Importance of the 6'-hydroxy group and its configuration for apramycin activity

ChemMedChem

Volumn 9, Issue 9, 2014, Pages 2074-2083

  Mandhapati, Appi R eddy ^a   Shcherbakov, Dimitri ^a   Duscha, Stefan ^a   Vasella, Andrea ^a   Böttger, Erik C ^a   Crich, David ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

aminoglycoside antibiotics; antibacterial activity; ototoxicity; ribosomes; RNA

Indexed keywords

ANTIINFECTIVE AGENT; APRAMYCIN; NEBRAMYCIN; PROTEIN SYNTHESIS INHIBITOR;

ANALOGS AND DERIVATIVES; ANIMAL; BACTERIUM; CARBOHYDRATE ANALYSIS; CELL FREE SYSTEM; DRUG EFFECTS; ENZYME ACTIVE SITE; MOLECULAR GENETICS; PROTEIN SYNTHESIS; RABBIT; RIBOSOME; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CARBOHYDRATE SEQUENCE; CATALYTIC DOMAIN; CELL-FREE SYSTEM; MOLECULAR SEQUENCE DATA; NEBRAMYCIN; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RABBITS; RIBOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85027946616     PISSN: None     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402146     Document Type: Article

References (0)