Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

Chemistry and Biology

Volumn 22, Issue 6, 2015, Pages 705-711

  Scott, John W ^a   Galic, Sandra ^a   Graham, Kate L ^b   Foitzik, Richard ^c   Ling, Naomi X Y ^a   Dite, Toby A ^a   Issa, Samah M A ^a   Langendorf, Chris G ^a   Weng, Qing Ping ^d   Thomas, Helen E ^b   Kay, Thomas W ^b   Birnberg, Neal C ^d   Steinberg, Gregory R ^e   Kemp, Bruce E ^a   Oakhill, Jonathan S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d Mercury Therapeutics Inc   (United States)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; ISOLEUCINE; MT47 100; PHENYLALANINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; GLUCOSE; ISOPROTEIN; MT47-100; PROTEIN BINDING; QUINOLINOL DERIVATIVE;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BINDING SITES; GLUCOSE; HUMANS; HYDROXYQUINOLINES; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION;

EID: 84935013342     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.05.011     Document Type: Article

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