Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Matsumoto, Mitsuharu ^a,b   Kurihara, Shin ^c,d   Kibe, Ryoko ^b   Ashida, Hisashi ^d   Benno, Yoshimi ^b  

^a Nishitama gun   (Japan)

^b RIKEN   (Japan)

^c KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LACTULOSE; LKM512; MUCIN 2; MUCIN 3; POLYAMINE; PROBIOTIC AGENT; RHAMNOSE; RNA 16S; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; SPERMINE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIFIDOBACTERIUM ANIMALIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA MICROARRAY; DOWN REGULATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES CULTURE; FEMALE; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; INFLAMMATION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LONGEVITY; MOUSE; MUCUS SECRETION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYAMINE SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA GENE; SENESCENCE; SKIN ULCER; SURVIVAL RATE; TIGHT JUNCTION; TUMOR; UPREGULATION; ANIMAL; BACTERIUM; BIFIDOBACTERIUM; CELL AGING; CHEMISTRY; CLASSIFICATION; COLON; CYTOLOGY; DRUG EFFECT; FECES; GENE EXPRESSION PROFILING; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; KAPLAN MEIER METHOD; METABOLISM; MICROBIOLOGY; MUCUS; NEOPLASM; PHYSIOLOGY; SECRETION;

BACTERIA (MICROORGANISMS); BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS; MAMMALIA; MUS;

ANIMALS; BACTERIA; BIFIDOBACTERIUM; CELL AGING; COLON; FECES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; KAPLAN-MEIER ESTIMATE; LONGEVITY; MICE; MICE, INBRED ICR; MUCUS; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYAMINES; PROBIOTICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL, 16S; SKIN ULCER; SPERMINE; TIGHT JUNCTIONS;

EID: 80051699548     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023652     Document Type: Article

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