Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates

EMBO Journal

Volumn 27, Issue 5, 2008, Pages 804-816

  Ng, Cherlyn ^a   Jackson, Rebecca A ^b   Buschdorf, Jan P ^b   Sun, Qingxiang ^a   Guy, Graeme R ^b   Sivaraman, J ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

c Cbl; EGFR; Met; Reverse binding; Sprouty; TKB domain; X ray crystallography

Indexed keywords

ARGININE; ASPARAGINE; CBL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHOTYROSINE; PROTEIN KINASE SYK; PROTEIN SH2; PROTEIN SPROUTY2; PROTEIN SPROUTY4; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; SPROUTY PROTEIN; UNCLASSIFIED DRUG; GROWTH FACTOR RECEPTOR; MET PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHOPEPTIDE; SIGNAL PEPTIDE; SPRY2 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; BINDING SITE; CELL LINE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SRC HOMOLOGY DOMAIN;

BINDING SITES; CELL LINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTORS, GROWTH FACTOR; SRC HOMOLOGY DOMAINS;

EID: 40949140084     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.18     Document Type: Article

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