Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apcmin-mediated intestinal cancer risk

Cancer Research

Volumn 71, Issue 6, 2011, Pages 2098-2107

  MacFarlane, Amanda J ^a,c   Perry, Cheryll A ^a   McEntee, Michael F ^b   Lin, David M ^a   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; PURINE; S ADENOSYLMETHIONINE; THYMIDINE KINASE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME MODIFICATION; ENZYME REGULATION; FOOD INTAKE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HEMIZYGOSITY; INTESTINE CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; PURINE SYNTHESIS;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; COLON; DIET; ENTEROCYTES; EPITHELIAL CELLS; FEMALE; FOLIC ACID; GENE EXPRESSION PROFILING; GLYCINE HYDROXYMETHYLTRANSFERASE; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PURINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; THYMINE NUCLEOTIDES;

EID: 79952743030     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1886     Document Type: Article

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