Coupling of drug protonation to the specific binding of aminoglycosides to the A site of 16 S rRNA: Elucidation of the number of drug amino groups involved and their identities

Journal of Molecular Biology

Volumn 326, Issue 5, 2003, Pages 1373-1387

  Kaul, Malvika ^a   Barbieri, Christopher M ^a   Kerrigan, John E ^a,b   Pilch, Daniel S ^a,b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

15N NMR; Aminoglycoside pKa values; Aminoglycoside RNA recognition; Isothermal titration calorimetry; rRNA binding linked aminoglycoside protonation

Indexed keywords

2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BUFFER; FRAMYCETIN; LIVIDOMYCIN; PAROMOMYCIN; PROTON; RNA;

ARTICLE; BINDING AFFINITY; CALORIMETRY; DRUG BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTON TRANSPORT; RNA BINDING; TITRIMETRY;

EID: 0037424612     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01452-3     Document Type: Article

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