Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

Biochemical Journal

Volumn 429, Issue 2, 2010, Pages 323-333

  Beall, Craig ^a   Piipari, Kaisa ^b   Al Qassab, Hind ^b   Smith, Mark A ^a,b   Parker, Nadeene ^c   Carling, David ^b   Viollet, Benoit ^d   Withers, Dominic J ^b   Ashford, Michael L J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d INSERM   (France)

Author keywords

cell; AMP activated protein kinase (AMPK); ATP sensitive potassium channel (K ATP); Glucokinase; Pancreas; Uncoupling protein 2 (UCP2)

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; GLUCOKINASE; PANCREAS; POTASSIUM CHANNELS; UNCOUPLING PROTEINS;

BODY FLUIDS; CELLS; CYTOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; INSULIN; PHYSIOLOGY; POTASSIUM; PROTEINS;

GLUCOSE;

AMP ACTIVATED PROTEIN KINASE ALPHA 2; GENIPIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; ADENOSINE TRIPHOSPHATE; AMPK ALPHA1 SUBUNIT, MOUSE; AMPK ALPHA2 SUBUNIT, MOUSE; GLUCOKINASE; GLUCOSE TRANSPORTER 2; INSULIN; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; SLC2A2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERPOLARIZATION; HYPOGLYCEMIA; INSULIN RELEASE; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HOMEOSTASIS; HYPOTHALAMUS; IN VITRO STUDY; METABOLISM; MOUSE MUTANT; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SECRETION; SIGNAL TRANSDUCTION;

MUS;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HOMEOSTASIS; HYPOGLYCEMIA; HYPOTHALAMUS; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; RATS; SIGNAL TRANSDUCTION;

EID: 77954737056     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100231     Document Type: Article

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