Design principles involving protein disorder facilitate specific substrate selection and degradation by the ubiquitin-proteasome system

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 6723-6731

  Guharoy, Mainak ^a,b   Bhowmick, Pallab ^a,b   Tompa, Peter ^a,b,c  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIODEGRADATION; PROTEINS;

BIOCHEMICAL EXPERIMENTS; CONFORMATIONAL FLEXIBILITY; DISORDERED REGIONS; ENZYMATIC ACTIVITIES; POST-TRANSLATIONAL MODIFICATIONS; SPECIFIC SUBSTRATES; STRUCTURAL DISORDERS; UBIQUITIN-PROTEASOME SYSTEM;

SUBSTRATES;

UBIQUITIN PROTEIN LIGASE E3; ATP DEPENDENT 26S PROTEASE; INTRINSICALLY DISORDERED PROTEIN; PROTEASOME; PROTEIN BINDING; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; BIOCHEMICAL ANALYSIS; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; DEGRON; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR BIOLOGY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN STRUCTURAL DISORDER; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; PROTEIN TRANSPORT; PROTEIN UNFOLDING; REVIEW; SHORT LINEAR MOTIF; SPECIFIC SUBSTRATE SELECTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; UBIQUITIN PROTEASOME SYSTEM; UBIQUITINATION; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE;

AMINO ACID MOTIFS; HUMANS; INTRINSICALLY DISORDERED PROTEINS; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84964789923     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R115.692665     Document Type: Review

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