Erratum: Expression of Concern: Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults (PLoS ONE (2013) 8:12 (e84171) DOI: 10.1371/journal.pone.0084171);Ginsenoside Rg-1 protects Retinal Pigment Epithelium (RPE) cells from cobalt chloride (CoCl2) and hypoxia assaults

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Li, Ke Ran ^a   Zhang, Zhi Qing ^b   Yao, Jin ^a   Zhao, Yu Xia ^a   Duan, Jing ^c   Cao, Cong ^b   Jiang, Qin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; COBALT CHLORIDE; EVEROLIMUS; GINSENOSIDE RG 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; PIGMENT CELL; PIGMENT EPITHELIUM; SURVIVAL RATE;

APOPTOSIS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; COBALT; CYTOPROTECTION; ENZYME ACTIVATION; GINSENOSIDES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPROTEIN COMPLEXES; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; TOR SERINE-THREONINE KINASES;

EID: 84893533496     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0304598     Document Type: Erratum

References (62)

1. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, et al. (2004) Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 23: 91-147. (Pubitemid 38180539)
2. Du ZJ, Yamamoto T, Ueda T, Suzuki M, Tano Y, et al. (2011) Activated protein C rescues the retina from ischemia-induced cell death. Invest Ophthalmol Vis Sci 52: 987-993.
3. Buettner C, Yeh GY, Phillips RS, Mittleman MA, Kaptchuk TJ (2006) Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother 40: 83-95. (Pubitemid 43221479)
4. Zhu D, Wu L, Li CR, Wang XW, Ma YJ, et al. (2009) Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem 108: 117-124.
5. Vogler BK, Pittler MH, Ernst E (1999) The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 55: 567-575. (Pubitemid 29489202)
6. Liu ZJ, Zhao M, Zhang Y, Xue JF, Chen NH (2010) Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase IIdependent signaling pathway. Brain Res 1333: 1-8.
7. Nag SA, Qin JJ, Wang W, Wang MH, Wang H, et al. (2012) Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Front Pharmacol 3: 25.
8. Huong NT, Matsumoto K, Kasai R, Yamasaki K, Watanabe H (1998) In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biol Pharm Bull 21: 978-981. (Pubitemid 28452381)
9. Liu Q, Kou JP, Yu BY (2011) Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation. Neurochem Int 58: 119-125.
10. Chen WF, Zhou LP, Chen L, Wu L, Gao QG, et al. (2013) Involvement of IGFI receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Abeta(2)(5)(-)(3)(5)-induced toxicity in PC12 cells. Neurochem Int 62: 1065-1071.
11. Li W, Chu Y, Zhang L, Yin L, Li L (2012) Ginsenoside Rg1 prevents SK-N-SH neuroblastoma cell apoptosis induced by supernatant from Abeta1-40-stimulated THP-1 monocytes. Brain Res Bull 88: 501-506.
12. Wu J, Pan Z, Wang Z, Zhu W, Shen Y, et al. (2012) Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology 63: 349-361.
13. Shen L, Han JZ, Li C, Yue SJ, Liu Y, et al. (2007) Protective effect of ginsenoside Rg1 on glutamate-induced lung injury. Acta Pharmacol Sin 28: 392-397.
14. Mu YY, Jing YY, Yu YH (2012) [Effects of intrathecal injection of ginsenoside Rg1 on the level of glutamate transporter in the arthritis rats with chronic morphine tolerance]. Zhongguo Zhong Xi Yi Jie He Za Zhi 32: 1539-1542.
15. Xu H, Jiang H, Wang J, Xie J (2010) Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology 58: 488-494.
16. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, et al. (2007) Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 52: 827-835. (Pubitemid 46227475)
17. Kim HJ, Kim P, Shin CY (2013) A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J Ginseng Res 37: 8-29.
18. Li JQ, Zhang XG, Zhang JT (1997) [Study on the anti-apoptotic mechanism of ginsenoside Rg1 in cultured cortical neurons]. Yao Xue Xue Bao 32: 406-410.
19. Liao B, Newmark H, Zhou R (2002) Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 173: 224-234. (Pubitemid 34151374)
20. Fang F, Chen X, Huang T, Lue LF, Luddy JS, et al. (2012) Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochim Biophys Acta 1822: 286-292.
21. Wang WX, Wang W, Chen KJ (2005) [Protective effect and mechanism of ginsenosides on central nerve system of animals]. Zhongguo Zhong Xi Yi Jie He Za Zhi 25: 89-93.
22. Wang QY, Liu F, Wu FJ, Li JL (2013) [Effects of ginsenoside Rg1 on the expressions of p-eRK1/2 and p-JNK in local cerebral ischemia/reperfusion injury rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi 33: 229-234.
23. Zong Y, Ai QL, Zhong LM, Dai JN, Yang P, et al. (2012) Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-gamma1 signaling pathway in murine BV-2 microglial cells. Curr Med Chem 19: 770-779.
24. Joo SS, Won TJ, Lee DI (2005) Reciprocal activity of ginsenosides in the production of proinflammatory repertoire, and their potential roles in neuroprotection in vivo. Planta Med 71: 476-481. (Pubitemid 40839784)
25. Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, et al. (2007) Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int Immunopharmacol 7: 313-320. (Pubitemid 46186170)
26. Boulton M, Dayhaw-Barker P (2001) The role of the retinal pigment epithelium: topographical variation and ageing changes. Eye (Lond) 15: 384-389. (Pubitemid 32600862)
27. Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85: 845-881.
28. Yap TA, Yan L, Patnaik A, Fearen I, Olmos D, et al. (2011) First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol 29: 4688-4695.
29. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC Jr, et al. (1996) Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J 15: 5256-5267. (Pubitemid 26336209)
30. Chen Z, Shen X, Shen F, Zhong W, Wu H, et al. (2013) TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomy-ocytes, inhibited by heat shock protein-70. Mol Cell Biochem 377: 35-44.
31. Chen L, Xu B, Liu L, Luo Y, Yin J, et al. (2010) Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest 90: 762-773.
32. Hardy P, Beauchamp M, Sennlaub F, Gobeil F Jr, Tremblay L, et al. (2005) New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. Prostaglandins Leukot Essent Fatty Acids 72: 301-325. (Pubitemid 40590052)
33. Chen XC, Chen Y, Zhu YG, Fang F, Chen LM (2002) Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 23: 829-834. (Pubitemid 35012987)
34. Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508.
35. Kim MH, Kim MO, Heo JS, Kim JS, Han HJ (2008) Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis 13: 295-304.
36. Kunz M, Ibrahim S, Koczan D, Thiesen HJ, Kohler HJ, et al. (2001) Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. Cell Growth Differ 12: 137-145. (Pubitemid 32677999)
37. Li C, Jackson RM (2002) Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 282: C227-241. (Pubitemid 34663181)
38. Yao J, Bi HE, Sheng Y, Cheng LB, Wendu RL, et al. (2013) Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis. Int J Mol Sci 14: 10355-10368.
39. Borutaite V (2008) AMPK, MAPK and Bax in the heart: some questions answered. Biochem J 412: e15-16.
40. Lee MS, Lee CM, Cha EY, Thuong PT, Bae K, et al. (2010) Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis. Phytother Res 24: 1857-1861.
41. Chen MB, Shen WX, Yang Y, Wu XY, Gu JH, et al. (2011) Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol 226: 1915-1925.
42. Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, et al. (2000) Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49: 527-531. (Pubitemid 30183739)
43. Mizushina Y, Iida A, Ohta K, Sugawara F, Sakaguchi K (2000) Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 350 Pt 3: 757-763.
44. Terai K, Hiramoto Y, Masaki M, Sugiyama S, Kuroda T, et al. (2005) AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol 25: 9554-9575. (Pubitemid 41507855)
45. Mihaylova MM, Shaw RJ (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13: 1016-1023.
46. Inoki K, Kim J, Guan KL (2012) AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol 52: 381-400.
47. Kang MR, Park SK, Lee CW, Cho IJ, Jo YN, et al. (2012) Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells. Oncol Rep 27: 1407-1412.
48. Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, et al. (2003) AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol 30: 151-161. (Pubitemid 36592509)
49. Meisse D, Van de Casteele M, Beauloye C, Hainault I, Kefas BA, et al. (2002) Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett 526: 38-42. (Pubitemid 35245688)
50. Du JH, Xu N, Song Y, Xu M, Lu ZZ, et al. (2005) AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK. Biochem Biophys Res Commun 337: 1139-1144. (Pubitemid 41509193)
51. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR 3rd, Young LH (2005) AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res 97: 872-879. (Pubitemid 41552672)
52. Okoshi R, Ozaki T, Yamamoto H, Ando K, Koida N, et al. (2008) Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem 283: 3979-3987.
53. Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H (2001) Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 287: 562-567. (Pubitemid 32917636)
54. Chen MB, Wu XY, Gu JH, Guo QT, Shen WX, et al. (2011) Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem Biophys 60: 311-322.
55. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226. (Pubitemid 351626684)
56. Yang XH, Zheng X, Cao JG, Xiang HL, Liu F, et al. (2010) 8-Bromo-7- methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. World J Gastroenterol 16: 3385-3393.
57. Cao C, Lu S, Kivlin R, Wallin B, Card E, et al. (2008) AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem 283: 28897-28908.
58. Wan X, Harkavy B, Shen N, Grohar P, Helman LJ (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26: 1932-1940. (Pubitemid 46474636)
59. Fernandes AF, Zhou J, Zhang X, Bian Q, Sparrow J, et al. (2008) Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8. J Biol Chem 283: 20745-20753.
60. Zhang X, Zhou J, Fernandes AF, Sparrow JR, Pereira P, et al. (2008) The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells. Invest Ophthalmol Vis Sci 49: 3622-3630.
61. Chen MB, Wu XY, Tao GQ, Liu CY, Chen J, et al. (2012) Perifosine sensitizes curcumin induced anti-colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro. Int J Cancer.
62. Zheng QY, Jin FS, Yao C, Zhang T, Zhang GH, et al. (2012) Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. Biochem Biophys Res Commun.