17:467-473.
-
(2002)
Mov Disord
, vol.17
, pp. 467-473
-
-
Gilio, F.1
Currà, A.2
Inghilleri, M.3
Lorenzano, C.4
Manfredi, M.5
Berardelli, A.6
-
116
-
-
84857790746
-
Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson's disease
-
Kishore A, Joseph T, Velayudhan B, Popa T, Meunier S. Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson's disease. Clin Neurophysiol 2012;123:822-828.
-
(2012)
Clin Neurophysiol
, vol.123
, pp. 822-828
-
-
Kishore, A.1
Joseph, T.2
Velayudhan, B.3
Popa, T.4
Meunier, S.5
-
117
-
-
36348941061
-
Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study
-
Bäumer T, Pramstaller PP, Siebner HR, et al. Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study. Neurology 2007;69:1976-1981.
-
(2007)
Neurology
, vol.69
, pp. 1976-1981
-
-
Bäumer, T.1
Pramstaller, P.P.2
Siebner, H.R.3
-
118
-
-
57049153993
-
Motor cortical physiology in patients and asymptomatic carriers of parkin gene mutations
-
Schneider SA, Talelli P, Cheeran BJ, Khan NL, Wood NW, Rothwell JC, Bhatia KP. Motor cortical physiology in patients and asymptomatic carriers of parkin gene mutations. Mov Disord 2008;23:1812-1819.
-
(2008)
Mov Disord
, vol.23
, pp. 1812-1819
-
-
Schneider, S.A.1
Talelli, P.2
Cheeran, B.J.3
Khan, N.L.4
Wood, N.W.5
Rothwell, J.C.6
Bhatia, K.P.7
-
119
-
-
84927605772
-
Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers
-
Helmich RC, Thaler A, van Nuenen BF, et al. Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers. Neurology 2015;84:399-406.
-
(2015)
Neurology
, vol.84
, pp. 399-406
-
-
Helmich, R.C.1
Thaler, A.2
van Nuenen, B.F.3
|