-
2
-
-
0038727936
-
Description of Parkinson's disease as a clinical syndrome
-
Fahn S. 2003. Description of Parkinson's disease as a clinical syndrome. Ann. N. Y. Acad. Sci. 991:1-14. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07458.x.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.991
, pp. 1-14
-
-
Fahn, S.1
-
3
-
-
63849246525
-
Protein structure prediction on the Web: a case study using the Phyre server
-
Kelley LA, Sternberg MJE. 2009. Protein structure prediction on the Web: a case study using the Phyre server. Nat. Protoc. 4:363-371. http://dx.doi.org/10.1038/nprot.2009.2.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 363-371
-
-
Kelley, L.A.1
Sternberg, M.J.E.2
-
4
-
-
0345118282
-
Roc, a Ras/GTPase domain in complex proteins
-
Bosgraaf L, Van Haastert PJ. 2003. Roc, a Ras/GTPase domain in complex proteins. Biochim. Biophys. Acta 1643:5-10. http://dx.doi.org/10.1016/j.bbamcr.2003.08.008.
-
(2003)
Biochim. Biophys. Acta
, vol.1643
, pp. 5-10
-
-
Bosgraaf, L.1
Van Haastert, P.J.2
-
5
-
-
84866635836
-
Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations
-
Mills RD, Mulhern TD, Cheng H-C, Culvenor JG. 2012. Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations. Biochem. Soc. Trans. 40:1086- 1089. http://dx.doi.org/10.1042/BST20120088.
-
(2012)
Biochem. Soc. Trans.
, vol.40
-
-
Mills, R.D.1
Mulhern, T.D.2
Cheng, H.-C.3
Culvenor, J.G.4
-
6
-
-
33646538477
-
Leucine-rich repeat kinase 2: relevance to Parkinson's disease
-
Guo L, Wang W, Chen SG. 2006. Leucine-rich repeat kinase 2: relevance to Parkinson's disease. Int. J. Biochem. Cell Biol. 38:1469-1475. http://dx.doi.org/10.1016/j.biocel.2006.02.009.
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 1469-1475
-
-
Guo, L.1
Wang, W.2
Chen, S.G.3
-
7
-
-
33748946787
-
LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample
-
Goldwurm S, Zini M, Di Fonzo A, De Gaspari D, Siri C, Simons EJ, van Doeselaar M, Tesei S, Antonini A, Canesi M, Zecchinelli A, Mariani C, Meucci N, Sacilotto G, Cilia R, Isaias IU, Bonetti A, Sironi F, Ricca S, Oostra BA, Bonifati V, Pezzoli G. 2006. LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample. Parkinsonism Relat. Disord. 12:410-419. http://dx.doi.org/10.1016/j.parkreldis.2006.04.001.
-
(2006)
Parkinsonism Relat. Disord.
, vol.12
, pp. 410-419
-
-
Goldwurm, S.1
Zini, M.2
Di Fonzo, A.3
De Gaspari, D.4
Siri, C.5
Simons, E.J.6
van Doeselaar, M.7
Tesei, S.8
Antonini, A.9
Canesi, M.10
Zecchinelli, A.11
Mariani, C.12
Meucci, N.13
Sacilotto, G.14
Cilia, R.15
Isaias, I.U.16
Bonetti, A.17
Sironi, F.18
Ricca, S.19
Oostra, B.A.20
Bonifati, V.21
Pezzoli, G.22
more..
-
8
-
-
33748876153
-
Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics
-
Bonifati V. 2006. Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur. J. Hum. Genet. 14:1061-1062. http://dx.doi.org/10.1038/sj.ejhg.5201695.
-
(2006)
Eur. J. Hum. Genet.
, vol.14
, pp. 1061-1062
-
-
Bonifati, V.1
-
9
-
-
84864743687
-
The G2385R variant of leucinerich repeat kinase 2 associated with Parkinson's disease is a partial loss-offunction mutation
-
Rudenko IN, Kaganovich A, Hauser DN, Beylina A, Chia R, Ding J, Maric D, Jaffe H, Cookson MR. 2012. The G2385R variant of leucinerich repeat kinase 2 associated with Parkinson's disease is a partial loss-offunction mutation. Biochem. J. 446:99-111. http://dx.doi.org/10.1042/BJ20120637.
-
(2012)
Biochem. J.
, vol.446
, pp. 99-111
-
-
Rudenko, I.N.1
Kaganovich, A.2
Hauser, D.N.3
Beylina, A.4
Chia, R.5
Ding, J.6
Maric, D.7
Jaffe, H.8
Cookson, M.R.9
-
10
-
-
77949514432
-
The WD40 domain is required for LRRK2 neurotoxicity
-
Jorgensen ND, Peng Y, Ho CC-Y, Rideout HJ, Petrey D, Liu P, Dauer WT. 2009. The WD40 domain is required for LRRK2 neurotoxicity. PLoS One 4:e8463. http://dx.doi.org/10.1371/journal.pone.0008463.
-
(2009)
PLoS One
, vol.4
-
-
Jorgensen, N.D.1
Peng, Y.2
Ho, C.C.-Y.3
Rideout, H.J.4
Petrey, D.5
Liu, P.6
Dauer, W.T.7
-
12
-
-
58149161238
-
Diversity of WD-repeat proteins
-
Smith TF. 2008. Diversity of WD-repeat proteins. Subcell. Biochem. 48: 20-30. http://dx.doi.org/10.1007/978-0-387-09595-0_3.
-
(2008)
Subcell. Biochem.
, vol.48
, pp. 20-30
-
-
Smith, T.F.1
-
13
-
-
79951534656
-
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
-
Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. 2011. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J. Neurosci. 31:2225- 2237. http://dx.doi.org/10.1523/JNEUROSCI.3730-10.2011.
-
(2011)
J. Neurosci.
, vol.31
-
-
Piccoli, G.1
Condliffe, S.B.2
Bauer, M.3
Giesert, F.4
Boldt, K.5
De Astis, S.6
Meixner, A.7
Sarioglu, H.8
Vogt-Weisenhorn, D.M.9
Wurst, W.10
Gloeckner, C.J.11
Matteoli, M.12
Sala, C.13
Ueffing, M.14
-
14
-
-
33846000636
-
Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease
-
Tan E-K. 2006. Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease. Ann. Acad. Med. Singapore 35:840- 842.
-
(2006)
Ann. Acad. Med. Singapore
, vol.35
-
-
Tan, E.-K.1
-
15
-
-
33846358949
-
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence
-
Tan EK, Zhao Y, Skipper L, Tan MG, Di Fonzo A, Sun L, Fook-Chong S, Tang S, Chua E, Yuen Y, Tan L, Pavanni R, Wong MC, Kolatkar P, Lu CS, Bonifati V, Liu JJ. 2007. The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence. Hum. Genet. 120:857- 863. http://dx.doi.org/10.1007/s00439-006-0268-0.
-
(2007)
Hum. Genet.
, vol.120
-
-
Tan, E.K.1
Zhao, Y.2
Skipper, L.3
Tan, M.G.4
Di Fonzo, A.5
Sun, L.6
Fook-Chong, S.7
Tang, S.8
Chua, E.9
Yuen, Y.10
Tan, L.11
Pavanni, R.12
Wong, M.C.13
Kolatkar, P.14
Lu, C.S.15
Bonifati, V.16
Liu, J.J.17
-
16
-
-
70349329841
-
LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis
-
Tan EK, Peng R, Wu YR, Wu RM, Wu-Chou YH, Tan LC, An XK, Chen CM, Fook-Chong S, Lu CS. 2009. LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B:1022-1023. http://dx.doi.org/10.1002/ajmg.b.30923.
-
(2009)
Am. J. Med. Genet. B Neuropsychiatr. Genet
, vol.150 B
, pp. 1022-1023
-
-
Tan, E.K.1
Peng, R.2
Wu, Y.R.3
Wu, R.M.4
Wu-Chou, Y.H.5
Tan, L.C.6
An, X.K.7
Chen, C.M.8
Fook-Chong, S.9
Lu, C.S.10
-
17
-
-
0027226219
-
Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serumfree medium combination
-
Brewer GJ, Torricelli JR, Evege EK, Price PJ. 1993. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serumfree medium combination. J. Neurosci. Res. 35:567-576. http://dx.doi.org/10.1002/jnr.490350513.
-
(1993)
J. Neurosci. Res.
, vol.35
, pp. 567-576
-
-
Brewer, G.J.1
Torricelli, J.R.2
Evege, E.K.3
Price, P.J.4
-
18
-
-
70349771201
-
Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag
-
Gloeckner CJ, Boldt K, Schumacher A, Ueffing M. 2009. Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag. Proteomics 564:359-372. http://dx.doi.org/10.1007/978-1-60761-157-8_21.
-
(2009)
Proteomics
, vol.564
, pp. 359-372
-
-
Gloeckner, C.J.1
Boldt, K.2
Schumacher, A.3
Ueffing, M.4
-
19
-
-
54449097915
-
RACK1, a new ADAM12 interacting protein, Contribution to liver fibrogenesis
-
J. Biol. Chem.
-
Bourd-Boittin K, Le Pabic H, Bonnier D, L'Helgoualc'h A, Théret N. 2008. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. J. Biol. Chem. 283:26000-26009. http://dx.doi.org/10.1074/jbc.M709829200.
-
(2008)
, vol.283
, pp. 26000-26009
-
-
Bourd-Boittin, K.1
Le Pabic, H.2
Bonnier, D.3
L'Helgoualc'h, A.4
Théret, N.5
-
20
-
-
31144443248
-
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
-
Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M. 2006. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum. Mol. Genet. 15:223-232. http://dx.doi.org/10.1093/hmg/ddi439.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 223-232
-
-
Gloeckner, C.J.1
Kinkl, N.2
Schumacher, A.3
Braun, R.J.4
O'Neill, E.5
Meitinger, T.6
Kolch, W.7
Prokisch, H.8
Ueffing, M.9
-
21
-
-
0029800074
-
Calcium influx via theNMDAreceptor induces immediate early gene transcription by aMAP kinase/ERK-dependent mechanism
-
Xia Z, Dudek H, Miranti CK, Greenberg ME. 1996. Calcium influx via theNMDAreceptor induces immediate early gene transcription by aMAP kinase/ERK-dependent mechanism. J. Neurosci. 16:5425-5436.
-
(1996)
J. Neurosci.
, vol.16
, pp. 5425-5436
-
-
Xia, Z.1
Dudek, H.2
Miranti, C.K.3
Greenberg, M.E.4
-
22
-
-
0027212498
-
Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
-
Frangioni JV, Neel BG. 1993. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210:179-187. http://dx.doi.org/10.1006/abio.1993.1170.
-
(1993)
Anal. Biochem.
, vol.210
, pp. 179-187
-
-
Frangioni, J.V.1
Neel, B.G.2
-
23
-
-
0020955120
-
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
-
Huttner WB, Schiebler W, Greengard P, De Camilli P. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J. Cell Biol. 96:1374-1388.
-
(1983)
J. Cell Biol.
, vol.96
, pp. 1374-1388
-
-
Huttner, W.B.1
Schiebler, W.2
Greengard, P.3
De Camilli, P.4
-
24
-
-
77954371738
-
Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking
-
Messa M, Congia S, Defranchi E, Valtorta F, Fassio A, Onofri F, Benfenati F. 2010. Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking. J. Cell Sci. 123:2256-2265. http://dx.doi.org/10.1242/jcs.068445.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 2256-2265
-
-
Messa, M.1
Congia, S.2
Defranchi, E.3
Valtorta, F.4
Fassio, A.5
Onofri, F.6
Benfenati, F.7
-
25
-
-
84873431777
-
ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions A method to directly monitor the active conformation of LRRK2?
-
Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ. 2013. ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2? J. Neurosci. Methods 214:62-68. http://dx.doi.org/10.1016/j .jneumeth.2012.12.015.
-
(2013)
J. Neurosci. Methods
, vol.214
, pp. 62-68
-
-
Gillardon, F.1
Kremmer, E.2
Froehlich, T.3
Ueffing, M.4
Hengerer, B.5
Gloeckner, C.J.6
-
26
-
-
29244448703
-
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
-
Olsen JV. 2005. Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol. Cell. Proteomics 4:2010-2021. http://dx.doi.org/10.1074/mcp.T500030-MCP200.
-
(2005)
Mol. Cell. Proteomics
, vol.4
, pp. 2010-2021
-
-
Olsen, J.V.1
-
27
-
-
0037108887
-
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
-
Keller A, Nesvizhskii AI, Kolker E, Aebersold R. 2002. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 74:5383-5392. http://dx.doi.org/10.1021/ac025747h.
-
(2002)
Anal. Chem.
, vol.74
, pp. 5383-5392
-
-
Keller, A.1
Nesvizhskii, A.I.2
Kolker, E.3
Aebersold, R.4
-
28
-
-
0042338362
-
A statistical model for identifying proteins by tandem mass spectrometry
-
Nesvizhskii AI, Keller A, Kolker E, Aebersold R. 2003. A statistical model for identifying proteins by tandem mass spectrometry. Anal. Chem. 75: 4646-4658. http://dx.doi.org/10.1021/ac0341261.
-
(2003)
Anal. Chem.
, vol.75
, pp. 4646-4658
-
-
Nesvizhskii, A.I.1
Keller, A.2
Kolker, E.3
Aebersold, R.4
-
29
-
-
0026719481
-
Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
-
Matteoli M, Takei K, Perin MS, Sudhof TC, De Camilli P. 1992. Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons. J. Cell Biol. 117:849-861. http://dx.doi.org/10.1083/jcb.117.4.849.
-
(1992)
J. Cell Biol.
, vol.117
, pp. 849-861
-
-
Matteoli, M.1
Takei, K.2
Perin, M.S.3
Sudhof, T.C.4
De Camilli, P.5
-
30
-
-
34548150255
-
Proteomic analysis of activity-dependent synaptic plasticity in hippocampal neurons
-
Piccoli G, Verpelli C, Tonna N, Romorini S, Alessio M, Nairn AC, Bachi A, Sala C. 2007. Proteomic analysis of activity-dependent synaptic plasticity in hippocampal neurons. J. Prot. Res. 6:3203-3215. http://dx.doi.org/10.1021/pr0701308.
-
(2007)
J. Prot. Res.
, vol.6
, pp. 3203-3215
-
-
Piccoli, G.1
Verpelli, C.2
Tonna, N.3
Romorini, S.4
Alessio, M.5
Nairn, A.C.6
Bachi, A.7
Sala, C.8
-
31
-
-
0033377664
-
EMAN: semiautomated software for high-resolution single-particle reconstructions
-
Ludtke SJ, Baldwin PR, Chiu W. 1999. EMAN: semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol. 128:82-97. http://dx.doi.org/10.1006/jsbi.1999.4174.
-
(1999)
J. Struct. Biol.
, vol.128
, pp. 82-97
-
-
Ludtke, S.J.1
Baldwin, P.R.2
Chiu, W.3
-
32
-
-
0033757806
-
The Protein Data Bank and the challenge of structural genomics
-
Berman HM, Bhat TN, Bourne PE, Feng Z, Gilliland G, Weissig H, Westbrook J. 2000. The Protein Data Bank and the challenge of structural genomics. Nat. Struct. Biol. 7(Suppl):957-959. http://dx.doi.org/10.1038/80734.
-
(2000)
Nat. Struct. Biol.
, vol.7
, Issue.SUPPL.
, pp. 957-959
-
-
Berman, H.M.1
Bhat, T.N.2
Bourne, P.E.3
Feng, Z.4
Gilliland, G.5
Weissig, H.6
Westbrook, J.7
-
33
-
-
0036616218
-
The Protein Data Bank
-
Berman HM, Battistuz T, Bhat TN, Bluhm WF, Bourne PE, Burkhardt K, Feng Z, Gilliland GL, Iype L, Jain S, Fagan P, Marvin J, Padilla D, Ravichandran V, Schneider B, Thanki N, Weissig H, Westbrook JD, Zardecki C. 2002. The Protein Data Bank. Acta Crystallogr. D. Biol. Crystallogr. 58:899-907. http://dx.doi.org/10.1107/S0907444902003451.
-
(2002)
Acta Crystallogr. D. Biol. Crystallogr.
, vol.58
, pp. 899-907
-
-
Berman, H.M.1
Battistuz, T.2
Bhat, T.N.3
Bluhm, W.F.4
Bourne, P.E.5
Burkhardt, K.6
Feng, Z.7
Gilliland, G.L.8
Iype, L.9
Jain, S.10
Fagan, P.11
Marvin, J.12
Padilla, D.13
Ravichandran, V.14
Schneider, B.15
Thanki, N.16
Weissig, H.17
Westbrook, J.D.18
Zardecki, C.19
-
34
-
-
52949130645
-
Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana
-
Ullah H, Scappini EL, Moon AF, Williams LV, Armstrong DL, Pedersen LC. 2008. Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana. Protein Sci. 17:1771-1780. http://dx.doi.org/10.1110/ps.035121.108.
-
(2008)
Protein Sci.
, vol.17
, pp. 1771-1780
-
-
Ullah, H.1
Scappini, E.L.2
Moon, A.F.3
Williams, L.V.4
Armstrong, D.L.5
Pedersen, L.C.6
-
35
-
-
0037093644
-
Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field
-
Krieger E, Koraimann G, Vriend G. 2002. Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field. Proteins 47:393-402. http://dx.doi.org/10.1002/prot.10104.
-
(2002)
Proteins
, vol.47
, pp. 393-402
-
-
Krieger, E.1
Koraimann, G.2
Vriend, G.3
-
36
-
-
0030339738
-
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR
-
Laskowski R, Rullmann JA, MacArthur M, Kaptein R, Thornton J. 1996. AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J. Biomol. NMR 8:477-486.
-
(1996)
J. Biomol. NMR
, vol.8
, pp. 477-486
-
-
Laskowski, R.1
Rullmann, J.A.2
MacArthur, M.3
Kaptein, R.4
Thornton, J.5
-
37
-
-
46549089664
-
LRRK2 regulates synaptic vesicle endocytosis
-
Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim C-H, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W. 2008. LRRK2 regulates synaptic vesicle endocytosis. Exp. Cell Res. 314: 2055-2065. http://dx.doi.org/10.1016/j.yexcr.2008.02.015.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 2055-2065
-
-
Shin, N.1
Jeong, H.2
Kwon, J.3
Heo, H.Y.4
Kwon, J.J.5
Yun, H.J.6
Kim, C.-H.7
Han, B.S.8
Tong, Y.9
Shen, J.10
Hatano, T.11
Hattori, N.12
Kim, K.S.13
Chang, S.14
Seol, W.15
-
38
-
-
77952391573
-
GTPase activity plays a key role in the pathobiology of LRRK2
-
Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. 2010. GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet. 6:e1000902. http://dx.doi.org/10.1371/journal.pgen.1000902.
-
(2010)
PLoS Genet.
, vol.6
-
-
Xiong, Y.1
Coombes, C.E.2
Kilaru, A.3
Li, X.4
Gitler, A.D.5
Bowers, W.J.6
Dawson, V.L.7
Dawson, T.M.8
Moore, D.J.9
-
39
-
-
78651065696
-
A QUICK screen for Lrrk2 interaction partners-leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics
-
Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M. 2011. A QUICK screen for Lrrk2 interaction partners-leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol. Cell Proteomics 10:M110.001172. http://dx.doi.org/10.1074/mcp.M110.001172.
-
(2011)
Mol. Cell Proteomics
, vol.10
-
-
Meixner, A.1
Boldt, K.2
Van Troys, M.3
Askenazi, M.4
Gloeckner, C.J.5
Bauer, M.6
Marto, J.A.7
Ampe, C.8
Kinkl, N.9
Ueffing, M.10
-
40
-
-
4744350970
-
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
-
Sengupta J, Nilsson J, Gursky R, Spahn CMT, Nissen P, Frank J. 2004. Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat. Struct. Mol. Biol. 10:957-962. http://dx.doi.org/10.1038/nsmb822.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.10
, pp. 957-962
-
-
Sengupta, J.1
Nilsson, J.2
Gursky, R.3
Spahn, C.M.T.4
Nissen, P.5
Frank, J.6
-
41
-
-
78651324347
-
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
-
Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, Jensen LJ, von Mering C. 2011. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39:D561-D568. http://dx.doi.org/10.1093/nar/gkq973.
-
(2011)
Nucleic Acids Res.
, vol.39
-
-
Szklarczyk, D.1
Franceschini, A.2
Kuhn, M.3
Simonovic, M.4
Roth, A.5
Minguez, P.6
Doerks, T.7
Stark, M.8
Muller, J.9
Bork, P.10
Jensen, L.J.11
von Mering, C.12
-
42
-
-
0242490780
-
Cytoscape: a software environment for integrated models of biomolecular interaction networks
-
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498-2504. http://dx.doi.org/10.1101/gr.1239303.
-
(2003)
Genome Res.
, vol.13
, pp. 2498-2504
-
-
Shannon, P.1
Markiel, A.2
Ozier, O.3
Baliga, N.S.4
Wang, J.T.5
Ramage, D.6
Amin, N.7
Schwikowski, B.8
Ideker, T.9
-
43
-
-
84891776413
-
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
-
Skibinski G, Nakamura K, Cookson MR, Finkbeiner S. 2014. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J. Neurosci. 34:418-433. http://dx.doi.org/10.1523/JNEUROSCI.2712-13.2014.
-
(2014)
J. Neurosci.
, vol.34
, pp. 418-433
-
-
Skibinski, G.1
Nakamura, K.2
Cookson, M.R.3
Finkbeiner, S.4
-
44
-
-
34547901041
-
Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation
-
Chernova T, Steinert JR, Guerin CJ, Nicotera P, Forsythe ID, Smith AG. 2007. Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. J. Neurosci. 27:8475-8485. http://dx.doi.org/10.1523/JNEUROSCI.0792-07.2007.
-
(2007)
J. Neurosci.
, vol.27
, pp. 8475-8485
-
-
Chernova, T.1
Steinert, J.R.2
Guerin, C.J.3
Nicotera, P.4
Forsythe, I.D.5
Smith, A.G.6
-
45
-
-
65649142038
-
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
-
Gloeckner CJ, Schumacher A, Boldt K, Ueffing M. 2009. The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J. Neurochem. 109:959- 968. http://dx.doi.org/10.1111/j.1471-4159.2009.06024.x.
-
(2009)
J. Neurochem.
, vol.109
-
-
Gloeckner, C.J.1
Schumacher, A.2
Boldt, K.3
Ueffing, M.4
-
46
-
-
33846562487
-
Parkinson's disease associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM. 2007. Parkinson's disease associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16:223-232. http://dx.doi.org/10.1093/hmg/ddl471.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
Andrabi, S.A.4
Li, X.5
Dikeman, D.6
Biskup, S.7
Zhang, Z.8
Lim, K.L.9
Dawson, V.L.10
Dawson, T.M.11
-
47
-
-
77956441086
-
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
-
Lee BD, Shin J-H, VanKampen J, Petrucelli L, West AB, Ko HS, Lee Y-I, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. 2010. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat. Med. 16:998-1000. http://dx.doi.org/10.1038/nm.2199.
-
(2010)
Nat. Med.
, vol.16
, pp. 998-1000
-
-
Lee, B.D.1
Shin, J.-H.2
VanKampen, J.3
Petrucelli, L.4
West, A.B.5
Ko, H.S.6
Lee, Y.-I.7
Maguire-Zeiss, K.A.8
Bowers, W.J.9
Federoff, H.J.10
Dawson, V.L.11
Dawson, T.M.12
-
48
-
-
84863012282
-
LRRK2 Parkinson disease mutations enhance its microtubule association
-
Kett LR, Boassa D, Ho CC-Y, Rideout HJ, Hu J, Terada M, Ellisman M, Dauer WT. 2012. LRRK2 Parkinson disease mutations enhance its microtubule association. Hum. Mol. Genet. 21:890-899. http://dx.doi.org/10.1093/hmg/ddr526.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 890-899
-
-
Kett, L.R.1
Boassa, D.2
Ho, C.C.-Y.3
Rideout, H.J.4
Hu, J.5
Terada, M.6
Ellisman, M.7
Dauer, W.T.8
-
49
-
-
33746267531
-
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
-
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR. 2006. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol. Dis. 23:329-341. http://dx.doi.org/10.1016/j.nbd.2006.04.001.
-
(2006)
Neurobiol. Dis.
, vol.23
, pp. 329-341
-
-
Greggio, E.1
Jain, S.2
Kingsbury, A.3
Bandopadhyay, R.4
Lewis, P.5
Kaganovich, A.6
van der Brug, M.P.7
Beilina, A.8
Blackinton, J.9
Thomas, K.J.10
Ahmad, R.11
Miller, D.W.12
Kesavapany, S.13
Singleton, A.14
Lees, A.15
Harvey, R.J.16
Harvey, K.17
Cookson, M.R.18
-
50
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B. 2008. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27:2432-2443. http://dx.doi.org/10.1038/emboj.2008.163.
-
(2008)
EMBO J.
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
Takahashi, R.4
Hasegawa, K.5
Oota, E.6
Lu, B.7
-
51
-
-
34447294546
-
Apoptotic mechanisms in mutant LRRK2-mediated cell death
-
Iaccarino C, Crosio C, Vitale C, Sanna G, Carri MT, Barone P. 2007. Apoptotic mechanisms in mutant LRRK2-mediated cell death. Hum. Mol. Genet. 16:1319-1326. http://dx.doi.org/10.1093/hmg/ddm080.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 1319-1326
-
-
Iaccarino, C.1
Crosio, C.2
Vitale, C.3
Sanna, G.4
Carri, M.T.5
Barone, P.6
-
52
-
-
84878904725
-
A method for WD40 repeat detection and secondary structure prediction
-
Wang Y, Jiang F, Zhuo Z, Wu X-H, Wu Y-D. 2013. A method for WD40 repeat detection and secondary structure prediction. PLoS One 8:e65705. http://dx.doi.org/10.1371/journal.pone.0065705.
-
(2013)
PLoS One
, vol.8
-
-
Wang, Y.1
Jiang, F.2
Zhuo, Z.3
Wu, X.-H.4
Wu, Y.-D.5
-
53
-
-
11144320747
-
Structural and functional analysis of essential premRNA splicing factor Prp19p
-
Ohi MD, Kooi CWV, Rosenberg JA, Ren L, Hirsch JP, Chazin WJ, Walz T, Gould KL. 2005. Structural and functional analysis of essential premRNA splicing factor Prp19p. Mol. Cell. Biol. 25:451-460. http://dx.doi.org/10.1128/MCB.25.1.451-460.2005.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 451-460
-
-
Ohi, M.D.1
Kooi, C.W.V.2
Rosenberg, J.A.3
Ren, L.4
Hirsch, J.P.5
Chazin, W.J.6
Walz, T.7
Gould, K.L.8
-
54
-
-
0027533267
-
Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro
-
Pryer NK, Salama NR, Schekman R, Kaiser CA. 1993. Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro. J. Cell Biol. 120:865-875. http://dx.doi.org/10.1083/jcb.120.4.865.
-
(1993)
J. Cell Biol.
, vol.120
, pp. 865-875
-
-
Pryer, N.K.1
Salama, N.R.2
Schekman, R.3
Kaiser, C.A.4
-
55
-
-
0028948853
-
The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance
-
Vaisman N, Tsouladze A, Robzyk K, Ben-Yehuda S, Kupiec M, Kassir Y. 1995. The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance. Mol. Gen. Genet. 247:123-136. http://dx.doi.org/10.1007/BF00705642.
-
(1995)
Mol. Gen. Genet.
, vol.247
, pp. 123-136
-
-
Vaisman, N.1
Tsouladze, A.2
Robzyk, K.3
Ben-Yehuda, S.4
Kupiec, M.5
Kassir, Y.6
-
56
-
-
77957242540
-
It's the machine that matters: predicting gene function and phenotype from protein networks
-
Wang PI, Marcotte EM. 2010. It's the machine that matters: predicting gene function and phenotype from protein networks. J. Proteomics 73: 2277-2289. http://dx.doi.org/10.1016/j.jprot.2010.07.005.
-
(2010)
J. Proteomics
, vol.73
, pp. 2277-2289
-
-
Wang, P.I.1
Marcotte, E.M.2
-
57
-
-
77951263230
-
Endosomal recycling regulation during cytokinesis
-
Ai E, Skop AR. 2009. Endosomal recycling regulation during cytokinesis. Commun. Integr. Biol. 2:444 - 447. http://dx.doi.org/10.4161/cib.2.5.8931.
-
(2009)
Commun. Integr. Biol.
, vol.2
-
-
Ai, E.1
Skop, A.R.2
-
58
-
-
76149134717
-
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
-
Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. 2010. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J. Neurosci. 30: 1788-1797. http://dx.doi.org/10.1523/JNEUROSCI.5604-09.2010.
-
(2010)
J. Neurosci.
, vol.30
, pp. 1788-1797
-
-
Li, X.1
Patel, J.C.2
Wang, J.3
Avshalumov, M.V.4
Nicholson, C.5
Buxbaum, J.D.6
Elder, G.A.7
Rice, M.E.8
Yue, Z.9
-
59
-
-
70149124508
-
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
-
Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. 2009. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc. Natl. Acad. Sci. 106:14622-14627. http://dx.doi.org/10.1073/pnas.0906334106.
-
(2009)
Proc. Natl. Acad. Sci.
, vol.106
, pp. 14622-14627
-
-
Tong, Y.1
Pisani, A.2
Martella, G.3
Karouani, M.4
Yamaguchi, H.5
Pothos, E.N.6
Shen, J.7
-
60
-
-
67649813448
-
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C. 2009. Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat. Neurosci. 12:826-828. http://dx.doi.org/10.1038/nn.2349.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 826-828
-
-
Li, Y.1
Liu, W.2
Oo, T.F.3
Wang, L.4
Tang, Y.5
Jackson-Lewis, V.6
Zhou, C.7
Geghman, K.8
Bogdanov, M.9
Przedborski, S.10
Beal, M.F.11
Burke, R.E.12
Li, C.13
-
61
-
-
78650209340
-
Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
-
Sossi V, de la Fuente-Fernández R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, Stoessl JA. 2010. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov. Disord. 25:2717-2723. http://dx.doi.org/10.1002/mds.23356.
-
(2010)
Mov. Disord.
, vol.25
, pp. 2717-2723
-
-
Sossi, V.1
de la Fuente-Fernández, R.2
Nandhagopal, R.3
Schulzer, M.4
McKenzie, J.5
Ruth, T.J.6
Aasly, J.O.7
Farrer, M.J.8
Wszolek, Z.K.9
Stoessl, J.A.10
-
62
-
-
33644822969
-
Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*
-
Berg D, Schweitzer KJ, Leitner P, Zimprich A, Lichtner P, Belcredi P, Brüssel T, Schulte C, Maass S, Nägele T, Wszolek ZK, Gasser T. 2005. Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*. Brain 128:3000-3011. http://dx.doi.org/10.1093/brain/awh666.
-
(2005)
Brain
, vol.128
, pp. 3000-3011
-
-
Berg, D.1
Schweitzer, K.J.2
Leitner, P.3
Zimprich, A.4
Lichtner, P.5
Belcredi, P.6
Brüssel, T.7
Schulte, C.8
Maass, S.9
Nägele, T.10
Wszolek, Z.K.11
Gasser, T.12
-
63
-
-
28544441389
-
Genetics of Parkinson's disease: LRRK2 on the rise
-
Brice A. 2005. Genetics of Parkinson's disease: LRRK2 on the rise. Brain 128:2760-2762. http://dx.doi.org/10.1093/brain/awh676.
-
(2005)
Brain
, vol.128
, pp. 2760-2762
-
-
Brice, A.1
-
64
-
-
68649097307
-
The genetics of Parkinson's syndromes: a critical review
-
Hardy J, Lewis P, Revesz T, Lees A, Paisan-Ruiz C. 2009. The genetics of Parkinson's syndromes: a critical review. Curr. Opin. Genet. Dev. 19:254- 265. http://dx.doi.org/10.1016/j.gde.2009.03.008.
-
(2009)
Curr. Opin. Genet. Dev
, vol.19
, pp. 254-265
-
-
Hardy, J.1
Lewis, P.2
Revesz, T.3
Lees, A.4
Paisan-Ruiz, C.5
|