TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells

JARO - Journal of the Association for Research in Otolaryngology

Volumn 12, Issue 6, 2011, Pages 729-740

  Stepanyan, Ruben S ^a   Indzhykulian, Artur A ^a   Catalinavelez Ortega A ^a   Boger, Erich T ^b   Steyger, Peter S ^c   Friedman, Thomas B ^b   Frolenkov, Gregory I ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

4 hydroxynonenal; Gentamicin; Organ of Corti; Ototoxicity; Reactive oxygen species; Transient receptor potential A1 channel

Indexed keywords

4 HYDROXYNONENAL; DYE; GENTAMICIN; PENICILLIN BINDING PROTEIN 2X; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; DRUG ACCUMULATION; DRUG CONJUGATION; DRUG UPTAKE; EXPLANT; GENETIC TRANSFECTION; HAIR CELL; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; ION CURRENT; KNOCKOUT MOUSE; LIPID PEROXIDATION; MECHANOTRANSDUCTION; MOUSE; NOISE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATCH CLAMP; PRIORITY JOURNAL; WILD TYPE;

ALDEHYDES; AMINOGLYCOSIDES; ANIMALS; CATIONS; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE PROTEINASE INHIBITORS; FLUORESCENT DYES; GENOTYPE; GENTAMICINS; HAIR CELLS, AUDITORY, OUTER; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; PYRIDINIUM COMPOUNDS; QUATERNARY AMMONIUM COMPOUNDS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; XANTHENES;

EID: 84855678573     PISSN: 15253961     EISSN: 14387573     Source Type: Journal    
DOI: 10.1007/s10162-011-0288-x     Document Type: Article

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