Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells

Biochemical and Biophysical Research Communications

Volumn 414, Issue 3, 2011, Pages 499-505

  Cao, Guo Fan ^a   Liu, Yuan ^a   Yang, Wen ^a   Wan, Jerry ^b   Yao, Jin ^a   Wan, Yinsheng ^b   Jiang, Qin ^a  

^a First Affiliated Hospital of Nanjing Medical University   (China)

^b PROVIDENCE COLLEGE   (United States)

Author keywords

Cell migration; Cell survival; Hydrogen peroxide; MTOR; Nerve growth factor; Retinal pigment epithelial cells

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; NERVE GROWTH FACTOR; RAPAMYCIN; S6 KINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL MIGRATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PHOSPHORYLATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; CYTOPROTECTION; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; MACULAR DEGENERATION; NERVE GROWTH FACTOR; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RETINAL PIGMENT EPITHELIUM; SIROLIMUS; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 80054956582     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.094     Document Type: Article

References (35)

1. Friedman D.S., O'Colmain B.J., Munoz B., et al. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 2004, 122:564-572.
2. Nowak J.Z. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol. Rep. 2006, 58:353-363.
3. X. Ding, M. Patel, C.C. Chan, Molecular pathology of age-related macular degeneration, Prog. Retin. Eye. Res. 28 (2009) 1-18.
4. Drobek-Slowik M., Karczewicz D., Safranow K. The potential role of oxidative stress in the pathogenesis of the age-related macular degeneration (AMD). Postepy. Hig. Med. Dosw. (Online) 2007, 61:28-37.
5. Nowak M., Gnitecki W., Jurowski P. The role of retinal oxygen metabolism in origin of age-related macular degeneration (AMD). Klin. Oczna. 2005, 107:715-718.
6. King A., Gottlieb E., Brooks D.G., et al. Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem. Photobiol. 2004, 79:470-475.
7. Deveraux Q.L., Takahashi R., Salvesen G.S., et al. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997, 388:300-304.
8. Kalariya N.M., Ramana K.V., Srivastava S.K., et al. Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp. Eye Res. 2008, 86:70-80.
9. Mohan R., Sivak J., Ashton P., et al. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J. Biol. Chem. 2000, 275:10405-10412.
10. Schutt F., Volcker H.E., Dithmar S. N-acetylcysteine improves lysosomal function and enhances the degradation of photoreceptor outer segments in cultured RPE cells. Klin. Monbl. Augenheilkd 2007, 224:580-584.
11. Chan C.M., Huang J.H., Lin H.H., et al. Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells. Mol. Vis. 2008, 14:2528-2534.
12. Chen Y., Gibson S.B. Is mitochondrial generation of reactive oxygen species a trigger for autophagy?. Autophagy 2008, 4:246-248.
13. Pacifici R.E., Davies K.J. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology 1991, 37:166-180.
14. Lanni C., Stanga S., Racchi M., et al. The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders. Curr. Pharm. Des. 2010, 16:698-717.
15. Snider W.D. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 1994, 77:627-638.
16. Micera A., Lambiase A., Aloe L., et al. Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases. Cytokine Growth Factor Rev. 2004, 15:411-417.
17. Lambiase A., Centofanti M., Micera A., et al. Nerve growth factor (NGF) reduces and NGF antibody exacerbates retinal damage induced in rabbit by experimental ocular hypertension. Graefes. Arch. Clin. Exp. Ophthalmol. 1997, 235:780-785.
18. Siliprandi R., Canella R., Carmignoto G. Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia. Invest. Ophthalmol. Vis. Sci. 1993, 34:3232-3245.
19. Lambiase A., Tirassa P., Micera A., et al. Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats. Invest. Ophthalmol. Vis. Sci. 2005, 46:3800-3806.
20. Lambiase A., Pagani L., Di Fausto V., et al. Nerve growth factor eye drop administrated on the ocular surface of rodents affects the nucleus basalis and septum: biochemical and structural evidence. Brain Res. 2007, 1127:45-51.
21. Defoe D.M., Grindstaff R.D. Epidermal growth factor stimulation of RPE cell survival: contribution of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Exp. Eye Res. 2004, 79:51-59.
22. Peng X.H., Karna P., O'Regan R.M., et al. Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Mol. Pharmacol. 2007, 71:101-111.
23. Jiang Q., Cao C., Lu S., et al. MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells. Int. J. Mol. Med. 2009, 23:771-777.
24. Albrecht-Buehler G. The phagokinetic tracks of 3T3 cells. Cell 1977, 11:395-404.
25. Liang F.Q., Godley B.F. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp. Eye Res. 2003, 76:397-403.
26. Tewari M., Quan L.T., O'Rourke K., et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995, 81:801-809.
27. Decker P., Isenberg D., Muller S. Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. J. Biol. Chem. 2000, 275:9043-9046.
28. Chan C.M., Huang J.H., Chiang H.S., et al. Effects of (-)-epigallocatechin gallate on RPE cell migration and adhesion. Mol. Vis. 2010, 16:586-595.
29. Kim Y.H., He S., Kase S., et al. Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes. Arch. Clin. Exp. Ophthalmol. 2009, 247:651-659.
30. Huang E.J., Reichardt L.F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 2003, 72:609-642.
31. Carling D. The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem. Sci. 2004, 29:18-24.
32. Inoki K., Ouyang H., Zhu T., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126:955-968.
33. J.S. Jaswal, M. Gandhi, B.A. Finegan, et al., p38 Mitogen activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP activated protein kinase, Am. J. Physiol. Heart Circ. Physiol. (2006).
34. Choi S.L., Kim S.J., Lee K.T., et al. The regulation of AMP-activated protein kinase by H(2)O(2). Biochem. Biophys. Res. Commun. 2001, 287:92-97.
35. Chen L., Xu B., Liu L., et al. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab. Invest. 2010, 90:762-773.