A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules

Journal of Pharmaceutical Sciences

Volumn 100, Issue 12, 2011, Pages 5115-5125

  Stackhouse, Nicole ^a   Miller, Amanda K ^a   Gadgil, Himanshu S ^a  

^a AMGEN INC   (United States)

Author keywords

Analytical biochemistry; Biopharmaceuticals characterization; Chromatography; Formulation; High throughput technologies; HPLC (high performance pressure liquid chromatography); LC MS

Indexed keywords

ASPARTIC ACID; DODECYL SULFATE SODIUM; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; MONOCLONAL ANTIBODY; PHENYL GROUP; PROLINE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL MODIFICATION; DEGRADATION; DRUG FORMULATION; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; OXIDATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 80054946415     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22710     Document Type: Article

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