Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling

Biochemical and Biophysical Research Communications

Volumn 443, Issue 2, 2014, Pages 447-452

  Cheng, Li Bo ^a,b   Cheng, Lei ^a   Bi, Hui E ^a   Zhang, Zhi Qing ^c   Yao, Jin ^a   Zhou, Xiao Zhong ^d   Jiang, Qin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Liyang Hospital of Traditional Chinese Medicine   (China)

^c SOOCHOW UNIVERSITY   (China)

^d THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Melanocyte stimulating hormone ( MSH); Age related macular degeneration (AMD); Apoptosis and Akt mTOR signaling; Melanocortin 1 receptor (MC1R); Retinal pigment epithelium (RPE)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALPHA INTERMEDIN; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; MELANOCORTIN 1 RECEPTOR; PERIFOSINE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; S6 KINASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VISUAL PIGMENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AGE RELATED MACULAR DEGENERATION (AMD); AGE-RELATED MACULAR DEGENERATION; AMD; APOPTOSIS AND AKT/MTOR SIGNALING; H(2)O(2); HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; MC1R; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 1 RECEPTOR (MC1R); MTOR; RETINAL PIGMENT EPITHELIUM; RETINAL PIGMENT EPITHELIUM (RPE); RPE; Α-MELANOCYTE STIMULATING HORMONE; Α-MELANOCYTE STIMULATING HORMONE (Α-MSH); Α-MSH;

ALPHA-MSH; ANIMALS; CELL LINE; CELL SURVIVAL; HUMANS; MICE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RECEPTOR, MELANOCORTIN, TYPE 1; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

EID: 84892439564     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.113     Document Type: Article

References (40)

1. D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen Prevalence of age-related macular degeneration in the United States Arch. Ophthalmol. 122 2004 564 572
2. Y. Chen, and S.B. Gibson Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 4 2008 246 248
3. R.E. Pacifici, and K.J. Davies Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited Gerontology 37 1991 166 180
4. H. Bartlett, and F. Eperjesi A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674] Nutr. J. 2 2003 12
5. S. Richer, W. Stiles, L. Statkute, J. Pulido, J. Frankowski, D. Rudy, K. Pei, M. Tsipursky, and J. Nyland Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial) Optometry 75 2004 216 230
6. G.F. Cao, Y. Liu, W. Yang, J. Wan, J. Yao, Y. Wan, and Q. Jiang Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells Biochem. Biophys. Res. Commun. 414 2011 499 505
7. J. Yao, H.E. Bi, Y. Sheng, L.B. Cheng, R.L. Wendu, C.H. Wang, G.F. Cao, and Q. Jiang Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis Int. J. Mol. Sci. 14 2013 10355 10368
8. A.J. Thody Alpha-MSH and the regulation of melanocyte function Ann. N. Y. Acad. Sci. 885 1999 217 229
9. T.A. Luger, T. Scholzen, and S. Grabbe The role of alpha-melanocyte- stimulating hormone in cutaneous biology J. Investig. Dermatol. Symp. Proc. 2 1997 87 93
10. J.M. Lipton, and A. Catania Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH Immunol. Today 18 1997 140 145
11. J.M. Lipton, A. Macaluso, M.E. Hiltz, and A. Catania Central administration of the peptide alpha-MSH inhibits inflammation in the skin Peptides 12 1991 795 798
12. I. Suzuki, R.D. Cone, S. Im, J. Nordlund, and Z.A. Abdel-Malek Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis Endocrinology 137 1996 1627 1633
13. Z.A. Abdel-Malek, A.L. Kadekaro, R.J. Kavanagh, A. Todorovic, L.N. Koikov, J.C. McNulty, P.J. Jackson, G.L. Millhauser, S. Schwemberger, G. Babcock, C. Haskell-Luevano, and J.J. Knittel Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity FASEB J. 20 2006 1561 1563
14. A.L. Kadekaro, H. Kanto, R. Kavanagh, and Z. Abdel-Malek Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival Ann. N. Y. Acad. Sci. 994 2003 359 365
15. M. Bohm, I. Wolff, T.E. Scholzen, S.J. Robinson, E. Healy, T.A. Luger, T. Schwarz, and A. Schwarz Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage J. Biol. Chem. 280 2005 5795 5802
16. A. Bar-Ilan, N. Savion, and N. Naveh Alpha melanocyte stimulating hormone (alpha-MSH) enhances eicosanoid production by bovine retinal pigment epithelium Prostaglandins 43 1992 31 44
17. C.P. Li, J. Yao, Z.F. Tao, X.M. Li, Q. Jiang, and B. Yan Epigallocatechin-gallate (EGCG) regulates autophagy in human retinal pigment epithelial cells: a potential role for reducing UVB light-induced retinal damage Biochem. Biophys. Res. Commun. 438 2013 739 745
18. S. Adachi, E. Morii, D. Kim, H. Ogihara, T. Jippo, A. Ito, Y.M. Lee, and Y. Kitamura Involvement of mi-transcription factor in expression of alpha-melanocyte-stimulating hormone receptor in cultured mast cells of mice J. Immunol. 164 2000 855 860
19. Y. Liu, G.F. Cao, J. Xue, J. Wan, Y. Wan, Q. Jiang, and J. Yao Tumor necrosis factor-alpha (TNF-alpha)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt/mTOR complex 1 (mTORC1), but not mTOR complex 2 (mTORC2) signaling Eur. J. Cell Biol. 91 2012 728 737
20. V. Chhajlani Distribution of cDNA for melanocortin receptor subtypes in human tissues Biochem. Mol. Biol. Int. 38 1996 73 80
21. J. Yao, Y. Liu, X. Wang, Y. Shen, S. Yuan, Y. Wan, and Q. Jiang UVB radiation induces human lens epithelial cell migration via NADPH oxidase-mediated generation of reactive oxygen species and up-regulation of matrix metalloproteinases Int. J. Mol. Med. 24 2009 153 159
22. Q. Jiang, C. Zhou, Z. Bi, and Y. Wan EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells J. Ocul. Pharmacol. Ther. 22 2006 93 102
23. N. Dumaz, and R. Marais Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels FEBS J. 272 2005 3491 3504
24. E.J. Huang, and L.F. Reichardt Trk receptors: roles in neuronal signal transduction Annu. Rev. Biochem. 72 2003 609 642
25. T.A. Luger, T.E. Scholzen, T. Brzoska, and M. Bohm New insights into the functions of alpha-MSH and related peptides in the immune system Ann. N. Y. Acad. Sci. 994 2003 133 140
26. K.G. Mountjoy, C.S. Wu, J. Cornish, and K.E. Callon Alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors Ann. N. Y. Acad. Sci. 994 2003 58 65
27. S.K. Manna, and B.B. Aggarwal Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents J. Immunol. 161 1998 2873 2880
28. G. Song, G. Ouyang, and S. Bao The activation of Akt/PKB signaling pathway and cell survival J. Cell Mol. Med. 9 2005 59 71
29. S.B. Kondapaka, S.S. Singh, G.P. Dasmahapatra, E.A. Sausville, and K.K. Roy Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation Mol. Cancer Ther. 2 2003 1093 1103
30. J.J. Gills, and P.A. Dennis Perifosine: update on a novel Akt inhibitor Curr. Oncol. Rep. 11 2009 102 110
31. H. Hirai, H. Sootome, Y. Nakatsuru, K. Miyama, S. Taguchi, K. Tsujioka, Y. Ueno, H. Hatch, P.K. Majumder, B.S. Pan, and H. Kotani MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo Mol. Cancer Ther. 9 2010 1956 1967
32. T.A. Yap, L. Yan, A. Patnaik, I. Fearen, D. Olmos, K. Papadopoulos, R.D. Baird, L. Delgado, A. Taylor, L. Lupinacci, R. Riisnaes, L.L. Pope, S.P. Heaton, G. Thomas, M.D. Garrett, D.M. Sullivan, J.S. de Bono, and A.W. Tolcher First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors J. Clin. Oncol. 29 2011 4688 4695
33. G.J. Brunn, J. Williams, C. Sabers, G. Wiederrecht, J.C. Lawrence Jr., and R.T. Abraham Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 EMBO J. 15 1996 5256 5267
34. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
35. B.T. Hennessy, D.L. Smith, P.T. Ram, Y. Lu, and G.B. Mills Exploiting the PI3K/AKT pathway for cancer drug discovery Nat. Rev. Drug Discovery 4 2005 988 1004
36. M. Laplante, and D.M. Sabatini MTOR signaling in growth control and disease Cell 149 2012 274 293
37. D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 2007 9 22
38. D.M. Sabatini MTOR and cancer: insights into a complex relationship Nat. Rev. Cancer 6 2006 729 734
39. J.R. Mills, Y. Hippo, F. Robert, S.M. Chen, A. Malina, C.J. Lin, U. Trojahn, H.G. Wendel, A. Charest, R.T. Bronson, S.C. Kogan, R. Nadon, D.E. Housman, S.W. Lowe, and J. Pelletier MTORC1 promotes survival through translational control of Mcl-1 Proc. Natl. Acad. Sci. U.S.A. 105 2008 10853 10858
40. K.S. Smalley A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int. J. Cancer 104 2003 527 532