Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: Implications for imprinting control from comparison with Igf2-H19

Human Molecular Genetics

Volumn 11, Issue 1, 2002, Pages 77-86

  Takada, Shuji ^a   Paulsen, Martina ^a,d   Tevendale, Maxine ^a   Tsai, Chen En ^a   Kelsey, Gavin ^b   Cattanach, Bruce M ^c   Ferguson Smith, Anne C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN; DLK 1 PROTEIN; GTL2 PROTEIN; H19 PROTEIN; NOTCH RECEPTOR; SOMATOMEDIN B; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ALLELE; ARTICLE; CHROMOSOME 12; CONTROLLED STUDY; FEMALE; FETUS; GENE LOCATION; GENETIC ANALYSIS; GENOME IMPRINTING; GERM LINE; INTRON; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN METHYLATION; TANDEM REPEAT;

RODENTIA;

EID: 0036151866     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.1.77     Document Type: Article

References (32)

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3. Genetic imprinting: Silencing elements have their say
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5. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
6. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
7. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
8. Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
9. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted
10. Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: Mouse Meg3/Gtl2 and human MEG3
11. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation
12. Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8
13. The role of the epidermal growth factor-like protein dlk in cell differentiation
14. Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region
15. Identification of an imprinted gene. Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q
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17. Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity
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19. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
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26. Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
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