Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

Nature Immunology

Volumn 3, Issue 9, 2002, Pages 859-866

  Hu, Xiaoyu ^a   Herrero, Carmen ^b   Li, Wai Ping ^b   Antoniv, Taras T ^b   Falck Pedersen, Erik ^a   Koch, Alisa E ^c   Woods, James M ^d   Haines, G Kenneth ^d   Ivashkiv, Lionel B ^a  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c Veterans Administration   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; JANUS KINASE; LIPOPOLYSACCHARIDE; STAT PROTEIN;

ACUTE DISEASE; ANIMAL CELL; ARTICLE; CELL STIMULATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SENSITIVITY ANALYSIS; SENSITIZATION; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 1; JANUS KINASE 2; MACROPHAGE ACTIVATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS;

EID: 0036734498     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni828     Document Type: Article

References (51)

1. Cellular responses to interferon-γ
2. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
3. Immune response in mice that lack the interferon-γ receptor
4. Infections in IFN-γR-I-deficient children
5. Chronic active hepatitis in transgenic mice expressing interferon-γ in the liver
6. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
7. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
8. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon γ in the epidermis
9. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-I (STAT-induced STAT inhibitor-I) deficient mice
10. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
11. SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine
12. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
13. STATs and gene regulation
14. How cells respond to interferons
15. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
16. Targeted disruption of the mouse STAT1 gene results in compromised innate immunity to viral disease
17. Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper cell subsets
18. H1 cells
19. A nuclear protein tyrosine phosphatase is required for the inactivation of STAT1
20. The role of protein tyrosine phosphatase SHP-I in the regulation of IFN-γ signaling in neural cells
21. Differential regulation of the α/β interferon-stimulated Jak/STAT pathway by the SH2 domain-containing tyrosine phosphatase SHPTPI
22. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway
23. Negative regulation of cytokine signaling pathways
24. Inhibition of STAT1-mediated gene activation by PIAS1
25. A transcriptional corepressor of STAT1 with an essential LXXLL signature motif
26. Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains
27. Functional role of type I and type II interferons inantiviral defense
28. A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated STAT5
29. Cytokine expression and cell activation in inflammatory arthritis
30. Endocytosis and molecular sorting
31. The human interleukin-2 receptor: Normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses
32. Biologic consequences of STAT1-independent IFN-signaling
33. STAT1-independent regulation of gene expression in response to IFN-γ
34. Serine phosphorylation of STATs
35. Arginine methylation of STAT1 modulates IFN-α/β-induced transcription
36. SOCS proteins: Negative regulators of cytokine signaling
37. Modulation of STAT signaling by STAT-interacting proteins
38. The STAT1 binding motif of the interferon-γ receptor is sufficient to mediate STAT5 activation and its repression by SOCS3
39. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity
40. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ
41. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
42. IFN-γ-dependent transcription of MHC class II IA is impaired in macrophages from aged mice
43. Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell-receptor-mediated feedback inhibition of T cell expansion
44. Inhibition of transcription factor STAT1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway
45. Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts
46. Contruction and characterization of hexon-chimeric adenoviruses: Specification of adenovirus serotype
47. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
48. Macrophage inflammatory protein-1 α. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
49. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis
50. Monoclonal antibodies defining shared human macrophage-endothelial antigens
51. Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages