De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 1, 2009, Pages 304-309

  Sigurdson, Christina J ^a,g   Nilsson, K Peter R ^a   Hornemann, Simone ^b   Heikenwalder, Mathias ^a   Manco, Giuseppe ^a   Schwarz, Petra ^a   Ott, David ^a   Rülicke, Thomas ^c   Liberski, Pawel P ^d   Julius, Christian ^a   Falsig, Jeppe ^a   Stitz, Lothar ^e   Wüthrich, Kurt ^b,f   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d MEDICAL UNIVERSITY OF LODZ   (Poland)

^e FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid; Neurodegeneration; Prion; Species barrier; Transgenic mice

Indexed keywords

MUTANT PROTEIN; PRION PROTEIN; PROTEINASE; PRP PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; GENE; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; GENETIC DISORDER; INOCULATION; LETHALITY; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; POINT MUTATION; PRION DISEASE; PRIORITY JOURNAL; PRNP GENE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STRAIN DIFFERENCE; TGA20 MOUSE; TRANSGENIC MOUSE; TRANSGENICS; VIRUS PLAQUE; VIRUS STRAIN; WILD TYPE;

ANIMALS; GENE TRANSFER TECHNIQUES; MICE; MICE, TRANSGENIC; POINT MUTATION; PRION DISEASES; PRIONS; PROTEIN CONFORMATION;

MUS; MUS MUSCULUS;

EID: 58549102983     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810680105     Document Type: Article

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