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Volumn 34, Issue 12, 2014, Pages 2147-2161

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(21)  Piccoli, Giovanni a,b   Onofri, Franco c   Cirnaru, Maria Daniela b   Kaiser, Christoph J O d   Jagtap, Pravinkumar a,d   Kastenmüller, Andreas d   Pischedda, Francesca b   Marte, Antonella c   von Zweydorf, Felix e   Vogt, Andreas a,e   Giesert, Florian a   Pan, Lifeng f   Antonucci, Flavia g   Kiel, Christina h   Zhang, Mingjie f   Weinkauf, Sevil d   Sattler, Michael a,d   Sala, Carlo b   Matteoli, Michela g   Ueffing, Marius a,e   more..

b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

EID: 84901320074     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00914-13     Document Type: Article
Times cited : (86)

References (64)
  • 2
    • 0038727936 scopus 로고    scopus 로고
    • Description of Parkinson's disease as a clinical syndrome
    • Fahn S. 2003. Description of Parkinson's disease as a clinical syndrome. Ann. N. Y. Acad. Sci. 991:1-14. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07458.x.
    • (2003) Ann. N. Y. Acad. Sci. , vol.991 , pp. 1-14
    • Fahn, S.1
  • 3
    • 63849246525 scopus 로고    scopus 로고
    • Protein structure prediction on the Web: a case study using the Phyre server
    • Kelley LA, Sternberg MJE. 2009. Protein structure prediction on the Web: a case study using the Phyre server. Nat. Protoc. 4:363-371. http://dx.doi.org/10.1038/nprot.2009.2.
    • (2009) Nat. Protoc. , vol.4 , pp. 363-371
    • Kelley, L.A.1    Sternberg, M.J.E.2
  • 4
    • 0345118282 scopus 로고    scopus 로고
    • Roc, a Ras/GTPase domain in complex proteins
    • Bosgraaf L, Van Haastert PJ. 2003. Roc, a Ras/GTPase domain in complex proteins. Biochim. Biophys. Acta 1643:5-10. http://dx.doi.org/10.1016/j.bbamcr.2003.08.008.
    • (2003) Biochim. Biophys. Acta , vol.1643 , pp. 5-10
    • Bosgraaf, L.1    Van Haastert, P.J.2
  • 5
    • 84866635836 scopus 로고    scopus 로고
    • Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations
    • Mills RD, Mulhern TD, Cheng H-C, Culvenor JG. 2012. Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations. Biochem. Soc. Trans. 40:1086- 1089. http://dx.doi.org/10.1042/BST20120088.
    • (2012) Biochem. Soc. Trans. , vol.40
    • Mills, R.D.1    Mulhern, T.D.2    Cheng, H.-C.3    Culvenor, J.G.4
  • 6
    • 33646538477 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2: relevance to Parkinson's disease
    • Guo L, Wang W, Chen SG. 2006. Leucine-rich repeat kinase 2: relevance to Parkinson's disease. Int. J. Biochem. Cell Biol. 38:1469-1475. http://dx.doi.org/10.1016/j.biocel.2006.02.009.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1469-1475
    • Guo, L.1    Wang, W.2    Chen, S.G.3
  • 8
    • 33748876153 scopus 로고    scopus 로고
    • Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics
    • Bonifati V. 2006. Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur. J. Hum. Genet. 14:1061-1062. http://dx.doi.org/10.1038/sj.ejhg.5201695.
    • (2006) Eur. J. Hum. Genet. , vol.14 , pp. 1061-1062
    • Bonifati, V.1
  • 9
    • 84864743687 scopus 로고    scopus 로고
    • The G2385R variant of leucinerich repeat kinase 2 associated with Parkinson's disease is a partial loss-offunction mutation
    • Rudenko IN, Kaganovich A, Hauser DN, Beylina A, Chia R, Ding J, Maric D, Jaffe H, Cookson MR. 2012. The G2385R variant of leucinerich repeat kinase 2 associated with Parkinson's disease is a partial loss-offunction mutation. Biochem. J. 446:99-111. http://dx.doi.org/10.1042/BJ20120637.
    • (2012) Biochem. J. , vol.446 , pp. 99-111
    • Rudenko, I.N.1    Kaganovich, A.2    Hauser, D.N.3    Beylina, A.4    Chia, R.5    Ding, J.6    Maric, D.7    Jaffe, H.8    Cookson, M.R.9
  • 12
    • 58149161238 scopus 로고    scopus 로고
    • Diversity of WD-repeat proteins
    • Smith TF. 2008. Diversity of WD-repeat proteins. Subcell. Biochem. 48: 20-30. http://dx.doi.org/10.1007/978-0-387-09595-0_3.
    • (2008) Subcell. Biochem. , vol.48 , pp. 20-30
    • Smith, T.F.1
  • 14
    • 33846000636 scopus 로고    scopus 로고
    • Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease
    • Tan E-K. 2006. Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease. Ann. Acad. Med. Singapore 35:840- 842.
    • (2006) Ann. Acad. Med. Singapore , vol.35
    • Tan, E.-K.1
  • 17
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serumfree medium combination
    • Brewer GJ, Torricelli JR, Evege EK, Price PJ. 1993. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serumfree medium combination. J. Neurosci. Res. 35:567-576. http://dx.doi.org/10.1002/jnr.490350513.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4
  • 18
    • 70349771201 scopus 로고    scopus 로고
    • Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag
    • Gloeckner CJ, Boldt K, Schumacher A, Ueffing M. 2009. Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag. Proteomics 564:359-372. http://dx.doi.org/10.1007/978-1-60761-157-8_21.
    • (2009) Proteomics , vol.564 , pp. 359-372
    • Gloeckner, C.J.1    Boldt, K.2    Schumacher, A.3    Ueffing, M.4
  • 19
    • 54449097915 scopus 로고    scopus 로고
    • RACK1, a new ADAM12 interacting protein, Contribution to liver fibrogenesis
    • J. Biol. Chem.
    • Bourd-Boittin K, Le Pabic H, Bonnier D, L'Helgoualc'h A, Théret N. 2008. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. J. Biol. Chem. 283:26000-26009. http://dx.doi.org/10.1074/jbc.M709829200.
    • (2008) , vol.283 , pp. 26000-26009
    • Bourd-Boittin, K.1    Le Pabic, H.2    Bonnier, D.3    L'Helgoualc'h, A.4    Théret, N.5
  • 21
    • 0029800074 scopus 로고    scopus 로고
    • Calcium influx via theNMDAreceptor induces immediate early gene transcription by aMAP kinase/ERK-dependent mechanism
    • Xia Z, Dudek H, Miranti CK, Greenberg ME. 1996. Calcium influx via theNMDAreceptor induces immediate early gene transcription by aMAP kinase/ERK-dependent mechanism. J. Neurosci. 16:5425-5436.
    • (1996) J. Neurosci. , vol.16 , pp. 5425-5436
    • Xia, Z.1    Dudek, H.2    Miranti, C.K.3    Greenberg, M.E.4
  • 22
    • 0027212498 scopus 로고
    • Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
    • Frangioni JV, Neel BG. 1993. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210:179-187. http://dx.doi.org/10.1006/abio.1993.1170.
    • (1993) Anal. Biochem. , vol.210 , pp. 179-187
    • Frangioni, J.V.1    Neel, B.G.2
  • 23
    • 0020955120 scopus 로고
    • Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
    • Huttner WB, Schiebler W, Greengard P, De Camilli P. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J. Cell Biol. 96:1374-1388.
    • (1983) J. Cell Biol. , vol.96 , pp. 1374-1388
    • Huttner, W.B.1    Schiebler, W.2    Greengard, P.3    De Camilli, P.4
  • 24
    • 77954371738 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking
    • Messa M, Congia S, Defranchi E, Valtorta F, Fassio A, Onofri F, Benfenati F. 2010. Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking. J. Cell Sci. 123:2256-2265. http://dx.doi.org/10.1242/jcs.068445.
    • (2010) J. Cell Sci. , vol.123 , pp. 2256-2265
    • Messa, M.1    Congia, S.2    Defranchi, E.3    Valtorta, F.4    Fassio, A.5    Onofri, F.6    Benfenati, F.7
  • 25
    • 84873431777 scopus 로고    scopus 로고
    • ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions A method to directly monitor the active conformation of LRRK2?
    • Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ. 2013. ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2? J. Neurosci. Methods 214:62-68. http://dx.doi.org/10.1016/j .jneumeth.2012.12.015.
    • (2013) J. Neurosci. Methods , vol.214 , pp. 62-68
    • Gillardon, F.1    Kremmer, E.2    Froehlich, T.3    Ueffing, M.4    Hengerer, B.5    Gloeckner, C.J.6
  • 26
    • 29244448703 scopus 로고    scopus 로고
    • Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
    • Olsen JV. 2005. Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol. Cell. Proteomics 4:2010-2021. http://dx.doi.org/10.1074/mcp.T500030-MCP200.
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 2010-2021
    • Olsen, J.V.1
  • 27
    • 0037108887 scopus 로고    scopus 로고
    • Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    • Keller A, Nesvizhskii AI, Kolker E, Aebersold R. 2002. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 74:5383-5392. http://dx.doi.org/10.1021/ac025747h.
    • (2002) Anal. Chem. , vol.74 , pp. 5383-5392
    • Keller, A.1    Nesvizhskii, A.I.2    Kolker, E.3    Aebersold, R.4
  • 28
    • 0042338362 scopus 로고    scopus 로고
    • A statistical model for identifying proteins by tandem mass spectrometry
    • Nesvizhskii AI, Keller A, Kolker E, Aebersold R. 2003. A statistical model for identifying proteins by tandem mass spectrometry. Anal. Chem. 75: 4646-4658. http://dx.doi.org/10.1021/ac0341261.
    • (2003) Anal. Chem. , vol.75 , pp. 4646-4658
    • Nesvizhskii, A.I.1    Keller, A.2    Kolker, E.3    Aebersold, R.4
  • 29
    • 0026719481 scopus 로고
    • Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
    • Matteoli M, Takei K, Perin MS, Sudhof TC, De Camilli P. 1992. Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons. J. Cell Biol. 117:849-861. http://dx.doi.org/10.1083/jcb.117.4.849.
    • (1992) J. Cell Biol. , vol.117 , pp. 849-861
    • Matteoli, M.1    Takei, K.2    Perin, M.S.3    Sudhof, T.C.4    De Camilli, P.5
  • 31
    • 0033377664 scopus 로고    scopus 로고
    • EMAN: semiautomated software for high-resolution single-particle reconstructions
    • Ludtke SJ, Baldwin PR, Chiu W. 1999. EMAN: semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol. 128:82-97. http://dx.doi.org/10.1006/jsbi.1999.4174.
    • (1999) J. Struct. Biol. , vol.128 , pp. 82-97
    • Ludtke, S.J.1    Baldwin, P.R.2    Chiu, W.3
  • 34
    • 52949130645 scopus 로고    scopus 로고
    • Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana
    • Ullah H, Scappini EL, Moon AF, Williams LV, Armstrong DL, Pedersen LC. 2008. Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana. Protein Sci. 17:1771-1780. http://dx.doi.org/10.1110/ps.035121.108.
    • (2008) Protein Sci. , vol.17 , pp. 1771-1780
    • Ullah, H.1    Scappini, E.L.2    Moon, A.F.3    Williams, L.V.4    Armstrong, D.L.5    Pedersen, L.C.6
  • 35
    • 0037093644 scopus 로고    scopus 로고
    • Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field
    • Krieger E, Koraimann G, Vriend G. 2002. Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field. Proteins 47:393-402. http://dx.doi.org/10.1002/prot.10104.
    • (2002) Proteins , vol.47 , pp. 393-402
    • Krieger, E.1    Koraimann, G.2    Vriend, G.3
  • 36
    • 0030339738 scopus 로고    scopus 로고
    • AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR
    • Laskowski R, Rullmann JA, MacArthur M, Kaptein R, Thornton J. 1996. AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J. Biomol. NMR 8:477-486.
    • (1996) J. Biomol. NMR , vol.8 , pp. 477-486
    • Laskowski, R.1    Rullmann, J.A.2    MacArthur, M.3    Kaptein, R.4    Thornton, J.5
  • 40
    • 4744350970 scopus 로고    scopus 로고
    • Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
    • Sengupta J, Nilsson J, Gursky R, Spahn CMT, Nissen P, Frank J. 2004. Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat. Struct. Mol. Biol. 10:957-962. http://dx.doi.org/10.1038/nsmb822.
    • (2004) Nat. Struct. Mol. Biol. , vol.10 , pp. 957-962
    • Sengupta, J.1    Nilsson, J.2    Gursky, R.3    Spahn, C.M.T.4    Nissen, P.5    Frank, J.6
  • 43
    • 84891776413 scopus 로고    scopus 로고
    • Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
    • Skibinski G, Nakamura K, Cookson MR, Finkbeiner S. 2014. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J. Neurosci. 34:418-433. http://dx.doi.org/10.1523/JNEUROSCI.2712-13.2014.
    • (2014) J. Neurosci. , vol.34 , pp. 418-433
    • Skibinski, G.1    Nakamura, K.2    Cookson, M.R.3    Finkbeiner, S.4
  • 44
    • 34547901041 scopus 로고    scopus 로고
    • Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation
    • Chernova T, Steinert JR, Guerin CJ, Nicotera P, Forsythe ID, Smith AG. 2007. Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. J. Neurosci. 27:8475-8485. http://dx.doi.org/10.1523/JNEUROSCI.0792-07.2007.
    • (2007) J. Neurosci. , vol.27 , pp. 8475-8485
    • Chernova, T.1    Steinert, J.R.2    Guerin, C.J.3    Nicotera, P.4    Forsythe, I.D.5    Smith, A.G.6
  • 45
    • 65649142038 scopus 로고    scopus 로고
    • The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
    • Gloeckner CJ, Schumacher A, Boldt K, Ueffing M. 2009. The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J. Neurochem. 109:959- 968. http://dx.doi.org/10.1111/j.1471-4159.2009.06024.x.
    • (2009) J. Neurochem. , vol.109
    • Gloeckner, C.J.1    Schumacher, A.2    Boldt, K.3    Ueffing, M.4
  • 50
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B. 2008. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27:2432-2443. http://dx.doi.org/10.1038/emboj.2008.163.
    • (2008) EMBO J. , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6    Lu, B.7
  • 52
    • 84878904725 scopus 로고    scopus 로고
    • A method for WD40 repeat detection and secondary structure prediction
    • Wang Y, Jiang F, Zhuo Z, Wu X-H, Wu Y-D. 2013. A method for WD40 repeat detection and secondary structure prediction. PLoS One 8:e65705. http://dx.doi.org/10.1371/journal.pone.0065705.
    • (2013) PLoS One , vol.8
    • Wang, Y.1    Jiang, F.2    Zhuo, Z.3    Wu, X.-H.4    Wu, Y.-D.5
  • 54
    • 0027533267 scopus 로고
    • Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro
    • Pryer NK, Salama NR, Schekman R, Kaiser CA. 1993. Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro. J. Cell Biol. 120:865-875. http://dx.doi.org/10.1083/jcb.120.4.865.
    • (1993) J. Cell Biol. , vol.120 , pp. 865-875
    • Pryer, N.K.1    Salama, N.R.2    Schekman, R.3    Kaiser, C.A.4
  • 55
    • 0028948853 scopus 로고
    • The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance
    • Vaisman N, Tsouladze A, Robzyk K, Ben-Yehuda S, Kupiec M, Kassir Y. 1995. The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance. Mol. Gen. Genet. 247:123-136. http://dx.doi.org/10.1007/BF00705642.
    • (1995) Mol. Gen. Genet. , vol.247 , pp. 123-136
    • Vaisman, N.1    Tsouladze, A.2    Robzyk, K.3    Ben-Yehuda, S.4    Kupiec, M.5    Kassir, Y.6
  • 56
    • 77957242540 scopus 로고    scopus 로고
    • It's the machine that matters: predicting gene function and phenotype from protein networks
    • Wang PI, Marcotte EM. 2010. It's the machine that matters: predicting gene function and phenotype from protein networks. J. Proteomics 73: 2277-2289. http://dx.doi.org/10.1016/j.jprot.2010.07.005.
    • (2010) J. Proteomics , vol.73 , pp. 2277-2289
    • Wang, P.I.1    Marcotte, E.M.2
  • 57
    • 77951263230 scopus 로고    scopus 로고
    • Endosomal recycling regulation during cytokinesis
    • Ai E, Skop AR. 2009. Endosomal recycling regulation during cytokinesis. Commun. Integr. Biol. 2:444 - 447. http://dx.doi.org/10.4161/cib.2.5.8931.
    • (2009) Commun. Integr. Biol. , vol.2
    • Ai, E.1    Skop, A.R.2
  • 58
    • 76149134717 scopus 로고    scopus 로고
    • Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    • Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. 2010. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J. Neurosci. 30: 1788-1797. http://dx.doi.org/10.1523/JNEUROSCI.5604-09.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 1788-1797
    • Li, X.1    Patel, J.C.2    Wang, J.3    Avshalumov, M.V.4    Nicholson, C.5    Buxbaum, J.D.6    Elder, G.A.7    Rice, M.E.8    Yue, Z.9
  • 63
    • 28544441389 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease: LRRK2 on the rise
    • Brice A. 2005. Genetics of Parkinson's disease: LRRK2 on the rise. Brain 128:2760-2762. http://dx.doi.org/10.1093/brain/awh676.
    • (2005) Brain , vol.128 , pp. 2760-2762
    • Brice, A.1
  • 64
    • 68649097307 scopus 로고    scopus 로고
    • The genetics of Parkinson's syndromes: a critical review
    • Hardy J, Lewis P, Revesz T, Lees A, Paisan-Ruiz C. 2009. The genetics of Parkinson's syndromes: a critical review. Curr. Opin. Genet. Dev. 19:254- 265. http://dx.doi.org/10.1016/j.gde.2009.03.008.
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 254-265
    • Hardy, J.1    Lewis, P.2    Revesz, T.3    Lees, A.4    Paisan-Ruiz, C.5


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