Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 2, 2003, Pages 473-477

  Miyadera, Hiroko ^a,d   Shiomi, Kazuro ^b   Ui, Hideaki ^b   Yamaguchi, Yuichi ^b   Masuma, Rokuro ^b   Tomoda, Hiroshi ^b   Miyoshi, Hideto ^c   Osanai, Arihiro ^a   Kita, Kiyoshi ^a   Omura, Satoshi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ATPENIN DERIVATIVE; CITRININ; CYTOCHROME C OXIDASE; ENZYME INHIBITOR; PYRIDONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BINDING SITES; CATTLE; ELECTRON TRANSPORT COMPLEX II; ENZYME INHIBITORS; MITOCHONDRIA; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PYRIDONES; RATS; SUCCINATE DEHYDROGENASE; UBIQUITIN;

MAMMALIA;

EID: 0037457881     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0237315100     Document Type: Article

References (44)

1. Hägerhäll, C. (1997) Biochim. Biophys. Acta 1320, 107-141.
2. Ackrell, B. A. C., Johnson, M. K., Gunsalus, R. P. & Cecchini, G. (1992) in Chemistry and Biochemistry of Flavoenzymes, ed. Muller, F. (CRC, London), Vol. III, pp. 229-297.
3. Ohnishi, T., Moser, C. C., Page, C. C., Dutton, P. L. & Yano, T. (2000) Struct. Fold. Dis. 8, R23-R32.
4. Lancaster, C. R. D., ed, (2002) Biochim. Biophys. Acta 1553.
5. Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D. & Suzuki, K. (1998) Nature 394, 694-697.
6. Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S. & Ishii, N. (2001) J. Biol. Chem. 276, 41553-41558.
7. Baysal, B. E., Rubinsterin, W. S. & Taschner, P. E. M. (2001) J. Mol. Med. 79, 495-503.
8. Astuti, D., Douglas, F., Lennard, T. W., Aligianis, I. A., Woodward, E. R., Evans, D. G. R., Eng, C., Latif, F. & Maher, E. R. (2001) Lancet 357, 1181-1182.
9. Baysal, B. E., Ferrell, R. E., Willett-Brozick, J. E., Lawrence, E. C., Myssiorek, D., Bosch, A., van der Mey, A., Taschner, P. E. M., Rubinstein, W. S., Myers, E. N., et al. (2000) Science 287, 848-851.
10. Gimenez-Ruqueplo, A.-P., Favier, J., Rustin, P., Mourad, J.-J., Plouin, P.-F., Corvol, P., Rötig, A. & Jeunemaitre, X. (2001) Am. J. Hum. Genet. 69, 1186-1197.
11. Taschner, P. E., Jansen, J. C., Baysal, B. E., Rosenberg, E. H., Brocker-Vriends, A. H., van Der Mey, A. G., van Ommen, G. J., Cornelisse, C. J. & Devilee, P. (2001) Genes Chromosomes Cancer 31, 274-281.
12. Badenhop, R. F., Cherian, S., Lord, R. S., Baysal, B. E., Taschner, P. E. & Schofield, P. R. (2001) Genes Chromosomes Cancer 31, 255-263.
13. Niemann, S. & Müller, U. (2000) Nat. Genet. 26, 268-270.
14. Astuti, D., Larif, F., Dallol, A., Dahia, P. L. M., Douglas, F., George, E., Sköldberg, F., Husebye, E. S., Eng, C. & Maher, E. R. (2001) Am. J. Hum. Genet. 69, 49-54.
15. Gimm, O., Armanios, M., Dziema, H., Neumann, H. P. H. & Eng, C. (2000) Cancer Res. 60, 6822-6825.
16. Rustin, P. & Rötig, A. (2002) Biochim. Biophys. Acta 1553, 117-122.
17. Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F. & Nissim, I. (2000) Proc. Natl. Acad. Sci. USA 97, 2826-2831.
18. Tielens, A. G. M. & Van Hellemond, J. J. (1998) Biochim. Biophys. Acta 1365, 71-78.
19. Kita, K., Hirawake, H., Miyadera, H., Amino, H. & Takeo, S. (2002) Biochim. Biophys. Acta 1553, 123-139.
20. Ui, H., Shiomi, K., Yamaguchi, Y., Masuma, R., Nagamitsu, T., Takano, D., Sunazuka, T., Namikoshi, M. & Omura, S. (2001) J. Antibiot. 54, 234-238.
21. Takano, D., Nagamitsu, T., Ui, H., Shiomi, K., Yamaguchi, Y., Masuma, R., Kuwajima, I. & Omura, S. (2001) Organ. Lett. 3, 2289-2291.
22. Omura, S., Miyadera, H., Ui, H., Shiomi, K., Yamaguchi, Y., Masuma, R., Nagamitsu, T., Takano, D., Sunazuka, T., Harder, A., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 60-62.
23. Dickinson, J. M., Hanson, J. R., Hitchcock, P. B. & Claydon, N. (1989) J. Chem. Soc. Perkin Trans. 1, 1885-1887.
24. Cutler, H. G. & Jacyno, J. M. (1991) Agric. Biol. Chem. 55, 2629-2631.
25. Omura, S., Tomoda, H., Kimura, K., Zhen, D.-Z., Kumagai, H., Igarashi, K., Imamura, N., Takahashi, Y., Tanaka, Y. & Iwai, Y. (1988) J. Antibiot. 41, 1769-1773.
26. Saruta, F., Kuramochi, T., Nakamura, K., Takamiya, S., Yu, Y., Aoki, T., Sekimizu, K., Kojima, S. & Kita, K. (1995) J. Biol. Chem. 270, 928-932.
27. Kita, K., Takamiya, S., Furushima, R., Ma, Y. C., Suzuki, H., Ozawa, T. & Oya, H. (1988) Biochim. Biophys. Acta 935, 130-140.
28. Kita, K., Vibat, C. R. T., Meinhardt, S., Guest, J. R. & Gennis, R. B. (1989) J. Biol. Chem. 264, 2672-2677.
29. Miyadera, H., Amino, H., Hiraishi, A., Taka, H., Murayama, K., Miyoshi, H., Sakamoto, K., Ishii, N., Hekimi, S. & Kita, K. (2001) J. Biol. Chem. 276, 7713-7716.
30. Kumagai, H., Nishida, H., Imamura, N., Tomoda, H. & Omura, S. (1990) J. Antibiot. 43, 1553-1558.
31. Oshino, K., Kumagai, H., Tomoda, H. & Omura, S. (1990) J. Antibiot. 43, 1064-1068.
32. Tan, A. K., Ramsay, R. R., Singer, T. P. & Miyoshi, H. (1993) J. Biol Chem. 268, 19328-19333.
33. Iverson, T. M., Luna-Chavez, C., Croal, L. R., Cecchini, G. & Rees, D. C. (2002) J. Biol. Chem. 277, 16124-16130.
34. Lancaster, C. R. D., Kröger, A., Auer, M. & Michel, H. (1999) Nature 402, 377-385.
35. Törnroth, S., Yankovskaya, V., Cecchini, G. & Iwata, S. (2002) Biochim. Biophys. Acta 1553, 171-176.
36. Matsson, M. & Hederstedt, L. (2001) J Bioenerg. Biomembr. 33, 99-105.
37. Matsson, M., Ackrell, B. A. C., Cochran, B. & Hederstedt, L. (1998) Arch. Microbiol. 170, 27-37.
38. Keon, J. P. R., White, G. A. & Hargreaves, J. A. (1991) Curr. Genet. 19, 475-481.
39. Broomfield, P. L. E. & Hargreaves, J. A. (1992) Curr. Genet. 22, 112-117.
40. Skinner, W., Bailey, A., Renwick, A., Keon, J., Gurr, S. & Hargreaves, J. (1998) Curr. Genet. 34, 393-398.
41. Chauvin, C., De Oliveira, F., Ronot, X., Mousseau, M., Leverve, X. & Fontaine, E. (2001) J. Biol. Chem. 276, 41394-41398.
42. Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V. & Greenamyre, J. T. (2001) Nat. Neurosci. 3, 1301-1306.
43. Gille, L. & Nohl, H. (2001) Arch. Biochem. Biophys. 388, 34-38.
44. Greene, J. G., Porter, R. H. P., Eller, R. V. & Greenamyre, T. J. (1993) J. Neurochem. 61, 1151-1154.