Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation

EMBO Molecular Medicine

Volumn 4, Issue 2, 2012, Pages 109-124

  Gilbert, Shila ^a   Zhang, Rongli ^b   Denson, Lee ^a   Moriggl, Richard ^c   Steinbrecher, Kris ^a   Shroyer, Noah ^a   Lin, James ^a   Han, Xiaonan ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b PEKING UNIVERSITY   (China)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Inflammatory bowel disease (IBD); Myosin light chain kinase (MLCK); Nuclear factor B (NF B); Signals transducers and activators of transcription (STAT) 5; Tight junction (TJ)

Indexed keywords

CASPASE 3; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYOSIN LIGHT CHAIN KINASE; PIROXICAM; PROTEIN BAX; PROTEIN ZO1; PROTEIN ZO2; STAT5 PROTEIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZONULA OCCLUDENS 3 PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CRYPT CELL; DNA BINDING; DRUG MECHANISM; ELECTRIC RESISTANCE; ENTERITIS; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; FEMALE; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; KNOCKOUT MOUSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TIGHT JUNCTION; WOUND HEALING;

ANIMALS; EPITHELIAL CELLS; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTESTINAL MUCOSA; MALE; MICE; MICE, KNOCKOUT; MYOSIN-LIGHT-CHAIN KINASE; STAT5 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 84863015820     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100192     Document Type: Article

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