Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

PLoS Pathogens

Volumn 11, Issue 4, 2015, Pages

  Bouybayoune, Ihssane ^a   Mantovani, Susanna ^a,g   Del Gallo, Federico ^b,h   Bertani, Ilaria ^a   Restelli, Elena ^a   Comerio, Liliana ^a   Tapella, Laura ^a   Baracchi, Francesca ^b   Fernández Borges, Natalia ^c   Mangieri, Michela ^d,i   Bisighini, Cinzia ^a   Beznoussenko, Galina V ^e   Paladini, Alessandra ^a   Balducci, Claudia ^a   Micotti, Edoardo ^a   Forloni, Gianluigi ^a   Castilla, Joaquín ^c,f   Fiordaliso, Fabio ^a   Tagliavini, Fabrizio ^d   Imeri, Luca ^b   Chiesa, Roberto ^a   more..

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CIC BIOGUNE   (Spain)

^d DEPARTMENT OF NEUROSURGERY   (Italy)

^e FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^f BASQUE FOUNDATION FOR SCIENCE   (Spain)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h UNIVERSITY OF VERONA   (Italy)

ⁱ Golgi Cenci Foundation   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN; PRION; PRNP PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BEHAVIOR ASSESSMENT; CHRONIC WASTING DISEASE AGENT; CIRCADIAN RHYTHM; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; ELECTROENCEPHALOGRAPHY; ELECTRON MICROSCOPY; FATAL FAMILIAL INSOMNIA; GENE MUTATION; GENETIC ANALYSIS; GLIOSIS; MOTOR DYSFUNCTION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRION DISEASE; PROTEIN FOLDING; RADIAL ARM MAZE TEST; REM SLEEP; ROTAROD TEST; SPATIAL MEMORY; VIRUS INFECTIVITY; WESTERN BLOTTING; WORKING MEMORY; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; GENETICS; MAZE TEST; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PRION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY;

MUS; MUS MUSCULUS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; INSOMNIA, FATAL FAMILIAL; MAGNETIC RESONANCE IMAGING; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; PHENOTYPE; PRION PROTEINS; PRIONS;

EID: 84929492772     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004796     Document Type: Article

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