메뉴 건너뛰기




Volumn 68, Issue 4, 2016, Pages 789-796

Janus kinases in inflammatory bowel disease: Four kinases for multiple purposes

Author keywords

Cytokine; IBD; JAK; Treatment

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 9; JANUS KINASE INHIBITOR; CYTOKINE; JANUS KINASE;

EID: 84965050669     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2016.04.001     Document Type: Review
Times cited : (18)

References (122)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 3
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • C. Abraham, and J.H. Cho Inflammatory bowel disease N Engl J Med 361 2009 2066 2078
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 4
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative colitis
    • S. Danese, and C. Fiocchi Ulcerative colitis N Engl J Med 365 18 2011 1713 1725
    • (2011) N Engl J Med , vol.365 , Issue.18 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 5
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • M.F. Neurath Cytokines in inflammatory bowel disease Nat Rev Immunol 14 5 2014 329 342
    • (2014) Nat Rev Immunol , vol.14 , Issue.5 , pp. 329-342
    • Neurath, M.F.1
  • 6
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • J.J. O'Shea, S.M. Holland, and L.M. Staudt JAKs and STATs in immunity, immunodeficiency, and cancer N Engl J Med 368 2 2013 161 170
    • (2013) N Engl J Med , vol.368 , Issue.2 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 7
    • 84883326055 scopus 로고    scopus 로고
    • A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors
    • S.J. Sohn, K. Barrett, A. Van Abbema, C. Chang, P.B. Kohli, H. Kanda, and et al. A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors J Immunol 191 5 2013 2205 2216
    • (2013) J Immunol , vol.191 , Issue.5 , pp. 2205-2216
    • Sohn, S.J.1    Barrett, K.2    Van Abbema, A.3    Chang, C.4    Kohli, P.B.5    Kanda, H.6
  • 8
    • 6544233336 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
    • T1 Hosokawa, K. Kusugami, K. Ina, T. Ando, M. Shinoda, A. Imada, and et al. Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease J Gastroenterol Hepatol 14 1999 987 996
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 987-996
    • Hosokawa, T.1    Kusugami, K.2    Ina, K.3    Ando, T.4    Shinoda, M.5    Imada, A.6
  • 9
    • 77949326158 scopus 로고    scopus 로고
    • Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    • S. Matsumoto, T. Hara, K. Mitsuyama, M. Yamamoto, O. Tsuruta, M. Sata, and et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model J Immunol 184 3 2010 1543 1551
    • (2010) J Immunol , vol.184 , Issue.3 , pp. 1543-1551
    • Matsumoto, S.1    Hara, T.2    Mitsuyama, K.3    Yamamoto, M.4    Tsuruta, O.5    Sata, M.6
  • 10
    • 0026607022 scopus 로고
    • Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
    • V. Gross, T. Andus, I. Caesar, M. Roth, and J. Schölmerich Evidence for continuous stimulation of interleukin-6 production in Crohn's disease Gastroenterology 102 1992 514 519
    • (1992) Gastroenterology , vol.102 , pp. 514-519
    • Gross, V.1    Andus, T.2    Caesar, I.3    Roth, M.4    Schölmerich, J.5
  • 11
    • 0027313034 scopus 로고
    • Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease
    • J.S. Hyams, J.E. Fitzgerald, W.R. Treem, N. Wyzga, and D.L. Kreutzer Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease Gastroenterology 104 1993 1285 1292
    • (1993) Gastroenterology , vol.104 , pp. 1285-1292
    • Hyams, J.S.1    Fitzgerald, J.E.2    Treem, W.R.3    Wyzga, N.4    Kreutzer, D.L.5
  • 12
    • 0027451455 scopus 로고
    • Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
    • H.C. Reinecker, M. Steffen, T. Witthoeft, I. Pflueger, S. Schreiber, R.P. MacDermott, and et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease Clin Exp Immunol 94 1993 174 181
    • (1993) Clin Exp Immunol , vol.94 , pp. 174-181
    • Reinecker, H.C.1    Steffen, M.2    Witthoeft, T.3    Pflueger, I.4    Schreiber, S.5    MacDermott, R.P.6
  • 13
    • 0029017776 scopus 로고
    • Elevation of interleukin-6 in inflammatory bowel disease is macrophage and epithelial cell-dependent
    • K. Kusugami, A. Fukatsu, M. Tanimoto, M. Shinoda, J. Haruta, A. Kuroiwa, and et al. Elevation of interleukin-6 in inflammatory bowel disease is macrophage and epithelial cell-dependent Dig Dis Sci 40 1995 949 959
    • (1995) Dig Dis Sci , vol.40 , pp. 949-959
    • Kusugami, K.1    Fukatsu, A.2    Tanimoto, M.3    Shinoda, M.4    Haruta, J.5    Kuroiwa, A.6
  • 14
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans-signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • R. Atreya, J. Mudter, S. Finotto, J. Müllberg, T. Jostock, S. Wirtz, and et al. Blockade of interleukin 6 trans-signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo Nat Med 6 2000 583 588
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Müllberg, J.4    Jostock, T.5    Wirtz, S.6
  • 15
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • D. Yen, J. Cheung, H. Scheerens, F. Poulet, T. McClanahan, B. McKenzie, and et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 J Clin Invest 116 2006 1310 1316
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3    Poulet, F.4    McClanahan, T.5    McKenzie, B.6
  • 16
    • 23944476094 scopus 로고    scopus 로고
    • Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
    • R1 Atreya, and M.F. Neurath Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer Clin Rev Allergy Immunol 28 3 2005 187 196
    • (2005) Clin Rev Allergy Immunol , vol.28 , Issue.3 , pp. 187-196
    • Atreya, R.1    Neurath, M.F.2
  • 17
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • M. Yamamoto, K. Yoshizaki, T. Kishimoto, and H. Ito IL-6 is required for the development of Th1 cell-mediated murine colitis J Immunol 164 9 2000 4878 4882
    • (2000) J Immunol , vol.164 , Issue.9 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 18
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • A. Kimura, and T. Kishimoto IL-6: regulator of Treg/Th17 balance Eur J Immunol 40 2010 1830 1835
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 20
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • L. Zhou, I.I. Ivanov, R. Spolski, R. Min, K. Shenderov, T. Egawa, and et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 9 2007 967 974
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 21
    • 51549089438 scopus 로고    scopus 로고
    • Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    • L.E. Sander, F. Obermeier, U. Dierssen, D.C. Kroy, A.K. Singh, U. Seidler, and et al. Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation J Immunol 181 5 2008 3586 3594
    • (2008) J Immunol , vol.181 , Issue.5 , pp. 3586-3594
    • Sander, L.E.1    Obermeier, F.2    Dierssen, U.3    Kroy, D.C.4    Singh, A.K.5    Seidler, U.6
  • 22
    • 84899722895 scopus 로고    scopus 로고
    • Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene
    • R. Al-Sadi, D. Ye, M. Boivin, S. Guo, M. Hashimi, L. Ereifej, and et al. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene PLOS ONE 9 3 2014 e85345 10.1371/journal.pone.0085345
    • (2014) PLOS ONE , vol.9 , Issue.3 , pp. e85345
    • Al-Sadi, R.1    Ye, D.2    Boivin, M.3    Guo, S.4    Hashimi, M.5    Ereifej, L.6
  • 23
    • 45549097533 scopus 로고    scopus 로고
    • IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
    • S.M. Dann, M.E. Spehlmann, D.C. Hammond, M. Iimura, K. Hase, L.J. Choi, and et al. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens J Immunol 180 10 2008 6816 6826
    • (2008) J Immunol , vol.180 , Issue.10 , pp. 6816-6826
    • Dann, S.M.1    Spehlmann, M.E.2    Hammond, D.C.3    Iimura, M.4    Hase, K.5    Choi, L.J.6
  • 24
    • 84918522920 scopus 로고    scopus 로고
    • IL-6 stimulates intestinal epithelial proliferation and repair after injury
    • K.A. Kuhn, N.A. Manieri, T.C. Liu, and T.S. Stappenbeck IL-6 stimulates intestinal epithelial proliferation and repair after injury PLOS ONE 9 12 2014 e114195 10.1371/journal.pone.0114195
    • (2014) PLOS ONE , vol.9 , Issue.12 , pp. e114195
    • Kuhn, K.A.1    Manieri, N.A.2    Liu, T.C.3    Stappenbeck, T.S.4
  • 25
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • S. Grivennikov, E. Karin, J. Terzic, D. Mucida, G.Y. Yu, S. Vallabhapurapu, and et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer Cancer Cell 15 2 2009 103 113
    • (2009) Cancer Cell , vol.15 , Issue.2 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 26
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • H. Ito, M. Takazoe, Y. Fukuda, T. Hibi, K. Kusugami, A. Andoh, and et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease Gastroenterology 126 4 2004 989 996
    • (2004) Gastroenterology , vol.126 , Issue.4 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3    Hibi, T.4    Kusugami, K.5    Andoh, A.6
  • 27
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
    • G. Trinchieri, S. Pflanz, and R.A. Kastelein The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses Immunity 19 2003 641 644
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 28
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
    • R.A. Kastelein, C.A. Hunter, and D.J. Cua Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation Annu Rev Immunol 25 2007 221 242
    • (2007) Annu Rev Immunol , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 29
    • 84930679365 scopus 로고    scopus 로고
    • Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
    • S.N. Harbour, C.L. Maynard, C.L. Zindl, T.R. Schoeb, and C.T. Weaver Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis Proc Natl Acad Sci U S A 112 22 2015 7061 7066
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.22 , pp. 7061-7066
    • Harbour, S.N.1    Maynard, C.L.2    Zindl, C.L.3    Schoeb, T.R.4    Weaver, C.T.5
  • 30
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: Common pathways with other diseases
    • C.W. Lees, J.C. Barrett, M. Parkes, and J. Satsangi New IBD genetics: common pathways with other diseases Gut 60 12 2011 1739 1753
    • (2011) Gut , vol.60 , Issue.12 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 31
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • W.J. Sandborn, C. Gasink, L.L. Gao, M.A. Blank, J. Johanns, C. Guzzo, and et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease N Engl J Med 367 16 2012 1519 1528
    • (2012) N Engl J Med , vol.367 , Issue.16 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3    Blank, M.A.4    Johanns, J.5    Guzzo, C.6
  • 32
    • 0028910222 scopus 로고
    • Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
    • C.M. Bacon, D.W. McVicar, J.R. Ortaldo, R.C. Rees, J.J. O'Shea, and J.A. Johnston Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12 J Exp Med 181 1 1995 399 404
    • (1995) J Exp Med , vol.181 , Issue.1 , pp. 399-404
    • Bacon, C.M.1    McVicar, D.W.2    Ortaldo, J.R.3    Rees, R.C.4    O'Shea, J.J.5    Johnston, J.A.6
  • 33
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    • C. Parham, M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, and et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 11 2002 5699 5708
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5699-5708
    • Parham, C.1    Chirica, M.2    Timans, J.3    Vaisberg, E.4    Travis, M.5    Cheung, J.6
  • 35
    • 34547138698 scopus 로고    scopus 로고
    • Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation
    • N. Tokumasa, A. Suto, S. Kagami, S. Furuta, K. Hirose, N. Watanabe, and et al. Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation Blood 110 2 2007 553 560
    • (2007) Blood , vol.110 , Issue.2 , pp. 553-560
    • Tokumasa, N.1    Suto, A.2    Kagami, S.3    Furuta, S.4    Hirose, K.5    Watanabe, N.6
  • 36
    • 33845897463 scopus 로고    scopus 로고
    • Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    • Y. Minegishi, M. Saito, T. Morio, K. Watanabe, K. Agematsu, S. Tsuchiya, and et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity Immunity 25 5 2006 745 755
    • (2006) Immunity , vol.25 , Issue.5 , pp. 745-755
    • Minegishi, Y.1    Saito, M.2    Morio, T.3    Watanabe, K.4    Agematsu, K.5    Tsuchiya, S.6
  • 37
    • 84928920020 scopus 로고    scopus 로고
    • TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
    • D. Diogo, L. Bastarache, K.P. Liao, R.R. Graham, R.S. Fulton, J.D. Greenberg, and et al. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits PLOS ONE 10 4 2015
    • (2015) PLOS ONE , vol.10 , Issue.4
    • Diogo, D.1    Bastarache, L.2    Liao, K.P.3    Graham, R.R.4    Fulton, R.S.5    Greenberg, J.D.6
  • 38
    • 79960392815 scopus 로고    scopus 로고
    • Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo
    • M. Ishizaki, T. Akimoto, R. Muromoto, M. Yokoyama, Y. Ohshiro, Y. Sekine, and et al. Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo J Immunol 187 1 2011 181 189
    • (2011) J Immunol , vol.187 , Issue.1 , pp. 181-189
    • Ishizaki, M.1    Akimoto, T.2    Muromoto, R.3    Yokoyama, M.4    Ohshiro, Y.5    Sekine, Y.6
  • 39
    • 84958631189 scopus 로고    scopus 로고
    • Intestinal epithelial cell tyrosine kinase 2 transduces IL-22 signals to protect from acute colitis
    • E. Hainzl, S. Stockinger, I. Rauch, S. Heider, D. Berry, C. Lassnig, and et al. Intestinal epithelial cell tyrosine kinase 2 transduces IL-22 signals to protect from acute colitis J Immunol 195 10 2015 5011 5024
    • (2015) J Immunol , vol.195 , Issue.10 , pp. 5011-5024
    • Hainzl, E.1    Stockinger, S.2    Rauch, I.3    Heider, S.4    Berry, D.5    Lassnig, C.6
  • 40
    • 49649119727 scopus 로고    scopus 로고
    • Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells
    • R. Nakamura, K. Shibata, H. Yamada, K. Shimoda, K. Nakayama, and Y. Yoshikai Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells J Immunol 181 3 2008 2071 2075
    • (2008) J Immunol , vol.181 , Issue.3 , pp. 2071-2075
    • Nakamura, R.1    Shibata, K.2    Yamada, H.3    Shimoda, K.4    Nakayama, K.5    Yoshikai, Y.6
  • 41
    • 0037260543 scopus 로고    scopus 로고
    • Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18
    • N. Sugimoto, M. Nakahira, H.J. Ahn, M. Micallef, T. Hamaoka, M. Kurimoto, and et al. Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18 Eur J Immunol 33 1 2003 243 251
    • (2003) Eur J Immunol , vol.33 , Issue.1 , pp. 243-251
    • Sugimoto, N.1    Nakahira, M.2    Ahn, H.J.3    Micallef, M.4    Hamaoka, T.5    Kurimoto, M.6
  • 42
    • 0029785080 scopus 로고    scopus 로고
    • A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
    • J.B. Demoulin, C. Uyttenhove, E. Van Roost, B. DeLestré, D. Donckers, J. Van Snick, and et al. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Mol Cell Biol 16 9 1996 4710 4716
    • (1996) Mol Cell Biol , vol.16 , Issue.9 , pp. 4710-4716
    • Demoulin, J.B.1    Uyttenhove, C.2    Van Roost, E.3    DeLestré, B.4    Donckers, D.5    Van Snick, J.6
  • 43
    • 0032502354 scopus 로고    scopus 로고
    • Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis
    • J.H. Bauer, K.D. Liu, Y. You, S.Y. Lai, and M.A. Goldsmith Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis J Biol Chem 273 15 1998 9255 9260
    • (1998) J Biol Chem , vol.273 , Issue.15 , pp. 9255-9260
    • Bauer, J.H.1    Liu, K.D.2    You, Y.3    Lai, S.Y.4    Goldsmith, M.A.5
  • 44
    • 79953043687 scopus 로고    scopus 로고
    • Jak1 has a dominant role over Jak3 in signal transduction through (c-containing cytokine receptors
    • C. Haan, C. Rolvering, F. Raulf, M. Kapp, P. Drückes, G. Thoma, and et al. Jak1 has a dominant role over Jak3 in signal transduction through (c-containing cytokine receptors Chem Biol 18 3 2011 314 323
    • (2011) Chem Biol , vol.18 , Issue.3 , pp. 314-323
    • Haan, C.1    Rolvering, C.2    Raulf, F.3    Kapp, M.4    Drückes, P.5    Thoma, G.6
  • 45
    • 84929486174 scopus 로고    scopus 로고
    • Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol
    • E.R. Goedken, M.A. Argiriadi, D.L. Banach, B.A. Fiamengo, S.E. Foley, K.E. Frank, and et al. Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol J Biol Chem 290 8 2015 4573 4589
    • (2015) J Biol Chem , vol.290 , Issue.8 , pp. 4573-4589
    • Goedken, E.R.1    Argiriadi, M.A.2    Banach, D.L.3    Fiamengo, B.A.4    Foley, S.E.5    Frank, K.E.6
  • 46
    • 84928584525 scopus 로고    scopus 로고
    • IL-9 and its receptor are predominantly involved in the pathogenesis of UC
    • N. Nalleweg, M.T. Chiriac, E. Podstawa, C. Lehmann, T.T. Rau, R. Atreya, and et al. IL-9 and its receptor are predominantly involved in the pathogenesis of UC Gut 64 5 2014 743 755
    • (2014) Gut , vol.64 , Issue.5 , pp. 743-755
    • Nalleweg, N.1    Chiriac, M.T.2    Podstawa, E.3    Lehmann, C.4    Rau, T.T.5    Atreya, R.6
  • 48
    • 84902653958 scopus 로고    scopus 로고
    • TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    • K. Gerlach, Y. Hwang, A. Nikolaev, R. Atreya, H. Dornhoff, S. Steiner, and et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells Nat Immunol 15 7 2014 676 686
    • (2014) Nat Immunol , vol.15 , Issue.7 , pp. 676-686
    • Gerlach, K.1    Hwang, Y.2    Nikolaev, A.3    Atreya, R.4    Dornhoff, H.5    Steiner, S.6
  • 50
    • 84949603945 scopus 로고    scopus 로고
    • IL-9 antibody injection suppresses the inflammation in colitis mice
    • A. Yuan, H. Yang, H. Qi, J. Cui, W. Hua, C. Li, and et al. IL-9 antibody injection suppresses the inflammation in colitis mice Biochem Biophys Res Commun 468 4 2015 921 926
    • (2015) Biochem Biophys Res Commun , vol.468 , Issue.4 , pp. 921-926
    • Yuan, A.1    Yang, H.2    Qi, H.3    Cui, J.4    Hua, W.5    Li, C.6
  • 51
    • 84893351700 scopus 로고    scopus 로고
    • Interleukin 10 receptor signaling: Master regulator of intestinal mucosal homeostasis in mice and humans
    • D.S. Shouval, J. Ouahed, A. Biswas, J.A. Goettel, B.H. Horwitz, C. Klein, and et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans Adv Immunol 122 2014 177 210
    • (2014) Adv Immunol , vol.122 , pp. 177-210
    • Shouval, D.S.1    Ouahed, J.2    Biswas, A.3    Goettel, J.A.4    Horwitz, B.H.5    Klein, C.6
  • 52
    • 0033523019 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
    • J.K. Riley, K. Takeda, S. Akira, and R.D. Schreiber Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action J Biol Chem 274 23 1999 16513 16521
    • (1999) J Biol Chem , vol.274 , Issue.23 , pp. 16513-16521
    • Riley, J.K.1    Takeda, K.2    Akira, S.3    Schreiber, R.D.4
  • 53
    • 0032076183 scopus 로고    scopus 로고
    • Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
    • S.J. Rodig, M.A. Meraz, J.M. White, P.A. Lampe, J.K. Riley, C.D. Arthur, and et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses Cell 93 3 1998 373 383
    • (1998) Cell , vol.93 , Issue.3 , pp. 373-383
    • Rodig, S.J.1    Meraz, M.A.2    White, J.M.3    Lampe, P.A.4    Riley, J.K.5    Arthur, C.D.6
  • 54
    • 84874260872 scopus 로고    scopus 로고
    • Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent
    • Z. Li, M. Gakovic, J. Ragimbeau, M.L. Eloranta, L. Rönnblom, F. Michel, and et al. Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent J Immunol 190 5 2013 2335 2344
    • (2013) J Immunol , vol.190 , Issue.5 , pp. 2335-2344
    • Li, Z.1    Gakovic, M.2    Ragimbeau, J.3    Eloranta, M.L.4    Rönnblom, L.5    Michel, F.6
  • 55
    • 84859777122 scopus 로고    scopus 로고
    • Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury
    • S.R. Hofmann, A. Rösen-Wolff, G.C. Tsokos, and C.M. Hedrich Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury Clin Immunol 143 2 2012 116 127
    • (2012) Clin Immunol , vol.143 , Issue.2 , pp. 116-127
    • Hofmann, S.R.1    Rösen-Wolff, A.2    Tsokos, G.C.3    Hedrich, C.M.4
  • 56
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Y.P. Rubtsov, J.P. Rasmussen, E.Y. Chi, J. Fontenot, L. Castelli, X. Ye, and et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces Immunity 28 4 2008 546 558 10.1016/j.immuni.2008.02.017
    • (2008) Immunity , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5    Ye, X.6
  • 57
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • R. Kühn, J. Löhler, D. Rennick, K. Rajewsky, and W. Müller Interleukin-10-deficient mice develop chronic enterocolitis Cell 75 2 1993 263 274
    • (1993) Cell , vol.75 , Issue.2 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 58
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • F. Powrie, R. Correa-Oliveira, S. Mauze, and R.L. Coffman Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity J Exp Med 179 2 1994 589 600
    • (1994) J Exp Med , vol.179 , Issue.2 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 59
    • 0036080009 scopus 로고    scopus 로고
    • Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice
    • H. De Winter, D. Elewaut, O. Turovskaya, M. Huflejt, C. Shimeld, A. Hagenbaugh, and et al. Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice Gastroenterology 122 7 2002 1829 1841
    • (2002) Gastroenterology , vol.122 , Issue.7 , pp. 1829-1841
    • De Winter, H.1    Elewaut, D.2    Turovskaya, O.3    Huflejt, M.4    Shimeld, C.5    Hagenbaugh, A.6
  • 60
    • 0034714188 scopus 로고    scopus 로고
    • Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
    • L. Steidler, W. Hans, L. Schotte, S. Neirynck, F. Obermeier, W. Falk, and et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 Science 289 5483 2000 1352 1355
    • (2000) Science , vol.289 , Issue.5483 , pp. 1352-1355
    • Steidler, L.1    Hans, W.2    Schotte, L.3    Neirynck, S.4    Obermeier, F.5    Falk, W.6
  • 61
    • 84900428511 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
    • D.S. Shouval, A. Biswas, J.A. Goettel, K. McCann, E. Conaway, N.S. Redhu, and et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function Immunity 40 5 2014 706 719
    • (2014) Immunity , vol.40 , Issue.5 , pp. 706-719
    • Shouval, D.S.1    Biswas, A.2    Goettel, J.A.3    McCann, K.4    Conaway, E.5    Redhu, N.S.6
  • 62
    • 79952052483 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 for induction of remission in Crohn's disease
    • F.E. Buruiana, I. Solà, and P. Alonso-Coello Recombinant human interleukin 10 for induction of remission in Crohn's disease Cochrane Database Syst Rev 10 11 2010 CD005109
    • (2010) Cochrane Database Syst Rev , vol.10 , Issue.11 , pp. CD005109
    • Buruiana, F.E.1    Solà, I.2    Alonso-Coello, P.3
  • 63
    • 0037072796 scopus 로고    scopus 로고
    • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
    • D. Lejeune, L. Dumoutier, S. Constantinescu, W. Kruijer, J.J. Schuringa, and J.C. Renauld Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10 J Biol Chem 277 37 2002 33676 33682
    • (2002) J Biol Chem , vol.277 , Issue.37 , pp. 33676-33682
    • Lejeune, D.1    Dumoutier, L.2    Constantinescu, S.3    Kruijer, W.4    Schuringa, J.J.5    Renauld, J.C.6
  • 66
    • 0037335747 scopus 로고    scopus 로고
    • Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3
    • L. Dumoutier, D. Lejeune, S. Hor, H. Fickenscher, and J.C. Renauld Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3 Biochem J 370 Pt 2 2003 391 396
    • (2003) Biochem J , vol.370 , pp. 391-396
    • Dumoutier, L.1    Lejeune, D.2    Hor, S.3    Fickenscher, H.4    Renauld, J.C.5
  • 67
    • 33645829078 scopus 로고    scopus 로고
    • IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    • S. Brand, F. Beigel, T. Olszak, K. Zitzmann, S.T. Eichhorst, J.M. Otte, and et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration Am J Physiol Gastrointest Liver Physiol 290 4 2006 G827 G838
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.4 , pp. G827-G838
    • Brand, S.1    Beigel, F.2    Olszak, T.3    Zitzmann, K.4    Eichhorst, S.T.5    Otte, J.M.6
  • 68
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • K. Sugimoto, A. Ogawa, E. Mizoguchi, Y. Shimomura, A. Andoh, A.K. Bhan, and et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis J Clin Invest 118 2 2008 534 544
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3    Shimomura, Y.4    Andoh, A.5    Bhan, A.K.6
  • 69
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • G. Pickert, C. Neufert, M. Leppkes, Y. Zheng, N. Wittkopf, M. Warntjen, and et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing J Exp Med 206 7 2009 1465 1472
    • (2009) J Exp Med , vol.206 , Issue.7 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5    Warntjen, M.6
  • 72
    • 84892482473 scopus 로고    scopus 로고
    • Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
    • X. Guo, J. Qiu, T. Tu, X. Yang, L. Deng, R.A. Anders, and et al. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection Immunity 40 1 2014 25 39
    • (2014) Immunity , vol.40 , Issue.1 , pp. 25-39
    • Guo, X.1    Qiu, J.2    Tu, T.3    Yang, X.4    Deng, L.5    Anders, R.A.6
  • 73
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • S. Kirchberger, D.J. Royston, O. Boulard, E. Thornton, F. Franchini, R.L. Szabady, and et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model J Exp Med 210 5 2013 917 931
    • (2013) J Exp Med , vol.210 , Issue.5 , pp. 917-931
    • Kirchberger, S.1    Royston, D.J.2    Boulard, O.3    Thornton, E.4    Franchini, F.5    Szabady, R.L.6
  • 74
    • 0036679853 scopus 로고    scopus 로고
    • GM-CSF in inflammation and autoimmunity
    • J.A. Hamilton GM-CSF in inflammation and autoimmunity Trends Immunol 23 2002 403 408
    • (2002) Trends Immunol , vol.23 , pp. 403-408
    • Hamilton, J.A.1
  • 75
    • 70349336496 scopus 로고    scopus 로고
    • The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease
    • T.R. Hercus, D. Thomas, M.A. Guthridge, P.G. Ekert, J. King-Scott, M.W. Parker, and et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease Blood 114 7 2009 1289 1298
    • (2009) Blood , vol.114 , Issue.7 , pp. 1289-1298
    • Hercus, T.R.1    Thomas, D.2    Guthridge, M.A.3    Ekert, P.G.4    King-Scott, J.5    Parker, M.W.6
  • 76
    • 15844389026 scopus 로고    scopus 로고
    • JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells
    • S. Watanabe, T. Itoh, and K.I. Arai JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells J Biol Chem 271 1996 12681 12686
    • (1996) J Biol Chem , vol.271 , pp. 12681-12686
    • Watanabe, S.1    Itoh, T.2    Arai, K.I.3
  • 77
    • 0028180569 scopus 로고
    • JAK2 associates with the bc chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
    • F.W. Quelle, N. Sato, B.A. Witthuhn, R.C. Inhorn, M. Eder, A. Miyajima, and et al. JAK2 associates with the bc chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region Mol Cell Biol 14 1994 4335 4341
    • (1994) Mol Cell Biol , vol.14 , pp. 4335-4341
    • Quelle, F.W.1    Sato, N.2    Witthuhn, B.A.3    Inhorn, R.C.4    Eder, M.5    Miyajima, A.6
  • 78
    • 0030953788 scopus 로고    scopus 로고
    • The kinase domain of Jak2 mediates induction of Bcl-2 and delays cell death in hematopoietic cells
    • I. Sakai, and A.S. Kraft The kinase domain of Jak2 mediates induction of Bcl-2 and delays cell death in hematopoietic cells J Biol Chem 272 1997 12350 12358
    • (1997) J Biol Chem , vol.272 , pp. 12350-12358
    • Sakai, I.1    Kraft, A.S.2
  • 79
    • 0032147055 scopus 로고    scopus 로고
    • Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5
    • S.E. Doyle, and J.C. Gasson Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5 Blood 92 3 1998 867 876
    • (1998) Blood , vol.92 , Issue.3 , pp. 867-876
    • Doyle, S.E.1    Gasson, J.C.2
  • 80
    • 0028963550 scopus 로고
    • Interleukin-3, granulocyte-macrophage colony-stimulating factor andinterleukin-5 transduce signals through two STAT5 homologs
    • A.L-F. Mui, H. Wakao, A-M. O'Farrell, N. Harada, and A. Miyajima Interleukin-3, granulocyte-macrophage colony-stimulating factor andinterleukin-5 transduce signals through two STAT5 homologs EMBO J 14 1995 1166 1175
    • (1995) EMBO J , vol.14 , pp. 1166-1175
    • Mui, A.L.-F.1    Wakao, H.2    O'Farrell, A.-M.3    Harada, N.4    Miyajima, A.5
  • 81
    • 0030056861 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes
    • M.F. Brizzi, M.G. Aronica, A. Rosso, G.P. Bagnara, Y. Yarden, and L. Pegoraro Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes J Biol Chem 271 7 1996 3562 3567
    • (1996) J Biol Chem , vol.271 , Issue.7 , pp. 3562-3567
    • Brizzi, M.F.1    Aronica, M.G.2    Rosso, A.3    Bagnara, G.P.4    Yarden, Y.5    Pegoraro, L.6
  • 82
    • 57049185731 scopus 로고    scopus 로고
    • The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation
    • Y. Xu, N.H. Hunt, and S. Bao The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation Cell Res 18 12 2008 1220 1229
    • (2008) Cell Res , vol.18 , Issue.12 , pp. 1220-1229
    • Xu, Y.1    Hunt, N.H.2    Bao, S.3
  • 83
    • 38849170507 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
    • S.K. Sainathan, E.M. Hanna, Q. Gong, K.S. Bishnupuri, Q. Luo, M. Colonna, and et al. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis Inflamm Bowel Dis 14 1 2008 88 99
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.1 , pp. 88-99
    • Sainathan, S.K.1    Hanna, E.M.2    Gong, Q.3    Bishnupuri, K.S.4    Luo, Q.5    Colonna, M.6
  • 84
    • 77149133137 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing
    • E. Bernasconi, L. Favre, M.H. Maillard, D. Bachmann, C. Pythoud, H. Bouzourene, and et al. Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing Inflamm Bowel Dis 16 3 2010 428 441
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.3 , pp. 428-441
    • Bernasconi, E.1    Favre, L.2    Maillard, M.H.3    Bachmann, D.4    Pythoud, C.5    Bouzourene, H.6
  • 85
    • 62949238310 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    • X. Han, K. Uchida, I. Jurickova, D. Koch, T. Willson, C. Samson, and et al. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease Gastroenterology 136 4 2009 1261 1271
    • (2009) Gastroenterology , vol.136 , Issue.4 , pp. 1261-1271
    • Han, X.1    Uchida, K.2    Jurickova, I.3    Koch, D.4    Willson, T.5    Samson, C.6
  • 86
    • 84884543521 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor autoantibodies: A marker of aggressive Crohn's disease
    • G. Gathungu, M.O. Kim, J.P. Ferguson, Y. Sharma, W. Zhang, S.M. Ng, and et al. Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease Inflamm Bowel Dis 19 8 2013 1671 1680
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.8 , pp. 1671-1680
    • Gathungu, G.1    Kim, M.O.2    Ferguson, J.P.3    Sharma, Y.4    Zhang, W.5    Ng, S.M.6
  • 87
    • 84889677565 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease
    • J. Däbritz, E. Bonkowski, C. Chalk, B.C. Trapnell, J. Langhorst, L.A. Denson, and et al. Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease Am J Gastroenterol 108 12 2013 1901 1910
    • (2013) Am J Gastroenterol , vol.108 , Issue.12 , pp. 1901-1910
    • Däbritz, J.1    Bonkowski, E.2    Chalk, C.3    Trapnell, B.C.4    Langhorst, J.5    Denson, L.A.6
  • 88
    • 84924358868 scopus 로고    scopus 로고
    • Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation
    • J. Däbritz, T. Weinhage, G. Varga, T. Wirth, K. Walscheid, A. Brockhausen, and et al. Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation J Immunol 194 5 2015 2424 2438
    • (2015) J Immunol , vol.194 , Issue.5 , pp. 2424-2438
    • Däbritz, J.1    Weinhage, T.2    Varga, G.3    Wirth, T.4    Walscheid, K.5    Brockhausen, A.6
  • 89
    • 84860557456 scopus 로고    scopus 로고
    • New therapies for inflammatory bowel disease: From the bench to the bedside
    • S. Danese New therapies for inflammatory bowel disease: from the bench to the bedside Gut 61 2012 918 932
    • (2012) Gut , vol.61 , pp. 918-932
    • Danese, S.1
  • 90
    • 55149102403 scopus 로고    scopus 로고
    • Inborn errors of interferon (IFN)-mediated immunity in humans: Insights into the respective roles of IFN-α/β, IFN-γ, and IFN-lambda in host defense
    • S.Y. Zhang, S. Boisson-Dupuis, A. Chapgier, K. Yang, J. Bustamante, A. Puel, and et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-α/β, IFN-γ, and IFN-lambda in host defense Immunol Rev 226 2008 29 40
    • (2008) Immunol Rev , vol.226 , pp. 29-40
    • Zhang, S.Y.1    Boisson-Dupuis, S.2    Chapgier, A.3    Yang, K.4    Bustamante, J.5    Puel, A.6
  • 92
    • 0027494653 scopus 로고
    • The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
    • M. Müller, J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, and et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction Nature 366 1993 129 166
    • (1993) Nature , vol.366 , pp. 129-166
    • Müller, M.1    Briscoe, J.2    Laxton, C.3    Guschin, D.4    Ziemiecki, A.5    Silvennoinen, O.6
  • 93
    • 0027914818 scopus 로고
    • Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway
    • D. Watling, D. Guschin, M. Müller, O. Silvennoinen, B.A. Witthuhn, F.W. Quelle, and et al. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway Nature 366 6451 1993 166 170
    • (1993) Nature , vol.366 , Issue.6451 , pp. 166-170
    • Watling, D.1    Guschin, D.2    Müller, M.3    Silvennoinen, O.4    Witthuhn, B.A.5    Quelle, F.W.6
  • 95
    • 0028175969 scopus 로고
    • Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor
    • K. Igarashi, G. Garotta, L. Ozmen, A. Ziemiecki, A.F. Wilks, A.G. Harpur, and et al. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor J Biol Chem 269 1994 14333 14336
    • (1994) J Biol Chem , vol.269 , pp. 14333-14336
    • Igarashi, K.1    Garotta, G.2    Ozmen, L.3    Ziemiecki, A.4    Wilks, A.F.5    Harpur, A.G.6
  • 96
    • 0030062769 scopus 로고    scopus 로고
    • Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state
    • J. Briscoe, N.C. Rogers, B.A. Witthuhn, D. Watling, A.G. Harpur, A.F. Wilks, and et al. Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state EMBO J 15 4 1996 799 809
    • (1996) EMBO J , vol.15 , Issue.4 , pp. 799-809
    • Briscoe, J.1    Rogers, N.C.2    Witthuhn, B.A.3    Watling, D.4    Harpur, A.G.5    Wilks, A.F.6
  • 97
    • 84897020107 scopus 로고    scopus 로고
    • Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation
    • E. Keil, D. Finkenstädt, C. Wufka, M. Trilling, P. Liebfried, B. Strobl, and et al. Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation Blood 123 4 2014 520 529
    • (2014) Blood , vol.123 , Issue.4 , pp. 520-529
    • Keil, E.1    Finkenstädt, D.2    Wufka, C.3    Trilling, M.4    Liebfried, P.5    Strobl, B.6
  • 99
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-γ genes
    • D.K. Dalton, S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart Multiple defects of immune cell function in mice with disrupted interferon-γ genes Science 259 1993 1739 1742
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 101
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-γ: Implications for immune responses and autoimmune diseases
    • X. Hu, and L.B. Ivashkiv Cross-regulation of signaling pathways by interferon-γ: implications for immune responses and autoimmune diseases Immunity 31 2009 539 550
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 102
    • 0030209985 scopus 로고    scopus 로고
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5 J Immunol 157 1996 1261 1270
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    De La Motte, C.5    Strong, S.A.6
  • 104
    • 0034056441 scopus 로고    scopus 로고
    • Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice
    • W. Hans, J. Schölmerich, V. Gross, and W. Falk Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice Eur Cytokine Netw 11 2000 67 74
    • (2000) Eur Cytokine Netw , vol.11 , pp. 67-74
    • Hans, W.1    Schölmerich, J.2    Gross, V.3    Falk, W.4
  • 105
    • 33750049009 scopus 로고    scopus 로고
    • Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
    • R. Ito, M. Shin-Ya, T. Kishida, A. Urano, R. Takada, J. Sakagami, and et al. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice Clin Exp Immunol 146 2006 330 338
    • (2006) Clin Exp Immunol , vol.146 , pp. 330-338
    • Ito, R.1    Shin-Ya, M.2    Kishida, T.3    Urano, A.4    Takada, R.5    Sakagami, J.6
  • 106
    • 77949937466 scopus 로고    scopus 로고
    • Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways
    • P. Nava, S. Koch, M.G. Laukoetter, W.Y. Lee, K. Kolegraff, C.T. Capaldo, and et al. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways Immunity 32 3 2010 392 402
    • (2010) Immunity , vol.32 , Issue.3 , pp. 392-402
    • Nava, P.1    Koch, S.2    Laukoetter, M.G.3    Lee, W.Y.4    Kolegraff, K.5    Capaldo, C.T.6
  • 107
    • 79251585955 scopus 로고    scopus 로고
    • IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    • L.E. Glover, K. Irizarry, M. Scully, E.L. Campbell, B.E. Bowers, C.M. Aherne, and et al. IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β J Immunol 186 3 2011 1790 1798
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1790-1798
    • Glover, L.E.1    Irizarry, K.2    Scully, M.3    Campbell, E.L.4    Bowers, B.E.5    Aherne, C.M.6
  • 108
    • 77952784918 scopus 로고    scopus 로고
    • IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis
    • S.Z. Sheikh, K. Matsuoka, T. Kobayashi, F. Li, T. Rubinas, and S.E. Plevy IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis J Immunol 184 8 2010 4069 4073
    • (2010) J Immunol , vol.184 , Issue.8 , pp. 4069-4073
    • Sheikh, S.Z.1    Matsuoka, K.2    Kobayashi, T.3    Li, F.4    Rubinas, T.5    Plevy, S.E.6
  • 109
    • 73949092345 scopus 로고    scopus 로고
    • Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study
    • W. Reinisch, W. de Villiers, L. Bene, L. Simon, I. Rácz, S. Katz, and et al. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study Inflamm Bowel Dis 16 2 2010 233 242
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.2 , pp. 233-242
    • Reinisch, W.1    De Villiers, W.2    Bene, L.3    Simon, L.4    Rácz, I.5    Katz, S.6
  • 110
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell 74 2 1993 227 236
    • (1993) Cell , vol.74 , Issue.2 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6
  • 111
    • 84863015820 scopus 로고    scopus 로고
    • Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    • S. Gilbert, R. Zhang, L. Denson, R. Moriggl, K. Steinbrecher, N. Shroyer, and et al. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation EMBO Mol Med 4 2 2012 109 124
    • (2012) EMBO Mol Med , vol.4 , Issue.2 , pp. 109-124
    • Gilbert, S.1    Zhang, R.2    Denson, L.3    Moriggl, R.4    Steinbrecher, K.5    Shroyer, N.6
  • 112
    • 84922504279 scopus 로고    scopus 로고
    • Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration
    • S. Gilbert, H. Nivarthi, C.N. Mayhew, Y.H. Lo, T.K. Noah, J. Vallance, and et al. Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration Stem Cell Reports 4 2 2015 209 225
    • (2015) Stem Cell Reports , vol.4 , Issue.2 , pp. 209-225
    • Gilbert, S.1    Nivarthi, H.2    Mayhew, C.N.3    Lo, Y.H.4    Noah, T.K.5    Vallance, J.6
  • 113
    • 84907226117 scopus 로고    scopus 로고
    • Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis
    • M.G. Works, F. Yin, C.C. Yin, Y. Yiu, K. Shew, T.T. Tran, and et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis J Immunol 193 7 2014 3278 3287
    • (2014) J Immunol , vol.193 , Issue.7 , pp. 3278-3287
    • Works, M.G.1    Yin, F.2    Yin, C.C.3    Yiu, Y.4    Shew, K.5    Tran, T.T.6
  • 114
    • 84976295951 scopus 로고    scopus 로고
    • Block Th1- and Th17-mediated immune responses and reduce disease progression in rodent models of delayed-type hypersensitivity and psoriasis
    • Selective Tyk2 Inhibitors [abstract]
    • W. Miao, C. Masse, J. Greenwood, R. Kapeller, Westlin.W. Potent, and Selective Tyk2 Inhibitors Block Th1- and Th17-mediated immune responses and reduce disease progression in rodent models of delayed-type hypersensitivity and psoriasis Arthritis Rheumatol 67 Suppl. 10 2015 [abstract]
    • (2015) Arthritis Rheumatol , vol.67
    • Miao, W.1    Masse, C.2    Greenwood, J.3    Kapeller, R.4    Potent, W.W.5
  • 115
    • 84970935850 scopus 로고    scopus 로고
    • Structure-based design and synthesis of 3-amino-1,5-dihydro-4h-pyrazolopyridin-4-one derivatives as tyrosine kinase 2 inhibitors
    • T. Yogo, H. Nagamiya, M. Seto, S. Sasaki, H. Shih-Chung, Y. Ohba, and et al. Structure-based design and synthesis of 3-amino-1,5-dihydro-4h-pyrazolopyridin-4-one derivatives as tyrosine kinase 2 inhibitors J Med Chem 59 2 2016 733 749
    • (2016) J Med Chem , vol.59 , Issue.2 , pp. 733-749
    • Yogo, T.1    Nagamiya, H.2    Seto, M.3    Sasaki, S.4    Shih-Chung, H.5    Ohba, Y.6
  • 116
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • W.J. Sandborn, S. Ghosh, J. Panes, I. Vranic, C. Su, S. Rousell, and et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis N Engl J Med 367 7 2012 616 624
    • (2012) N Engl J Med , vol.367 , Issue.7 , pp. 616-624
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Su, C.5    Rousell, S.6
  • 117
    • 84976307365 scopus 로고    scopus 로고
    • http://www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-positive-top-line-results-from-two-phase-3-trials-of-oral-tofacitinib-in-adults-with-moderate-to-severe-ulcerative-colitis; 2015.
    • (2015)
  • 118
    • 84906792069 scopus 로고    scopus 로고
    • A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease
    • W.J. Sandborn, S. Ghosh, J. Panes, I. Vranic, W. Wang, W. Niezychowski, and et al. A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease Clin Gastroenterol Hepatol 12 9 2014 1485 1493
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.9 , pp. 1485-1493
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Wang, W.5    Niezychowski, W.6
  • 119
    • 84887112200 scopus 로고    scopus 로고
    • Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis
    • J. Mishra, R.K. Verma, G. Alpini, F. Meng, and N. Kumar Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis J Biol Chem 288 44 2013 31795 31806
    • (2013) J Biol Chem , vol.288 , Issue.44 , pp. 31795-31806
    • Mishra, J.1    Verma, R.K.2    Alpini, G.3    Meng, F.4    Kumar, N.5
  • 120
    • 84885103906 scopus 로고    scopus 로고
    • Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases
    • L. Van Rompaey, R. Galien, E.M. van der Aar, P. Clement-Lacroix, L. Nelles, B. Smets, and et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases J Immunol 191 7 2013 3568 3577
    • (2013) J Immunol , vol.191 , Issue.7 , pp. 3568-3577
    • Van Rompaey, L.1    Galien, R.2    Van Der Aar, E.M.3    Clement-Lacroix, P.4    Nelles, L.5    Smets, B.6
  • 121
    • 85020962261 scopus 로고    scopus 로고
    • GLPG0634, the first selective JAK1 inhibitor, shows strong activity in the mouse DSS-colitis model
    • D. Merciris, C. Delachaume, V. De Vriendt, A.L. Boutet, L. Perret, M.C. Ceccotti, and et al. GLPG0634, the first selective JAK1 inhibitor, shows strong activity in the mouse DSS-colitis model J Crohns Colitis 8 Suppl. 1 2014 S92
    • (2014) J Crohns Colitis , vol.8 , pp. S92
    • Merciris, D.1    Delachaume, C.2    De Vriendt, V.3    Boutet, A.L.4    Perret, L.5    Ceccotti, M.C.6
  • 122
    • 84976322693 scopus 로고    scopus 로고
    • http://www.glpg.com/docs/view/5665ff4ee8e93-en; 2015.
    • (2015)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.