Critical molecular determinants of α7 nicotinic acetylcholine receptor allosteric activation: Separation of direct allosteric activation and positive allosteric modulation

Journal of Biological Chemistry

Volumn 291, Issue 10, 2016, Pages 5049-5067

  Horenstein, Nicole A ^a   Papke, Roger L ^b   Kulkarni, Abhijit R ^c   Chaturbhuj, Ganesh U ^c   Stokes, Clare ^b   Manther, Khan ^b   Thakur, Ganesh A ^c  

^a University of Florida   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SULFUR COMPOUNDS; TOBACCO;

ALLOSTERIC ACTIVATION; ALLOSTERIC MODULATION; EXTRACELLULAR DOMAINS; MOLECULAR DETERMINANTS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); POSITIVE ALLOSTERIC MODULATOR; TETRAHYDROQUINOLINE;

CHEMICAL ACTIVATION;

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYL 3 ISOXAZOLYL)UREA; BUNGAROTOXIN RECEPTOR; GAT 107; NICOTINIC AGENT; UNCLASSIFIED DRUG; 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-METHYLISOXAZOL-3-YL)UREA; 4-(4-BROMOPHENYL)-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA(C)QUINOLINE-8-SULFONAMIDE; CARBANILAMIDE DERIVATIVE; ISOXAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; SULFONAMIDE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; SYNTHESIS; XENOPUS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; AMINO ACID SEQUENCE; ANIMALS; HUMANS; ISOXAZOLES; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; NICOTINIC AGONISTS; PHENYLUREA COMPOUNDS; QUINOLINES; SULFONAMIDES; XENOPUS;

EID: 84964579535     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.692392     Document Type: Article

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