Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

Science

Volumn 348, Issue 6240, 2015, Pages 1251-1255

  Gaudet, Ryan G ^a   Sintsova, Anna ^a   Buckwalter, Carolyn M ^a   Leung, Nelly ^a   Cochrane, Alan ^a   Li, Jianjun ^b   Cox, Andrew D ^b   Moffat, Jason ^a,c   Gray Owen, Scott D ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARBOHYDRATE DERIVATIVE; HEPTOSE 1,7 BISPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TRAF INTERACTING PROTEIN WITH FORKHEAD ASSOCIATED DOMAIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; FLAGELLIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SUGAR PHOSPHATE; T2BP PROTEIN, HUMAN;

BACTERIUM; CELL ORGANELLE; DETECTION METHOD; GENOME; IMMUNE RESPONSE; IMMUNITY; MAMMAL; METABOLITE; MOLECULAR ANALYSIS; MONOSACCHARIDE; PATHOGEN; POLYSACCHARIDE; PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; BACTERIAL METABOLISM; BIOSYNTHESIS; CONTROLLED STUDY; CYTOSOL; INNATE IMMUNITY; MAMMAL CELL; METABOLITE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; BURKHOLDERIA; CHEMISTRY; ESCHERICHIA COLI; GENETIC SCREENING; GENETICS; GRAM NEGATIVE BACTERIUM; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; JURKAT CELL LINE; METABOLISM; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; NEGIBACTERIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BURKHOLDERIA; CYTOSOL; ESCHERICHIA COLI; FLAGELLIN; GENETIC TESTING; GRAM-NEGATIVE BACTERIA; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; JURKAT CELLS; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; NF-KAPPA B; RNA INTERFERENCE; SUGAR PHOSPHATES; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84931023881     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa4921     Document Type: Article

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