Serum γ-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria

Clinica Chimica Acta

Volumn 403, Issue 1-2, 2009, Pages 234-240

  Jo, Sook Kyoung ^a   Lee, Won Young ^b   Rhee, Eun Jung ^b   Won, Jong Chul ^c   Jung, Chan Hee ^d   Park, Cheol Young ^b   Oh, Ki Won ^b   Park, Sung Woo ^b   Kim, Sun Woo ^b  

^a SAM Anyang Hospital   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Glutamyl transferase; Alanine aminotransferase; International Diabetes Federation; Metabolic syndrome

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AGED; AGED, 80 AND OVER; AMERICAN HEART ASSOCIATION; AREA UNDER CURVE; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; INTERNATIONAL AGENCIES; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; UNITED STATES;

EID: 64849089976     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.03.035     Document Type: Article

References (38)

1. Nemesanszky E., and Lott J.A. γ-Glutamyltransferase and its isoenzymes: progress and problems. Clin Chem 31 (1985) 797-803
2. Whitfield J.B. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 38 (2001) 263-355
3. Nannipieri M., Gonzales C., Baldi S., et al. Mexico City diabetes study. Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study. Diabetes Care 28 (2005) 1757-1762
4. Lee D.H., Silventoinen K., Jacobs D.R., Jousilahti P., and Tuomileto J. γ-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women. J Clin Endocrinol Metab 89 (2004) 5410-5414
5. Perry I.J., Wannamethee S.G., and Shaper A.G. Prospective study of serum γ-glutamyltransferase and risk of NIDDM. Diabetes Care 21 (1998) 732-737
6. Stranges S., Trevisan M., Dorn J.M., Dmochowski J., and Donahue R.P. Body fat distribution, liver enzymes, and risk of hypertension: evidence from the Western New York Study. Hypertension 46 (2005) 1186-1193
7. Wannamethee G., Ebrahim S., and Shaper A.G. Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 142 (1995) 699-708
8. Lee D.S., Evans J.C., Robins S.J., et al. Gamma glutamyltransferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol 27 (2007) 127-133
9. Schindhelm R.K., Diamant M., Dekker J.M., et al. Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes Metab Res Rev 22 (2006) 437-443
10. Marchesini G., Brizi M., Bianchi G., et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50 (2001) 1844-1850
11. Lann D., and LeRoith D. Insulin resistance as the underlying cause for the metabolic syndrome. Med Clin North Am 91 (2007) 1063-1077
12. Alberti K.G., Zimmet P., and Shaw J. International Diabetes Federation. The metabolic syndrome-a new worldwide definition. Lancet 366 (2005) 1059-1062
13. Grundy S.M., Cleeman J.I., Daniels S.R., et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112 (2005) 2735-2752
14. Wallace T.M., Utzschneider K.M., Tong J., et al. Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat. Diabetes Care 30 (2007) 2673-2678
15. André P., Balkau B., Vol S., Charles M.A., and Eschwège E. DESIR Study Group. Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort. Diabetes Care 30 (2007) 2355-2361
16. Lee M.Y., Koh S.B., Koh J.H., et al. Relationship between gamma-glutamyltransferase and metabolic syndrome in a Korean population. Diabet Med 25 (2008) 469-475
17. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28 (1985) 412-419
18. Dekker J.M., Girman C., Rhodes T., et al. Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation 112 (2005) 666-673
19. Hunt K.J., Resendez R.G., Williams K., Haffner S.M., and Stern M.P. National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study. Circulation 110 (2004) 1251-1257
20. Katzmarzyk P.T., Janssen I., Ross R., Church T.S., and Blair S.N. The importance of waist circumference in the definition of metabolic syndrome: prospective analyses of mortality in men. Diabetes Care 29 (2006) 404-409
21. Sundstrom J., Riserus U., Byberg L., et al. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 332 (2006) 878-882
22. Lorenzo C., Williams K., Hunt K.J., and Haffner S.M. The National Cholesterol Education Program-Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care 30 (2007) 8-13
23. Lakka H.M., Laaksonen D.E., Lakka T.A., et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288 (2002) 2709-2716
24. Kang Y.H., Min H.K., Son S.M., Kim I.J., and Kim Y.K. The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults. Diabetes Res Clin Pract 77 (2007) 306-313
25. Lippi G., Targher G., Montagnana M., Salvagno G.L., and Guidi G.C. Relationship between gamma-glutamyltransferase, lipids and lipoprotein(a) in the general population. Clin Chim Acta 384 (2007) 163-166
26. Lieberman M.W., Barrios R., Carter B.Z., et al. Gamma-glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?. Am J Pathol 147 (1995) 1175-1185
27. Whitfield J.B. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 38 (2001) 263-355
28. Lee D.H., Blomhoff R., and Jacobs D.R. Is serum gamma glutamytransferase a marker of oxidative stress?. Free Radic Res 38 (2004) 535-539
29. Lee D.H., Ha M.H., Kam S., et al. A strong secular trend in serum gamma-glutamytransferase from 1996 to 2003, among South Korean Men. Am J Epidemiol 163 (2006) 57-65
30. Blaha M., and Elasy T.A. Clinical use of the metabolic syndrome: why the confusion?. Clin Diabetes 24 (2006) 125-131
31. Stark A.A. Oxidative metabolism of glutathione by gamma-glutamyl transpeptidase and peroxisome proliferation: the relevance to hepatocarcinogenesis: a hypothesis. Mutagenesis 6 (1991) 241-245
32. Evans J.L., Goldfine I.D., Maddux B.A., and Grodsky G.M. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?. Diabetes 52 (2003) 1-8
33. Giral P., Jacob N., Dourmap C., et al. Elevated gamma-glutamyltransferase activity and perturbed thiol profile are associated with features of metabolic syndrome. Arterioscler Thromb Vasc Biol 28 (2008) 587-593
34. Dixon J.B., Bhathal P.S., and O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121 (2001) 91-100
35. Ikai E., Ishizaki M., Suzuki Y., et al. Association between hepatic steatosis, insulin resistance and hyperinsulinemia as related to hypertension in alcohol consumers and obese people. J Hum Hypertens 9 (1995) 101-105
36. Westerbacka J., Corner A., Tiikkainen M., et al. Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 47 (2004) 1360-1369
37. Hanley A.J., Wagenknecht L.E., Festa A., D'Agostino Jr. R.B., and Haffner S.M. Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Diabetes Care 30 (2007) 1819-1827
38. Fraser A., Ebrahim S., Smith G.D., and Lawlor D.A. A comparison of associations of alanine aminotramsferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes. Hepatology 46 (2007) 158-165