메뉴 건너뛰기




Volumn 7, Issue 11, 2008, Pages 3470-3479

Dithiolethiones for cancer chemoprevention: Where do we stand?

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DITHIOLE 2 THIONE; 3H 1,2 DITHIOLE 3 ONE; 3H 1,2 DITHIOLE 3 THIONE; 4 CHLORO 5 METHYL 3H 1,2 DITHIOLE 3 THIONE; 4 ETHYL 3H 1,2 DITHIOLE 3 THIONE; 4 METHYL 5 (2 PYRAZINYL) 3H 1,2 DITHIOLE 3 ONE; 4 METHYL 5 PYRAZINYL 3H 1,2 DITHIOLE 3 ONE; 4 METHYL 5 PYRAZINYL 3H 1,2 DITHIOLE 3 THIONE; 4 PHENYL 3H 1,2 DITHIOLE 3 THIONE; 4,5 DIMETHYL 3H 1,2 DITHIOLE 3 THIONE; 4,5,6,7 TETRAHYDROBENZO[C] 1,2 DITHIOLE 3 THIONE; 5 (4 HYDROXYPHENYL) 3H 1,2 DITHIOLE 3 THIONE; 5 (4 METHOXYPHENYL) 3H 1,2 DITHIOLE 3 THIONE; 5 ETHYL 3H 1,2 DITHIOLE 3 THIONE; 5 METHYL 3H 1,2 DITHIOLE 3 THIONE; 5 PHENYL 3H 1,2 DITHIOLE 3 THIONE; 5 TERT BUTYL 3H 1,2 DITHIOLE 3 THIONE; 5,4 METHYL 3H 1,2 DITHIOLE 3 THIONE; 5,6 DIHYDROCYCLOPENTA[C] 1,2 DITHIOLE 3 (4H)THIONE; 7 METHYL 6,8 BIS(METHYLTHIO)H PYRROLO[1,2]PYRAZINE; DITHIOL DERIVATIVE; DRUG METABOLITE; ENZYME; OLTIPRAZ; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 56249128623     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0625     Document Type: Review
Times cited : (104)

References (96)
  • 1
    • 56249085382 scopus 로고    scopus 로고
    • Barbaglia GA. Ueber den Sulfovaleraldehyd. Ber Dtsch Chem Ges 1884;17:2654-5.
    • Barbaglia GA. Ueber den Sulfovaleraldehyd. Ber Dtsch Chem Ges 1884;17:2654-5.
  • 3
    • 0039151214 scopus 로고
    • The chemistry of the 1,2-dithiole ring
    • Kharasch H, Meyers CY, editors, Pergamon Press;
    • Lozac'h N, Vialle J. The chemistry of the 1,2-dithiole ring. In: Kharasch H, Meyers CY, editors. The chemistry of organic sulfur compounds (volume 2). Pergamon Press; 1966. p. 257-85.
    • (1966) The chemistry of organic sulfur compounds , vol.2 , pp. 257-285
    • Lozac'h, N.1    Vialle, J.2
  • 5
    • 0021082001 scopus 로고
    • Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity
    • Ansher SS, Dolan P, Bueding E. Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity. Hepatology 1983;3:932-5.
    • (1983) Hepatology , vol.3 , pp. 932-935
    • Ansher, S.S.1    Dolan, P.2    Bueding, E.3
  • 8
    • 0022763396 scopus 로고
    • Inhibitory effects of 5-(2-pyrazinyl)-4-methyl- 1,2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
    • Wattenberg LW, Bueding E. Inhibitory effects of 5-(2-pyrazinyl)-4-methyl- 1,2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard. Carcinogenesis 1986;7:1379-81.
    • (1986) Carcinogenesis , vol.7 , pp. 1379-1381
    • Wattenberg, L.W.1    Bueding, E.2
  • 10
    • 0028658301 scopus 로고
    • Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI Chemoprevention Drug Development Program
    • Steele VE, Moon RC, Lubet RA, et al. Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: methods and results from the NCI Chemoprevention Drug Development Program. J Cell Biochem Suppl 1994;20:32-54.
    • (1994) J Cell Biochem Suppl , vol.20 , pp. 32-54
    • Steele, V.E.1    Moon, R.C.2    Lubet, R.A.3
  • 11
    • 0035866819 scopus 로고    scopus 로고
    • Modulation of biomarkers by chemopreventive agents in smoke-exposed rats
    • Izzotti A, Balansky RM, D'Agostini F, et al. Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer Res 2001;61:2472-9.
    • (2001) Cancer Res , vol.61 , pp. 2472-2479
    • Izzotti, A.1    Balansky, R.M.2    D'Agostini, F.3
  • 13
    • 0027156962 scopus 로고
    • Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats
    • Rao CV, Rivenson A, Katiwalla M, Kelloff GJ, Reddy BS. Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats. Cancer Res 1993;53:2502-6.
    • (1993) Cancer Res , vol.53 , pp. 2502-2506
    • Rao, C.V.1    Rivenson, A.2    Katiwalla, M.3    Kelloff, G.J.4    Reddy, B.S.5
  • 14
    • 0036152493 scopus 로고    scopus 로고
    • The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth
    • Ruggeri BA, Robinson C, Angeles T, Wilkinson JT, Clapper ML. The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. Clin Cancer Res 2002;8:267-74.
    • (2002) Clin Cancer Res , vol.8 , pp. 267-274
    • Ruggeri, B.A.1    Robinson, C.2    Angeles, T.3    Wilkinson, J.T.4    Clapper, M.L.5
  • 15
    • 26844474369 scopus 로고    scopus 로고
    • Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent
    • Crowell JA, Page JG, Rodman LE, et al. Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent. Fundam Appl Toxicol 1997;35:9-21.
    • (1997) Fundam Appl Toxicol , vol.35 , pp. 9-21
    • Crowell, J.A.1    Page, J.G.2    Rodman, L.E.3
  • 16
    • 0024810730 scopus 로고
    • Toxicity of thiols and disulphides: Involvement of free-radical species
    • Munday R. Toxicity of thiols and disulphides: involvement of free-radical species. Free Radic Biol Med 1989;7:659-73.
    • (1989) Free Radic Biol Med , vol.7 , pp. 659-673
    • Munday, R.1
  • 17
    • 0022978104 scopus 로고
    • Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice
    • Stohs SJ, Lawson TA, Anderson L, Bueding E. Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice. Mech Ageing Dev 1986;37:137-45.
    • (1986) Mech Ageing Dev , vol.37 , pp. 137-145
    • Stohs, S.J.1    Lawson, T.A.2    Anderson, L.3    Bueding, E.4
  • 18
    • 0023122773 scopus 로고
    • Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice
    • Davies MH, Blacker AM, Schnell RC. Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice. Biochem Pharmacol 1987;36:568-70.
    • (1987) Biochem Pharmacol , vol.36 , pp. 568-570
    • Davies, M.H.1    Blacker, A.M.2    Schnell, R.C.3
  • 19
    • 9544250360 scopus 로고    scopus 로고
    • Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz
    • O'Dwyer PJ, Szarka CE, Yao KS, et al. Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. J Clin Invest 1996;98:1210-7.
    • (1996) J Clin Invest , vol.98 , pp. 1210-1217
    • O'Dwyer, P.J.1    Szarka, C.E.2    Yao, K.S.3
  • 20
    • 17144467847 scopus 로고    scopus 로고
    • Chronic dosing of oltipraz in people at increased risk for colorectal cancer
    • Szarka CE, Yao KS, Pfeiffer GR, et al. Chronic dosing of oltipraz in people at increased risk for colorectal cancer. Cancer Detect Prev 2001;25:352-61.
    • (2001) Cancer Detect Prev , vol.25 , pp. 352-361
    • Szarka, C.E.1    Yao, K.S.2    Pfeiffer, G.R.3
  • 21
    • 16944362010 scopus 로고    scopus 로고
    • Oltipraz chemoprevention trial in Qidong, People's Republic of China: Study design and clinical outcomes
    • Jacobson LP, Zhang BC, Zhu YR, et al. Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes. Cancer Epidemiol Biomarkers Prev 1997;6:257-65.
    • (1997) Cancer Epidemiol Biomarkers Prev , vol.6 , pp. 257-265
    • Jacobson, L.P.1    Zhang, B.C.2    Zhu, Y.R.3
  • 22
    • 0021894612 scopus 로고
    • The chemotherapy of schistosomiasis
    • Archer S. The chemotherapy of schistosomiasis. Annu Rev Pharmacol Toxicol 1985;25:485-508.
    • (1985) Annu Rev Pharmacol Toxicol , vol.25 , pp. 485-508
    • Archer, S.1
  • 23
    • 0033577057 scopus 로고    scopus 로고
    • 1 by oltipraz in residents of Qidong, People's Republic of China
    • 1 by oltipraz in residents of Qidong, People's Republic of China. J Natl Cancer Inst 1999;91:347-54.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 347-354
    • Wang, J.S.1    Shen, X.2    He, X.3
  • 25
    • 0028856209 scopus 로고
    • Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz
    • Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol 1995;135:45-57.
    • (1995) Toxicol Appl Pharmacol , vol.135 , pp. 45-57
    • Buetler, T.M.1    Gallagher, E.P.2    Wang, C.3    Stahl, D.L.4    Hayes, J.D.5    Eaton, D.L.6
  • 26
    • 0023204238 scopus 로고
    • Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4- methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones
    • Kensler TW, Egner PA, Dolan PM, Groopman JD, Roebuck BD. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4- methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res 1987;47:4271-7.
    • (1987) Cancer Res , vol.47 , pp. 4271-4277
    • Kensler, T.W.1    Egner, P.A.2    Dolan, P.M.3    Groopman, J.D.4    Roebuck, B.D.5
  • 27
    • 4644328941 scopus 로고    scopus 로고
    • Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
    • Iida K, Itoh K, Kumagai Y, et al. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 2004;64:6424-31.
    • (2004) Cancer Res , vol.64 , pp. 6424-6431
    • Iida, K.1    Itoh, K.2    Kumagai, Y.3
  • 28
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    • Ramos-Gomez M, Kwak MK, Dolan PM, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A 2001;98:3410-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.K.2    Dolan, P.M.3
  • 29
    • 0037356451 scopus 로고    scopus 로고
    • Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
    • Ramos-Gomez M, Dolan PM, Itoh K, Yamamoto M, Kensler TW. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 2003;24:461-7.
    • (2003) Carcinogenesis , vol.24 , pp. 461-467
    • Ramos-Gomez, M.1    Dolan, P.M.2    Itoh, K.3    Yamamoto, M.4    Kensler, T.W.5
  • 30
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 2003;278:8135-45.
    • (2003) J Biol Chem , vol.278 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 34
    • 36949019757 scopus 로고    scopus 로고
    • Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: Implications for dithiolethione chemoprotection
    • Jia Z, Zhu H, Trush MA, Misra HP, Li Y. Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotection. Mol Cell Biochem 2008;307:185-91.
    • (2008) Mol Cell Biochem , vol.307 , pp. 185-191
    • Jia, Z.1    Zhu, H.2    Trush, M.A.3    Misra, H.P.4    Li, Y.5
  • 35
    • 0033731182 scopus 로고    scopus 로고
    • Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
    • Huang HC, Nguyen T, Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A 2000;97:12475-80.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12475-12480
    • Huang, H.C.1    Nguyen, T.2    Pickett, C.B.3
  • 36
    • 0026319263 scopus 로고
    • Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin
    • Jaiswal AK. Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. Biochemistry 1991;30:10647-53.
    • (1991) Biochemistry , vol.30 , pp. 10647-10653
    • Jaiswal, A.K.1
  • 37
    • 0038683154 scopus 로고    scopus 로고
    • Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: A target for chemoprevention
    • Yao KS, O'Dwyer PJ. Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention. Biochem Pharmacol 2003;66:15-23.
    • (2003) Biochem Pharmacol , vol.66 , pp. 15-23
    • Yao, K.S.1    O'Dwyer, P.J.2
  • 38
    • 0037219987 scopus 로고    scopus 로고
    • Mechanism of rat UDP- glucuronosyltransferase 1A6 induction by oltipraz: Evidence for a contribution of the aryl hydrocarbon receptor pathway
    • Auyeung DJ, Kessler FK, Ritter JK. Mechanism of rat UDP- glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the aryl hydrocarbon receptor pathway. Mol Pharmacol 2003;63:119-27.
    • (2003) Mol Pharmacol , vol.63 , pp. 119-127
    • Auyeung, D.J.1    Kessler, F.K.2    Ritter, J.K.3
  • 39
    • 0034014663 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane
    • Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chem Res Toxicol 2000;13:245-52.
    • (2000) Chem Res Toxicol , vol.13 , pp. 245-252
    • Langouët, S.1    Furge, L.L.2    Kerriguy, N.3    Nakamura, K.4    Guillouzo, A.5    Guengerich, F.P.6
  • 40
    • 0028865229 scopus 로고
    • 1 metabolism in human hepatocytes in primary culture
    • 1 metabolism in human hepatocytes in primary culture. Cancer Res 1995;55:5574-9.
    • (1995) Cancer Res , vol.55 , pp. 5574-5579
    • Langouët, S.1    Coles, B.2    Morel, F.3
  • 41
    • 0031426029 scopus 로고    scopus 로고
    • Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture
    • Langouët S, Mahéo K, Berthou F, et al. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis 1997;18:1343-9.
    • (1997) Carcinogenesis , vol.18 , pp. 1343-1349
    • Langouët, S.1    Mahéo, K.2    Berthou, F.3
  • 42
    • 0035135934 scopus 로고    scopus 로고
    • Differential effects of oltipraz on CYP1A and CYP2B in rat lung
    • Le Ferrec E, Ilyin G, Mahéo K, et al. Differential effects of oltipraz on CYP1A and CYP2B in rat lung. Carcinogenesis 2001;22:49-55.
    • (2001) Carcinogenesis , vol.22 , pp. 49-55
    • Le Ferrec, E.1    Ilyin, G.2    Mahéo, K.3
  • 46
    • 0037025336 scopus 로고    scopus 로고
    • Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent
    • Le Ferrec E, Lagadic-Gossmann D, Rauch C, et al. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. J Biol Chem 2002;277:24780-7.
    • (2002) J Biol Chem , vol.277 , pp. 24780-24787
    • Le Ferrec, E.1    Lagadic-Gossmann, D.2    Rauch, C.3
  • 47
    • 0041341933 scopus 로고    scopus 로고
    • Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element
    • Miao W, Hu L, Kandouz M, Batist G. Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element. Mol Pharmacol 2003;64:346-54.
    • (2003) Mol Pharmacol , vol.64 , pp. 346-354
    • Miao, W.1    Hu, L.2    Kandouz, M.3    Batist, G.4
  • 48
    • 0026501721 scopus 로고
    • Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione
    • Kensler TW, Groopman JD, Eaton DL, Curphey TJ, Roebuck BD. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione. Carcinogenesis 1992;13:95-100.
    • (1992) Carcinogenesis , vol.13 , pp. 95-100
    • Kensler, T.W.1    Groopman, J.D.2    Eaton, D.L.3    Curphey, T.J.4    Roebuck, B.D.5
  • 49
    • 0022289870 scopus 로고
    • 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes
    • 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes. Arzneimittelforschung 1985;35:1431-6.
    • (1985) Arzneimittelforschung , vol.35 , pp. 1431-1436
    • Heusse, D.1    Marlard, M.2    Bredenbac, J.3
  • 50
    • 0034489194 scopus 로고    scopus 로고
    • Pharmacokinetics of the chemopreventive agent oltipraz and of its metabolite M3 in human subjects after a single oral dose
    • O'Dwyer PJ, Szarka C, Brennan JM, Laub PB, Gallo JM. Pharmacokinetics of the chemopreventive agent oltipraz and of its metabolite M3 in human subjects after a single oral dose. Clin Cancer Res 2000;6:4692-6.
    • (2000) Clin Cancer Res , vol.6 , pp. 4692-4696
    • O'Dwyer, P.J.1    Szarka, C.2    Brennan, J.M.3    Laub, P.B.4    Gallo, J.M.5
  • 51
    • 0028178821 scopus 로고
    • Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
    • Egner PA, Kensler TW, Prestera T, et al. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis 1994;15:177-81.
    • (1994) Carcinogenesis , vol.15 , pp. 177-181
    • Egner, P.A.1    Kensler, T.W.2    Prestera, T.3
  • 52
    • 0022739951 scopus 로고
    • 1,2-Dithiol-3-thione analogs: Effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells
    • De Long MJ, Dolan P, Santamaria AB, Bueding E. 1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells. Carcinogenesis 1986;7:977-80.
    • (1986) Carcinogenesis , vol.7 , pp. 977-980
    • De Long, M.J.1    Dolan, P.2    Santamaria, A.B.3    Bueding, E.4
  • 53
    • 0030922023 scopus 로고    scopus 로고
    • Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells
    • O'Dwyer PJ, Clayton M, Halbherr T, Myers CB, Yao K. Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells. Clin Cancer Res 1997;3:783-91.
    • (1997) Clin Cancer Res , vol.3 , pp. 783-791
    • O'Dwyer, P.J.1    Clayton, M.2    Halbherr, T.3    Myers, C.B.4    Yao, K.5
  • 54
    • 33746089578 scopus 로고    scopus 로고
    • Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction
    • Ko MS, Lee SJ, Kim JW, Lim JW, Kim SG. Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction. Drug Metab Dispos 2006;34:1353-60.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1353-1360
    • Ko, M.S.1    Lee, S.J.2    Kim, J.W.3    Lim, J.W.4    Kim, S.G.5
  • 55
    • 0020590683 scopus 로고
    • Comparison of the metabolism of oltipraz in the mouse, rat and monkey and in man. Distribution of the metabolites in each species
    • Bieder A, Decouvelaere B, Gaillard C, et al. Comparison of the metabolism of oltipraz in the mouse, rat and monkey and in man. Distribution of the metabolites in each species. Arzneimittelforschung 1983;33:1289-97.
    • (1983) Arzneimittelforschung , vol.33 , pp. 1289-1297
    • Bieder, A.1    Decouvelaere, B.2    Gaillard, C.3
  • 56
    • 34548158239 scopus 로고    scopus 로고
    • Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: A novel pathway for cancer chemoprevention
    • Velayutham M, Muthukumaran RB, Sostaric JZ, McCraken J, Fishbein JC, Zweier JL. Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention. Free Radic Biol Med 2007;43:1076-85.
    • (2007) Free Radic Biol Med , vol.43 , pp. 1076-1085
    • Velayutham, M.1    Muthukumaran, R.B.2    Sostaric, J.Z.3    McCraken, J.4    Fishbein, J.C.5    Zweier, J.L.6
  • 58
    • 0030200740 scopus 로고    scopus 로고
    • Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity
    • Bouthillier L, Charbonneau M, Brodeur J. Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity. Toxicol Appl Pharmacol 1996;139:177-85.
    • (1996) Toxicol Appl Pharmacol , vol.139 , pp. 177-185
    • Bouthillier, L.1    Charbonneau, M.2    Brodeur, J.3
  • 59
    • 0030745630 scopus 로고    scopus 로고
    • Chemopreventive efficacy of anethole trithione, N-acetyl-L- cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model
    • Lubet RA, Steele VE, Eto I, Juliana MM, Kelloff GJ, Grubbs CJ. Chemopreventive efficacy of anethole trithione, N-acetyl-L- cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model. Int J Cancer 1997;72:95-101.
    • (1997) Int J Cancer , vol.72 , pp. 95-101
    • Lubet, R.A.1    Steele, V.E.2    Eto, I.3    Juliana, M.M.4    Kelloff, G.J.5    Grubbs, C.J.6
  • 60
    • 0027290648 scopus 로고
    • Chemoprevention of colon carcinogenesis by organosulfur compounds
    • Reddy BS, Rao CV, Rivenson A, Kelloff G. Chemoprevention of colon carcinogenesis by organosulfur compounds. Cancer Res 1993;53:3493-8.
    • (1993) Cancer Res , vol.53 , pp. 3493-3498
    • Reddy, B.S.1    Rao, C.V.2    Rivenson, A.3    Kelloff, G.4
  • 61
    • 0031751308 scopus 로고    scopus 로고
    • Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells
    • Khanna S, Sen CK, Roy S, Christen MO, Packer L. Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells. Biochem Pharmacol 1998;56:61-9.
    • (1998) Biochem Pharmacol , vol.56 , pp. 61-69
    • Khanna, S.1    Sen, C.K.2    Roy, S.3    Christen, M.O.4    Packer, L.5
  • 62
    • 0029185523 scopus 로고
    • Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione
    • Christen MO, Fackir L, Jore D. Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. Methods Enzymol 1995;252:324-31.
    • (1995) Methods Enzymol , vol.252 , pp. 324-331
    • Christen, M.O.1    Fackir, L.2    Jore, D.3
  • 63
    • 0022532783 scopus 로고
    • A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione
    • Mansuy D, Sassi A, Dansette PM, Plat M. A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione. Biochem Biophys Res Commun 1986;135:1015-21.
    • (1986) Biochem Biophys Res Commun , vol.135 , pp. 1015-1021
    • Mansuy, D.1    Sassi, A.2    Dansette, P.M.3    Plat, M.4
  • 64
    • 0037014797 scopus 로고    scopus 로고
    • A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia
    • Lam S, MacAulay C, le Riche JC, et al. A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. J Natl Cancer Inst 2002;94:1001-9.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1001-1009
    • Lam, S.1    MacAulay, C.2    le Riche, J.C.3
  • 65
    • 84985853280 scopus 로고
    • 14C-trithioparamethoxyphenylpropene in mice
    • 14C-trithioparamethoxyphenylpropene in mice. Scand J Dent Res 1985;93:249-52.
    • (1985) Scand J Dent Res , vol.93 , pp. 249-252
    • Isacsson, G.1    Singer, P.2
  • 66
    • 0020559822 scopus 로고
    • Identification and quantitation of a metabolite of anethol dithiolthione in rat and mouse urine using high-performance liquid chromatography
    • Masoud AN, Bueding E. Identification and quantitation of a metabolite of anethol dithiolthione in rat and mouse urine using high-performance liquid chromatography. J Chromatogr 1983;276:111-9.
    • (1983) J Chromatogr , vol.276 , pp. 111-119
    • Masoud, A.N.1    Bueding, E.2
  • 68
    • 0023930873 scopus 로고
    • Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
    • Prochaska HJ, Santamaria AB. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem 1988;169:328-36.
    • (1988) Anal Biochem , vol.169 , pp. 328-336
    • Prochaska, H.J.1    Santamaria, A.B.2
  • 70
    • 0031888590 scopus 로고    scopus 로고
    • Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents
    • Doherty GP, Leith MK, Wang X, Curphey TJ, Begleiter A. Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents. Br J Cancer 1998;77:1241-52.
    • (1998) Br J Cancer , vol.77 , pp. 1241-1252
    • Doherty, G.P.1    Leith, M.K.2    Wang, X.3    Curphey, T.J.4    Begleiter, A.5
  • 71
    • 0035871961 scopus 로고    scopus 로고
    • Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines
    • Begleiter A, Leith MK, Doherty GP, Digbya TJ, Pan S. Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines. Biochem Pharmacol 2001;61:955-64.
    • (2001) Biochem Pharmacol , vol.61 , pp. 955-964
    • Begleiter, A.1    Leith, M.K.2    Doherty, G.P.3    Digbya, T.J.4    Pan, S.5
  • 72
    • 33644770021 scopus 로고    scopus 로고
    • Structure-activity relationships in the induction of phase II enzymes by derivatives of 3H-1,2-dithiole-3- thione in rats
    • Munday R, Zhang Y, Munday CM, Li J. Structure-activity relationships in the induction of phase II enzymes by derivatives of 3H-1,2-dithiole-3- thione in rats. Chem Biol Interact 2006;160:115-22.
    • (2006) Chem Biol Interact , vol.160 , pp. 115-122
    • Munday, R.1    Zhang, Y.2    Munday, C.M.3    Li, J.4
  • 73
    • 0031684074 scopus 로고    scopus 로고
    • Identification of dithiolethiones with better chemopreventive properties than oltipraz
    • Maxuitenko YY, Libby AH, Joyner HH, et al. Identification of dithiolethiones with better chemopreventive properties than oltipraz. Carcinogenesis 1998;19:1609-15.
    • (1998) Carcinogenesis , vol.19 , pp. 1609-1615
    • Maxuitenko, Y.Y.1    Libby, A.H.2    Joyner, H.H.3
  • 74
    • 4544287555 scopus 로고    scopus 로고
    • Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: Dose-response study in rats
    • Munday R, Munday CM. Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: dose-response study in rats. Carcinogenesis 2004;25:1721-5.
    • (2004) Carcinogenesis , vol.25 , pp. 1721-1725
    • Munday, R.1    Munday, C.M.2
  • 75
    • 0346888662 scopus 로고    scopus 로고
    • Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz
    • Roebuck BD, Curphey TJ, Li Y, et al. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz. Carcinogenesis 2003;24:1919-28.
    • (2003) Carcinogenesis , vol.24 , pp. 1919-1928
    • Roebuck, B.D.1    Curphey, T.J.2    Li, Y.3
  • 76
    • 0034522265 scopus 로고    scopus 로고
    • Oral toxicity of 1,2-dithiole-3-thione, a potential cancer chemopreventive agent, in the rat
    • Brown AP, Morrissey RL, Tolhurst TA, Crowell JA, Levine BS. Oral toxicity of 1,2-dithiole-3-thione, a potential cancer chemopreventive agent, in the rat. Int J Toxicol 2000;19:375-81.
    • (2000) Int J Toxicol , vol.19 , pp. 375-381
    • Brown, A.P.1    Morrissey, R.L.2    Tolhurst, T.A.3    Crowell, J.A.4    Levine, B.S.5
  • 77
    • 34249727213 scopus 로고    scopus 로고
    • Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: Enhanced activity for degradation of abnormal protein
    • Kwak MK, Huang B, Chang H, Kim JA, Kensler TW. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sci 2007;80:2411-20.
    • (2007) Life Sci , vol.80 , pp. 2411-2420
    • Kwak, M.K.1    Huang, B.2    Chang, H.3    Kim, J.A.4    Kensler, T.W.5
  • 78
    • 33947219969 scopus 로고    scopus 로고
    • The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells
    • Andringa G, Jongenelen CA, Halfhide L, Drukarch B. The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells. Neurosci Lett 2007;416:76-81.
    • (2007) Neurosci Lett , vol.416 , pp. 76-81
    • Andringa, G.1    Jongenelen, C.A.2    Halfhide, L.3    Drukarch, B.4
  • 79
    • 40449129950 scopus 로고    scopus 로고
    • Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    • Munday R, Mhawech-Fauceglia P, Munday CM, et al. Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res 2008;68:1593-600.
    • (2008) Cancer Res , vol.68 , pp. 1593-1600
    • Munday, R.1    Mhawech-Fauceglia, P.2    Munday, C.M.3
  • 80
    • 1942452892 scopus 로고    scopus 로고
    • Isothiocyanates in the chemoprevention of bladder cancer
    • Tang L, Zhang Y. Isothiocyanates in the chemoprevention of bladder cancer. Curr Drug Metab 2004;5:193-201.
    • (2004) Curr Drug Metab , vol.5 , pp. 193-201
    • Tang, L.1    Zhang, Y.2
  • 81
    • 0028179948 scopus 로고
    • Chemoprevention of OH-BBN-induced bladder cancer in mice by oltipraz, alone and in combination with 4-HPR and DFMO
    • Moon RC, Kelloff GJ, Detrisac CJ, Steele VE, Thomas CF, Sigman CC. Chemoprevention of OH-BBN-induced bladder cancer in mice by oltipraz, alone and in combination with 4-HPR and DFMO. Anticancer Res 1994;14:5-11.
    • (1994) Anticancer Res , vol.14 , pp. 5-11
    • Moon, R.C.1    Kelloff, G.J.2    Detrisac, C.J.3    Steele, V.E.4    Thomas, C.F.5    Sigman, C.C.6
  • 82
    • 0029682493 scopus 로고    scopus 로고
    • Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz
    • Rao CV, Rivenson A, Zang E, Steele V, Kelloff G, Reddy BS. Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz. Cancer Res 1996;56:3395-8.
    • (1996) Cancer Res , vol.56 , pp. 3395-3398
    • Rao, C.V.1    Rivenson, A.2    Zang, E.3    Steele, V.4    Kelloff, G.5    Reddy, B.S.6
  • 83
    • 0025783095 scopus 로고
    • Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats
    • Rao CV, Tokomo K, Kelloff G, Reddy BS. Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats. Carcinogenesis 1991;12:1051-5.
    • (1991) Carcinogenesis , vol.12 , pp. 1051-1055
    • Rao, C.V.1    Tokomo, K.2    Kelloff, G.3    Reddy, B.S.4
  • 84
    • 0038796599 scopus 로고    scopus 로고
    • Induction of NAD(P)H quinone:oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats
    • Begleiter A, Sivananthan K, Curphey TJ, Bird RP. Induction of NAD(P)H quinone:oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. Cancer Epidemiol Biomarkers Prev 2003;12:566-72.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 566-572
    • Begleiter, A.1    Sivananthan, K.2    Curphey, T.J.3    Bird, R.P.4
  • 85
    • 0029921139 scopus 로고    scopus 로고
    • Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat
    • Wargovich MJ, Chen CD, Jimenez A, et al. Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 1996;5:355-60.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 355-360
    • Wargovich, M.J.1    Chen, C.D.2    Jimenez, A.3
  • 86
  • 87
    • 0025925257 scopus 로고
    • 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry
    • 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res 1991;51:5501-6.
    • (1991) Cancer Res , vol.51 , pp. 5501-5506
    • Roebuck, B.D.1    Liu, Y.L.2    Rogers, A.E.3    Groopman, J.D.4    Kensler, T.W.5
  • 88
    • 0027296535 scopus 로고
    • Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis
    • Bolton MG, Muñoz A, Jacobson LP, et al. Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis. Cancer Res 1993;53:3499-504.
    • (1993) Cancer Res , vol.53 , pp. 3499-3504
    • Bolton, M.G.1    Muñoz, A.2    Jacobson, L.P.3
  • 89
    • 0029048396 scopus 로고
    • Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
    • Primiano T, Egner PA, Sutter TR, Kelloff GJ, Roebuck BD, Kensler TW. Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res 1995;55:4319-24.
    • (1995) Cancer Res , vol.55 , pp. 4319-4324
    • Primiano, T.1    Egner, P.A.2    Sutter, T.R.3    Kelloff, G.J.4    Roebuck, B.D.5    Kensler, T.W.6
  • 90
    • 4444370784 scopus 로고
    • Mechanisms of chemoprotection against aflatoxin-induced hepatocarcinogenesis by oltipraz
    • Nygaard OF, Upton AC, editors, New York: Plenum Press;
    • Kensler TW, Davidson NE, Egner PA, et al. Mechanisms of chemoprotection against aflatoxin-induced hepatocarcinogenesis by oltipraz. In: Nygaard OF, Upton AC, editors. Anticarcinogenesis and radiation protection 2. New York: Plenum Press; 1991. p. 315-22.
    • (1991) Anticarcinogenesis and radiation protection , vol.2 , pp. 315-322
    • Kensler, T.W.1    Davidson, N.E.2    Egner, P.A.3
  • 91
    • 33747876093 scopus 로고    scopus 로고
    • The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model
    • Sharma S, Gao P, Steele VE. The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. Carcinogenesis 2006;27:1721-7.
    • (2006) Carcinogenesis , vol.27 , pp. 1721-1727
    • Sharma, S.1    Gao, P.2    Steele, V.E.3
  • 92
    • 0034729356 scopus 로고    scopus 로고
    • Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters
    • Son HY, Nishikawa A, Furukawa F, et al. Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters. Cancer Lett 2000;153:211-8.
    • (2000) Cancer Lett , vol.153 , pp. 211-218
    • Son, H.Y.1    Nishikawa, A.2    Furukawa, F.3
  • 93
    • 0029133232 scopus 로고
    • Chemopreventive activity of oltipraz against N-nitrosobis(2-oxopropyl)- amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters
    • Clapper ML, Wood M, Leahy K, Lang D, Miknyoczki S, Ruggeri BA. Chemopreventive activity of oltipraz against N-nitrosobis(2-oxopropyl)- amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. Carcinogenesis 1995;16:2159-65.
    • (1995) Carcinogenesis , vol.16 , pp. 2159-2165
    • Clapper, M.L.1    Wood, M.2    Leahy, K.3    Lang, D.4    Miknyoczki, S.5    Ruggeri, B.A.6
  • 94
    • 0028295163 scopus 로고
    • Chemoprevention of respiratory tract neoplasia in the hamster by oltipraz, alone and in combination
    • Moon RC, Rao KVN, Detrisac CJ, Kelloff GJ, Steele VE, Doody LA. Chemoprevention of respiratory tract neoplasia in the hamster by oltipraz, alone and in combination. Int J Oncol 1994;4:661-7.
    • (1994) Int J Oncol , vol.4 , pp. 661-667
    • Moon, R.C.1    Rao, K.V.N.2    Detrisac, C.J.3    Kelloff, G.J.4    Steele, V.E.5    Doody, L.A.6
  • 95
    • 0031926513 scopus 로고    scopus 로고
    • Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N′-nitro-N-nitrosoguanidine
    • Nishikawa A, Tanakamura Z, Furukawa F, et al. Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis 1998;19:365-8.
    • (1998) Carcinogenesis , vol.19 , pp. 365-368
    • Nishikawa, A.1    Tanakamura, Z.2    Furukawa, F.3
  • 96
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A 2002;99:7610-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.