Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

Journal of Parkinson's disease

Volumn 4, Issue 3, 2014, Pages 483-498

  Walker, Matthew D ^a   Volta, Mattia ^a   Cataldi, Stefano ^a   Dinelle, Katherine ^a   Beccano Kelly, Dayne ^a   Munsie, Lise ^a   Kornelsen, Rick ^a   Mah, Chenoa ^a   Chou, Patrick ^a   Co, Kimberley ^a   Khinda, Jaskaran ^a   Mroczek, Marta ^a   Bergeron, Sabrina ^a   Yu, Katrina ^a   Cao, Li P ing ^a   Funk, Natalja ^a   Ott, Thomas ^a   Galter, Dagmar ^a   Riess, Olaf ^a   Biskup, Saskia ^a   Milnerwood, Austen J ^a   Stoessl, A Jon ^a   Farrer, Matthew J ^a   Sossi, Vesna ^a   more..

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

brain imaging; dopamine; dopaminergic neurons; human; LRRK2 protein; Parkinson's disease; positron emission tomography; transgenic rats

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; LRRK2 PROTEIN, HUMAN; PHOSPHOPROTEIN DARPP 32; PPP1R1B PROTEIN, RAT; PROTEIN SERINE THREONINE KINASE; SLC18A2 PROTEIN, RAT; TYROSINE 3 MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORTER;

ANIMAL; BRAIN; DISEASE MODEL; GENETICS; HUMAN; MALE; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; PARKINSON DISEASE; PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; RAT; ROTAROD TEST; SCINTISCANNING; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MALE; MOTOR ACTIVITY; NEOSTRIATUM; PARKINSON DISEASE; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECEPTORS, DOPAMINE D2; ROTAROD PERFORMANCE TEST; TYROSINE 3-MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84928611110     PISSN: None     EISSN: 1877718X     Source Type: Journal    
DOI: 10.3233/JPD-140344     Document Type: Article

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