TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Diogo, Dorothée ^a,b,c,ac   Bastarache, Lisa ^d   Liao, Katherine P ^a   Graham, Robert R ^e   Fulton, Robert S ^f   Greenberg, Jeffrey D ^g   Eyre, Steve ^h   Bowes, John ^h   Cui, Jing ^a   Lee, Annette ⁱ   Pappas, Dimitrios A ^j   Kremer, Joel M ^k   Barton, Anne ^h   Coenen, Marieke J H ^l   Franke, Barbara ^m   Kiemeney, Lambertus A ^l   Mariette, Xavier ^n,o   Richard Miceli, Corrine ^n,o   Canhão, Helena ^p,q   Fonseca, João E ^p,q   De Vries, Niek ^r   Tak, Paul P ^r,ad   Crusius, J Bart A ^s   Nurmohamed, Michael T ^t   Kurreeman, Fina ^u   Mikuls, Ted R ^v   Okada, Yukinori ^a,b,ae   Stahl, Eli A ^a,b,af   Larson, David E ^f   Deluca, Tracie L ^f   O'Laughlin, Michelle ^f   Fronick, Catrina C ^f   Fulton, Lucinda L ^f   Kosoy, Roman ^w   Ransom, Michael ^w   Bhangale, Tushar R ^e   Ortmann, Ward ^e   Cagan, Andrew ^x   Gainer, Vivian ^x   Karlson, Elizabeth W ^a   Kohane, Isaac ^x   Murphy, Shawn N ^x   Martin, Javier ^y   Zhernakova, Alexandra ^u,z   Klareskog, Lars ^aa   Padyukov, Leonid ^aa   Worthington, Jane ^h,ag   Mardis, Elaine R ^f   Seldin, Michael F ^v   Gregersen, Peter K ⁱ   Behrens, Timothy ^e   Raychaudhuri, Soumya ^a,b,c,h   Denny, Joshua C ^d,ab   Plenge, Robert M ^a,b,ac   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c LABORATORY FOR MOLECULAR MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e GENENTECH INC   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g NYU HOSPITAL FOR JOINT DISEASES   (United States)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ Arthritis Research UK Epidemiology Unit University of Manchester Manchester Academic Health Sciences Centre ^*  (United States)

^j Feinstein Institute for Medical Research North Shore Long Island Jewish Health System ^*  (United States)

^k Center for Rheumatology LLP   (United States)

^l RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^m RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ UNIVERSITÉ PARIS SACLAY   (France)

^o BICÊTRE HOSPITAL   (France)

^p UNIVERSITY OF LISBON   (Portugal)

^q HOSPITAL DE SANTA MARIA   (Portugal)

^r UNIVERSITY OF AMSTERDAM   (Netherlands)

^s VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^t Academic Center Amsterdam   (Netherlands)

^u LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^v UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x PARTNERS HEALTHCARE   (United States)

^y INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^z UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^aa KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^ab VANDERBILT UNIVERSITY   (United States)

^ac MERCK RESEARCH LABORATORIES   (United States)

^ad UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ae GLAXOSMITHKLINE   (United Kingdom)

^af RIKEN Center for Integrative Medical Sciences   (Japan)

^ag MOUNT SINAI SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE 1; CELL ADHESION MOLECULE; PROTEIN KINASE TYK2;

ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXON; GENE; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; PATHOGENESIS; PHENOTYPE; PLEIOTROPY; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS; TYK2 GENE; ELECTRONIC HEALTH RECORD; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; CELL ADHESION MOLECULES; ELECTRONIC HEALTH RECORDS; EXONS; GENETIC LOCI; GENETIC PLEIOTROPY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; TYK2 KINASE;

EID: 84928920020     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122271     Document Type: Article

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