Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis

International Journal of Molecular Sciences

Volumn 14, Issue 5, 2013, Pages 10355-10368

  Yao, Jin ^a   Bi, Hui E ^a   Sheng, Yi ^a   Cheng, Li Bo ^a,b   Wendu, Ri Le ^a   Wang, Cheng Hu ^a   cao, Guo Fan ^a   Jiang, Qin ^a  

^a First Affiliated Hospital of Nanjing Medical University   (China)

^b Liyang Hospital of Traditional Chinese Medicine   (China)

Author keywords

Age related macular degeneration (AMD); Ceramide; ER stress and AMPK; ROS; RPE cell apoptosis; UV

Indexed keywords

5 AMINO 1 BETA D RIBOFURANOSYL IMIDAZOLE 4 CARBOXAMIDE; ADENYLATE KINASE; CERAMIDE; ENZYME ACTIVATOR; FUMONISIN B1; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SALUBRINAL; UNCLASSIFIED DRUG; CINNAMIC ACID DERIVATIVE; FUMONISIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N-CAPROYLSPHINGOSINE; OXIDIZING AGENT; THIOUREA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPOGENESIS; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; ANALOGS AND DERIVATIVES; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; RADIATION RESPONSE; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CERAMIDES; CINNAMATES; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FUMONISINS; HUMANS; HYDROGEN PEROXIDE; OXIDANTS; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; THIOUREA; ULTRAVIOLET RAYS;

EID: 84878231533     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140510355     Document Type: Article

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