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Volumn 180, Issue 10, 2008, Pages 6816-6826

IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINE; GAMMA INTERFERON; GLYCINE; INTERLEUKIN 6; NITRIC OXIDE; PROTEIN BCL 3; PROTEIN BCL XL; PROTEIN CIAP 2; PROTEIN MCL 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 45549097533     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.10.6816     Document Type: Article
Times cited : (155)

References (55)
  • 1
    • 0031984684 scopus 로고    scopus 로고
    • Diarrheagenic Escherichia coli
    • Nataro, J. P., and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11: 142-201.
    • (1998) Clin. Microbiol. Rev , vol.11 , pp. 142-201
    • Nataro, J.P.1    Kaper, J.B.2
  • 2
    • 0038339444 scopus 로고    scopus 로고
    • Adheion of enteropathogenic Escherichia coli to host cells
    • Nougayrede, J. P., P. J. Fernandes, and M. S. Donnenberg. 2003. Adheion of enteropathogenic Escherichia coli to host cells. Cell. Microbiol. 5: 359-372.
    • (2003) Cell. Microbiol , vol.5 , pp. 359-372
    • Nougayrede, J.P.1    Fernandes, P.J.2    Donnenberg, M.S.3
  • 3
    • 0029803669 scopus 로고    scopus 로고
    • Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodenlium eaeA mutant: Induction of an immunoglobulin A response to intimin and EspB
    • Frankel, G., A. D. Phillips, M. Novakova, H. Field, D. C. Candy, D. B. Schauer, G. Douce, and G. Dougan. 1996. Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodenlium eaeA mutant: induction of an immunoglobulin A response to intimin and EspB. Infect. Immun. 64: 5315-5325.
    • (1996) Infect. Immun , vol.64 , pp. 5315-5325
    • Frankel, G.1    Phillips, A.D.2    Novakova, M.3    Field, H.4    Candy, D.C.5    Schauer, D.B.6    Douce, G.7    Dougan, G.8
  • 4
    • 0035029103 scopus 로고    scopus 로고
    • Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hypcrplasia
    • Luperchio, S. A., and D. B. Schauer. 2001. Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hypcrplasia. Microbes Infect. 3: 333-340.
    • (2001) Microbes Infect , vol.3 , pp. 333-340
    • Luperchio, S.A.1    Schauer, D.B.2
  • 5
    • 0018718860 scopus 로고
    • The ultrastructure of transmissible murine colonic hyperplasia
    • Johnson, E., and S. W. Barthold. 1979. The ultrastructure of transmissible murine colonic hyperplasia. Am. J. Pathol. 97: 291-313.
    • (1979) Am. J. Pathol , vol.97 , pp. 291-313
    • Johnson, E.1    Barthold, S.W.2
  • 6
    • 0027492999 scopus 로고
    • The cae gene of Citrobacter freundii bio-type 4280 is necessary for colonization in transmissible murine colonic hyperplasia
    • Schauer, D. B., and S. Falkow. 1993. The cae gene of Citrobacter freundii bio-type 4280 is necessary for colonization in transmissible murine colonic hyperplasia. Infect. Immun. 61: 4654-4661.
    • (1993) Infect. Immun , vol.61 , pp. 4654-4661
    • Schauer, D.B.1    Falkow, S.2
  • 7
    • 0036128828 scopus 로고    scopus 로고
    • Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
    • Vallance, B. A., W. Deng, L. A. Knodler, and B. B. Finlay. 2002. Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect. Immun. 70: 2070-2081.
    • (2002) Infect. Immun , vol.70 , pp. 2070-2081
    • Vallance, B.A.1    Deng, W.2    Knodler, L.A.3    Finlay, B.B.4
  • 9
    • 0347364688 scopus 로고    scopus 로고
    • Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium. an attaching and effacing pathogen
    • Bry, L., and M. B. Brenner. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium. an attaching and effacing pathogen. J. Immunol. 172: 433-441.
    • (2004) J. Immunol , vol.172 , pp. 433-441
    • Bry, L.1    Brenner, M.B.2
  • 10
    • 0036839654 scopus 로고    scopus 로고
    • Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice
    • Vallance, B. A., W. Deng, M. De Grado, C. Chan, K. Jacobson, and B. B. Finlay. 2002. Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice. Infect. Immun. 70: 6424-6435.
    • (2002) Infect. Immun , vol.70 , pp. 6424-6435
    • Vallance, B.A.1    Deng, W.2    De Grado, M.3    Chan, C.4    Jacobson, K.5    Finlay, B.B.6
  • 11
    • 0037083505 scopus 로고    scopus 로고
    • Impaired resistance and enhanced pathology during infection with a noninvasive, attach-ing-effacing enteric bacterial pathogen, Citrobacter rodenlium. in mice lacking IL-12 or IFN-γ
    • Simmons, C. P., N. S. Goncalves, M. Ghaem-Maghami, M. Bajaj-EIliott, S. Clare, B. Neves, G. Frankel, G. Dougan, and T. T. MacDonald. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attach-ing-effacing enteric bacterial pathogen, Citrobacter rodenlium. in mice lacking IL-12 or IFN-γ. J. Immunol. 168: 1804-1812.
    • (2002) J. Immunol , vol.168 , pp. 1804-1812
    • Simmons, C.P.1    Goncalves, N.S.2    Ghaem-Maghami, M.3    Bajaj-EIliott, M.4    Clare, S.5    Neves, B.6    Frankel, G.7    Dougan, G.8    MacDonald, T.T.9
  • 12
    • 0034773205 scopus 로고    scopus 로고
    • Critical role for tumor necrosis factor α in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis
    • Goncalves, N. S., M. Ghaem-Maghami, G. Monteleone, G. Frankel, G. Dougan, D. J. Lewis, C. P. Simmons, and T. T. MacDonald. 2001. Critical role for tumor necrosis factor α in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect. Immun. 69: 6651-6659.
    • (2001) Infect. Immun , vol.69 , pp. 6651-6659
    • Goncalves, N.S.1    Ghaem-Maghami, M.2    Monteleone, G.3    Frankel, G.4    Dougan, G.5    Lewis, D.J.6    Simmons, C.P.7    MacDonald, T.T.8
  • 15
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6): A molecule with both beneficial and destructive potentials
    • Gadient, R. A., and U. H. Otten. 1997. Interleukin-6 (IL-6): a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 52: 379-390.
    • (1997) Prog. Neurobiol , vol.52 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 16
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine: 40 years in immunology
    • Kishimoto, T. 2005. Interleukin-6: from basic science to medicine: 40 years in immunology. Annu. Rev. Immunol. 23: 1-21.
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 17
    • 0023851809 scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
    • Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 1 67: 332-344.
    • (1988) J. Exp. Med , vol.1 , Issue.67 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3    Matsuda, T.4    Horii, Y.5    Nakajima, K.6    Kishimoto, T.7
  • 19
    • 0029934454 scopus 로고    scopus 로고
    • IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection
    • Bromander, A. K., L. Ekman, M. Kopf, J. G. Nedrud, and N. Y. Lycke. 1996. IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection. J. Immunol. 156: 4290-4297.
    • (1996) J. Immunol , vol.156 , pp. 4290-4297
    • Bromander, A.K.1    Ekman, L.2    Kopf, M.3    Nedrud, J.G.4    Lycke, N.Y.5
  • 21
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto, M., K. Yoshizaki, T. Kishimoto, and H. Ito. 2000. IL-6 is required for the development of Th1 cell-mediated murine colitis. J. Immunol. 164: 4878-4882.
    • (2000) J. Immunol , vol.164 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 22
    • 0024404853 scopus 로고
    • IL-6 inhibits lipopolysaccharide-in-duced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice
    • Aderka, D., J. M. Le, and J. Vilcek. 1989. IL-6 inhibits lipopolysaccharide-in-duced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J. Immunol. 143: 3517-3523.
    • (1989) J. Immunol , vol.143 , pp. 3517-3523
    • Aderka, D.1    Le, J.M.2    Vilcek, J.3
  • 23
    • 0025805971 scopus 로고
    • Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor β inhibit acute inflammation
    • Ulich, T. R., S. Yin, K. Guo, E. S. Yi, D. Remick, and J. del Castillo. 1991. Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor β inhibit acute inflammation. Am. J. Pathol. 138: 1097-1101.
    • (1991) Am. J. Pathol , vol.138 , pp. 1097-1101
    • Ulich, T.R.1    Yin, S.2    Guo, K.3    Yi, E.S.4    Remick, D.5    del Castillo, J.6
  • 24
    • 0029007193 scopus 로고
    • Interleukin-6-deficient mice are highly susceptible to Lisleria monocytogenes infection: Correlation with inefficient neutrophitia
    • Dalrymple, S. A., L. A. Lucian, R. Slattery, T. McNeil, D. M. Aud, S. Fuchino, F. Lee, and R. Murray. 1995. Interleukin-6-deficient mice are highly susceptible to Lisleria monocytogenes infection: correlation with inefficient neutrophitia. Infect. Immun. 63: 2262-2268.
    • (1995) Infect. Immun , vol.63 , pp. 2262-2268
    • Dalrymple, S.A.1    Lucian, L.A.2    Slattery, R.3    McNeil, T.4    Aud, D.M.5    Fuchino, S.6    Lee, F.7    Murray, R.8
  • 27
    • 0027224059 scopus 로고
    • Clinico-pathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper, H. S., S. N. Murthy, R. S. Shah, and D. J. Sedergran. 1993. Clinico-pathologic study of dextran sulfate sodium experimental murine colitis. Lab. Invest. 69: 238-249.
    • (1993) Lab. Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 28
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F. R., L. Eckmann, T. F. Greten, J. M. Park, Z. W. Li, L. J. Egan, M. F. Kagnoff, and M. Karin. 2004. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 29
    • 0041806533 scopus 로고    scopus 로고
    • Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2
    • Nishihara, H., S. Kizaka-Kondoh, P. A. Insel, and L. Eckmann. 2003. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc. Natl. Acad. Sci. USA 100: 8921-8926.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8921-8926
    • Nishihara, H.1    Kizaka-Kondoh, S.2    Insel, P.A.3    Eckmann, L.4
  • 30
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 31
    • 2942558688 scopus 로고    scopus 로고
    • Increased and long-term generation of dcndritic cells with reduced function from IL-6-deficient bone marrow
    • Bleier, J. I., V. G. Pillarisetty, A. B. Shah, and R. P. DeMatteo. 2004. Increased and long-term generation of dcndritic cells with reduced function from IL-6-deficient bone marrow. J. Immunol. 172: 7408-7416.
    • (2004) J. Immunol , vol.172 , pp. 7408-7416
    • Bleier, J.I.1    Pillarisetty, V.G.2    Shah, A.B.3    DeMatteo, R.P.4
  • 32
    • 0036399823 scopus 로고    scopus 로고
    • How host-microbial interactions shape the nutrient environment of the mammalian intestine
    • Hooper, L. V., T. Midtvedt, and J. I. Gordon. 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22: 283-307.
    • (2002) Annu. Rev. Nutr , vol.22 , pp. 283-307
    • Hooper, L.V.1    Midtvedt, T.2    Gordon, J.I.3
  • 33
    • 34247264918 scopus 로고    scopus 로고
    • Interleukin-6 induces keratin expression in intestinal epithelial cells: Potential role of keratin-8 in interleukin-6-induced barrier function alterations
    • Wang, L., S. Srinivasan, A. L. Theiss, D. Merlin, and S. V. Sitaraman. 2007. Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations. J. Biol. Chem. 282: 8219-8227.
    • (2007) J. Biol. Chem , vol.282 , pp. 8219-8227
    • Wang, L.1    Srinivasan, S.2    Theiss, A.L.3    Merlin, D.4    Sitaraman, S.V.5
  • 34
    • 2542552037 scopus 로고    scopus 로고
    • Protective role of interleukin-6 during Yersinia enlerocolitica infection is mediated through the modulation of inflammatory cytokines
    • Dube, P. H., S. A. Handley, J. Lewis, and V. L. Miller. 2004. Protective role of interleukin-6 during Yersinia enlerocolitica infection is mediated through the modulation of inflammatory cytokines. Infect. Immun. 72: 3561-3570.
    • (2004) Infect. Immun , vol.72 , pp. 3561-3570
    • Dube, P.H.1    Handley, S.A.2    Lewis, J.3    Miller, V.L.4
  • 35
    • 0037369799 scopus 로고    scopus 로고
    • Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice
    • Zhou, P., E. Li, N. Zhu, J. Robertson, T. Nash, and S. M. Singer. 2003. Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice. Infect. Immun. 71: 1566-1568.
    • (2003) Infect. Immun , vol.71 , pp. 1566-1568
    • Zhou, P.1    Li, E.2    Zhu, N.3    Robertson, J.4    Nash, T.5    Singer, S.M.6
  • 36
    • 0037369751 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite
    • Bienz, M., W. J. Dai, M. Welle, B. Gottstein, and N. Muller. 2003. Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite. Infect. Immun. 71: 1569-1573.
    • (2003) Infect. Immun , vol.71 , pp. 1569-1573
    • Bienz, M.1    Dai, W.J.2    Welle, M.3    Gottstein, B.4    Muller, N.5
  • 39
    • 0346249810 scopus 로고    scopus 로고
    • Mucosal defences against Giardia
    • Eckmann, L. 2003. Mucosal defences against Giardia. Parasite Immunol. 25: 259-270.
    • (2003) Parasite Immunol , vol.25 , pp. 259-270
    • Eckmann, L.1
  • 40
    • 4544302531 scopus 로고    scopus 로고
    • Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium
    • Wiles, S., S. Clare, J. Harker, A. Huett, D. Young, G. Dougan, and G. Frankel. 2004. Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cell. Microbiol. 6: 963-972.
    • (2004) Cell. Microbiol , vol.6 , pp. 963-972
    • Wiles, S.1    Clare, S.2    Harker, J.3    Huett, A.4    Young, D.5    Dougan, G.6    Frankel, G.7
  • 41
    • 0034065413 scopus 로고    scopus 로고
    • Protective immunity to rotavirus shedding in the ab-sence of interleukin-6: Th1 cells and immunoglobulin A develop normally
    • VanCott, J. L., M. A. Franco, H. B. Greenberg, S. Sabbaj, B. Tang, R. Murray, and J. R. McGhee. 2000. Protective immunity to rotavirus shedding in the ab-sence of interleukin-6: Th1 cells and immunoglobulin A develop normally. J. Virol. 74: 5250-5256.
    • (2000) J. Virol , vol.74 , pp. 5250-5256
    • VanCott, J.L.1    Franco, M.A.2    Greenberg, H.B.3    Sabbaj, S.4    Tang, B.5    Murray, R.6    McGhee, J.R.7
  • 42
    • 17044404692 scopus 로고    scopus 로고
    • Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    • Iimura, M., R. L. Gallo, K. Hase, Y. Miyamoto, L. Eckmann, and M. F. Kagnoff. 2005. Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 174: 4901-4907.
    • (2005) J. Immunol , vol.174 , pp. 4901-4907
    • Iimura, M.1    Gallo, R.L.2    Hase, K.3    Miyamoto, Y.4    Eckmann, L.5    Kagnoff, M.F.6
  • 44
    • 0031160086 scopus 로고    scopus 로고
    • IL-6 induction of protein-DNA complexes via a novel regulatory region of the induc-ible nitric oxide synthase gene promoter: Role of octamer binding proteins
    • Sawada, T., L. A. Falk, P. Rao, W. J. Murphy, and D. H. Pluznik. 1997. IL-6 induction of protein-DNA complexes via a novel regulatory region of the induc-ible nitric oxide synthase gene promoter: role of octamer binding proteins. J. Immunol. 158: 5267-5276.
    • (1997) J. Immunol , vol.158 , pp. 5267-5276
    • Sawada, T.1    Falk, L.A.2    Rao, P.3    Murphy, W.J.4    Pluznik, D.H.5
  • 47
    • 33748469912 scopus 로고    scopus 로고
    • Correlation between cyclical epithelial barrier dysfunction and bacterial translo-cation in the relapses of intestinal inflammation
    • Porras, M., M. T. Martin, P. C. Yang, J. Jury, M. H. Perdue, and P. Vergara. 2006. Correlation between cyclical epithelial barrier dysfunction and bacterial translo-cation in the relapses of intestinal inflammation. Inflamm. Bowel Dis. 12: 843-852.
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 843-852
    • Porras, M.1    Martin, M.T.2    Yang, P.C.3    Jury, J.4    Perdue, M.H.5    Vergara, P.6
  • 48
    • 0031252807 scopus 로고    scopus 로고
    • Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli
    • Savkovic, S. D., A. Koutsouris, and G. Hecht. 1997. Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli. Am. J. Physiol. 273:C1160-C1167.
    • (1997) Am. J. Physiol , vol.273
    • Savkovic, S.D.1    Koutsouris, A.2    Hecht, G.3
  • 49
    • 0037111523 scopus 로고    scopus 로고
    • Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAPymyeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages
    • Schilling, D., K. Thomas, K. Nixdorff, S. N. Vogel, and M. J. Fenton. 2002. Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAPymyeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. J. Immunol. 169: 5874-5880.
    • (2002) J. Immunol , vol.169 , pp. 5874-5880
    • Schilling, D.1    Thomas, K.2    Nixdorff, K.3    Vogel, S.N.4    Fenton, M.J.5
  • 50
    • 38049174332 scopus 로고    scopus 로고
    • Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-in-duced colitis
    • Gibson, D. L., C. Ma, C. M. Rosenberger, K. S. B. Bergstrom, Y. Valdez, J. T. Huang, M. A. Khan, and B. A. Vallance. 2008. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-in-duced colitis. Cell. Microbiol. 10: 388-403.
    • (2008) Cell. Microbiol , vol.10 , pp. 388-403
    • Gibson, D.L.1    Ma, C.2    Rosenberger, C.M.3    Bergstrom, K.S.B.4    Valdez, Y.5    Huang, J.T.6    Khan, M.A.7    Vallance, B.A.8
  • 51
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya, R., J. Mudter, S. Finotto, J. Mullberg, T. Jostock, S. Wirtz, M. Schutz, B. Bartsch, M. Holtmann, C. Becker, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat. Med. 6: 583-588.
    • (2000) Nat. Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6    Schutz, M.7    Bartsch, B.8    Holtmann, M.9    Becker, C.10
  • 54
    • 29144528036 scopus 로고    scopus 로고
    • STAT3-mediated transcription of Bcl-2, Mcl-1 and C-IAP2 prevents apoptosis in polyamine-depleted cells
    • Bhattacharya, S., R. M. Ray, and L. R. Johnson. 2005. STAT3-mediated transcription of Bcl-2, Mcl-1 and C-IAP2 prevents apoptosis in polyamine-depleted cells. Biochem. J. 392: 335-344.
    • (2005) Biochem. J , vol.392 , pp. 335-344
    • Bhattacharya, S.1    Ray, R.M.2    Johnson, L.R.3


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