Identification of SCF ubiquitin ligase substrates by global protein stability profiling

Science

Volumn 322, Issue 5903, 2008, Pages 923-929

  Yen, Hsueh Chi Sherry ^a   Elledge, Stephen J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; GREEN FLUORESCENT PROTEIN; HEMAGGLUTININ; HYBRID PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3;

APOPTOSIS; DISEASE; IDENTIFICATION METHOD; MAMMAL; PROTEIN; SUBSTRATE;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE REGULATION; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; FLUORESCENCE ACTIVATED CELL SORTING; GENE TECHNOLOGY; HUMAN; HUMAN CELL; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; WESTERN BLOTTING;

APOPTOSIS; CDC25 PHOSPHATASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CULLIN PROTEINS; GREEN FLUORESCENT PROTEINS; HALF-LIFE; HUMANS; LUMINESCENT PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPEN READING FRAMES; PROTEIN STABILITY; PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 55849133733     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160462     Document Type: Article

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