Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation

Genome Research

Volumn 10, Issue 11, 2000, Pages 1711-1718

  Wylie, Andrew A ^a,b   Murphy, Susan K ^a   Orton, Terry C ^b   Jirtle, Randy L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NOTCH RECEPTOR; RNA; SOMATOMEDIN B;

ARTICLE; BINDING SITE; CHROMOSOME 14Q; CONTROLLED STUDY; DNA METHYLATION; ENHANCER REGION; EXTRACHROMOSOMAL INHERITANCE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE ISOLATION; GENE LOCATION; GENE SEQUENCE; GENETIC ORGANIZATION; GENOME IMPRINTING; HAPLOIDY; HUMAN; HUMAN TISSUE; MOLECULAR EVOLUTION; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; RNA TRANSLATION; SEQUENCE HOMOLOGY; SHEEP; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

AMINO ACID MOTIFS; ANIMALS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 14; DNA METHYLATION; GENES, HOMEOBOX; GENOMIC IMPRINTING; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MEMBRANE PROTEINS; MICE; OPEN READING FRAMES; PROTEIN STRUCTURE, TERTIARY; RNA, UNTRANSLATED;

EID: 0033665434     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.161600     Document Type: Article

References (36)

1. Notch signaling
2. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
3. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: Molecular cloning and expression pattern during development and growth of the endocrine pancreas
4. Genomic imprinting in the mouse: Possible final analysis
5. Polar overdominance at the ovine callipyge locus
6. Comparative mapping of the ovine clpg locus
7. Genomic imprinting: Implications for human disease
8. Two fetal antigens (FA-1 and FA-2) and endometrial proteins (PP12 and PP14) isolated from amniotic fluid: Preliminary observations in fetal and maternal tissues
9. Structural conservation of Notch receptors and ligands
10. Evaluation of the ovine callipyge locus: I. Relative chromosomal position and gene action
11. Genomic imprinting and the strange case of the insulin-like growth factor II receptor
12. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
13. Molecular markers of neuroendocrine development and evidence of environmental regulation
14. Imprinted genes, cognition and behaviour
15. A role for pref-1 and HES-1 in thymocyte development
16. M6P/IGF2R imprinting evolution in mammals
17. The role of the epidermal growth factor-like protein dlk in cell differentiation
18. DLK, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line
19. Uniparental disomy in humans: Development of an imprinting map and its implications for prenatal diagnosis
20. High-resolution gametic map of the sheep callipyge region: Linkage heterogeneity among rams detected by sperm typing
21. Towards a molecular understanding of Prader-Willi and Angelman
22. Identification of an imprinted gene, Meg3/Gtl2, and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome
23. A catalogue of imprinted genes and parent-of-origin effects in humans and animals
24. Imprinting in Prader-Willi and Angelman syndromes
25. Implication of ZOG protein (zona glomerulosa-specific protein) in zone development of the adrenal cortex
26. Pref-1, SF-1 and adrenocortical zonation
27. Genomic imprinting. Silence across the border
28. Igf2 imprinting in development and disease
29. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted
30. Gtl2(lacZ), an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype
31. The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA
32. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
33. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
34. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
35. Location of enhancers is essential for the imprinting of H19 and Igf2 genes
36. Two regulatory domains flank the mouse H19 gene