Quantitation of metabolic and radiobiological effects of 6- aminonicotinamide in RIF-1 tumor cells in vitro

Cancer Research

Volumn 57, Issue 18, 1997, Pages 3956-3962

  Street, James C ^a   Alfieri, Alan A ^a,b   Koutcher, Jason A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINONICOTINAMIDE; CREATINE PHOSPHATE; PHOSPHATE;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; DNA REPAIR; DRUG EFFECT; DRUG METABOLISM; ENZYME INHIBITION; GLYCOLYSIS; HIGH ENERGY PHOSPHATE; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ASSAY; RADIOBIOLOGY; TUMOR CELL;

6-AMINONICOTINAMIDE; GAMMA RAYS; GLYCOLYSIS; LACTATES; MAGNETIC RESONANCE SPECTROSCOPY; PENTOSE PHOSPHATE PATHWAY; PHOSPHOCREATINE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0030823969     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Koutcher, J. A., Alfieri, A. A., Stolfi, R. L., Devitt, M. L., Colofiore, J. R., and Martin, D. S. Potentiation of a three drug chemotherapy regimen by radiation. Cancer Res., 53: 3518-3523, 1993.
2. Martin, D. S. In: Metabolism and Action of Anti-cancer Drugs, pp. 91-140. G. Powis and R. A. Prough (eds.). London: Taylor and Francis, 1987.
3. Herter, F. P., Weissman, S. G., Thompson, H. G., Hyman, G., and Martin, D. S. Clinical experience with 6-aminonicotinamide. Cancer Res., 21: 31-37, 1961.
4. Varnes, M. E. Inhibition of pentose cycle of A549 cells by 6-aminonicotinamide: consequences for aerobic and hypoxic radiation response and for radiosensitizer action. Natl. Cancer Inst. Monogr. 6: 199-202, 1988.
5. Berger, N. A., Catino, D. M., and Vietti, T. J. Synergistic antileukemic effect of 6-aminonicotinamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on L1210 cells in vitro and in vivo. Cancer Res., 42: 4382-4386, 1982.
6. Ames, M. M., Walker, D. L., Reid, J. M., Svingen, P. A., Budihardjo, I., Kaufmann, S. H., Covey, J. M., Alley, M. C., and Hollingshead, M. G. 6-Aminonicotinamide: murine plasma pharmacokinetics and modulation of drug resistance. Proc. Am. Assoc. Cancer Res., 37: 1965, 1996.
7. Belfi, C. A., Chatterjee, S., Gosky, D. M., Berger, S. J., and Berger, N. A. Colon cancer cells exhibit increased in vitro sensitivity to cross linking alkylating agents after 6-aminonicotinamide treatment. Proc. Am. Assoc. Cancer Res. 37: 2576, 1996.
8. 31P NMR and tumor growth delay studies. Magn. Reson. Med., in press, 1996.
9. 31P NMR investigation of effect of 6-aminonicotinamide on metabolism of RIF-1 tumor cells in vitro. J. Biol. Chem., 271: 4113-4119, 1996.
10. 31P NMR of pentose phosphate pathway block secondary to biochemical modulation. NMR Biomed., in press, 1996.
11. 31P-magnetic resonance spectroscopic study. Biochem. Biophys. Res. Commun., 164: 947-953, 1989.
12. Chatterjee, S., Cheng, M-F., Berger, R. B., Berger, S. J., and Berger, N. A. Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide. Cancer Res., 55: 868-873, 1995.
13. Lee, A. S. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem. Sci., 12: 20-23, 1987.
14. 31P nuclear magnetic resonance measurements of metabolic changes postradiation. Cancer Res., 55: 1248-1254, 1995.
15. Ballon, D., Mahmood, U., Jakubowski, A., and Koutcher, J. A. Resolution enhanced NMR spectroscopy in biological systems via magnetic susceptibility matched sample immersion chambers. Magn. Reson. Med., 30: 754-758, 1993.
16. 15N n.m.r. study of nitrogen metabolism in cultured mammalian cells. Biochem. J., 291: 485-492, 1993.
17. 13C]glucose. Anal. Biochem., 185: 235-237, 1990.
18. 1H magnetic resonance spectroscopy study. NMR Biomed., 1: 20-26, 1988.
19. Herken, H. H., Keller, K., Lange, K., and Kolbe, H. Brain disorders induced by pharmacological blockade of the pentose phosphate pathway. Biochem. Biophys. Res. Commun., 36: 93-100.
20. Kahana, S. E., Lowry, O. H., Schulz, D. W., Passonneau, J. V., and Crawford, E. J. The kinetics of phosphoglucoseisomerase. J. Biol. Chem., 235: 2178-2184, 1960.
21. Krebs, H. A., and Eggleston, L. V. The regulation of the pentose phosphate cycle in rat liver. In: G. Weber (ed.), Advances in Enzyme Regulation, Vol. 12, pp. 421-434. New York: Pergamon Press, 1974.
22. Tuttle, S. W., Varnes, M. E., Mitchell, J. B., and Biaglow, J. E. Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity. Int. J. Radiat. Oncol. Biol. Phys., 22: 671-675, 1992.
23. Pandolfi, P. P., Sonati, F., Rivi, R., Mason, P., Grosveld, F., and Luzzatto, L. Targeted disruption of the housekeeping gene encoding glucose-6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J., 14: 5209-5215, 1995.
24. Roberts, W., Kartha, M., and Sagone, A. L., Jr. Effect of irradiation on the hexose monophosphate shunt pathway of human lymphocytes. Radiat. Res., 79: 601-610, 1979.
25. Hunting, D., Gowans, B., and Henderson, J. F. Effects of 6-aminonicotinamide on cell growth, poly(ADP-ribose) synthesis and nucleotide metabolism. Biochem. Pharmacol., 34: 3999-4003, 1985.
26. Jain, V. K., Porschen, W., and Feinendegen, L. E. Optimization of cancer therapy. II. Effects of combining 2-deoxy-D-glucose treatment with γ-irradiation on sarcoma-180. Indian J. Exp. Biol., 15: 714-718.
27. Jain, V. K., Kalia, V. K., Sharma, R., Maharajan, V. and Menon, M. Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int. J: Radiat. Oncol. Biol. Phys., 11: 943-950, 1985.
28. Purohit, S. C., and Pohlit, W. Experimental evaluation of the glucose antimetabolite, 2-deoxy-D-glucose (2-DG) as a possible adjuvant to radiotherapy of tumors. I. Kinetics of growth and survival of Ehrlich ascites tumor cells (EATC) in vitro and of growth of solid tumors after 2-DG and X-irradiation. Int. J. Radiat. Oncol. Biol. Phys., 8: 495-499, 1982.
29. Sheffield, V. C., and Seegmiller, R. E. Impaired energy metabolism as an initial step in the mechanism for 6-aminonicotinamide-induced limb malformation. J. Embryol. Exp. Morphol., 59: 217-222, 1980.
30. Ritter, E. J., Scott, W. J., and Wilson, J. G. Inhibition of ATP synthesis associated with 6-aminonicotinamide (6AN) teratogenesis in rat embryos. Teratology, 12: 233-238, 1975.