Brain-specific Phgdh deletion reveals a pivotal role for l-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain

Journal of Biological Chemistry

Volumn 285, Issue 53, 2010, Pages 41380-41390

  Yang, Jung Hoon ^a   Wada, Akira ^a   Yoshida, Kazuyuki ^b,c   Miyoshi, Yurika ^d   Sayano, Tomoko ^a   Esaki, Kayoko ^a   Kinoshita, Masami O ^c,d   Tomonaga, Shozo ^a   Azuma, Norihiro ^b   Watanabe, Masahiko ^e   Hamase, Kenji ^a   Zaitsu, Kiyoshi ^a   MacHida, Takeo ^d   Messing, Albee ^f   Itohara, Shigeyoshi ^c   Hirabayashi, Yoshio ^c   Furuya, Shigeki ^a,c  

^a KYUSHU UNIVERSITY   (Japan)

^b UTSUNOMIYA UNIVERSITY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d SAITAMA UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT BRAIN; CEREBRAL CORTEX; D-3- PHOSPHOGLYCERATE DEHYDROGENASE; D-SERINE; GLUTAMATE RECEPTOR; HPLC ANALYSIS; KNOCK OUTS; L-SERINE; MAMMALIAN BRAIN; N METHYL D ASPARTATE RECEPTOR; N-METHYL-D-ASPARTATE; NEURONAL CIRCUITS; NMDA RECEPTOR; PROTEIN EXPRESSION LEVELS; RATE LIMITING FACTORS; SERINE RACEMASE; STEADY-STATE LEVEL;

BIOCHEMISTRY; BRAIN; MAMMALS; PHOSPHORYLATION; PLANTS (BOTANY); TRANSCRIPTION;

AMINO ACIDS;

DEXTRO SERINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOGLYCERATE DEHYDROGENASE; RACEMASE; SERINE;

ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CATALYSIS; CONTROLLED STUDY; ENANTIOMER; FEMALE; GENE DELETION; GENE FREQUENCY; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GENE DELETION; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, KNOCKOUT; N-METHYLASPARTATE; PHOSPHOGLYCERATE DEHYDROGENASE; PHOSPHORYLATION; SCHIZOPHRENIA; SERINE;

MAMMALIA; MUS;

EID: 78650664020     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.187443     Document Type: Article

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