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Volumn 87, Issue 2, 2013, Pages 383-396

Nrf2-mediated redox signaling in arsenic carcinogenesis: A review

Author keywords

Arsenic; Carcinogenicity; Chemoprevention; Nrf2; Oxidative stress

Indexed keywords

ARSENIC; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

EID: 84873703254     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0920-5     Document Type: Article
Times cited : (68)

References (120)
  • 1
    • 77953298499 scopus 로고    scopus 로고
    • Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells
    • 1:CAS:528:DC%2BC3cXptV2ltr8%3D
    • Abiko Y, Shinkai Y, Sumi D, Kumagai Y (2010) Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. J Toxicol Sc 35:419-423
    • (2010) J Toxicol Sc , vol.35 , pp. 419-423
    • Abiko, Y.1    Shinkai, Y.2    Sumi, D.3    Kumagai, Y.4
  • 2
    • 84873739306 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ASTDR). Accessed on 6 May 2012
    • Agency for Toxic Substances and Disease Registry (ASTDR) (2012) http://www.atsdr.cdc.gov/substances/toxsubstance.asp?toxid=3. Accessed on 6 May 2012
    • (2012)
  • 4
    • 79954416526 scopus 로고    scopus 로고
    • The cytoprotective role of the Keap1-Nrf2 pathway
    • 21365312 1:CAS:528:DC%2BC3MXisFKks7w%3D
    • Baird L, Dinkova-Kostova AT (2011) The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol 85:241-272
    • (2011) Arch Toxicol , vol.85 , pp. 241-272
    • Baird, L.1    Dinkova-Kostova, A.T.2
  • 5
    • 0026561311 scopus 로고
    • Arsenic ingestion and internal cancers: A review
    • 1570813 1:STN:280:DyaK383jvVCltg%3D%3D
    • Bates MN, Smith AH, Hopenhayn-Rich C (1992) Arsenic ingestion and internal cancers: a review. Am J Epidemiol 135:462-476
    • (1992) Am J Epidemiol , vol.135 , pp. 462-476
    • Bates, M.N.1    Smith, A.H.2    Hopenhayn-Rich, C.3
  • 6
    • 0036801404 scopus 로고    scopus 로고
    • Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite
    • 12426126 1:CAS:528:DC%2BD38XovFKhsL8%3D
    • Bau DT, Wang TS, Chung CH, Wang AS, Jan KY (2002) Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite. Environ Health Perspect 110:753-756
    • (2002) Environ Health Perspect , vol.110 , pp. 753-756
    • Bau, D.T.1    Wang, T.S.2    Chung, C.H.3    Wang, A.S.4    Jan, K.Y.5
  • 7
    • 79952271561 scopus 로고    scopus 로고
    • Nrf2 and NFκB and their concerted modulation in cancer pathogenesis and progression
    • 1:CAS:528:DC%2BC3cXnslGisrc%3D
    • Bellezza I, Mierla AL, Minelli A (2010) Nrf2 and NFκB and their concerted modulation in cancer pathogenesis and progression. Cancers 2:483-497
    • (2010) Cancers , vol.2 , pp. 483-497
    • Bellezza, I.1    Mierla, A.L.2    Minelli, A.3
  • 8
    • 77951775608 scopus 로고    scopus 로고
    • Oxidative stress in cancer and neurodegenerative diseases: Prevention and treatment by dietary antioxidants
    • D. Kozyrev V. Slutsky (eds) Nova Science Publishers, Inc New York
    • Bishayee A, Darvesh AS (2010) Oxidative stress in cancer and neurodegenerative diseases: prevention and treatment by dietary antioxidants. In: Kozyrev D, Slutsky V (eds) Handbook of free radicals: formation, types and effects. Nova Science Publishers, Inc, New York, pp 1-55
    • (2010) Handbook of Free Radicals: Formation, Types and Effects , pp. 1-55
    • Bishayee, A.1    Darvesh, A.S.2
  • 9
    • 77953229913 scopus 로고    scopus 로고
    • Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis
    • 1:CAS:528:DC%2BC3cXht1Gju7zF
    • Bishayee A, Barnes KF, Bhatia D, Darvesh AS, Carroll RT (2010) Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res 3:753-763
    • (2010) Cancer Prev Res , vol.3 , pp. 753-763
    • Bishayee, A.1    Barnes, K.F.2    Bhatia, D.3    Darvesh, A.S.4    Carroll, R.T.5
  • 10
    • 79958214540 scopus 로고    scopus 로고
    • Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms
    • 21389260 1:CAS:528:DC%2BC3MXntFClu7o%3D
    • Bishayee A, Bhatia D, Thoppil RJ, Darvesh AS, Nevo E, Lansky EP (2011) Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis 32:888-896
    • (2011) Carcinogenesis , vol.32 , pp. 888-896
    • Bishayee, A.1    Bhatia, D.2    Thoppil, R.J.3    Darvesh, A.S.4    Nevo, E.5    Lansky, E.P.6
  • 11
    • 77952270944 scopus 로고    scopus 로고
    • Curcumin protects DNA damage in a chronically arsenic exposed population of West Bengal
    • 20056736 1:CAS:528:DC%2BC3cXosFeiu7w%3D
    • Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy M (2010a) Curcumin protects DNA damage in a chronically arsenic exposed population of West Bengal. Hum Exp Toxicol 29:513-524
    • (2010) Hum Exp Toxicol , vol.29 , pp. 513-524
    • Biswas, J.1    Sinha, D.2    Mukherjee, S.3    Roy, S.4    Siddiqi, M.5    Roy, M.6
  • 12
    • 77955828074 scopus 로고    scopus 로고
    • Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice
    • 20593964
    • Biswas J, Roy S, Mukherjee S, Sinha D, Roy M (2010b) Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pac J Cancer Prev 11:239-247
    • (2010) Asian Pac J Cancer Prev , vol.11 , pp. 239-247
    • Biswas, J.1    Roy, S.2    Mukherjee, S.3    Sinha, D.4    Roy, M.5
  • 13
    • 84873744189 scopus 로고    scopus 로고
    • One century of arsenic exposure in Latin America: A review of history and occurrence from 14 countries
    • [Epub ahead of print]. PMID: 21959248
    • Bundschuh J, Litter MI, Parvez F, Román-Ross G, Nicolli HB, Jean JS, Liu CW, López D, Armienta MA, Guilherme LR, Cuevas AG, Cornejo L, Cumbal L,Toujaguez R (2011) One century of arsenic exposure in Latin America: a review of history and occurrence from 14 countries. Sci Total Environ [Epub ahead of print]. PMID: 21959248
    • (2011) Sci Total Environ
    • Bundschuh J, L.1
  • 16
    • 0026498334 scopus 로고
    • Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water
    • 1419632 1:STN:280:DyaK3s%2FktFSguw%3D%3D
    • Chen CJ, Chen CW, Wu MM, Kuo TL (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br J Cancer 66:888-892
    • (1992) Br J Cancer , vol.66 , pp. 888-892
    • Chen, C.J.1    Chen, C.W.2    Wu, M.M.3    Kuo, T.L.4
  • 17
    • 0037447171 scopus 로고    scopus 로고
    • Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells
    • 12702573 1:CAS:528:DC%2BD3sXivFyns7c%3D
    • Chen GQ, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S (2003) Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Cancer Res 63:1853-1859
    • (2003) Cancer Res , vol.63 , pp. 1853-1859
    • Chen, G.Q.1    Zhou, L.2    Styblo, M.3    Walton, F.4    Jing, Y.5    Weinberg, R.6    Chen, Z.7    Waxman, S.8
  • 18
    • 35448936777 scopus 로고    scopus 로고
    • Inorganic arsenic in drinking water and bladder cancer: A meta-analysis for dose-response assessment
    • 17159272 1:CAS:528:DC%2BD28Xht1OntrfN
    • Chu HA, Crawford-Brown DJ (2006) Inorganic arsenic in drinking water and bladder cancer: a meta-analysis for dose-response assessment. Int J Environ Res Public Health 3:316-322
    • (2006) Int J Environ Res Public Health , vol.3 , pp. 316-322
    • Chu, H.A.1    Crawford-Brown, D.J.2
  • 19
    • 0141752795 scopus 로고    scopus 로고
    • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
    • 14517290 1:CAS:528:DC%2BD3sXotVSrur0%3D
    • Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198-7209
    • (2003) Mol Cell Biol , vol.23 , pp. 7198-7209
    • Cullinan, S.B.1    Zhang, D.2    Hannink, M.3    Arvisais, E.4    Kaufman, R.J.5    Diehl, J.A.6
  • 20
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges-Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
    • 15367669 1:CAS:528:DC%2BD2cXnvVakt7k%3D
    • Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA (2004) The Keap1-BTB protein is an adaptor that bridges-Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 24:8477-8486
    • (2004) Mol Cell Biol , vol.24 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 21
    • 84873737879 scopus 로고    scopus 로고
    • Modulation of the Nrf2 signaling pathway by chemopreventive dietary phytoconstituents
    • S. Shankar R. Srivastava (eds) Springer Science+Business Media B.V New York
    • Darvesh AS, Bishayee A (2012) Modulation of the Nrf2 signaling pathway by chemopreventive dietary phytoconstituents. In: Shankar S, Srivastava R (eds) Nutr, diet and cancer. Springer Science+Business Media B.V, New York, pp 521-540
    • (2012) Nutr, Diet and Cancer , pp. 521-540
    • Darvesh, A.S.1    Bishayee, A.2
  • 23
    • 29644435115 scopus 로고    scopus 로고
    • The role of Keap1 in cellular protective responses
    • 16359168 1:CAS:528:DC%2BD2MXht1WisbvI
    • Dinkova-Kostova AT, Holtzclaw WD, Kensler TW (2005) The role of Keap1 in cellular protective responses. Chem Res Toxicol 18:1779-1791
    • (2005) Chem Res Toxicol , vol.18 , pp. 1779-1791
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Kensler, T.W.3
  • 24
    • 54149084936 scopus 로고    scopus 로고
    • Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
    • 1:CAS:528:DC%2BD1cXhtFOis7bK
    • Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD (2008) Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Persp 116:1154-1161
    • (2008) Environ Health Persp , vol.116 , pp. 1154-1161
    • Du, Y.1    Villeneuve, N.F.2    Wang, X.J.3    Sun, Z.4    Chen, W.5    Li, J.6    Lou, H.7    Wong, P.K.8    Zhang, D.D.9
  • 25
    • 0035750172 scopus 로고    scopus 로고
    • Toxic metals and oxidative stress. Part I. Mechanisms involved in metal-induced oxidative damage
    • 11895129 1:CAS:528:DC%2BD3MXos1ait7s%3D
    • Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress. Part I. Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1:529-539
    • (2001) Curr Top Med Chem , vol.1 , pp. 529-539
    • Ercal, N.1    Gurer-Orhan, H.2    Aykin-Burns, N.3
  • 26
    • 79959363492 scopus 로고    scopus 로고
    • Arsenic-induced oxidative stress and its reversibility
    • 21554949 1:CAS:528:DC%2BC3MXnslKgtrw%3D
    • Flora SJ (2011) Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 51:257-281
    • (2011) Free Radic Biol Med , vol.51 , pp. 257-281
    • Flora, S.J.1
  • 27
    • 84858069261 scopus 로고    scopus 로고
    • Antioxidant activity of food constituents: An overview
    • 22102161
    • Gülçin I (2012) Antioxidant activity of food constituents: an overview. Arch Toxicol 86:345-391
    • (2012) Arch Toxicol , vol.86 , pp. 345-391
    • Gülçin, I.1
  • 30
    • 63549121490 scopus 로고    scopus 로고
    • Nrf2 and Keap1 mutations: Permanent activation of an adaptive response in cancer
    • 19321346 1:CAS:528:DC%2BD1MXksVSkt7k%3D
    • Hayes JD, McMahon M (2009) Nrf2 and Keap1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34:176-188
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 31
    • 77958130983 scopus 로고    scopus 로고
    • Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    • 20446772 1:CAS:528:DC%2BC3cXht12ltL7F
    • Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT (2010) Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid Redox Signal 13:1713-1748
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1713-1748
    • Hayes, J.D.1    McMahon, M.2    Chowdhry, S.3    Dinkova-Kostova, A.T.4
  • 32
    • 73949112805 scopus 로고    scopus 로고
    • Critical cysteine residues of Kelch-Like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2
    • 1:CAS:528:DC%2BC3cXis1yrsQ%3D%3D
    • He X, Ma Q (2010) Critical cysteine residues of Kelch-Like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2. J Pharmacol Exp Therap 332:66-75
    • (2010) J Pharmacol Exp Therap , vol.332 , pp. 66-75
    • He, X.1    Ma, Q.2
  • 33
    • 0035877643 scopus 로고    scopus 로고
    • Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
    • 11274184 1:CAS:528:DC%2BD3MXksFGlsrc%3D
    • He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J (2001) Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276:20858-20865
    • (2001) J Biol Chem , vol.276 , pp. 20858-20865
    • He, C.H.1    Gong, P.2    Hu, B.3    Stewart, D.4    Choi, M.E.5    Choi, A.M.6    Alam, J.7
  • 34
    • 33747643517 scopus 로고    scopus 로고
    • Arsenic induces NAD(P)H-quinone oxidoreductase i by disrupting the Nrf2-Keap1-Cul3 complex and recruiting Nrf2-Maf to the antioxidant response element enhancer
    • 16785233 1:CAS:528:DC%2BD28XotVCmtb0%3D
    • He X, Chen MG, Lin GX, Ma Q (2006) Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2-Keap1-Cul3 complex and recruiting Nrf2-Maf to the antioxidant response element enhancer. J Biol Chem 281:23620-23631
    • (2006) J Biol Chem , vol.281 , pp. 23620-23631
    • He, X.1    Chen, M.G.2    Lin, G.X.3    Ma, Q.4
  • 35
    • 77958114117 scopus 로고    scopus 로고
    • Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: Antioxidant coupled with antiinflammatory
    • 20486765 1:CAS:528:DC%2BC3cXht12ltL7O
    • Hu R, Saw CL-L, Yu R, Kong A-NT (2010) Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory. Antioxid Redox Signal 13:1679-1698
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1679-1698
    • Hu, R.1    Saw, C.-L.2    Yu, R.3    Kong, A.-N.4
  • 36
    • 84873732249 scopus 로고    scopus 로고
    • International Agency for Research on Cancer (IARC) monographs on the evaluation of carcinogenic risks to humans, supplement 7: overall evaluations of carcinogenicity: An updating of IARC monographs volumes 1 to 42 Accessed on 26 June 2011
    • International Agency for Research on Cancer (IARC) monographs on the evaluation of carcinogenic risks to humans, supplement 7: overall evaluations of carcinogenicity: An updating of IARC monographs volumes 1 to 42. http://monographs.iarc.fr/ENG/Monographs/suppl17-19. Accessed on 26 June 2011
  • 37
    • 84873706414 scopus 로고    scopus 로고
    • Integrated Risk Information System (IRIS) Accessed on 27 July 2011
    • Integrated Risk Information System (IRIS). http://www.epa.gov/IRIS/. Accessed on 27 July 2011
  • 39
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • 9887101 1:CAS:528:DyaK1MXnvF2qsg%3D%3D
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 40
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
    • 12653965 1:CAS:528:DC%2BD3sXivFOjuro%3D
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8:379-391
    • (2003) Genes Cells , vol.8 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5    Yamamoto, M.6
  • 41
    • 33744953050 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
    • 16513647 1:CAS:528:DC%2BD28Xjslensbk%3D
    • Jain AK, Jaiswal AK (2006) Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 281:12132-12134
    • (2006) J Biol Chem , vol.281 , pp. 12132-12134
    • Jain, A.K.1    Jaiswal, A.K.2
  • 42
    • 23844475091 scopus 로고    scopus 로고
    • Nuclear import and export signals in control of Nrf2
    • 15901726 1:CAS:528:DC%2BD2MXntVegsLg%3D
    • Jain AK, Bloom DA, Jaiswal AK (2005) Nuclear import and export signals in control of Nrf2. J Biol Chem 280:29158-29168
    • (2005) J Biol Chem , vol.280 , pp. 29158-29168
    • Jain, A.K.1    Bloom, D.A.2    Jaiswal, A.K.3
  • 43
    • 33644649421 scopus 로고    scopus 로고
    • Nrf2: A potential molecular target for cancer chemoprevention by natural compounds
    • 16487042 1:CAS:528:DC%2BD28XhsFOqtrY%3D
    • Jeong W-S, Jun M, Kong AH-NGT (2006) Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 8:99-106
    • (2006) Antioxid Redox Signal , vol.8 , pp. 99-106
    • Jeong, W.-S.1    Jun, M.2    Kong, A.-N.3
  • 44
    • 69749108385 scopus 로고    scopus 로고
    • Nrf2 protects against As(III)-induced damage in mouse liver and bladder
    • 19538980 1:CAS:528:DC%2BD1MXhtV2rtrfI
    • Jiang T, Huang Z, Chan JY, Zhang DD (2009) Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol 240:8-14
    • (2009) Toxicol Appl Pharmacol , vol.240 , pp. 8-14
    • Jiang, T.1    Huang, Z.2    Chan, J.Y.3    Zhang, D.D.4
  • 46
    • 0035034848 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element mediated rGSTA2 induction in H4IIE cells
    • 11306698 1:CAS:528:DC%2BD3MXjt1aqtrs%3D
    • Kang KW, Cho MK, Lee CH, Kim SG (2001) Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element mediated rGSTA2 induction in H4IIE cells. Mol Pharmacol 59:1147-1156
    • (2001) Mol Pharmacol , vol.59 , pp. 1147-1156
    • Kang, K.W.1    Cho, M.K.2    Lee, C.H.3    Kim, S.G.4
  • 48
    • 79953225194 scopus 로고    scopus 로고
    • Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization
    • 21196497 1:CAS:528:DC%2BC3MXisVyqt70%3D
    • Kawai Y, Garduño L, Theodore M, Yang J, Arinze IJ (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286:7629-7640
    • (2011) J Biol Chem , vol.286 , pp. 7629-7640
    • Kawai, Y.1    Garduño, L.2    Theodore, M.3    Yang, J.4    Arinze, I.J.5
  • 49
    • 56249107263 scopus 로고    scopus 로고
    • Dietary cancer chemopreventive agents - Targeting inflammation and Nrf2 signaling pathway
    • 18937168 1:CAS:528:DC%2BD1cXhtl2hsb3N
    • Khor TO, Yu S, Kong AN (2008) Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway. Planta Med 74:1540-1547
    • (2008) Planta Med , vol.74 , pp. 1540-1547
    • Khor, T.O.1    Yu, S.2    Kong, A.N.3
  • 51
    • 33846557949 scopus 로고    scopus 로고
    • Association of arsenic-contaminated drinking-water with prevalence of skin cancer in Wisconsin's Fox River Valley
    • 17195561
    • Knobeloch LM, Zierold KM, Anderson HA (2006) Association of arsenic-contaminated drinking-water with prevalence of skin cancer in Wisconsin's Fox River Valley. J Health Popul Nutr 24:206-213
    • (2006) J Health Popul Nutr , vol.24 , pp. 206-213
    • Knobeloch, L.M.1    Zierold, K.M.2    Anderson, H.A.3
  • 52
    • 0036668466 scopus 로고    scopus 로고
    • Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system
    • 12167159 1:CAS:528:DC%2BD38Xmslyju7Y%3D
    • Kobayashi M, Itoh K, Suzuki T, Osanai H, Nishikawa K, Katoh Y, Takagi Y, Yamamoto M (2002) Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 7:807-820
    • (2002) Genes Cells , vol.7 , pp. 807-820
    • Kobayashi, M.1    Itoh, K.2    Suzuki, T.3    Osanai, H.4    Nishikawa, K.5    Katoh, Y.6    Takagi, Y.7    Yamamoto, M.8
  • 53
    • 33344469643 scopus 로고    scopus 로고
    • Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
    • 16354693 1:CAS:528:DC%2BD28Xjslaqtr8%3D
    • Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M (2006) Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 26:221-229
    • (2006) Mol Cell Biol , vol.26 , pp. 221-229
    • Kobayashi, A.1    Kang, M.I.2    Watai, Y.3    Tong, K.I.4    Shibata, T.5    Uchida, K.6    Yamamoto, M.7
  • 54
    • 0035212419 scopus 로고    scopus 로고
    • Induction of xenobiotic enzymes by the MAPkinase pathway and the antioxidant or electrophile response element (ARE = EpRE)
    • 11768769 1:CAS:528:DC%2BD38XjvVGrug%3D%3D
    • Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R, Mandlekar S (2001) Induction of xenobiotic enzymes by the MAPkinase pathway and the antioxidant or electrophile response element (ARE = EpRE). Drug Metab Rev 33:255-271
    • (2001) Drug Metab Rev , vol.33 , pp. 255-271
    • Kong, A.N.1    Owuor, E.2    Yu, R.3    Hebbar, V.4    Chen, C.5    Hu, R.6    Mandlekar, S.7
  • 55
    • 33847075357 scopus 로고    scopus 로고
    • Arsenic: Signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity
    • 17002598 1:CAS:528:DC%2BD2sXit1alt7o%3D
    • Kumagai Y, Sumi D (2007) Arsenic: signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity. Annu Rev Pharmacol Toxicol 47:243-262
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 243-262
    • Kumagai, Y.1    Sumi, D.2
  • 56
    • 77649270763 scopus 로고    scopus 로고
    • Targeting Nrf2 signaling for cancer chemoprevention
    • 19732782 1:CAS:528:DC%2BC3cXjt1GktLs%3D
    • Kwak MK, Knesler TW (2010) Targeting Nrf2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol 244:66-76
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 66-76
    • Kwak, M.K.1    Knesler, T.W.2
  • 58
    • 19444379739 scopus 로고    scopus 로고
    • Nrf2 as a novel molecular target for chemoprevention
    • 15914268 1:CAS:528:DC%2BD2MXks1Ggsbc%3D
    • Lee JS, Surh YJ (2005) Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 224:171-184
    • (2005) Cancer Lett , vol.224 , pp. 171-184
    • Lee, J.S.1    Surh, Y.J.2
  • 59
    • 0035827505 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase, not extracellular signal-related kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells
    • 11274155 1:CAS:528:DC%2BD3MXktlKnsrg%3D
    • Lee JM, Hanson JM, Chu WA, Johnson JA (2001) Phosphatidylinositol 3-kinase, not extracellular signal-related kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J Biol Chem 276:20011-20016
    • (2001) J Biol Chem , vol.276 , pp. 20011-20016
    • Lee, J.M.1    Hanson, J.M.2    Chu, W.A.3    Johnson, J.A.4
  • 60
    • 59849113546 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2-mediated antioxidant response
    • 18618599 1:CAS:528:DC%2BD1MXitlCls7k%3D
    • Li W, Kong AN (2009) Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog 48:91-104
    • (2009) Mol Carcinog , vol.48 , pp. 91-104
    • Li, W.1    Kong, A.N.2
  • 61
    • 33748752586 scopus 로고    scopus 로고
    • Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
    • 16790425 1:CAS:528:DC%2BD28XptlKmtr0%3D
    • Li W, Yu SW, Kong AN (2006) Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. J Biol Chem 281:27251-27263
    • (2006) J Biol Chem , vol.281 , pp. 27251-27263
    • Li, W.1    Yu, S.W.2    Kong, A.N.3
  • 62
    • 55949120110 scopus 로고    scopus 로고
    • Activation of Nrf2-antioxidant signaling attenuates NFκB- inflammatory response and elicits apoptosis
    • 18694732 1:CAS:528:DC%2BD1cXhtl2qtLfI
    • Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN (2008) Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis. Biochem Pharmacol 76:1485-1489
    • (2008) Biochem Pharmacol , vol.76 , pp. 1485-1489
    • Li, W.1    Khor, T.O.2    Xu, C.3    Shen, G.4    Jeong, W.S.5    Yu, S.6    Kong, A.N.7
  • 63
    • 84879600996 scopus 로고    scopus 로고
    • Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes
    • doi: 10.1002/tox.20731. PMID: 21809430
    • Li B, Li X, Zhu B, Zhang X, Wang Y, Xu Y, Wang H, Hou Y, Zheng Q, Sun G (2011) Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes. Environ Toxicol. doi: 10.1002/tox.20731. PMID: 21809430
    • (2011) Environ Toxicol.
    • Li, B.1    Li, X.2    Zhu, B.3    Zhang, X.4    Wang, Y.5    Xu, Y.6    Wang, H.7    Hou, Y.8    Zheng, Q.9    Sun, G.10
  • 64
    • 3242779441 scopus 로고    scopus 로고
    • Speciation of arsenic in biological samples
    • 15276410 1:CAS:528:DC%2BD2cXmtVaiurg%3D
    • Mandal BK, Ogra Y, Anzai K, Suzuki KT (2004) Speciation of arsenic in biological samples. Toxicol Appl Pharmacol 198:307-318
    • (2004) Toxicol Appl Pharmacol , vol.198 , pp. 307-318
    • Mandal, B.K.1    Ogra, Y.2    Anzai, K.3    Suzuki, K.T.4
  • 67
    • 33644659847 scopus 로고    scopus 로고
    • Induction of endogenous Nrf2/Small Maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells
    • 16487037 1:CAS:528:DC%2BD28XhsFOqtr8%3D
    • Massrieh W, Derjuga A, Blank V (2006) Induction of endogenous Nrf2/Small Maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. Antioxid Redox Signal 8:53-59
    • (2006) Antioxid Redox Signal , vol.8 , pp. 53-59
    • Massrieh, W.1    Derjuga, A.2    Blank, V.3
  • 68
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • 12682069 1:CAS:528:DC%2BD3sXksVems7g%3D
    • McMahon M, Itoh K, Yamamoto M, Hayes JD (2003) Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278:21592-21600
    • (2003) J Biol Chem , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 69
    • 3843104763 scopus 로고    scopus 로고
    • Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
    • 15143058 1:CAS:528:DC%2BD2cXlslOrsbg%3D
    • McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD (2004) Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem 279:31556-31567
    • (2004) J Biol Chem , vol.279 , pp. 31556-31567
    • McMahon, M.1    Thomas, N.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 70
    • 20844459336 scopus 로고    scopus 로고
    • Arsenic: In search of an antidote to a global poison
    • Mead MN (2005) Arsenic: in search of an antidote to a global poison. Env Health Persp 113:A378-A386
    • (2005) Env Health Persp , vol.113
    • Mead, M.N.1
  • 71
    • 77950494559 scopus 로고    scopus 로고
    • Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism
    • 20083128 1:CAS:528:DC%2BC3cXksVehu7s%3D
    • Meng D, Wang X, Chang Q, Hitron A, Zhang Z, Xu M, Chen G, Luo J, Jiang B, Fang J, Shi X (2010) Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Toxicol Appl Pharmacol 244:291-299
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 291-299
    • Meng, D.1    Wang, X.2    Chang, Q.3    Hitron, A.4    Zhang, Z.5    Xu, M.6    Chen, G.7    Luo, J.8    Jiang, B.9    Fang, J.10    Shi, X.11
  • 72
    • 0025095542 scopus 로고
    • Transition-metals as catalysts of autooxidation reactions
    • 2182396 1:CAS:528:DyaK3MXltlSisrk%3D
    • Miller DM, Buettner GR, Aust SD (1990) Transition-metals as catalysts of autooxidation reactions. Free Radic Biol Med 8:95-108
    • (1990) Free Radic Biol Med , vol.8 , pp. 95-108
    • Miller, D.M.1    Buettner, G.R.2    Aust, S.D.3
  • 73
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • 15519281 1:CAS:528:DC%2BD2cXptFKktbk%3D
    • Motohashi H, Yamamoto M (2004) Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549-557
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 74
    • 57449111441 scopus 로고    scopus 로고
    • Regulatory potential for concerted modulation of Nrf2- and NFκB I-mediated gene expression in inflammation and carcinogenesis
    • 19050705 1:CAS:528:DC%2BD1cXhsVOnu7bJ
    • Nair S, Doh ST, Chan JY, Kong AN, Cai L (2008) Regulatory potential for concerted modulation of Nrf2- and NFκB I-mediated gene expression in inflammation and carcinogenesis. Br J Cancer 99:2070-2082
    • (2008) Br J Cancer , vol.99 , pp. 2070-2082
    • Nair, S.1    Doh, S.T.2    Chan, J.Y.3    Kong, A.N.4    Cai, L.5
  • 75
    • 0034685897 scopus 로고    scopus 로고
    • Transcriptional regulation of the antioxidant response element: Activation by Nrf2 and repression by MafK
    • 10747902 1:CAS:528:DC%2BD3cXjsFamsLY%3D
    • Nguyen T, Huang HC, Pickett CB (2000) Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK. J Biol Chem 275:15466-15473
    • (2000) J Biol Chem , vol.275 , pp. 15466-15473
    • Nguyen, T.1    Huang, H.C.2    Pickett, C.B.3
  • 76
    • 0142058235 scopus 로고    scopus 로고
    • Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: Involvement of hydrogen peroxide
    • 14567983 1:CAS:528:DC%2BD3sXotVCitL8%3D
    • Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP (2003) Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Exp Cell Res 290:234-245
    • (2003) Exp Cell Res , vol.290 , pp. 234-245
    • Pi, J.1    Qu, W.2    Reece, J.M.3    Kumagai, Y.4    Waalkes, M.P.5
  • 78
    • 0345276611 scopus 로고    scopus 로고
    • Mechanism of arsenic carcinogenesis: An integrated approach
    • 14643412 1:CAS:528:DC%2BD3sXpt1eruro%3D
    • Rossman TG (2003) Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533:37-65
    • (2003) Mutat Res , vol.533 , pp. 37-65
    • Rossman, T.G.1
  • 79
    • 58149401848 scopus 로고    scopus 로고
    • Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells
    • 1:CAS:528:DC%2BD1MXmtlejtg%3D%3D
    • Roy M, Sinha D, Mukherjee S, Paul S, Bhattacharya RK (2008) Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells. Ind J Exp Biol 46:690-697
    • (2008) Ind J Exp Biol , vol.46 , pp. 690-697
    • Roy, M.1    Sinha, D.2    Mukherjee, S.3    Paul, S.4    Bhattacharya, R.K.5
  • 80
    • 79551551136 scopus 로고    scopus 로고
    • Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India
    • 21332098 1:CAS:528:DC%2BC3MXhtFCisbw%3D
    • Roy M, Sinha D, Mukherjee S, Biswas J (2011) Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev 20:123-131
    • (2011) Eur J Cancer Prev , vol.20 , pp. 123-131
    • Roy, M.1    Sinha, D.2    Mukherjee, S.3    Biswas, J.4
  • 81
    • 33744950387 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
    • 16551619 1:CAS:528:DC%2BD28XkslGqsbY%3D
    • Salazar M, Rojo AI, Velasco D, de Sagarra RM, Cuadrado A (2006) Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 281:14841-14851
    • (2006) J Biol Chem , vol.281 , pp. 14841-14851
    • Salazar, M.1    Rojo, A.I.2    Velasco, D.3    De Sagarra, R.M.4    Cuadrado, A.5
  • 82
    • 2542418930 scopus 로고    scopus 로고
    • Regulation of Nrf2 transactivation domain activity: The differential effect of mitogen- activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein
    • 15020583 1:CAS:528:DC%2BD2cXkt1Gis7w%3D
    • Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, Kong AN (2004) Regulation of Nrf2 transactivation domain activity: the differential effect of mitogen- activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem 279:23052-23060
    • (2004) J Biol Chem , vol.279 , pp. 23052-23060
    • Shen, G.1    Hebbar, V.2    Nair, S.3    Xu, C.4    Li, W.5    Lin, W.6    Keum, Y.S.7    Han, J.8    Gallo, M.A.9    Kong, A.N.10
  • 83
    • 0742289410 scopus 로고    scopus 로고
    • Oxidative mechanism of arsenic toxicity and carcinogenesis
    • 14971647 1:CAS:528:DC%2BD3sXps1Shu78%3D
    • Shi H, Shi X, Liu KJ (2004) Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem 255:67-78
    • (2004) Mol Cell Biochem , vol.255 , pp. 67-78
    • Shi, H.1    Shi, X.2    Liu, K.J.3
  • 84
    • 33644882749 scopus 로고    scopus 로고
    • Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes
    • 16516206 1:CAS:528:DC%2BD28Xis1Whsbg%3D
    • Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y (2006) Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Lett 580:1771-1774
    • (2006) FEBS Lett , vol.580 , pp. 1771-1774
    • Shinkai, Y.1    Sumi, D.2    Fukami, I.3    Ishii, T.4    Kumagai, Y.5
  • 86
    • 83455234831 scopus 로고    scopus 로고
    • Antagonistic role of tea against sodium arsenite-induced oxidative DNA damage and repair inhibition in Swiss albino mice
    • 22181980 1:CAS:528:DC%2BC38Xht12ltLY%3D
    • Sinha D, Roy M (2011) Antagonistic role of tea against sodium arsenite-induced oxidative DNA damage and repair inhibition in Swiss albino mice. J Environ Pathol Toxicol Oncol 30:311-322
    • (2011) J Environ Pathol Toxicol Oncol , vol.30 , pp. 311-322
    • Sinha, D.1    Roy, M.2
  • 88
    • 33645467780 scopus 로고    scopus 로고
    • Modulation of arsenic induced DNA damage by tea as assessed by single cell gel electrophoresis
    • Sinha D, Roy M, Siddiqi M, Bhattacharya RK (2005a) Modulation of arsenic induced DNA damage by tea as assessed by single cell gel electrophoresis. Int J Cancer Prev 2:145-154
    • (2005) Int J Cancer Prev , vol.2 , pp. 145-154
    • Sinha, D.1    Roy, M.2    Siddiqi, M.3    Bhattacharya, R.K.4
  • 89
    • 18944372595 scopus 로고    scopus 로고
    • Amelioration of sodium arsenite-induced clastogenicity by tea extracts in Chinese hamster V79 cells
    • 15831085 1:CAS:528:DC%2BD2MXjslGiurY%3D
    • Sinha D, Bhattacharya RK, Siddiqi M, Roy M (2005b) Amelioration of sodium arsenite-induced clastogenicity by tea extracts in Chinese hamster V79 cells. J Environ Pathol Toxicol Oncol 24:129-140
    • (2005) J Environ Pathol Toxicol Oncol , vol.24 , pp. 129-140
    • Sinha, D.1    Bhattacharya, R.K.2    Siddiqi, M.3    Roy, M.4
  • 90
    • 15044357460 scopus 로고    scopus 로고
    • Arsenic-induced micronuclei formation in mammalian cells and its counteraction by tea
    • 15715508 1:CAS:528:DC%2BD2MXisVensb0%3D
    • Sinha D, Roy M, Siddiqi M, Bhattacharya RK (2005c) Arsenic-induced micronuclei formation in mammalian cells and its counteraction by tea. J Environ Pathol Toxicol Oncol 24:45-56
    • (2005) J Environ Pathol Toxicol Oncol , vol.24 , pp. 45-56
    • Sinha, D.1    Roy, M.2    Siddiqi, M.3    Bhattacharya, R.K.4
  • 91
    • 38049032471 scopus 로고    scopus 로고
    • In vitro mitigation of arsenic toxicity by tea polyphenols in human lymphocytes
    • 18197836 1:CAS:528:DC%2BD2sXhsVGisLbK
    • Sinha D, Dey S, Bhattacharya RK, Roy M (2007) In vitro mitigation of arsenic toxicity by tea polyphenols in human lymphocytes. J Environ Pathol Toxicol Oncol 26:207-220
    • (2007) J Environ Pathol Toxicol Oncol , vol.26 , pp. 207-220
    • Sinha, D.1    Dey, S.2    Bhattacharya, R.K.3    Roy, M.4
  • 92
  • 93
    • 77649179856 scopus 로고    scopus 로고
    • Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice
    • 20096321 1:CAS:528:DC%2BC3cXivFGktLk%3D
    • Sinha D, Roy S, Roy M (2010) Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. Food Chem Toxicol 48:1032-1039
    • (2010) Food Chem Toxicol , vol.48 , pp. 1032-1039
    • Sinha, D.1    Roy, S.2    Roy, M.3
  • 94
    • 79954424076 scopus 로고    scopus 로고
    • Nrf2: Control of sensitivity to carcinogens
    • 21369766 1:CAS:528:DC%2BC3MXis1yhsbc%3D
    • Slocum SL, Kensler TW (2011) Nrf2: control of sensitivity to carcinogens. Arch Toxicol 85:273-284
    • (2011) Arch Toxicol , vol.85 , pp. 273-284
    • Slocum, S.L.1    Kensler, T.W.2
  • 96
    • 66349129338 scopus 로고    scopus 로고
    • Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
    • 19273602 1:CAS:528:DC%2BD1MXlvFWjsr4%3D
    • Sun Z, Chin YE, Zhang DD (2009) Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol 29:2658-2672
    • (2009) Mol Cell Biol , vol.29 , pp. 2658-2672
    • Sun, Z.1    Chin, Y.E.2    Zhang, D.D.3
  • 97
    • 80052366402 scopus 로고    scopus 로고
    • Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response
    • 21820459 1:CAS:528:DC%2BC3MXhtV2itrvP
    • Sun Y, Kojima C, Chignell C, Mason R, Waalkes MP (2011) Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. Toxicol Appl Pharmacol 255:242-250
    • (2011) Toxicol Appl Pharmacol , vol.255 , pp. 242-250
    • Sun, Y.1    Kojima, C.2    Chignell, C.3    Mason, R.4    Waalkes, M.P.5
  • 98
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • 14570043 1:CAS:528:DC%2BD3sXotFChsLw%3D
    • Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 99
    • 46049085866 scopus 로고    scopus 로고
    • NF-κB and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities
    • 18296353 1:CAS:528:DC%2BD1cXmtFymsL0%3D
    • Surh YJ (2008) NF-κB and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pac J Clin Nutr 17:269-272
    • (2008) Asia Pac J Clin Nutr , vol.17 , pp. 269-272
    • Surh, Y.J.1
  • 100
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • 18937164 1:CAS:528:DC%2BD1cXhtl2hsb3M
    • Surh YJ, Kundu JK, Na HK (2008) Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74:1526-1539
    • (2008) Planta Med , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 101
    • 0242468787 scopus 로고    scopus 로고
    • Carcinogenic and systemic health effects associated with arsenic exposure - A critical review
    • 14585726 1:CAS:528:DC%2BD3sXosVGhu7Y%3D
    • Tchounwou PB, Patlolla AK, Centeno JA (2003) Carcinogenic and systemic health effects associated with arsenic exposure - a critical review. Toxicol Pathol 31:575-588
    • (2003) Toxicol Pathol , vol.31 , pp. 575-588
    • Tchounwou, P.B.1    Patlolla, A.K.2    Centeno, J.A.3
  • 102
    • 84864745796 scopus 로고    scopus 로고
    • Black currant anthocyanins abrogate oxidative stress through Nrf2-mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma
    • [Epub ahead of print]. PMID: 22873220
    • Thoppil RJ, Bhatia D, Barnes KF, Háznagy-Radnai E, Hohmann J, Darvesh AS, Bishayee A (2012) Black currant anthocyanins abrogate oxidative stress through Nrf2-mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Curr Cancer Drug Targets [Epub ahead of print]. PMID: 22873220
    • (2012) Curr Cancer Drug Targets
    • Thoppil Rj, B.1
  • 103
    • 33344463325 scopus 로고    scopus 로고
    • Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
    • 16581765 1:CAS:528:DC%2BD28Xjs1Slsbw%3D
    • Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol 26:2887-2900
    • (2006) Mol Cell Biol , vol.26 , pp. 2887-2900
    • Tong, K.I.1    Katoh, Y.2    Kusunoki, H.3    Itoh, K.4    Tanaka, T.5    Yamamoto, M.6
  • 104
    • 38449092368 scopus 로고    scopus 로고
    • Health effects of early life exposure to arsenic
    • 18226075 1:CAS:528:DC%2BD1cXhvF2gsbs%3D
    • Vahter M (2008) Health effects of early life exposure to arsenic. Basic Clin Pharmacol Toxicol 102:204-211
    • (2008) Basic Clin Pharmacol Toxicol , vol.102 , pp. 204-211
    • Vahter, M.1
  • 106
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinine oxidoreductase 1 gene
    • 8962164 1:CAS:528:DyaK28XnsVOrsLY%3D
    • Venugopal R, Jaiswal AK (1996) Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinine oxidoreductase 1 gene. Proc Natl Acad Sci USA 93:14960-14965
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 107
    • 0032542213 scopus 로고    scopus 로고
    • Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
    • 9872330 1:CAS:528:DyaK1MXlsFajtQ%3D%3D
    • Venugopal R, Jaiswal AK (1998) Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene 17:3145-3156
    • (1998) Oncogene , vol.17 , pp. 3145-3156
    • Venugopal, R.1    Jaiswal, A.K.2
  • 108
    • 1242296811 scopus 로고    scopus 로고
    • Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
    • 14764894 1:CAS:528:DC%2BD2cXhs1Sku7k%3D
    • Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P (2004) Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci 101:2040-2045
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 2040-2045
    • Wakabayashi, N.1    Dinkova-Kostova, A.T.2    Holtzclaw, W.D.3    Kang, M.I.4    Kobayashi, A.5    Yamamoto, M.6    Kensler, T.W.7    Talalay, P.8
  • 110
    • 36049010730 scopus 로고    scopus 로고
    • Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity
    • 17765279 1:CAS:528:DC%2BD2sXhtlals73L
    • Wang XJ, Sun Z, Chen W, Eblin KE, Gandolfi JA, Zhang DD (2007) Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225:206-213
    • (2007) Toxicol Appl Pharmacol , vol.225 , pp. 206-213
    • Wang, X.J.1    Sun, Z.2    Chen, W.3    Eblin, K.E.4    Gandolfi, J.A.5    Zhang, D.D.6
  • 111
    • 46749152185 scopus 로고    scopus 로고
    • Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: Enhanced Keap1-Cul3 interaction
    • 18417180 1:CAS:528:DC%2BD1cXosVOjsLo%3D
    • Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD (2008) Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol 230:383-389
    • (2008) Toxicol Appl Pharmacol , vol.230 , pp. 383-389
    • Wang, X.J.1    Sun, Z.2    Chen, W.3    Li, Y.4    Villeneuve, N.F.5    Zhang, D.D.6
  • 112
    • 84866030482 scopus 로고    scopus 로고
    • Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: Roles of ROS, NF-κB, and MAPK pathways
    • 22488045 1:CAS:528:DC%2BC38Xlt1ymsb8%3D
    • Wang L, Kou MC, Weng CY, Hu LW, Wang YJ, Wu MJ (2012) Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways. Arch Toxicol 86:879-896
    • (2012) Arch Toxicol , vol.86 , pp. 879-896
    • Wang, L.1    Kou, M.C.2    Weng, C.Y.3    Hu, L.W.4    Wang, Y.J.5    Wu, M.J.6
  • 113
    • 77952827500 scopus 로고    scopus 로고
    • The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells
    • 20657484 1:CAS:528:DC%2BC3cXmt1OktLk%3D
    • Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD (2010) The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules 15:3338-3355
    • (2010) Molecules , vol.15 , pp. 3338-3355
    • Wondrak, G.T.1    Villeneuve, N.F.2    Lamore, S.D.3    Bause, A.S.4    Jiang, T.5    Zhang, D.D.6
  • 115
    • 0025274032 scopus 로고
    • Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical
    • 2158319 1:CAS:528:DyaK3cXktVWrtrs%3D
    • Yamanaka K, Hoshino M, Okamoto M, Sawamura R, Hasegawa A, Okada S (1990) Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical. Biochem Biophys Res Commun 168:58-64
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 58-64
    • Yamanaka, K.1    Hoshino, M.2    Okamoto, M.3    Sawamura, R.4    Hasegawa, A.5    Okada, S.6
  • 116
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • 14585973 1:CAS:528:DC%2BD3sXovVKjtr4%3D
    • Zhang DD, Hannink M (2003) Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:8137-8151
    • (2003) Mol Cell Biol , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 117
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • 15572695 1:CAS:528:DC%2BD2cXhtFSgsr%2FL
    • Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M (2004) Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-10953
    • (2004) Mol Cell Biol , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 118
    • 84857139744 scopus 로고    scopus 로고
    • Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo
    • 22155346 1:CAS:528:DC%2BC38XjtVygsLk%3D
    • Zhang X, Su Y, Zhang M, Sun Z (2012) Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo. Cancer Lett 318:93-98
    • (2012) Cancer Lett , vol.318 , pp. 93-98
    • Zhang, X.1    Su, Y.2    Zhang, M.3    Sun, Z.4
  • 119
    • 77957240142 scopus 로고    scopus 로고
    • Nrf2-ARE signaling pathway and natural products for cancer chemoprevention
    • 20638930 1:CAS:528:DC%2BC3cXht1ertLbN
    • Zhao CR, Gao ZH, Qu XJ (2010) Nrf2-ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol 34:523-533
    • (2010) Cancer Epidemiol , vol.34 , pp. 523-533
    • Zhao, C.R.1    Gao, Z.H.2    Qu, X.J.3
  • 120
    • 84859395513 scopus 로고    scopus 로고
    • Cross-Regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    • 22476201 1:CAS:528:DC%2BC38XmslCmtLs%3D
    • Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J (2012) Cross-Regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ Health Perspect 120:583-589
    • (2012) Environ Health Perspect , vol.120 , pp. 583-589
    • Zhao, R.1    Hou, Y.2    Zhang, Q.3    Woods, C.G.4    Xue, P.5    Fu, J.6    Yarborough, K.7    Guan, D.8    Andersen, M.E.9    Pi, J.10


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