Manipulating the prion protein gene sequence and expression levels with CRISPR/Cas9

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Kaczmarczyk, Lech ^a   Mende, Ylva ^b   Zevnik, Branko ^b   Jackson, Walker S ^a  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PRION PROTEIN; PRNP PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; GENE SEQUENCE; GENE TARGETING; MALE; MOUSE; NONHUMAN; PRNP GENE; ANIMAL; C57BL MOUSE; CELL LINE; GENE VECTOR; GENETICS; HUMAN; KNOCKOUT MOUSE; PRION DISEASE; PROCEDURES; UPREGULATION;

ANIMALS; CELL LINE; CRISPR-CAS SYSTEMS; FEMALE; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; GENE TARGETING; GENETIC VECTORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRION DISEASES; PRION PROTEINS; UP-REGULATION;

EID: 84966373352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154604     Document Type: Article

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