Assessing the effects of high methionine intake on DNA methylation

Journal of Nutrition

Volumn 136, Issue 6, 2006, Pages

  Waterland, Robert A ^a  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

DNA methylation; Epigenetic; Epigenomic; Methionine; Nutrition; Viable yellow agouti

Indexed keywords

BETAINE; CHOLINE; CYANOCOBALAMIN; CYTOSINE; DINUCLEOTIDE; FOLIC ACID; GUANINE; HOMOCYSTEINE; METHIONINE; METHYL GROUP; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

BIOSENSOR; CANCER; CLINICAL TRIAL; CONFERENCE PAPER; DEVELOPMENTAL DISORDER; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE EXACERBATION; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENOME; HUMAN; MAMMAL; NONHUMAN; PHENOTYPE; SCHIZOPHRENIA;

AGOUTI; MAMMALIA;

EID: 33646790538     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.6.1706s     Document Type: Conference Paper

References (23)

1. Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429:457-63.
2. Jiang YH, Bressler J, Beaudet AL. Epigenetics and human disease. Annu Rev Genomics Hum Genet. 2004;5:479-510.
3. Maier S, Olek A. Diabetes: a candidate disease for efficient DNA methylation profiling. J Nutr. 2002;132:2440S-3S.
4. Corwin EJ. The concept of epigenetics and its role in the development of cardiovascular disease: commentary on "new and emerging theories of cardiovascular disease". Biol Res Nurs. 2004;6:11-6.
5. Waterland RA. Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms? In: Hernell O, Schmitz, J., editors. Feeding during late infancy and early childhood: impact on health. Vevey: Nestec; 2005.
6. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33: Suppl:245-54.
7. Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science. 2001;293:1089-93.
8. Peterson CL, Laniel MA. Histones and histone modifications. Curr Biol. 2004;14:R546-51.
9. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23:5293-300.
10. Ingrosso D, Cimmino A, Perna AF, Masella L, De Santo NG, De Bonis ML, Vacca M, D'Esposito M, D'Urso M, et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet. 2003;361:1693-9.
11. Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem. 1986;261:1582-7.
12. Finkelstein JD. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998;157: Suppl 2:S40-4.
13. Regina M, Korhonen VP, Smith TK, Alakuijala L, Eloranta TO. Methionine toxicity in the rat in relation to hepatic accumulation of S-adenosylmethionine: prevention by dietary stimulation of the hepatic transsulfuration pathway. Arch Biochem Biophys. 1993;300:598-607.
14. Rowling MJ, McMullen MH, Chipman DC, Schalinske KL. Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr. 2002;132:2545-50.
15. Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA. 2002;99:17095-100.
16. Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci USA. 2005;102:12578-83.
17. Devlin AM, Arning E, Bottiglieri T, Faraci FM, Rozen R, Lentz SR. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood. 2004;103:2624-9.
18. Duhl DM, Vrieling H, Miller KA, Wolff GL, Barsh GS. Neomorphic agouti mutations in obese yellow mice. Nat Genet. 1994;8:59-65.
19. Wolff GL, Kodell RL, Moore SR, Cooney CA. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 1998;12:949-57.
20. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004;20:63-8.
21. Song F, Smith JF, Kimura MT, Morrow AD, Matsuyama T, Nagase H, Held WA. Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci USA. 2005;102:3336-41.
22. van Steensel B, Henikoff S. Epigenomic profiling using microarrays. Biotechniques. 2003;35:346-50, 52-4, 56-7.
23. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, et al. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005;37:645-51.