-
1
-
-
1542719049
-
The Niemann-Pick disease genes: Regulators of cellular cholesterol homeostasis
-
D.S. Ory The Niemann-Pick disease genes: regulators of cellular cholesterol homeostasis Trends Cardiovasc Med 14 2004 66 72
-
(2004)
Trends Cardiovasc Med
, vol.14
, pp. 66-72
-
-
Ory, D.S.1
-
2
-
-
79957903652
-
Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin
-
J.E. Vance, and K.B. Peake Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin Curr Opin Lipidol 22 2011 204 209
-
(2011)
Curr Opin Lipidol
, vol.22
, pp. 204-209
-
-
Vance, J.E.1
Peake, K.B.2
-
3
-
-
2942665893
-
Cellular pathology of Niemann-Pick type C disease
-
E. Ikonen, and M. Holtta-Vuori Cellular pathology of Niemann-Pick type C disease Semin Cell Dev Biol 15 2004 445 454
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 445-454
-
-
Ikonen, E.1
Holtta-Vuori, M.2
-
4
-
-
67649275699
-
Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells
-
B. Karten, K.B. Peake, and J.E. Vance Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells Biochim Biophys Acta 1791 2009 659 670
-
(2009)
Biochim Biophys Acta
, vol.1791
, pp. 659-670
-
-
Karten, B.1
Peake, K.B.2
Vance, J.E.3
-
5
-
-
84876849121
-
Niemann-Pick diseases
-
M.T. Vanier Niemann-Pick diseases Handb Clin Neurol 113 2013 1717 1721
-
(2013)
Handb Clin Neurol
, vol.113
, pp. 1717-1721
-
-
Vanier, M.T.1
-
6
-
-
84905033032
-
Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin
-
J.E. Vance, and B. Karten Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin J Lipid Res 55 2014 1609 1621
-
(2014)
J Lipid Res
, vol.55
, pp. 1609-1621
-
-
Vance, J.E.1
Karten, B.2
-
7
-
-
84890404443
-
Synthesis of 2-hydroxypropyl-beta-cyclodextrin/pluronic-based polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics
-
Y.A. Mondjinou, L.A. McCauliff, A. Kulkarni, L. Paul, S.H. Hyun, Z. Zhang, Z. Wu, M. Wirth, J. Storch, and D.H. Thompson Synthesis of 2-hydroxypropyl-beta-cyclodextrin/pluronic-based polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics Biomacromolecules 14 2013 4189 4197
-
(2013)
Biomacromolecules
, vol.14
, pp. 4189-4197
-
-
Mondjinou, Y.A.1
McCauliff, L.A.2
Kulkarni, A.3
Paul, L.4
Hyun, S.H.5
Zhang, Z.6
Wu, Z.7
Wirth, M.8
Storch, J.9
Thompson, D.H.10
-
8
-
-
84894065946
-
Collaborative development of 2-hydroxypropyl-beta-cyclodextrin for the treatment of Niemann-Pick type C1 disease
-
E.A. Ottinger, M.L. Kao, N. Carrillo-Carrasco, N. Yanjanin, R.K. Shankar, M. Janssen, M. Brewster, I. Scott, X. Xu, J. Cradock, P. Terse, S.J. Dehdashti, J. Marugan, W. Zheng, L. Portilla, A. Hubbs, W.J. Pavan, J. Heiss, C.H. Vite, S.U. Walkley, D.S. Ory, S.A. Silber, F.D. Porter, C.P. Austin, and J.C. McKew Collaborative development of 2-hydroxypropyl-beta-cyclodextrin for the treatment of Niemann-Pick type C1 disease Curr Top Med Chem 14 2014 330 339
-
(2014)
Curr Top Med Chem
, vol.14
, pp. 330-339
-
-
Ottinger, E.A.1
Kao, M.L.2
Carrillo-Carrasco, N.3
Yanjanin, N.4
Shankar, R.K.5
Janssen, M.6
Brewster, M.7
Scott, I.8
Xu, X.9
Cradock, J.10
Terse, P.11
Dehdashti, S.J.12
Marugan, J.13
Zheng, W.14
Portilla, L.15
Hubbs, A.16
Pavan, W.J.17
Heiss, J.18
Vite, C.H.19
Walkley, S.U.20
Ory, D.S.21
Silber, S.A.22
Porter, F.D.23
Austin, C.P.24
McKew, J.C.25
more..
-
9
-
-
79851476221
-
Niemann-Pick type C disease: Molecular mechanisms and potential therapeutic approaches
-
A.I. Rosenbaum, and F.R. Maxfield Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches J Neurochem 116 2011 789 795
-
(2011)
J Neurochem
, vol.116
, pp. 789-795
-
-
Rosenbaum, A.I.1
Maxfield, F.R.2
-
10
-
-
84886303330
-
Treatment of Niemann-Pick type C disease by histone deacetylase inhibitors
-
P. Helquist, F.R. Maxfield, N.L. Wiech, and O. Wiest Treatment of Niemann-Pick type C disease by histone deacetylase inhibitors Neurotherapeutics 10 2013 688 697
-
(2013)
Neurotherapeutics
, vol.10
, pp. 688-697
-
-
Helquist, P.1
Maxfield, F.R.2
Wiech, N.L.3
Wiest, O.4
-
11
-
-
77957226432
-
Oxidative stress in Niemann-Pick disease, type C
-
R. Fu, N.M. Yanjanin, S. Bianconi, W.J. Pavan, and F.D. Porter Oxidative stress in Niemann-Pick disease, type C Mol Genet Metab 101 2010 214 218
-
(2010)
Mol Genet Metab
, vol.101
, pp. 214-218
-
-
Fu, R.1
Yanjanin, N.M.2
Bianconi, S.3
Pavan, W.J.4
Porter, F.D.5
-
12
-
-
84893192165
-
Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick type c1-deficient murine brain
-
B.E. Kennedy, V.G. Leblanc, T.M. Mailman, D. Fice, I. Burton, T.K. Karakach, and B. Karten Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick type c1-deficient murine brain PLoS One 8 2013 e82685
-
(2013)
PLoS One
, vol.8
, pp. e82685
-
-
Kennedy, B.E.1
Leblanc, V.G.2
Mailman, T.M.3
Fice, D.4
Burton, I.5
Karakach, T.K.6
Karten, B.7
-
13
-
-
84881600379
-
Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1
-
R. Fu, C.A. Wassif, N.M. Yanjanin, D.E. Watkins-Chow, L.L. Baxter, A. Incao, L. Liscum, R. Sidhu, S. Firnkes, M. Graham, D.S. Ory, F.D. Porter, and W.J. Pavan Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1 Hum Mol Genet 22 2013 3508 3523
-
(2013)
Hum Mol Genet
, vol.22
, pp. 3508-3523
-
-
Fu, R.1
Wassif, C.A.2
Yanjanin, N.M.3
Watkins-Chow, D.E.4
Baxter, L.L.5
Incao, A.6
Liscum, L.7
Sidhu, R.8
Firnkes, S.9
Graham, M.10
Ory, D.S.11
Porter, F.D.12
Pavan, W.J.13
-
14
-
-
79959232858
-
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma
-
X. Jiang, R. Sidhu, F.D. Porter, N.M. Yanjanin, A.O. Speak, D.T. te Vruchte, F.M. Platt, H. Fujiwara, D.E. Scherrer, J. Zhang, D.J. Dietzen, J.E. Schaffer, and D.S. Ory A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma J Lipid Res 52 2011 1435 1445
-
(2011)
J Lipid Res
, vol.52
, pp. 1435-1445
-
-
Jiang, X.1
Sidhu, R.2
Porter, F.D.3
Yanjanin, N.M.4
Speak, A.O.5
Te Vruchte, D.T.6
Platt, F.M.7
Fujiwara, H.8
Scherrer, D.E.9
Zhang, J.10
Dietzen, D.J.11
Schaffer, J.E.12
Ory, D.S.13
-
16
-
-
84868124278
-
Quantitative proteomic analysis of Niemann-Pick disease, type C1 cerebellum identifies protein biomarkers and provides pathological insight
-
S.M. Cologna, X.S. Jiang, P.S. Backlund, C.V. Cluzeau, M.K. Dail, N.M. Yanjanin, S. Siebel, C.L. Toth, H.S. Jun, C.A. Wassif, A.L. Yergey, and F.D. Porter Quantitative proteomic analysis of Niemann-Pick disease, type C1 cerebellum identifies protein biomarkers and provides pathological insight PLoS One 7 2012 e47845
-
(2012)
PLoS One
, vol.7
, pp. e47845
-
-
Cologna, S.M.1
Jiang, X.S.2
Backlund, P.S.3
Cluzeau, C.V.4
Dail, M.K.5
Yanjanin, N.M.6
Siebel, S.7
Toth, C.L.8
Jun, H.S.9
Wassif, C.A.10
Yergey, A.L.11
Porter, F.D.12
-
18
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
M.M. Suzuki, and A. Bird DNA methylation landscapes: provocative insights from epigenomics Nat Rev Genet 9 2008 465 476
-
(2008)
Nat Rev Genet
, vol.9
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
19
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
M. Okano, D.W. Bell, D.A. Haber, and E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
20
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
E. Li, T.H. Bestor, and R. Jaenisch Targeted mutation of the DNA methyltransferase gene results in embryonic lethality Cell 69 1992 915 926
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
21
-
-
36849072573
-
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
-
J. Sharif, M. Muto, S. Takebayashi, I. Suetake, A. Iwamatsu, T.A. Endo, J. Shinga, Y. Mizutani-Koseki, T. Toyoda, K. Okamura, S. Tajima, K. Mitsuya, M. Okano, and H. Koseki The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA Nature 450 2007 908 912
-
(2007)
Nature
, vol.450
, pp. 908-912
-
-
Sharif, J.1
Muto, M.2
Takebayashi, S.3
Suetake, I.4
Iwamatsu, A.5
Endo, T.A.6
Shinga, J.7
Mizutani-Koseki, Y.8
Toyoda, T.9
Okamura, K.10
Tajima, S.11
Mitsuya, K.12
Okano, M.13
Koseki, H.14
-
22
-
-
0027535235
-
Effects of DNA methylation on DNA-binding proteins and gene expression
-
P.H. Tate, and A.P. Bird Effects of DNA methylation on DNA-binding proteins and gene expression Curr Opin Genet Dev 3 1993 226 231
-
(1993)
Curr Opin Genet Dev
, vol.3
, pp. 226-231
-
-
Tate, P.H.1
Bird, A.P.2
-
23
-
-
84888994574
-
Cross-talk between site-specific transcription factors and DNA methylation states
-
A. Blattler, and P.J. Farnham Cross-talk between site-specific transcription factors and DNA methylation states J Biol Chem 288 2013 34287 34294
-
(2013)
J Biol Chem
, vol.288
, pp. 34287-34294
-
-
Blattler, A.1
Farnham, P.J.2
-
24
-
-
0024081657
-
Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter
-
F. Watt, and P.L. Molloy Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter Genes Dev 2 1988 1136 1143
-
(1988)
Genes Dev
, vol.2
, pp. 1136-1143
-
-
Watt, F.1
Molloy, P.L.2
-
25
-
-
22844457491
-
DNA methylation and human disease
-
K.D. Robertson DNA methylation and human disease Nat Rev Genet 6 2005 597 610
-
(2005)
Nat Rev Genet
, vol.6
, pp. 597-610
-
-
Robertson, K.D.1
-
26
-
-
0030768084
-
Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene
-
S.K. Loftus, J.A. Morris, E.D. Carstea, J.Z. Gu, C. Cummings, A. Brown, J. Ellison, K. Ohno, M.A. Rosenfeld, D.A. Tagle, P.G. Pentchev, and W.J. Pavan Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene Science 277 1997 232 235
-
(1997)
Science
, vol.277
, pp. 232-235
-
-
Loftus, S.K.1
Morris, J.A.2
Carstea, E.D.3
Gu, J.Z.4
Cummings, C.5
Brown, A.6
Ellison, J.7
Ohno, K.8
Rosenfeld, M.A.9
Tagle, D.A.10
Pentchev, P.G.11
Pavan, W.J.12
-
27
-
-
36148989929
-
High-throughput tissue extraction protocol for NMR- and MS-based metabolomics
-
H. Wu, A.D. Southam, A. Hines, and M.R. Viant High-throughput tissue extraction protocol for NMR- and MS-based metabolomics Anal Biochem 372 2008 204 212
-
(2008)
Anal Biochem
, vol.372
, pp. 204-212
-
-
Wu, H.1
Southam, A.D.2
Hines, A.3
Viant, M.R.4
-
28
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
-
(2001)
Nucleic Acids Res
, vol.29
, pp. e45
-
-
Pfaffl, M.W.1
-
29
-
-
0033067814
-
Chromatin immunoprecipitation assays in acetylation mapping of higher eukaryotes
-
C. Crane-Robinson, F.A. Myers, T.R. Hebbes, A.L. Clayton, and A.W. Thorne Chromatin immunoprecipitation assays in acetylation mapping of higher eukaryotes Methods Enzymol 304 1999 533 547
-
(1999)
Methods Enzymol
, vol.304
, pp. 533-547
-
-
Crane-Robinson, C.1
Myers, F.A.2
Hebbes, T.R.3
Clayton, A.L.4
Thorne, A.W.5
-
30
-
-
74049144071
-
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain
-
J. Wang, I.C. Weaver, A. Gauthier-Fisher, H. Wang, L. He, J. Yeomans, F. Wondisford, D.R. Kaplan, and F.D. Miller CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain Dev Cell 18 2010 114 125
-
(2010)
Dev Cell
, vol.18
, pp. 114-125
-
-
Wang, J.1
Weaver, I.C.2
Gauthier-Fisher, A.3
Wang, H.4
He, L.5
Yeomans, J.6
Wondisford, F.7
Kaplan, D.R.8
Miller, F.D.9
-
31
-
-
0037089805
-
Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease
-
V. Voikar, H. Rauvala, and E. Ikonen Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease Behav Brain Res 132 2002 1 10
-
(2002)
Behav Brain Res
, vol.132
, pp. 1-10
-
-
Voikar, V.1
Rauvala, H.2
Ikonen, E.3
-
32
-
-
0029935376
-
Neuronal metabolism of branched-chain amino acids: Flux through the aminotransferase pathway in synaptosomes
-
M. Yudkoff, Y. Daikhin, D. Nelson, I. Nissim, and M. Erecinska Neuronal metabolism of branched-chain amino acids: flux through the aminotransferase pathway in synaptosomes J Neurochem 66 1996 2136 2145
-
(1996)
J Neurochem
, vol.66
, pp. 2136-2145
-
-
Yudkoff, M.1
Daikhin, Y.2
Nelson, D.3
Nissim, I.4
Erecinska, M.5
-
33
-
-
0031239010
-
Brain metabolism of branched-chain amino acids
-
M. Yudkoff Brain metabolism of branched-chain amino acids Glia 21 1997 92 98
-
(1997)
Glia
, vol.21
, pp. 92-98
-
-
Yudkoff, M.1
-
34
-
-
84871441513
-
Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes?
-
D.L. Rothman, H.M. De Feyter, P.K. Maciejewski, and K.L. Behar Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochem Res 37 2012 2597 2612
-
(2012)
Neurochem Res
, vol.37
, pp. 2597-2612
-
-
Rothman, D.L.1
De Feyter, H.M.2
Maciejewski, P.K.3
Behar, K.L.4
-
35
-
-
0023434105
-
Light microscopic immunocytochemical localization of pyruvate dehydrogenase complex in rat brain: Topographical distribution and relation to cholinergic and catecholaminergic nuclei
-
T.A. Milner, C. Aoki, K.F. Sheu, J.P. Blass, and V.M. Pickel Light microscopic immunocytochemical localization of pyruvate dehydrogenase complex in rat brain: topographical distribution and relation to cholinergic and catecholaminergic nuclei J Neurosci 7 1987 3171 3190
-
(1987)
J Neurosci
, vol.7
, pp. 3171-3190
-
-
Milner, T.A.1
Aoki, C.2
Sheu, K.F.3
Blass, J.P.4
Pickel, V.M.5
-
36
-
-
84921925903
-
Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1alpha
-
E.K. Lucas, C.S. Reid, L.J. McMeekin, S.E. Dougherty, C.L. Floyd, and R.M. Cowell Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1alpha Front Cell Neurosci 8 2015 441
-
(2015)
Front Cell Neurosci
, vol.8
, pp. 441
-
-
Lucas, E.K.1
Reid, C.S.2
McMeekin, L.J.3
Dougherty, S.E.4
Floyd, C.L.5
Cowell, R.M.6
-
37
-
-
34548689595
-
D-Amino acid oxidase and serine racemase in human brain: Normal distribution and altered expression in schizophrenia
-
L. Verrall, M. Walker, N. Rawlings, I. Benzel, J.N. Kew, P.J. Harrison, and P.W. Burnet d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia Eur J Neurosci 26 2007 1657 1669
-
(2007)
Eur J Neurosci
, vol.26
, pp. 1657-1669
-
-
Verrall, L.1
Walker, M.2
Rawlings, N.3
Benzel, I.4
Kew, J.N.5
Harrison, P.J.6
Burnet, P.W.7
-
38
-
-
0040784159
-
Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)
-
H.L. LeGros Jr., A.B. Halim, A.M. Geller, and M. Kotb Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II) J Biol Chem 275 2000 2359 2366
-
(2000)
J Biol Chem
, vol.275
, pp. 2359-2366
-
-
LeGros, H.L.1
Halim, A.B.2
Geller, A.M.3
Kotb, M.4
-
39
-
-
45049086037
-
Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus
-
S.E. Brown, I.C.G. Weaver, M.J. Meaney, and M. Szyf Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus Neurosci Letters 440 2008 49 53
-
(2008)
Neurosci Letters
, vol.440
, pp. 49-53
-
-
Brown, S.E.1
Weaver, I.C.G.2
Meaney, M.J.3
Szyf, M.4
-
40
-
-
2342557977
-
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
-
A.S. Yang, M.R. Estecio, K. Doshi, Y. Kondo, E.H. Tajara, and J.P. Issa A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements Nucleic Acids Res 32 2004 e38
-
(2004)
Nucleic Acids Res
, vol.32
, pp. e38
-
-
Yang, A.S.1
Estecio, M.R.2
Doshi, K.3
Kondo, Y.4
Tajara, E.H.5
Issa, J.P.6
-
41
-
-
33144488275
-
Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
-
R.A. Waterland, J.R. Lin, C.A. Smith, and R.L. Jirtle Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus Hum Mol Genet 15 2006 705 716
-
(2006)
Hum Mol Genet
, vol.15
, pp. 705-716
-
-
Waterland, R.A.1
Lin, J.R.2
Smith, C.A.3
Jirtle, R.L.4
-
42
-
-
34250007660
-
Genomic organization and imprinting of the Peg3 domain in bovine
-
J. Kim, A. Bergmann, J.H. Choo, and L. Stubbs Genomic organization and imprinting of the Peg3 domain in bovine Genomics 90 2007 85 92
-
(2007)
Genomics
, vol.90
, pp. 85-92
-
-
Kim, J.1
Bergmann, A.2
Choo, J.H.3
Stubbs, L.4
-
43
-
-
84949561279
-
Regulation and function of the peg3 imprinted domain
-
H. He, and J. Kim Regulation and function of the peg3 imprinted domain Genomics Inform 12 2014 105 113
-
(2014)
Genomics Inform
, vol.12
, pp. 105-113
-
-
He, H.1
Kim, J.2
-
44
-
-
0034994067
-
Epigenetic silencing of PEG3 gene expression in human glioma cell lines
-
S. Maegawa, H. Yoshioka, N. Itaba, N. Kubota, S. Nishihara, Y. Shirayoshi, E. Nanba, and M. Oshimura Epigenetic silencing of PEG3 gene expression in human glioma cell lines Mol Carcinog 31 2001 1 9
-
(2001)
Mol Carcinog
, vol.31
, pp. 1-9
-
-
Maegawa, S.1
Yoshioka, H.2
Itaba, N.3
Kubota, N.4
Nishihara, S.5
Shirayoshi, Y.6
Nanba, E.7
Oshimura, M.8
-
45
-
-
0033665434
-
Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation
-
A.A. Wylie, S.K. Murphy, T.C. Orton, and R.L. Jirtle Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation Genome Res 10 2000 1711 1718
-
(2000)
Genome Res
, vol.10
, pp. 1711-1718
-
-
Wylie, A.A.1
Murphy, S.K.2
Orton, T.C.3
Jirtle, R.L.4
-
46
-
-
0036151866
-
Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: Implications for imprinting control from comparison with Igf2-H19
-
S. Takada, M. Paulsen, M. Tevendale, C.E. Tsai, G. Kelsey, B.M. Cattanach, and A.C. Ferguson-Smith Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19 Hum Mol Genet 11 2002 77 86
-
(2002)
Hum Mol Genet
, vol.11
, pp. 77-86
-
-
Takada, S.1
Paulsen, M.2
Tevendale, M.3
Tsai, C.E.4
Kelsey, G.5
Cattanach, B.M.6
Ferguson-Smith, A.C.7
-
47
-
-
77954330008
-
Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia
-
R. Rao, K. Ennis, J.D. Long, K. Ugurbil, R. Gruetter, and I. Tkac Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia J Neurochem 114 2010 728 738
-
(2010)
J Neurochem
, vol.114
, pp. 728-738
-
-
Rao, R.1
Ennis, K.2
Long, J.D.3
Ugurbil, K.4
Gruetter, R.5
Tkac, I.6
-
48
-
-
50049090056
-
Truncation of the krebs cycle during hypoglycemic coma
-
G.R. Sutherland, R.L. Tyson, and R.N. Auer Truncation of the krebs cycle during hypoglycemic coma Med Chem 4 2008 379 385
-
(2008)
Med Chem
, vol.4
, pp. 379-385
-
-
Sutherland, G.R.1
Tyson, R.L.2
Auer, R.N.3
-
49
-
-
79952518030
-
Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: Importance of the pyruvate recycling pathway and glutamine oxidation
-
A.I. Amaral, A.P. Teixeira, U. Sonnewald, and P.M. Alves Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: importance of the pyruvate recycling pathway and glutamine oxidation J Neurosci Res 89 2011 700 710
-
(2011)
J Neurosci Res
, vol.89
, pp. 700-710
-
-
Amaral, A.I.1
Teixeira, A.P.2
Sonnewald, U.3
Alves, P.M.4
-
50
-
-
35848962945
-
Glutamine as an energy substrate in cultured neurons during glucose deprivation
-
L. Peng, L. Gu, H. Zhang, X. Huang, E. Hertz, and L. Hertz Glutamine as an energy substrate in cultured neurons during glucose deprivation J Neurosci Res 85 2007 3480 3486
-
(2007)
J Neurosci Res
, vol.85
, pp. 3480-3486
-
-
Peng, L.1
Gu, L.2
Zhang, H.3
Huang, X.4
Hertz, E.5
Hertz, L.6
-
51
-
-
35548983491
-
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
-
D. Lovatt, U. Sonnewald, H.S. Waagepetersen, A. Schousboe, W. He, J.H. Lin, X. Han, T. Takano, S. Wang, F.J. Sim, S.A. Goldman, and M. Nedergaard The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex J Neurosci 27 2007 12255 12266
-
(2007)
J Neurosci
, vol.27
, pp. 12255-12266
-
-
Lovatt, D.1
Sonnewald, U.2
Waagepetersen, H.S.3
Schousboe, A.4
He, W.5
Lin, J.H.6
Han, X.7
Takano, T.8
Wang, S.9
Sim, F.J.10
Goldman, S.A.11
Nedergaard, M.12
-
52
-
-
78650664020
-
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain
-
J.H. Yang, A. Wada, K. Yoshida, Y. Miyoshi, T. Sayano, K. Esaki, M.O. Kinoshita, S. Tomonaga, N. Azuma, M. Watanabe, K. Hamase, K. Zaitsu, T. Machida, A. Messing, S. Itohara, Y. Hirabayashi, and S. Furuya Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain J Biol Chem 285 2010 41380 41390
-
(2010)
J Biol Chem
, vol.285
, pp. 41380-41390
-
-
Yang, J.H.1
Wada, A.2
Yoshida, K.3
Miyoshi, Y.4
Sayano, T.5
Esaki, K.6
Kinoshita, M.O.7
Tomonaga, S.8
Azuma, N.9
Watanabe, M.10
Hamase, K.11
Zaitsu, K.12
Machida, T.13
Messing, A.14
Itohara, S.15
Hirabayashi, Y.16
Furuya, S.17
-
53
-
-
0035478412
-
3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain
-
M. Yamasaki, K. Yamada, S. Furuya, J. Mitoma, Y. Hirabayashi, and M. Watanabe 3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain J Neurosci 21 2001 7691 7704
-
(2001)
J Neurosci
, vol.21
, pp. 7691-7704
-
-
Yamasaki, M.1
Yamada, K.2
Furuya, S.3
Mitoma, J.4
Hirabayashi, Y.5
Watanabe, M.6
-
54
-
-
12944301005
-
L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons
-
S. Furuya, T. Tabata, J. Mitoma, K. Yamada, M. Yamasaki, A. Makino, T. Yamamoto, M. Watanabe, M. Kano, and Y. Hirabayashi L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons Proc Natl Acad Sci U S A 97 2000 11528 11533
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11528-11533
-
-
Furuya, S.1
Tabata, T.2
Mitoma, J.3
Yamada, K.4
Yamasaki, M.5
Makino, A.6
Yamamoto, T.7
Watanabe, M.8
Kano, M.9
Hirabayashi, Y.10
-
55
-
-
80054707774
-
Serine racemase and the serine shuttle between neurons and astrocytes
-
H. Wolosker Serine racemase and the serine shuttle between neurons and astrocytes Biochim Biophys Acta 1814 2011 1558 1566
-
(2011)
Biochim Biophys Acta
, vol.1814
, pp. 1558-1566
-
-
Wolosker, H.1
-
56
-
-
84879810709
-
Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice
-
E.V. Abarinov, A.E. Beaudin, M.S. Field, C.A. Perry, R.H. Allen, S.P. Stabler, and P.J. Stover Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice J Nutr 143 2013 1028 1035
-
(2013)
J Nutr
, vol.143
, pp. 1028-1035
-
-
Abarinov, E.V.1
Beaudin, A.E.2
Field, M.S.3
Perry, C.A.4
Allen, R.H.5
Stabler, S.P.6
Stover, P.J.7
-
57
-
-
54449100192
-
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
-
A.J. MacFarlane, X. Liu, C.A. Perry, P. Flodby, R.H. Allen, S.P. Stabler, and P.J. Stover Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice J Biol Chem 283 2008 25846 25853
-
(2008)
J Biol Chem
, vol.283
, pp. 25846-25853
-
-
MacFarlane, A.J.1
Liu, X.2
Perry, C.A.3
Flodby, P.4
Allen, R.H.5
Stabler, S.P.6
Stover, P.J.7
-
58
-
-
0037064008
-
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses
-
K. Herbig, E.P. Chiang, L.R. Lee, J. Hills, B. Shane, and P.J. Stover Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses J Biol Chem 277 2002 38381 38389
-
(2002)
J Biol Chem
, vol.277
, pp. 38381-38389
-
-
Herbig, K.1
Chiang, E.P.2
Lee, L.R.3
Hills, J.4
Shane, B.5
Stover, P.J.6
-
59
-
-
79952743030
-
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk
-
A.J. Macfarlane, C.A. Perry, M.F. McEntee, D.M. Lin, and P.J. Stover Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk Cancer Res 71 2011 2098 2107
-
(2011)
Cancer Res
, vol.71
, pp. 2098-2107
-
-
Macfarlane, A.J.1
Perry, C.A.2
McEntee, M.F.3
Lin, D.M.4
Stover, P.J.5
-
60
-
-
84864010293
-
Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
-
O.S. Anderson, K.E. Sant, and D.C. Dolinoy Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation J Nutr Biochem 23 2012 853 859
-
(2012)
J Nutr Biochem
, vol.23
, pp. 853-859
-
-
Anderson, O.S.1
Sant, K.E.2
Dolinoy, D.C.3
-
62
-
-
84862248102
-
Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate's role
-
K.S. Crider, T.P. Yang, R.J. Berry, and L.B. Bailey Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role Adv Nutr 3 2012 21 38
-
(2012)
Adv Nutr
, vol.3
, pp. 21-38
-
-
Crider, K.S.1
Yang, T.P.2
Berry, R.J.3
Bailey, L.B.4
-
63
-
-
33646790538
-
Assessing the effects of high methionine intake on DNA methylation
-
R.A. Waterland Assessing the effects of high methionine intake on DNA methylation J Nutr 136 2006 1706S 1710S
-
(2006)
J Nutr
, vol.136
, pp. 1706S-1710S
-
-
Waterland, R.A.1
-
64
-
-
79955983760
-
The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats
-
C.L. Amaral, B. Bueno Rde, R.V. Burim, R.H. Queiroz, L. Bianchi Mde, and L.M. Antunes The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats Mutat Res 722 2011 78 83
-
(2011)
Mutat Res
, vol.722
, pp. 78-83
-
-
Amaral, C.L.1
Bueno Rde, B.2
Burim, R.V.3
Queiroz, R.H.4
Bianchi Mde, L.5
Antunes, L.M.6
-
65
-
-
24644518545
-
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
-
E. Dong, R.C. Agis-Balboa, M.V. Simonini, D.R. Grayson, E. Costa, and A. Guidotti Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia Proc Natl Acad Sci U S A 102 2005 12578 12583
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 12578-12583
-
-
Dong, E.1
Agis-Balboa, R.C.2
Simonini, M.V.3
Grayson, D.R.4
Costa, E.5
Guidotti, A.6
-
66
-
-
84988935069
-
Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
-
eCollection 2014
-
R. Edgar, P.P. Tan, E. Portales-Casamar, and P. Pavlidis Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression Epigenetics Chromatin 7 2014 28 eCollection 2014
-
(2014)
Epigenetics Chromatin
, vol.7
, pp. 28
-
-
Edgar, R.1
Tan, P.P.2
Portales-Casamar, E.3
Pavlidis, P.4
-
68
-
-
77954842322
-
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes
-
H. Wu, V. Coskun, J. Tao, W. Xie, W. Ge, K. Yoshikawa, E. Li, Y. Zhang, and Y.E. Sun Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes Science 329 2010 444 448
-
(2010)
Science
, vol.329
, pp. 444-448
-
-
Wu, H.1
Coskun, V.2
Tao, J.3
Xie, W.4
Ge, W.5
Yoshikawa, K.6
Li, E.7
Zhang, Y.8
Sun, Y.E.9
-
69
-
-
34250643467
-
Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan
-
S. Nguyen, K. Meletis, D. Fu, S. Jhaveri, and R. Jaenisch Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan Dev Dyn 236 2007 1663 1676
-
(2007)
Dev Dyn
, vol.236
, pp. 1663-1676
-
-
Nguyen, S.1
Meletis, K.2
Fu, D.3
Jhaveri, S.4
Jaenisch, R.5
-
70
-
-
33749241112
-
Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development
-
D. Watanabe, K. Uchiyama, and K. Hanaoka Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development Neuroscience 142 2006 727 737
-
(2006)
Neuroscience
, vol.142
, pp. 727-737
-
-
Watanabe, D.1
Uchiyama, K.2
Hanaoka, K.3
-
71
-
-
16444381345
-
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system
-
J. Feng, H. Chang, E. Li, and G. Fan Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system J Neurosci Res 79 2005 734 746
-
(2005)
J Neurosci Res
, vol.79
, pp. 734-746
-
-
Feng, J.1
Chang, H.2
Li, E.3
Fan, G.4
-
72
-
-
84871563384
-
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
-
M. Mellen, P. Ayata, S. Dewell, S. Kriaucionis, and N. Heintz MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system Cell 151 2012 1417 1430
-
(2012)
Cell
, vol.151
, pp. 1417-1430
-
-
Mellen, M.1
Ayata, P.2
Dewell, S.3
Kriaucionis, S.4
Heintz, N.5
-
73
-
-
0035093830
-
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
-
R.Z. Chen, S. Akbarian, M. Tudor, and R. Jaenisch Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice Nat Genet 27 2001 327 331
-
(2001)
Nat Genet
, vol.27
, pp. 327-331
-
-
Chen, R.Z.1
Akbarian, S.2
Tudor, M.3
Jaenisch, R.4
-
74
-
-
0032830639
-
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
-
R.E. Amir, I.B. Van den Veyver, M. Wan, C.Q. Tran, U. Francke, and H.Y. Zoghbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat Genet 23 1999 185 188
-
(1999)
Nat Genet
, vol.23
, pp. 185-188
-
-
Amir, R.E.1
Van Den Veyver, I.B.2
Wan, M.3
Tran, C.Q.4
Francke, U.5
Zoghbi, H.Y.6
-
75
-
-
33344471941
-
Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice
-
T. Gemelli, O. Berton, E.D. Nelson, L.I. Perrotti, R. Jaenisch, and L.M. Monteggia Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice Biol Psychiatry 59 2006 468 476
-
(2006)
Biol Psychiatry
, vol.59
, pp. 468-476
-
-
Gemelli, T.1
Berton, O.2
Nelson, E.D.3
Perrotti, L.I.4
Jaenisch, R.5
Monteggia, L.M.6
-
76
-
-
77649339642
-
MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons
-
N. Kishi, and J.D. Macklis MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons Exp Neurol 222 2010 51 58
-
(2010)
Exp Neurol
, vol.222
, pp. 51-58
-
-
Kishi, N.1
Macklis, J.D.2
-
78
-
-
67650462249
-
DNA hypomethylation in the origin and pathogenesis of human diseases
-
I.P. Pogribny, and F.A. Beland DNA hypomethylation in the origin and pathogenesis of human diseases Cell Mol Life Sci 66 2009 2249 2261
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2249-2261
-
-
Pogribny, I.P.1
Beland, F.A.2
-
79
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
A. Eden, F. Gaudet, A. Waghmare, and R. Jaenisch Chromosomal instability and tumors promoted by DNA hypomethylation Science 300 2003 455
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
80
-
-
77957366305
-
DNA methylation and cancer
-
M. Kulis, and M. Esteller DNA methylation and cancer Adv Genet 70 2010 27 56
-
(2010)
Adv Genet
, vol.70
, pp. 27-56
-
-
Kulis, M.1
Esteller, M.2
-
81
-
-
34548661490
-
DNA methylation and cancer-associated genetic instability
-
M. Ehrlich DNA methylation and cancer-associated genetic instability Adv Exp Med Biol 570 2005 363 392
-
(2005)
Adv Exp Med Biol
, vol.570
, pp. 363-392
-
-
Ehrlich, M.1
-
82
-
-
77952414230
-
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
-
E.M. Wolff, H.M. Byun, H.F. Han, S. Sharma, P.W. Nichols, K.D. Siegmund, A.S. Yang, P.A. Jones, and G. Liang Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer PLoS Genet 6 2010 e1000917
-
(2010)
PLoS Genet
, vol.6
, pp. e1000917
-
-
Wolff, E.M.1
Byun, H.M.2
Han, H.F.3
Sharma, S.4
Nichols, P.W.5
Siegmund, K.D.6
Yang, A.S.7
Jones, P.A.8
Liang, G.9
-
83
-
-
84904565384
-
Mobile DNA elements in the generation of diversity and complexity in the brain
-
J.A. Erwin, M.C. Marchetto, and F.H. Gage Mobile DNA elements in the generation of diversity and complexity in the brain Nat Rev Neurosci 15 2014 497 506
-
(2014)
Nat Rev Neurosci
, vol.15
, pp. 497-506
-
-
Erwin, J.A.1
Marchetto, M.C.2
Gage, F.H.3
-
84
-
-
77957970301
-
Epigenetic modifications and human disease
-
A. Portela, and M. Esteller Epigenetic modifications and human disease Nat Biotechnol 28 2010 1057 1068
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1057-1068
-
-
Portela, A.1
Esteller, M.2
-
85
-
-
33847065486
-
The epigenomics of cancer
-
P.A. Jones, and S.B. Baylin The epigenomics of cancer Cell 128 2007 683 692
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
|