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Volumn 23, Issue 5, 2016, Pages 821-836

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(54)  Yavari, Arash a,b   Stocker, Claire J c   Ghaffari, Sahar a,b   Wargent, Edward T c   Steeples, Violetta a,b   Czibik, Gabor a,b   Pinter, Katalin a,b   Bellahcene, Mohamed a,b   Woods, Angela d   Martínez De Morentin, Pablo B e   Cansell, Céline e   Lam, Brian Y H f   Chuster, André g   Petkevicius, Kasparas f   Nguyen Tu, Marie Sophie d   Martinez Sanchez, Aida d   Pullen, Timothy J d   Oliver, Peter L a   Stockenhuber, Alexander a,b   Nguyen, Chinh a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

GAMMA 2 AMP ACTIVATED PROTEIN KINASE; GHRELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; UNCLASSIFIED DRUG;

EID: 84964600616     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.04.003     Document Type: Article
Times cited : (84)

References (70)
  • 3
    • 84858383401 scopus 로고    scopus 로고
    • Diabetes mellitus and the β cell: The last ten years
    • F.M. Ashcroft, and P. Rorsman Diabetes mellitus and the β cell: the last ten years Cell 148 2012 1160 1171
    • (2012) Cell , vol.148 , pp. 1160-1171
    • Ashcroft, F.M.1    Rorsman, P.2
  • 5
    • 84903778851 scopus 로고    scopus 로고
    • Prevention of chronic disease in the 21st century: Elimination of the leading preventable causes of premature death and disability in the USA
    • U.E. Bauer, P.A. Briss, R.A. Goodman, and B.A. Bowman Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA Lancet 384 2014 45 52
    • (2014) Lancet , vol.384 , pp. 45-52
    • Bauer, U.E.1    Briss, P.A.2    Goodman, R.A.3    Bowman, B.A.4
  • 6
    • 77954737056 scopus 로고    scopus 로고
    • Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia
    • C. Beall, K. Piipari, H. Al-Qassab, M.A. Smith, N. Parker, D. Carling, B. Viollet, D.J. Withers, and M.L. Ashford Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia Biochem. J. 429 2010 323 333
    • (2010) Biochem. J. , vol.429 , pp. 323-333
    • Beall, C.1    Piipari, K.2    Al-Qassab, H.3    Smith, M.A.4    Parker, N.5    Carling, D.6    Viollet, B.7    Withers, D.J.8    Ashford, M.L.9
  • 7
    • 0035872209 scopus 로고    scopus 로고
    • Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
    • E. Blair, C. Redwood, H. Ashrafian, M. Oliveira, J. Broxholme, B. Kerr, A. Salmon, I. Ostman-Smith, and H. Watkins Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis Hum. Mol. Genet. 10 2001 1215 1220
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1215-1220
    • Blair, E.1    Redwood, C.2    Ashrafian, H.3    Oliveira, M.4    Broxholme, J.5    Kerr, B.6    Salmon, A.7    Ostman-Smith, I.8    Watkins, H.9
  • 8
    • 84925873653 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms across evolution
    • L. Chantranupong, R.L. Wolfson, and D.M. Sabatini Nutrient-sensing mechanisms across evolution Cell 161 2015 67 83
    • (2015) Cell , vol.161 , pp. 67-83
    • Chantranupong, L.1    Wolfson, R.L.2    Sabatini, D.M.3
  • 10
    • 0034654362 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
    • P.C. Cheung, I.P. Salt, S.P. Davies, D.G. Hardie, and D. Carling Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding Biochem. J. 346 2000 659 669
    • (2000) Biochem. J. , vol.346 , pp. 659-669
    • Cheung, P.C.1    Salt, I.P.2    Davies, S.P.3    Hardie, D.G.4    Carling, D.5
  • 12
    • 33744514139 scopus 로고    scopus 로고
    • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
    • B. Cool, B. Zinker, W. Chiou, L. Kifle, N. Cao, M. Perham, R. Dickinson, A. Adler, G. Gagne, R. Iyengar, and et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Cell Metab. 3 2006 403 416
    • (2006) Cell Metab. , vol.3 , pp. 403-416
    • Cool, B.1    Zinker, B.2    Chiou, W.3    Kifle, L.4    Cao, N.5    Perham, M.6    Dickinson, R.7    Adler, A.8    Gagne, G.9    Iyengar, R.10
  • 14
    • 0038584871 scopus 로고    scopus 로고
    • Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
    • G. da Silva Xavier, I. Leclerc, A. Varadi, T. Tsuboi, S.K. Moule, and G.A. Rutter Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression Biochem. J. 371 2003 761 774
    • (2003) Biochem. J. , vol.371 , pp. 761-774
    • Da Silva Xavier, G.1    Leclerc, I.2    Varadi, A.3    Tsuboi, T.4    Moule, S.K.5    Rutter, G.A.6
  • 15
    • 0024839973 scopus 로고
    • Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay
    • S.P. Davies, D. Carling, and D.G. Hardie Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay Eur. J. Biochem. 186 1989 123 128
    • (1989) Eur. J. Biochem. , vol.186 , pp. 123-128
    • Davies, S.P.1    Carling, D.2    Hardie, D.G.3
  • 16
    • 84866108680 scopus 로고    scopus 로고
    • Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons
    • M.O. Dietrich, and T.L. Horvath Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons Nat. Rev. Drug Discov. 11 2012 675 691
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 675-691
    • Dietrich, M.O.1    Horvath, T.L.2
  • 17
    • 84884877043 scopus 로고    scopus 로고
    • Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
    • M.O. Dietrich, Z.W. Liu, and T.L. Horvath Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity Cell 155 2013 188 199
    • (2013) Cell , vol.155 , pp. 188-199
    • Dietrich, M.O.1    Liu, Z.W.2    Horvath, T.L.3
  • 19
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars: Molecular progress confronts an expanding epidemic
    • J.S. Flier Obesity wars: molecular progress confronts an expanding epidemic Cell 116 2004 337 350
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 22
    • 65349152290 scopus 로고    scopus 로고
    • Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: Novel mechanisms integrating HSL and ATGL
    • M.P. Gaidhu, S. Fediuc, N.M. Anthony, M. So, M. Mirpourian, R.L. Perry, and R.B. Ceddia Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL J. Lipid Res. 50 2009 704 715
    • (2009) J. Lipid Res. , vol.50 , pp. 704-715
    • Gaidhu, M.P.1    Fediuc, S.2    Anthony, N.M.3    So, M.4    Mirpourian, M.5    Perry, R.L.6    Ceddia, R.B.7
  • 23
    • 0242637318 scopus 로고    scopus 로고
    • MTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    • K.M. Hannan, Y. Brandenburger, A. Jenkins, K. Sharkey, A. Cavanaugh, L. Rothblum, T. Moss, G. Poortinga, G.A. McArthur, R.B. Pearson, and R.D. Hannan mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF Mol. Cell. Biol. 23 2003 8862 8877
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8862-8877
    • Hannan, K.M.1    Brandenburger, Y.2    Jenkins, A.3    Sharkey, K.4    Cavanaugh, A.5    Rothblum, L.6    Moss, T.7    Poortinga, G.8    McArthur, G.A.9    Pearson, R.B.10    Hannan, R.D.11
  • 24
    • 84919621076 scopus 로고    scopus 로고
    • AMPK - Sensing energy while talking to other signaling pathways
    • D.G. Hardie AMPK - sensing energy while talking to other signaling pathways Cell Metab. 20 2014 939 952
    • (2014) Cell Metab. , vol.20 , pp. 939-952
    • Hardie, D.G.1
  • 25
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor - Identification of a potent inverse agonist
    • B. Holst, A. Cygankiewicz, T.H. Jensen, M. Ankersen, and T.W. Schwartz High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist Mol. Endocrinol. 17 2003 2201 2210
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 26
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 27
    • 84932109475 scopus 로고    scopus 로고
    • PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain
    • T.E. Jensen, F.A. Ross, M. Kleinert, L. Sylow, J.R. Knudsen, G.J. Gowans, D.G. Hardie, and E.A. Richter PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain Biochem. J. 467 2015 461 472
    • (2015) Biochem. J. , vol.467 , pp. 461-472
    • Jensen, T.E.1    Ross, F.A.2    Kleinert, M.3    Sylow, L.4    Knudsen, J.R.5    Gowans, G.J.6    Hardie, D.G.7    Richter, E.A.8
  • 28
    • 64849089976 scopus 로고    scopus 로고
    • Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria
    • S.K. Jo, W.Y. Lee, E.J. Rhee, J.C. Won, C.H. Jung, C.Y. Park, K.W. Oh, S.W. Park, and S.W. Kim Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria Clin. Chim. Acta 403 2009 234 240
    • (2009) Clin. Chim. Acta , vol.403 , pp. 234-240
    • Jo, S.K.1    Lee, W.Y.2    Rhee, E.J.3    Won, J.C.4    Jung, C.H.5    Park, C.Y.6    Oh, K.W.7    Park, S.W.8    Kim, S.W.9
  • 29
    • 77954694568 scopus 로고    scopus 로고
    • Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin
    • Z. Jovanovic, Y.C. Tung, B.Y. Lam, S. O'Rahilly, and G.S. Yeo Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin J. Neuroendocrinol. 22 2010 915 925
    • (2010) J. Neuroendocrinol. , vol.22 , pp. 915-925
    • Jovanovic, Z.1    Tung, Y.C.2    Lam, B.Y.3    O'Rahilly, S.4    Yeo, G.S.5
  • 30
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Cell Metab. 1 2005 15 25
    • (2005) Cell Metab. , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 34
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • J.C. Levy, D.R. Matthews, and M.P. Hermans Correct homeostasis model assessment (HOMA) evaluation uses the computer program Diabetes Care 21 1998 2191 2192
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 35
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, B. Jiang, O. Park, Z. Luo, E. Lefai, J.Y. Shyy, and et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab. 13 2011 376 388
    • (2011) Cell Metab. , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6    Park, O.7    Luo, Z.8    Lefai, E.9    Shyy, J.Y.10
  • 36
    • 84863012024 scopus 로고    scopus 로고
    • Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone
    • T. Liu, D. Kong, B.P. Shah, C. Ye, S. Koda, A. Saunders, J.B. Ding, Z. Yang, B.L. Sabatini, and B.B. Lowell Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone Neuron 73 2012 511 522
    • (2012) Neuron , vol.73 , pp. 511-522
    • Liu, T.1    Kong, D.2    Shah, B.P.3    Ye, C.4    Koda, S.5    Saunders, A.6    Ding, J.B.7    Yang, Z.8    Sabatini, B.L.9    Lowell, B.B.10
  • 38
    • 77950908035 scopus 로고    scopus 로고
    • "control" laboratory rodents are metabolically morbid: Why it matters
    • B. Martin, S. Ji, S. Maudsley, and M.P. Mattson "Control" laboratory rodents are metabolically morbid: why it matters Proc. Natl. Acad. Sci. USA 107 2010 6127 6133
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 6127-6133
    • Martin, B.1    Ji, S.2    Maudsley, S.3    Mattson, M.P.4
  • 39
    • 84936123498 scopus 로고    scopus 로고
    • DICER inactivation identifies pancreatic β-cell "disallowed" genes targeted by microRNAs
    • A. Martinez-Sanchez, M.S. Nguyen-Tu, and G.A. Rutter DICER inactivation identifies pancreatic β-cell "disallowed" genes targeted by microRNAs Mol. Endocrinol. 29 2015 1067 1079
    • (2015) Mol. Endocrinol. , vol.29 , pp. 1067-1079
    • Martinez-Sanchez, A.1    Nguyen-Tu, M.S.2    Rutter, G.A.3
  • 41
    • 84894170947 scopus 로고    scopus 로고
    • The central nervous system sites mediating the orexigenic actions of ghrelin
    • B.L. Mason, Q. Wang, and J.M. Zigman The central nervous system sites mediating the orexigenic actions of ghrelin Annu. Rev. Physiol. 76 2014 519 533
    • (2014) Annu. Rev. Physiol. , vol.76 , pp. 519-533
    • Mason, B.L.1    Wang, Q.2    Zigman, J.M.3
  • 45
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011-2012
    • C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal Prevalence of childhood and adult obesity in the United States, 2011-2012 JAMA 311 2014 806 814
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 46
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • M.M. Ollmann, B.D. Wilson, Y.K. Yang, J.A. Kerns, Y. Chen, I. Gantz, and G.S. Barsh Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 278 1997 135 138
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 47
    • 82355161907 scopus 로고    scopus 로고
    • High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
    • D. Pesta, and E. Gnaiger High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle Methods Mol. Biol. 810 2012 25 58
    • (2012) Methods Mol. Biol. , vol.810 , pp. 25-58
    • Pesta, D.1    Gnaiger, E.2
  • 48
    • 84877601932 scopus 로고    scopus 로고
    • When less is more: The forbidden fruits of gene repression in the adult β-cell
    • T.J. Pullen, and G.A. Rutter When less is more: the forbidden fruits of gene repression in the adult β-cell Diabetes Obes. Metab. 15 2013 503 512
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 503-512
    • Pullen, T.J.1    Rutter, G.A.2
  • 49
  • 53
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 56
    • 14244254196 scopus 로고    scopus 로고
    • Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
    • K.A. Takahashi, and R.D. Cone Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons Endocrinology 146 2005 1043 1047
    • (2005) Endocrinology , vol.146 , pp. 1043-1047
    • Takahashi, K.A.1    Cone, R.D.2
  • 59
    • 0346732321 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics
    • T. Tsuboi, G. da Silva Xavier, I. Leclerc, and G.A. Rutter 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics J. Biol. Chem. 278 2003 52042 52051
    • (2003) J. Biol. Chem. , vol.278 , pp. 52042-52051
    • Tsuboi, T.1    Da Silva Xavier, G.2    Leclerc, I.3    Rutter, G.A.4
  • 63
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • M.G. Willesen, P. Kristensen, and J. Rømer Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat Neuroendocrinology 70 1999 306 316
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Rømer, J.3
  • 66
  • 67
    • 80052922112 scopus 로고    scopus 로고
    • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    • Y. Yang, D. Atasoy, H.H. Su, and S.M. Sternson Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop Cell 146 2011 992 1003
    • (2011) Cell , vol.146 , pp. 992-1003
    • Yang, Y.1    Atasoy, D.2    Su, H.H.3    Sternson, S.M.4
  • 68
    • 84866666334 scopus 로고    scopus 로고
    • Unraveling the brain regulation of appetite: Lessons from genetics
    • G.S. Yeo, and L.K. Heisler Unraveling the brain regulation of appetite: lessons from genetics Nat. Neurosci. 15 2012 1343 1349
    • (2012) Nat. Neurosci. , vol.15 , pp. 1343-1349
    • Yeo, G.S.1    Heisler, L.K.2
  • 69
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • B.B. Zhang, G. Zhou, and C. Li AMPK: an emerging drug target for diabetes and the metabolic syndrome Cell Metab. 9 2009 407 416
    • (2009) Cell Metab. , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3


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