메뉴 건너뛰기




Volumn 33, Issue 4, 2014, Pages 385-399

Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation

Author keywords

Dynamic proteomics; Protein profile similarity screening; Quantitative proteomics; TMT labeling; Ubiquitination dependent protein degradation

Indexed keywords

ANAPHASE PROMOTING COMPLEX; KIF18A ENZYME; KIF2C ENZYME; KIF4A ENZYME; KIFC1 ENZYME; KINESIN; UNCLASSIFIED DRUG;

EID: 84897823745     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201385876     Document Type: Article
Times cited : (59)

References (78)
  • 1
    • 0001218562 scopus 로고
    • The statistical analysis of compositional data
    • Aitchison J (1982) The statistical analysis of compositional data. J R Stat Soc Series B 44: 139-177
    • (1982) J R Stat Soc Series B , vol.44 , pp. 139-177
    • Aitchison, J.1
  • 4
    • 28844439263 scopus 로고    scopus 로고
    • Identification of ubiquitin ligase substrates by in vitro expression cloning
    • Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW (2005) Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol 399: 404-414
    • (2005) Methods Enzymol , vol.399 , pp. 404-414
    • Ayad, N.G.1    Rankin, S.2    Ooi, D.3    Rape, M.4    Kirschner, M.W.5
  • 5
    • 0027453616 scopus 로고
    • Model-based Gaussian and non-Gaussian clustering
    • Banfield JD, Raftery AE (1993) Model-based Gaussian and non-Gaussian clustering. Biometrics 49: 803-821
    • (1993) Biometrics , vol.49 , pp. 803-821
    • Banfield, J.D.1    Raftery, A.E.2
  • 7
    • 38049053535 scopus 로고    scopus 로고
    • Compositions: A unified R package to analyze compositional data
    • van den Boogaart KG, Tolosana-Delgado R (2008) compositions: a unified R package to analyze compositional data. Comput Geosci 34: 320-338
    • (2008) Comput Geosci , vol.34 , pp. 320-338
    • Van Den-Boogaart, K.G.1    Tolosana-Delgado, R.2
  • 9
    • 33846348374 scopus 로고    scopus 로고
    • Combining expression and comparative evolutionary analysis. The COBRA gene family
    • Brady SM, Song S, Dhugga KS, Rafalski JA, Benfey PN (2007b) Combining expression and comparative evolutionary analysis. The COBRA gene family. Plant Physiol 143: 172-187
    • (2007) Plant Physiol , vol.143 , pp. 172-187
    • Brady, S.M.1    Song, S.2    Dhugga, K.S.3    Rafalski, J.A.4    Benfey, P.N.5
  • 10
  • 11
    • 65249162890 scopus 로고    scopus 로고
    • Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules
    • Cai S, Weaver LN, Ems-McClung SC, Walczak CE (2009b) Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell 20: 1348-1359
    • (2009) Mol Biol Cell , vol.20 , pp. 1348-1359
    • Cai, S.1    Weaver, L.N.2    Ems-Mcclung, S.C.3    Walczak, C.E.4
  • 12
    • 0033145508 scopus 로고    scopus 로고
    • Temporal and spatial control of cyclin B1 destruction in metaphase
    • Clute P, Pines J (1999) Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol 1: 82-87
    • (1999) Nat Cell Biol , vol.1 , pp. 82-87
    • Clute, P.1    Pines, J.2
  • 14
    • 12344309497 scopus 로고    scopus 로고
    • Requirements for the destruction of human Aurora-A
    • Crane R, Kloepfer A, Ruderman JV (2004b) Requirements for the destruction of human Aurora-A. J Cell Sci 117: 5975-5983
    • (2004) J Cell Sci , vol.117 , pp. 5975-5983
    • Crane, R.1    Kloepfer, A.2    Ruderman, J.V.3
  • 17
    • 0024565997 scopus 로고
    • Cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF
    • Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D (1989) Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56: 829-838
    • (1989) Cell , vol.56 , pp. 829-838
    • Draetta, G.1    Luca, F.2    Westendorf, J.3    Brizuela, L.4    Ruderman, J.5    Beach, D.6
  • 18
    • 35848955186 scopus 로고    scopus 로고
    • Human kid is degraded by the APC/C-Cdh1 but not by the APC/C-Cdc20
    • Feine O, Zur A, Mahbubani H, Brandeis M (2007) Human kid is degraded by the APC/C-Cdh1 but not by the APC/C-Cdc20. Cell Cycle 6: 2516-2523
    • (2007) Cell Cycle , vol.6 , pp. 2516-2523
    • Feine, O.1    Zur, A.2    Mahbubani, H.3    Brandeis, M.4
  • 19
    • 55249088712 scopus 로고    scopus 로고
    • APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase
    • Floyd S, Pines J, Lindon C (2008) APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase. Curr Biol 18: 1649-1658
    • (2008) Curr Biol , vol.18 , pp. 1649-1658
    • Floyd, S.1    Pines, J.2    Lindon, C.3
  • 21
    • 0035998835 scopus 로고    scopus 로고
    • Model-based clustering, discriminant analysis, and density estimation
    • Fraley C, Raftery A (2002) Model-based clustering, discriminant analysis, and density estimation. J Am Stat Assoc 97: 611-631
    • (2002) J Am Stat Assoc , vol.97 , pp. 611-631
    • Fraley, C.1    Raftery, A.2
  • 25
    • 0026089183 scopus 로고
    • Cyclin is degraded by the ubiquitin pathway
    • Glotzer M, Murray AW, Kirschner MW (1991) Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138
    • (1991) Nature , vol.349 , pp. 132-138
    • Glotzer, M.1    Murray, A.W.2    Kirschner, M.W.3
  • 26
    • 0035940430 scopus 로고    scopus 로고
    • Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p
    • Gordon DM, Roof DM (2001) Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p. Proc Natl Acad Sci USA 98: 12515-12520
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12515-12520
    • Gordon, D.M.1    Roof, D.M.2
  • 28
    • 0037166938 scopus 로고    scopus 로고
    • Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
    • Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J (2002) Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol 157: 1125-1137
    • (2002) J Cell Biol , vol.157 , pp. 1125-1137
    • Hagting, A.1    Den Elzen, N.2    Vodermaier, H.C.3    Waizenegger, I.C.4    Peters, J.M.5    Pines, J.6
  • 29
    • 84878881252 scopus 로고    scopus 로고
    • Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex
    • He J, Chao WC, Zhang Z, Yang J, Cronin N, Barford D (2013) Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell 50: 649-660
    • (2013) Mol Cell , vol.50 , pp. 649-660
    • He, J.1    Chao, W.C.2    Zhang, Z.3    Yang, J.4    Cronin, N.5    Barford, D.6
  • 30
    • 0035196619 scopus 로고    scopus 로고
    • Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence
    • Hildebrandt ER, Hoyt MA (2001) Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence. Mol Biol Cell 12: 3402-3416
    • (2001) Mol Biol Cell , vol.12 , pp. 3402-3416
    • Hildebrandt, E.R.1    Hoyt, M.A.2
  • 31
    • 47549083849 scopus 로고    scopus 로고
    • Positive feedback sharpens the anaphase switch
    • Holt LJ, Krutchinsky AN, Morgan DO (2008) Positive feedback sharpens the anaphase switch. Nature 454: 353-357
    • (2008) Nature , vol.454 , pp. 353-357
    • Holt, L.J.1    Krutchinsky, A.N.2    Morgan, D.O.3
  • 32
    • 79959735228 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells
    • Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA (2011) Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal 4: rs5
    • (2011) Sci Signal , vol.4
    • Kettenbach, A.N.1    Schweppe, D.K.2    Faherty, B.K.3    Pechenick, D.4    Pletnev, A.A.5    Gerber, S.A.6
  • 35
    • 0029004815 scopus 로고
    • A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
    • King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW (1995) A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81: 279-288
    • (1995) Cell , vol.81 , pp. 279-288
    • King, R.W.1    Peters, J.M.2    Tugendreich, S.3    Rolfe, M.4    Hieter, P.5    Kirschner, M.W.6
  • 37
    • 0036714512 scopus 로고    scopus 로고
    • Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
    • Littlepage LE, Ruderman JV (2002) Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev 16: 2274-2285
    • (2002) Genes Dev , vol.16 , pp. 2274-2285
    • Littlepage, L.E.1    Ruderman, J.V.2
  • 39
    • 84859078891 scopus 로고    scopus 로고
    • GPS-ARM: Computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes
    • Liu Z, Yuan F, Ren J, Cao J, Zhou Y, Yang Q, Xue Y (2012) GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes. PLoS One 7: e34370
    • (2012) PLoS One , vol.7
    • Liu, Z.1    Yuan, F.2    Ren, J.3    Cao, J.4    Zhou, Y.5    Yang, Q.6    Xue, Y.7
  • 41
    • 70349974263 scopus 로고    scopus 로고
    • Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages
    • Malik R, Lenobel R, Santamaria A, Ries A, Nigg EA, Korner R (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8: 4553-4563
    • (2009) J Proteome Res , vol.8 , pp. 4553-4563
    • Malik, R.1    Lenobel, R.2    Santamaria, A.3    Ries, A.4    Nigg, E.A.5    Korner, R.6
  • 42
    • 0032511148 scopus 로고    scopus 로고
    • Geminin, an inhibitor of DNA replication, is degraded during mitosis
    • McGarry TJ, Kirschner MW (1998) Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93: 1043-1053
    • (1998) Cell , vol.93 , pp. 1043-1053
    • McGarry, T.J.1    Kirschner, M.W.2
  • 43
    • 0003336439 scopus 로고
    • Mixture models: Inference and application to clustering
    • New York: Marcel Dekker
    • McLachlan GJ, Basford KE (1988) Mixture Models: Inference and Application to Clustering, Vol. 84, Statistics: Textbooks and Monographs. New York: Marcel Dekker
    • (1988) Statistics: Textbooks and Monographs , vol.84
    • McLachlan, G.J.1    Basford, K.E.2
  • 44
    • 62449196769 scopus 로고    scopus 로고
    • Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays
    • Merbl Y, Kirschner MW (2009) Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci USA 106: 2543-2548
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2543-2548
    • Merbl, Y.1    Kirschner, M.W.2
  • 45
    • 24344465919 scopus 로고    scopus 로고
    • Analysis of the kinesin superfamily: Insights into structure and function
    • Miki H, Okada Y, Hirokawa N (2005) Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol 15: 467-476
    • (2005) Trends Cell Biol , vol.15 , pp. 467-476
    • Miki, H.1    Okada, Y.2    Hirokawa, N.3
  • 46
    • 0032702315 scopus 로고    scopus 로고
    • The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle
    • Mountain V, Simerly C, Howard L, Ando A, Schatten G, Compton DA (1999) The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. J Cell Biol 147: 351-366
    • (1999) J Cell Biol , vol.147 , pp. 351-366
    • Mountain, V.1    Simerly, C.2    Howard, L.3    Ando, A.4    Schatten, G.5    Compton, D.A.6
  • 47
    • 0024978338 scopus 로고
    • Cyclin synthesis drives the early embryonic cell cycle
    • Murray AW, Kirschner MW (1989) Cyclin synthesis drives the early embryonic cell cycle. Nature 339: 275-280
    • (1989) Nature , vol.339 , pp. 275-280
    • Murray, A.W.1    Kirschner, M.W.2
  • 48
    • 0024978344 scopus 로고
    • The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
    • Murray AW, Solomon MJ, Kirschner MW (1989) The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339: 280-286
    • (1989) Nature , vol.339 , pp. 280-286
    • Murray, A.W.1    Solomon, M.J.2    Kirschner, M.W.3
  • 49
    • 0021644144 scopus 로고
    • Fitting straight lines to point patterns
    • Murtag F, Raftery A (1984) Fitting straight lines to point patterns. Pattern Recogn 17: 479-483
    • (1984) Pattern Recogn , vol.17 , pp. 479-483
    • Murtag, F.1    Raftery, A.2
  • 50
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6: 369-381
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 54
    • 33747589184 scopus 로고    scopus 로고
    • The anaphase promoting complex/cyclosome: A machine designed to destroy
    • Peters JM (2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 7: 644-656
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 644-656
    • Peters, J.M.1
  • 55
    • 0034654399 scopus 로고    scopus 로고
    • The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
    • Pfleger CM, Kirschner MW (2000) The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 14: 655-665
    • (2000) Genes Dev , vol.14 , pp. 655-665
    • Pfleger, C.M.1    Kirschner, M.W.2
  • 56
    • 10344247126 scopus 로고    scopus 로고
    • Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
    • Rape M, Kirschner MW (2004) Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432: 588-595
    • (2004) Nature , vol.432 , pp. 588-595
    • Rape, M.1    Kirschner, M.W.2
  • 57
    • 30344466977 scopus 로고    scopus 로고
    • The processivity of multiubiquitination by the APC determines the order of substrate degradation
    • Rape M, Reddy SK, Kirschner MW (2006) The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell 124: 89-103
    • (2006) Cell , vol.124 , pp. 89-103
    • Rape, M.1    Reddy, S.K.2    Kirschner, M.W.3
  • 59
    • 80053905112 scopus 로고    scopus 로고
    • Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability
    • Reinhold WC, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V (2011) Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability. PLoS One 6: e25991
    • (2011) PLoS One , vol.6
    • Reinhold, W.C.1    Erliandri, I.2    Liu, H.3    Zoppoli, G.4    Pommier, Y.5    Larionov, V.6
  • 61
    • 0024834127 scopus 로고
    • An essential G1 function for cyclin-like proteins in yeast
    • Richardson HE, Wittenberg C, Cross F, Reed SI (1989) An essential G1 function for cyclin-like proteins in yeast. Cell 59: 1127-1133
    • (1989) Cell , vol.59 , pp. 1127-1133
    • Richardson, H.E.1    Wittenberg, C.2    Cross, F.3    Reed, S.I.4
  • 62
    • 33646794376 scopus 로고    scopus 로고
    • Cytostatic factor: An activity that puts the cell cycle on hold
    • Schmidt A, Rauh NR, Nigg EA, Mayer TU (2006) Cytostatic factor: an activity that puts the cell cycle on hold. J Cell Sci 119: 1213-1218
    • (2006) J Cell Sci , vol.119 , pp. 1213-1218
    • Schmidt, A.1    Rauh, N.R.2    Nigg, E.A.3    Mayer, T.U.4
  • 63
    • 84872849589 scopus 로고    scopus 로고
    • Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex
    • Sedgwick GG, Hayward DG, Di Fiore B, Pardo M, Yu L, Pines J, Nilsson J (2013) Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. EMBO J 32: 303-314
    • (2013) EMBO J , vol.32 , pp. 303-314
    • Sedgwick, G.G.1    Hayward, D.G.2    Di Fiore, B.3    Pardo, M.4    Yu, L.5    Pines, J.6    Nilsson, J.7
  • 65
    • 66749190541 scopus 로고    scopus 로고
    • FLEXIQuant: A novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides
    • Singh S, Springer M, Steen J, Kirschner MW, Steen H (2009) FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res 8: 2201-2210
    • (2009) J Proteome Res , vol.8 , pp. 2201-2210
    • Singh, S.1    Springer, M.2    Steen, J.3    Kirschner, M.W.4    Steen, H.5
  • 68
    • 0000120766 scopus 로고
    • Estimating the dimension of a model
    • Swartz G (1978) Estimating the dimension of a model. Ann Stat 6: 461-464
    • (1978) Ann Stat , vol.6 , pp. 461-464
    • Swartz, G.1
  • 69
    • 84868551354 scopus 로고    scopus 로고
    • Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
    • Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X (2012) Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci USA 109: 18419-18424
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18419-18424
    • Tian, W.1    Li, B.2    Warrington, R.3    Tomchick, D.R.4    Yu, H.5    Luo, X.6
  • 70
    • 0037138452 scopus 로고    scopus 로고
    • Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities
    • Villerbu N, Gaben AM, Redeuilh G, Mester J (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer 97: 761-769
    • (2002) Int J Cancer , vol.97 , pp. 761-769
    • Villerbu, N.1    Gaben, A.M.2    Redeuilh, G.3    Mester, J.4
  • 72
    • 0031020735 scopus 로고    scopus 로고
    • XCTK2: A kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts
    • Walczak CE, Verma S, Mitchison TJ (1997) XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. J Cell Biol 136: 859-870
    • (1997) J Cell Biol , vol.136 , pp. 859-870
    • Walczak, C.E.1    Verma, S.2    Mitchison, T.J.3
  • 74
    • 82955187009 scopus 로고    scopus 로고
    • Optimization of cell lysis and protein digestion protocols for the analysis of HeLa S3 cells by LC-MS/MS
    • Winter D, Steen H (2011) Optimization of cell lysis and protein digestion protocols for the analysis of HeLa S3 cells by LC-MS/MS. Proteomics 11: 4726-4730
    • (2011) Proteomics , vol.11 , pp. 4726-4730
    • Winter, D.1    Steen, H.2
  • 75
    • 79960726254 scopus 로고    scopus 로고
    • Phosphatases: Providing safe passage through mitotic exit
    • Wurzenberger C, Gerlich DW (2011) Phosphatases: providing safe passage through mitotic exit. Nat Rev Mol Cell Biol 12: 469-482
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 469-482
    • Wurzenberger, C.1    Gerlich, D.W.2
  • 77
    • 21844473254 scopus 로고    scopus 로고
    • Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
    • Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W (2005) Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell 16: 3187-3199
    • (2005) Mol Biol Cell , vol.16 , pp. 3187-3199
    • Zhu, C.1    Zhao, J.2    Bibikova, M.3    Leverson, J.D.4    Bossy-Wetzel, E.5    Fan, J.B.6    Abraham, R.T.7    Jiang, W.8
  • 78
    • 0033575347 scopus 로고    scopus 로고
    • Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
    • Zou H, McGarry TJ, Bernal T, Kirschner MW (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285: 418-422
    • (1999) Science , vol.285 , pp. 418-422
    • Zou, H.1    McGarry, T.J.2    Bernal, T.3    Kirschner, M.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.