Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: Formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress

Diabetes

Volumn 57, Issue 1, 2008, Pages 41-49

  Blatnik, Matthew ^a   Frizzell, Norma ^a   Thorpe, Suzanne R ^a   Baynes, John W ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FUMARIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; S (2 SUCCINYL)CYSTEINE; STREPTOZOCIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE; FUMARIC ACID DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); PEPTIDE FRAGMENT; S-(2-SUCCINYL)CYSTEINE;

ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; GASTROCNEMIUS MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MICHAEL ADDITION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; QUADRUPOLE MASS SPECTROMETRY; RAT; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; ISOLATION AND PURIFICATION; KINETICS; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYSTEINE; DIABETES MELLITUS, EXPERIMENTAL; FUMARATES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); KINETICS; MASS SPECTROMETRY; MITOCHONDRIA; MUSCLE, SKELETAL; PEPTIDE FRAGMENTS; RATS;

EID: 38449085406     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-0838     Document Type: Article

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