Application of glycodiversification: Expedient synthesis and antibacterial evaluation of a library of kanamycin B analogues

Organic Letters

Volumn 6, Issue 9, 2004, Pages 1381-1384

  Li, Jie ^a   Wang, Jinhua ^a   Czyryca, Przemyslaw Greg ^a   Chang, Huiwen ^a   Orsak, Thomas W ^b   Evanson, Richard ^b   Chang, Cheng Wei Tom ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KANAMYCIN B;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; MICROBIOLOGICAL EXAMINATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; KANAMYCIN; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; RNA, RIBOSOMAL, 16S; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2442556115     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0497685     Document Type: Article

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27. Score function was based on Amber 96 force-field as implemented in HyperChem 7.0 and the solvent-accessible surface methodology to account for the hydration effects. The program was developed for drug design, not specifically for the calculation of absolute binding affinity. Therefore, we look for the tendency in binding rather than the meaning interpreted from the absolute numbers of binding. Nevertheless, the calculated binding scores have tendencies consistent with the compounds that have known binding affinity from the in vitro experiment. More details can be found in Supporting Information.
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29. Please refer to Supporting Information for figures from molecular modeling.
30. E. coli (TG1) (APH3′-I) and E. coli (TG1) (AAC6′/APH2″) .