Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases

Genome Research

Volumn 24, Issue 8, 2014, Pages 1371-1383

  Remy, Séverine ^a,b   Tesson, Laurent ^a,b   Menoret, Séverine ^a,b   Usal, Claire ^a,b   De Cian, Anne ^c   Thepenier, Virginie ^a,b   Thinard, Reynald ^a,b   Baron, Daniel ^a   Charpentier, Marine ^c   Renaud, Jean Baptiste ^c   Buelow, Roland ^d   Cost, Gregory J ^e   Giovannangeli, Carine ^c   Fraichard, Alexandre ^f   Concordet, Jean Paul ^c   Anegon, Ignacio ^a,b  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b Platform Transgenic Rats Nantes IBiSA CNRS   (France)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^d Open Monoclonal Technology Inc   (United States)

^e SANGAMO BIOSCIENCES INC   (United States)

^f GenOway   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE 1; IGHM PROTEIN; NUCLEASE; PLASMID DNA; PROTEIN; ROSA26 PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN; RESTRICTION ENDONUCLEASE;

ALLELE; ANIMAL; ANIMAL CELL; ARTICLE; BIRTH RATE; CHROMOSOME; CONTROLLED STUDY; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA INTEGRATION; DNA SEQUENCE; DONOR; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; EXON; GENE EXPRESSION; GENE LOCUS; GENE TARGETING; GENETIC TRANSFECTION; GENOTYPE; HOMOLOGY DIRECTED REPAIR; HUMAN; INDEL MUTATION; INTRON; MALE; MICROINJECTION; MODEL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PRONUCLEUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; ULTRAVIOLET RADIATION; ZYGOTE; BIOSYNTHESIS; CELL CULTURE; FEMALE; GENETIC ENGINEERING; GENETICS; NUCLEOTIDE SEQUENCE; RECOMBINATION REPAIR; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA RESTRICTION ENZYMES; FEMALE; GENE TARGETING; GENETIC ENGINEERING; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MICROINJECTIONS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECOMBINANT PROTEINS; RECOMBINATIONAL DNA REPAIR; ZYGOTE;

EID: 84905649363     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.171538.113     Document Type: Article

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