Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Dong, Jian ^a   Yan, Dong ^a   Chen, Shao yu ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; ALCOHOL; TRANSCRIPTION FACTOR NRF2; 1,2 DITHIOL 3 THIONE; 1,2-DITHIOL-3-THIONE; ANTIOXIDANT; THIOKETONE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; DRUG MECHANISM; NONHUMAN; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; ANIMAL; DRUG EFFECT; DRUG SCREENING; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CYTOPROTECTION; DRUG EVALUATION, PRECLINICAL; ETHANOL; MICE; NF-E2-RELATED FACTOR 2; PC12 CELLS; PROTEIN STABILITY; RATS; THIONES; THIOPHENES;

EID: 79751488104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016845     Document Type: Article

References (59)

1. Abel EL, Sokol RJ (1986) Fetal alcohol syndrome is now leading cause of mental retardation. Lancet 2: 1222.
2. Burd L (2004) Fetal alcohol syndrome. Am J Med Genet Part C-Semin Med Genetics 127C: 1-2.
3. Cartwright MM, Smith SM (1995) Increased Cell-Death and Reduced Neural Crest Cell Numbers in Ethanol-Exposed Embryos - Partial Basis for the Fetal Alcohol Syndrome Phenotype. Alcohol Clin Exp Res 19: 378-386.
4. Chen SY, Sulik KK (1996) Free radicals and ethanol-induced cytotoxicity in neural crest cells. Alcohol Clin Exp Res 20: 1071-1076.
5. Dong J, Sulik KK, Chen SY (2010) The role of NOX enzymes in ethanolinduced oxidative stress and apoptosis in mouse embryos. Toxicol Lett 193: 94-100.
6. Dunty WC Jr., Chen SY, Zucker RM, Dehart DB, Sulik KK (2001) Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications for alcohol-related birth defects and neurodevelopmental disorder. Alcohol Clin Exp Res 25: 1523-1535.
7. Kotch LE, Sulik KK (1992) Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated facial and brain anomalies. Am J Med Genet 44: 168-176.
8. West JR, Chen WJA, Pantazis NJ (1994) Fetal Alcohol Syndrome - the Vulnerability of the Developing Brain and Possible Mechanisms of Damage. Metabol Brain Dise 9: 291-322.
9. Chen SY, Sulik KK (2000) Iron-mediated free radical injury in ethanol-exposed mouse neural crest cells. J Pharmacol Exp Ther 294: 134-140.
10. De A, Boyadjieva NI, Pastorcic M, Reddy BV, Sarkar DK (1994) Cyclic-Amp and Ethanol Interact to Control Apoptosis and Differentiation in Hypothalamic Beta-Endorphin Neurons. Journal of Biological Chemistry 269: 26697-26704.
11. Olney JW, Tenkova T, Dikranian K, Qin YQ, Labruyere J, et al. (2002) Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Developmental Brain Research 133: 115-126.
12. Tran TD, Jackson HD, Horn KH, Goodlett CR (2005) Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats. Alcohol Clin Exp Res 29: 117-129.
13. Napper RM, West JR (1995) Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: a stereological investigation. J Comp Neurol 362: 283-292.
14. Chen SY, Wilkemeyer MF, Sulik KK, Charness ME (2001) Octanol antagonism of ethanol teratogenesis. FASEB J 15: 1649-1651.
15. Chen SY, Dehart DB, Sulik KK (2004) Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic, EUK-134. FASEB J 18: 1234-1236.
16. Dong J, Sulik KK, Chen SY (2008) Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders. Antioxid Redox Signal 10: 2023-2033.
17. Henderson GI, Chen JJ, Schenker S (1999) Ethanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci 4: D541-D550.
18. Kotch LE, Chen SY, Sulik KK (1995) Ethanol-induced teratogenesis: free radical damage as a possible mechanism. Teratol 52: 128-136.
19. Ramachandran V, Watts LT, Maffi SK, Chen JJ, Schenker S, et al. (2003) Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons. J Neurosci Res 74: 577-588.
20. Nguyen T, Nioi P, Pickett CB (2009) The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress. J Biol Chem 284: 13291-13295.
21. Zhang DD (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metabol Rev 38: 769-789.
22. Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, et al. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes to Cells 8: 379-391.
23. McMahon M, Itoh K, Yamamoto M, Hayes JD (2003) Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. Journal of Biological Chemistry 278: 21592-21600.
24. Nguyen T, Sherratt PJ, Nioi P, Yang CS, Pickett CB (2005) Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. Journal of Biological Chemistry 280: 32485-32492.
25. Zhang DD, Hannink M (2003) Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Molecular and Cellular Biology 23: 8137-8151.
26. Kensler TW, Wakabayash N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology 47: 89-116.
27. Li WG, Kong AN (2009) Molecular Mechanisms of Nrf2-Mediated Antioxidant Response. Mol Carcinogen 48: 91-104.
28. Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB (2003) Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element - Degradation of Nrf2 by the 26 S proteasome. J Biol Chem 278: 4536-4541.
29. Stewart D, Killeen E, Naquin R, Alam S, Alam J (2003) Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. Journal of Biological Chemistry 278: 2396-2402.
30. Fahey JW, Zalcmann AT, Talalay P (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochem 56: 5-51.
31. Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR (2006) Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H- 1,2-dithiole-3-thione. Physiol Genomics 24: 144-153.
32. Munday R, Munday CM (2004) Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: dose-response study in rats. Carcinogenesis 25: 1721-1725.
33. Koh K, Cha Y, Kim S, Kim J (2009) tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation. Biochem Biophy Res Comm 380: 449-453.
34. Talalay P, Fahey JW (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutri 131: 3027S-3033S.
35. Otieno MA, Kensler TW, Guyton KZ (2000) Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo. Free Radical Biol Med 28: 944-952.
36. Burton NC, Kensler TW, Guilarte TR (2006) In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicol 27: 1094-1100.
37. Cao ZX, Zhu H, Zhang L, Zhao X, Zweier JL, et al. (2006) Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injury. Exp Biol Med 231: 1353-1364.
38. Delfino-Machin M, Chipperfield TR, Rodrigues FS, Kelsh RN (2007) The proliferating field of neural crest stem cells. Dev Dyn 236: 3242-3254.
39. Hall BK (2008) The neural crest and neural crest cells: discovery and significance for theories of embryonic organization. J Biosci 33: 781-793.
40. Teng L, Labosky PA (2006) Neural crest stem cells. Adv Exp Med Biol 589: 206-212.
41. Smith SM (1997) Alcohol-induced cell death in the embryo. Alcohol Health Res.World 21: 287-295.
42. Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth-factor. Proceedings of the National Academy of Sciences of the United States of America 73: 2424-2428.
43. Luo J, West JR, Cook RT, Pantazis NJ (1999) Ethanol induces cell death and cell cycle delay in cultures of pheochromocytoma PC12 cells. Alcohol Clini Exp Res 23: 644-656.
44. Oberdoerster J, Kamer AR, Rabin RA (1998) Differential effect of ethanol on PC12 cell death. J Pharmacol Exp Ther 287: 359-365.
45. Pantazis NJ, Dohrman DP, Luo J, Goodlett CR, West JR (1992) Alcohol Reduces the Number of Pheochromocytoma (Pc12) Cells in Culture. Alcohol 9: 171-180.
46. Kotlo KU, Yehiely F, Efimova E, Harasty H, Hesabi B, et al. (2003) Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells. Oncogene 22: 797-806.
47. Zhang JD, Hung AC, Ng PY, Nakayama K, Hu YY, et al. (2009) PKC delta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis. Biochem Biophy Res Comm 386: 750-756.
48. Danilov CA, Chandirasekaran K, Racz J, Soane L, Zielke C, et al. (2009) Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation. Glia 57: 645-656.
49. He XQ, Lin GX, Chen MG, Zhang JX, Ma Q (2007) Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. Toxicol Sci 98: 298-309.
50. He XQ, Chen MG, Ma Q (2008) Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem Res Toxicol 21: 1375-1383.
51. Yan D, Dong J, Sulik KK, Chen SY (2010) Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. Biochem Pharmacol 80: 144-149.
52. Korashy HM, El-Kadi AOS (2006) Transcriptional regulation of the NAD(P)H: quinone oxidoreductase 1 and glutathione S-transferase Ya genes by mercury, lead, and copper. Drug Metabolism and Disposition 34: 152-165.
53. Knorr-Wittmann C, Hengstermann A, Gebel S, Alam J, Muller T (2005) Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke. Free Radical Biol Med 39: 1438-1448.
54. Gong PF, Cederbaum AI (2006) Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem 281: 14573-14579.
55. Cullinan SB, Gordan JD, Jin JO, Harper JW, Diehl JA (2004) The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 24: 8477-8486.
56. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130-7139.
57. Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M (2004) Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24: 10941-10953.
58. Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, et al. (2001) Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 480: 305-315.
59. Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol 577: 17-27.